Works by Takaomi C. Saido

Results: 234

Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock‐In Mouse Model of Amyloidopathy.

Published in:

Genes, Brain & Behavior, 2025, v. 24, n. 3, p. 1, doi. 10.1111/gbb.70024

By:

Dumont, Julie R.;
Sheppard, Paul A. S.;
Fodor, Chris;
Coto, M. Alexander;
Yang, Sabrina;
Saito, Takashi;
Saido, Takaomi C.;
Rylett, R. Jane;
Prado, Marco A. M.;
Bussey, Timothy J.;
Saksida, Lisa M.;
Prado, Vania F.

Publication type:

Article

Correction: Long-term systemic androgen deprivation partially modulates neuroinflammation in male AppNL−G−F/NL−G−F mice.

Published in:

2025

By:

Maekawa, Kasumi;
Sobue, Akira;
Komine, Okiru;
Saito, Yuko;
Murayama, Shigeo;
Saido, Takaomi C.;
Saito, Takashi;
Yamanaka, Koji

Publication type:

Correction Notice

The Role of Neprilysin and Insulin-Degrading Enzyme in the Etiology of Sporadic Alzheimer's Disease.

Published in:

Journal of Neuroscience, 2025, v. 45, n. 23, p. 1, doi. 10.1523/JNEUROSCI.2152-24.2025

By:

Takahiro Morito;
Shoko Hashimoto;
Risa Takamura;
Naoto Watamura;
Naomasa Kakiya;
Ryo Fujioka;
Naomi Mihara;
Misaki Sekiguchi;
Kaori Watanabe-Iwata;
Naoko Kamano;
Mohan Qi;
Yukio Matsuba;
Satoshi Tsubuki;
Takashi Saito;
Nobuhisa Iwata;
Hiroki Sasaguri;
Saido, Takaomi C.

Publication type:

Article

Evaluation of the Alterations in Central Cholinergic Neurotransmission in Aging and Amyloid Precursor Protein Knock‐In Mice.

Published in:

Journal of Neurochemistry, 2025, v. 169, n. 5, p. 1, doi. 10.1111/jnc.70081

By:

Nagai‐Arakawa, Itsumi;
Muramatsu, Ikunobu;
Uwada, Junsuke;
Tsuda, Yo;
Tokunaga, Akinori;
Irie, Ai;
Maeda, Hideyuki;
Madokoro, Yuta;
Sato, Toyohiro;
Uchida, Yuto;
Saito, Takashi;
Saido, Takaomi C.;
Sada, Kiyonao;
Masuoka, Takayoshi;
Matsukawa, Noriyuki

Publication type:

Article

Looking beyond the standard version of the Morris water task in the assessment of mouse models of cognitive deficits.

Published in:

Hippocampus, 2019, v. 29, n. 1, p. 3, doi. 10.1002/hipo.22999

By:

Mehla, Jogender;
Deibel, Scott H.;
Faraji, Jamshid;
Saito, Takashi;
Saido, Takaomi C;
Mohajerani, Majid H.;
McDonald, Robert J.

Publication type:

Article

Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates.

Published in:

Hippocampus, 2003, v. 13, n. 7, p. 791, doi. 10.1002/hipo.10127

By:

Yamashima, Tetsumori;
Tonchev, Anton B.;
Tsukada, Toshiyuki;
Saido, Takaomi C.;
Imajoh-Ohmi, Shinobu;
Momoi, Takashi;
Kominami, Eiki

Publication type:

Article

Correction: Hoshi et al. High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer's Disease. Metabolites 2022, 12 , 355.

Published in:

2023

By:

Hoshi, Kyoka;
Kanno, Mayumi;
Abe, Mitsunari;
Murakami, Takenobu;
Ugawa, Yoshikazu;
Goto, Aya;
Honda, Takashi;
Saito, Takashi;
Saido, Takaomi C.;
Yamaguchi, Yoshiki;
Miyajima, Masakazu;
Furukawa, Katsutoshi;
Arai, Hiroyuki;
Hashimoto, Yasuhiro

Publication type:

Correction Notice

High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer's Disease.

Published in:

Metabolites (2218-1989), 2022, v. 12, n. 4, p. N.PAG, doi. 10.3390/metabo12040355

By:

Hoshi, Kyoka;
Kanno, Mayumi;
Abe, Mitsunari;
Murakami, Takenobu;
Ugawa, Yoshikazu;
Goto, Aya;
Honda, Takashi;
Saito, Takashi;
Saido, Takaomi C.;
Yamaguchi, Yoshiki;
Miyajima, Masakazu;
Furukawa, Katsutoshi;
Arai, Hiroyuki;
Hashimoto, Yasuhiro

Publication type:

Article

Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimer's Disease.

Published in:

Metabolites (2218-1989), 2021, v. 11, n. 9, p. 616, doi. 10.3390/metabo11090616

By:

Hoshi, Kyoka;
Ito, Hiromi;
Abe, Eriko;
Fuwa, Takashi J.;
Kanno, Mayumi;
Murakami, Yuta;
Abe, Mitsunari;
Murakami, Takenobu;
Yoshihara, Akioh;
Ugawa, Yoshikazu;
Saito, Takashi;
Saido, Takaomi C.;
Matsumoto, Kana;
Yamaguchi, Yoshiki;
Furukawa, Katsutoshi;
Arai, Hiroyuki;
Kanai, Mitsuyasu;
Miyajima, Masakazu;
Arai, Hajime;
Ogawa, Norihiro

Publication type:

Article

Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer's Disease-Related Pathological Progression in the Hippocampus of AppNL-G-F/NL-G-F Mice.

Published in:

Frontiers in Pharmacology, 2020, p. 1, doi. 10.3389/fphar.2020.00307

By:

Hongo, Nobuko;
Takamura, Yusaku;
Nishimaru, Hiroshi;
Matsumoto, Jumpei;
Tobe, Kazuyuki;
Saito, Takashi;
Saido, Takaomi C.;
Nishijo, Hisao

Publication type:

Article

Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.

Published in:

Cell Death & Disease, 2021, v. 12, n. 8, p. 1, doi. 10.1038/s41419-021-04062-3

By:

Bettegazzi, Barbara;
Sebastian Monasor, Laura;
Bellani, Serena;
Codazzi, Franca;
Restelli, Lisa Michelle;
Colombo, Alessio Vittorio;
Deigendesch, Nikolaus;
Frank, Stephan;
Saito, Takashi;
Saido, Takaomi C.;
Lammich, Sven;
Tahirovic, Sabina;
Grohovaz, Fabio;
Zacchetti, Daniele

Publication type:

Article

Correction: T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.

Published in:

2019

By:

Wang, Shuo;
Yabuki, Yasushi;
Matsuo, Kazuya;
Xu, Jing;
Izumi, Hisanao;
Sakimura, Kenji;
Saito, Takashi;
Saido, Takaomi C.;
Fukunaga, Kohji

Publication type:

Correction Notice

T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.

Published in:

PLoS ONE, 2018, v. 13, n. 12, p. 1, doi. 10.1371/journal.pone.0206986

By:

Wang, Shuo;
Yabuki, Yasushi;
Matsuo, Kazuya;
Xu, Jing;
Izumi, Hisanao;
Sakimura, Kenji;
Saito, Takashi;
Saido, Takaomi C.;
Fukunaga, Kohji

Publication type:

Article

Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's β‐amyloid proteins.

Published in:

Journal of Neuroscience Research, 2006, v. 84, n. 2, p. 427, doi. 10.1002/jnr.20891

By:

Hironori Fujiwara;
Koh Iwasaki;
Katsutoshi Furukawa;
Takashi Seki;
Mei He;
Masahiro Maruyama;
Naoki Tomita;
Yukitsuka Kudo;
Makoto Higuchi;
Takaomi C. Saido;
Sumihiro Maeda;
Akihiko Takashima;
Masahiko Hara;
Yasushi Ohizumi;
Hiroyuki Arai

Publication type:

Article

Somatostatin regulates brain amyloidßpeptide Aß42 through modulation of proteolytic degradation.

Published in:

Nature Medicine, 2005, v. 11, n. 4, p. 434, doi. 10.1038/nm1206

By:

Saito, Takashi;
Iwata, Nobuhisa;
Tsubuki, Satoshi;
Takaki, Yoshie;
Takano, Jiro;
Huang, Shu-Ming;
Suemoto, Takahiro;
Higuchi, Makoto;
Saido, Takaomi C.

Publication type:

Article

Reply to: 'Clearance of amyloid b-peptide from brain: transport or metabolism?'.

Published in:

Nature Medicine, 2000, v. 6, n. 7, p. 718, doi. 10.1038/77399

By:

Iwata, Nobuhisa;
Tsubuki, Satoshi;
Hama, Emi;
Takaki, Yoshie;
Shirotani, Keiro;
Saido, Takaomi C.

Publication type:

Article

Identification of the major Aβ1?42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition.

Published in:

Nature Medicine, 2000, v. 6, n. 2, p. 143, doi. 10.1038/72237

By:

Iwata, Nobuhisa;
Tsubuki, Satoshi;
Takaki, Yoshie;
Watanabe, Kaori;
Sekiguchi, Misaki;
Hosoki, Emi;
Kawashima-Morishima, Maho;
Lee, Hahn-Jun;
Hama, Emi;
Sekine-Aizawa, Yoko;
Saido, Takaomi C.

Publication type:

Article

Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension.

Published in:

American Journal of Respiratory Cell & Molecular Biology, 2016, v. 54, n. 3, p. 384, doi. 10.1165/rcmb.2015-0151OC

By:

Kovacs, Laszlo;
Weihong Han;
Rafikov, Ruslan;
Bagi, Zsolt;
Offermanns, Stefan;
Saido, Takaomi C.;
Black, Stephen M.;
Yunchao Su

Publication type:

Article

Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease.

Published in:

Proceedings of the Japan Academy, Series B Physical & biological sciences, 2013, v. 89, n. 7, p. 321, doi. 10.2183/pjab.89.321

By:

SAIDO, Takaomi C.;
SUZUKI, Kunihiko

Publication type:

Article

Capillary cerebral amyloid angiopathy identifies a distinct APOE ε4-associated subtype of sporadic Alzheimer’s disease.

Published in:

Acta Neuropathologica, 2010, v. 120, n. 2, p. 169, doi. 10.1007/s00401-010-0707-9

By:

Thal, Dietmar Rudolf;
Papassotiropoulos, Andreas;
Saido, Takaomi C.;
Griffin, W. Sue T.;
Mrak, Robert E.;
Kölsch, Heike;
Tredici, Kelly Del;
Attems, Johannes;
Ghebremedhin, Estifanos

Publication type:

Article

Apolipoprotein E co-localizes with newly formed amyloid β-protein (Aβ) deposits lacking immunoreactivity against N-terminal epitopes of Aβ in a genotype-dependent manner.

Published in:

Acta Neuropathologica, 2005, v. 110, n. 5, p. 459, doi. 10.1007/s00401-005-1053-1

By:

Thal, Dietmar Rudolf;
Capetillo-Zarate, Estibaliz;
Schultz, Christian;
Rüb, Udo;
Saido, Takaomi C.;
Yamaguchi, Haruyasu;
Haass, Christian;
Griffin, W. Sue T.;
Del Tredici, Kelly;
Braak, Heiko;
Ghebremedhin, Estifanos

Publication type:

Article

Diffuse plaques associated with astroglial amyloid β protein, possibly showing a disappearing stage of senile plaques.

Published in:

Acta Neuropathologica, 1998, v. 95, n. 3, p. 217, doi. 10.1007/s004010050790

By:

Yamaguchi, H.;
Sugihara, Shiro;
Ogawa, Akira;
Saido, Takaomi C.;
Ihara, Yasuo

Publication type:

Article

Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease.

Published in:

Aging Cell, 2023, v. 22, n. 11, p. 1, doi. 10.1111/acel.13994

By:

Izuo, Naotaka;
Watanabe, Nobuhiro;
Noda, Yoshihiro;
Saito, Takashi;
Saido, Takaomi C.;
Yokote, Koutaro;
Hotta, Harumi;
Shimizu, Takahiko

Publication type:

Article

Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.

Published in:

Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01404-w

By:

Carpanini, Sarah M.;
Torvell, Megan;
Bevan, Ryan J.;
Byrne, Robert A. J.;
Daskoulidou, Nikoleta;
Saito, Takashi;
Saido, Takaomi C.;
Taylor, Philip R.;
Hughes, Timothy R.;
Zelek, Wioleta M.;
Morgan, B. Paul

Publication type:

Article

Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis.

Published in:

Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01398-5

By:

Jiang, Richeng;
Smailovic, Una;
Haytural, Hazal;
Tijms, Betty M.;
Li, Hao;
Haret, Robert Mihai;
Shevchenko, Ganna;
Chen, Gefei;
Abelein, Axel;
Gobom, Johan;
Frykman, Susanne;
Sekiguchi, Misaki;
Fujioka, Ryo;
Watamura, Naoto;
Sasaguri, Hiroki;
Nyström, Sofie;
Hammarström, Per;
Saido, Takaomi C.;
Jelic, Vesna;
Syvänen, Stina

Publication type:

Article

The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research.

Published in:

Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-020-01102-5

By:

Vandenabeele, Marjan;
Veys, Lien;
Lemmens, Sophie;
Hadoux, Xavier;
Gelders, Géraldine;
Masin, Luca;
Serneels, Lutgarde;
Theunis, Jan;
Saito, Takashi;
Saido, Takaomi C.;
Jayapala, Murali;
De Boever, Patrick;
De Strooper, Bart;
Stalmans, Ingeborg;
van Wijngaarden, Peter;
Moons, Lieve;
De Groef, Lies

Publication type:

Article

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.

Published in:

Acta Neuropathologica Communications, 2021, v. 9, n. 1, p. 1, doi. 10.1186/s40478-020-01099-x

By:

Sobue, Akira;
Komine, Okiru;
Hara, Yuichiro;
Endo, Fumito;
Mizoguchi, Hiroyuki;
Watanabe, Seiji;
Murayama, Shigeo;
Saito, Takashi;
Saido, Takaomi C.;
Sahara, Naruhiko;
Higuchi, Makoto;
Ogi, Tomoo;
Yamanaka, Koji

Publication type:

Article

NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.72034

By:

Pohlkamp, Theresa;
Xunde Xian;
Wong, Connie H.;
Durakoglugil, Murat S.;
Werthmann, Gordon Chandler;
Saido, Takaomi C.;
Evers, Bret M.;
White III, Charles L.;
Connor, Jade;
Hammer, Robert E.;
Herz, Joachim

Publication type:

Article

Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer's disease.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.71879

By:

Xiaoting Wu;
Takashi Saito;
Saido, Takaomi C.;
Barron, Anna M.;
Ruedl, Christiane

Publication type:

Article

Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer's disease in adult Alzheimer's model AppNL-G-F mice.

Published in:

Frontiers in Aging Neuroscience, 2024, p. 1, doi. 10.3389/fnagi.2024.1361847

By:

Suzuko Ochi;
Kumiko Yamada;
Takashi Saito;
Saido, Takaomi C.;
Mitsuo Iinuma;
Kagaku Azuma;
Kin-Ya Kubo

Publication type:

Article

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse.

Published in:

Frontiers in Aging Neuroscience, 2023, p. 1, doi. 10.3389/fnagi.2023.1265151

By:

Benskey, Matthew J.;
Panoushek, Spencer;
Takashi Saito;
Saido, Takaomi C.;
Grabinski, Tessa;
Kanaan, Nicholas M.

Publication type:

Article

Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation.

Published in:

Cell Death & Disease, 2024, v. 15, n. 11, p. 1, doi. 10.1038/s41419-024-07249-6

By:

Sobue, Akira;
Komine, Okiru;
Endo, Fumito;
Kakimi, Chihiro;
Miyoshi, Yuka;
Kawade, Noe;
Watanabe, Seiji;
Saito, Yuko;
Murayama, Shigeo;
Saido, Takaomi C.;
Saito, Takashi;
Yamanaka, Koji

Publication type:

Article

Anti-Aβ Drug Screening Platform Using Human iPS Cell- Derived Neurons for the Treatment of Alzheimer's Disease.

Published in:

PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0025788

By:

Yahata, Naoki;
Asai, Masashi;
Kitaoka, Shiho;
Takahashi, Kazutoshi;
Asaka, Isao;
Hioki, Hiroyuki;
Kaneko, Takeshi;
Maruyama, Kei;
Saido, Takaomi C.;
Nakahata, Tatsutoshi;
Asada, Takashi;
Yamanaka, Shinya;
Iwata, Nobuhisa;
Inoue, Haruhisa

Publication type:

Article

Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model.

Published in:

Frontiers in Systems Neuroscience, 2017, p. 1, doi. 10.3389/fnsys.2017.00048

By:

Tomoaki Nakazono;
Lam, Travis N.;
Patel, Ayushi Y.;
Masashi Kitazawa;
Takashi Saito;
Saido, Takaomi C.;
Igarashi, Kei M.

Publication type:

Article

Longer Forms of Amyloid β Protein: Implications for the Mechanism of Intramembrane Cleavage by γ-Secretase.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 2, p. 436, doi. 10.1523/JNEUROSCI.1575-04.2005

By:

Qi-Takahara, Yue;
Morishima-Kawashima, Maho;
Tanimura, Yu;
Dolios, Georgia;
Hirotani, Naoko;
Horikoshi, Yuko;
Kametani, Fuyuki;
Maeda, Masahiro;
Saido, Takaomi C.;
Wang, Rong;
Ihara, Yasuo

Publication type:

Article

Presynaptic Localization of Neprilysin Contributes to Efficient Clearance of Amyloid-β Peptide in Mouse Brain.

Published in:

Journal of Neuroscience, 2004, v. 24, n. 4, p. 991, doi. 10.1523/JNEUROSCI.4792-03.2004

By:

Iwata, Nobuhisa;
Mizukami, Hiroaki;
Shirotani, Keiro;
Takaki, Yoshie;
Muramatsu, Shin-ichi;
Lu, Bao;
Gerard, Norma P.;
Gerard, Craig;
Ozawa, Keiya;
Saido, Takaomi C.

Publication type:

Article

APP mouse models for Alzheimer's disease preclinical studies.

Published in:

EMBO Journal, 2017, v. 36, n. 17, p. 2473, doi. 10.15252/embj.201797397

By:

Sasaguri, Hiroki;
Nilsson, Per;
Hashimoto, Shoko;
Nagata, Kenichi;
Saito, Takashi;
De Strooper, Bart;
Hardy, John;
Vassar, Robert;
Winblad, Bengt;
Saido, Takaomi C

Publication type:

Article

Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.

Published in:

FASEB Journal, 2020, v. 34, n. 2, p. 2425, doi. 10.1096/fj.201901028RR

By:

Shinohara, Mitsuru;
Tashiro, Yoshitaka;
Shinohara, Motoko;
Hirokawa, Junko;
Suzuki, Kaoru;
Onishi‐Takeya, Miyuki;
Mukouzono, Masahiro;
Takeda, Shuko;
Saito, Takashi;
Fukumori, Akio;
Saido, Takaomi C.;
Morishita, Ryuichi;
Sato, Naoyuki

Publication type:

Article

Mechanistic involvement of the calpain-calpastatin system in Alzheimer neuropathology.

Published in:

FASEB Journal, 2012, v. 26, n. 3, p. 1204, doi. 10.1096/fj.11-187740

By:

Higuchi, Makoto;
Iwata, Nobuhisa;
Matsuba, Yukio;
Takano, Jiro;
Suemoto, Takahiro;
Maeda, Jun;
Ji, Bin;
Ono, Maiko;
Staufenbiel, Matthias;
Suhara, Tetsuya;
Saido, Takaomi C.

Publication type:

Article

An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model.

Published in:

FASEB Journal, 2011, v. 25, n. 10, p. 3720, doi. 10.1096/fj.11-182154

By:

Asai, Masashi;
Yagishita, Sosuke;
Iwata, Nobuhisa;
Saido, Takaomi C.;
Ishiura, Shoichi;
Maruyama, Kei

Publication type:

Article

Activation of calpain-1 in human carotid artery atherosclerotic lesions.

Published in:

2009

By:

Gonçalves I;
Nitulescu M;
Saido TC;
Dias N;
Pedro LM;
E Fernandes JF;
Ares MP;
Pörn-Ares I;
Gonçalves, Isabel;
Nitulescu, Mihaela;
Saido, Takaomi C;
Dias, Nuno;
Pedro, Luis M;
E Fernandes, José Fernandes;
Ares, Mikko P S;
Pörn-Ares, Isabella

Publication type:

journal article

Therapeutic strategies of Alzheimer's disease through manipulation of Aβ metabolism: a focus on Aβ-degrading peptidase, neprilysin.

Published in:

Drug Development Research, 2002, v. 56, n. 2, p. 171, doi. 10.1002/ddr.10073

By:

Fukami, Shinjiro;
Iwata, Nobuhisa;
Saido, Takaomi C.

Publication type:

Article

Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease.

Published in:

Inflammation & Regeneration, 2023, v. 43, n. 1, p. 1, doi. 10.1186/s41232-023-00257-7

By:

Kaneko, Ryusei;
Matsui, Ako;
Watanabe, Mahiro;
Harada, Yoshihiro;
Kanamori, Mitsuhiro;
Awata, Natsumi;
Kawazoe, Mio;
Takao, Tomoaki;
Kobayashi, Yutaro;
Kikutake, Chie;
Suyama, Mikita;
Saito, Takashi;
Saido, Takaomi C.;
Ito, Minako

Publication type:

Article

Experimental evidence that readily diffusible forms of Aβ from Alzheimer's disease brain have seeding activity.

Published in:

Acta Neuropathologica Communications, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40478-025-02032-w

By:

Song, Simin;
Liu, Qianmin;
Chen, Ruixiang;
Chen, Ping;
Tao, Min;
Li, Siyao;
Guo, Liping;
Zhu, Xixi;
Liu, Yan;
Liu, Lu;
Sasaguri, Hiroki;
Saito, Takashi;
Saido, Takaomi C.;
Walsh, Dominic M.;
Zhang, Zhangjin;
Hong, Wei

Publication type:

Article

Animal models of tauopathies.

Published in:

Neuropathology, 2006, v. 26, n. 5, p. 491, doi. 10.1111/j.1440-1789.2006.00685.x

By:

Higuchi, Makoto;
Saido, Takaomi C.;
Suhara, Tetsuya

Publication type:

Article

Characteristics of cerebral β amyloid deposition in four non-demented patients in their forties with a high apolipoprotein E ε4 allele frequency.

Published in:

Neuropathology, 1997, v. 17, n. 4, p. 326, doi. 10.1111/j.1440-1789.1997.tb00061.x

By:

Sugihara, Shiro;
Saunders, Ann M.;
Ogawa, Akira;
Nakazato, Yoichi;
Saido, Takaomi C.;
Yamaguchi, Haruyasu

Publication type:

Article

Visual screening and analysis for kinase-regulated membrane trafficking pathways that are involved in extensive β-amyloid secretion.

Published in:

Genes to Cells, 2009, v. 14, n. 3, p. 355, doi. 10.1111/j.1365-2443.2008.01274.x

By:

Adachi, Atsuhiro;
Kano, Fumi;
Saido, Takaomi C.;
Murata, Masayuki

Publication type:

Article

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.

Published in:

Human Molecular Genetics, 2014, v. 23, n. 15, p. 3975, doi. 10.1093/hmg/ddu112

By:

Diepenbroek, Meike;
Casadei, Nicolas;
Esmer, Hakan;
Saido, Takaomi C.;
Takano, Jiro;
Kahle, Philipp J.;
Nixon, Ralph A;
Rao, Mala V.;
Melki, Ronald;
Pieri, Laura;
Helling, Stefan;
Marcus, Katrin;
Krueger, Rejko;
Masliah, Eliezer;
Riess, Olaf;
Nuber, Silke

Publication type:

Article

Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).

Published in:

Human Molecular Genetics, 2013, v. 22, n. 3, p. 508, doi. 10.1093/hmg/dds449

By:

Hübener, Jeannette;
Weber, Jonasz Jeremiasz;
Richter, Claudia;
Honold, Lisa;
Weiss, Andreas;
Murad, Fabronia;
Breuer, Peter;
Wüllner, Ullrich;
Bellstedt, Peter;
Paquet-Durand, Francois;
Takano, Jiro;
Saido, Takaomi C.;
Riess, Olaf;
Nguyen, Huu Phuc

Publication type:

Article

Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice.

Published in:

Nature Communications, 2023, n. 1, p. 1, doi. 10.1038/s41467-023-36519-8

By:

Park, Hanseul;
Cho, Byounggook;
Kim, Hongwon;
Saito, Takashi;
Saido, Takaomi C.;
Won, Kyoung-Jae;
Kim, Jongpil

Publication type:

Article