Works by Tajkhorshid, Emad

Results: 58

Voltage sensor conformations induced by LQTS-associated mutations in hERG potassium channels.

Published in:

Nature Communications, 2025, v. 18, n. 1, p. 1, doi. 10.1038/s41467-025-62472-9

By:

Chan, Aaron N.;
Quach, Co D.;
Handlin, Lucas J.;
Lessie, Erin N.;
Tajkhorshid, Emad;
Dai, Gucan

Publication type:

Article

Beyond nothingness in the formation and functional relevance of voids in polymer films.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46584-2

By:

Kalutantirige, Falon C.;
Jinlong He;
Lehan Yao;
Cotty, Stephen;
Shan Zhou;
Smith, John W.;
Tajkhorshid, Emad;
Schroeder, Charles M.;
Moore, Jeffrey S.;
An, Hyosung;
Xiao Su;
Ying Li;
Qian Chen

Publication type:

Article

Myr-Arf1 conformational flexibility at the membrane surface sheds light on the interactions with ArfGAP ASAP1.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43008-5

By:

Zhang, Yue;
Soubias, Olivier;
Pant, Shashank;
Heinrich, Frank;
Vogel, Alexander;
Li, Jess;
Li, Yifei;
Clifton, Luke A.;
Daum, Sebastian;
Bacia, Kirsten;
Huster, Daniel;
Randazzo, Paul A.;
Lösche, Mathias;
Tajkhorshid, Emad;
Byrd, R. Andrew

Publication type:

Article

Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42937-5

By:

Tang, Qingyu;
Sinclair, Matt;
Hasdemir, Hale S.;
Stein, Richard A.;
Karakas, Erkan;
Tajkhorshid, Emad;
Mchaourab, Hassane S.

Publication type:

Article

Aquaporin-7: A Dynamic Aquaglyceroporin With Greater Water and Glycerol Permeability Than Its Bacterial Homolog GlpF.

Published in:

Frontiers in Physiology, 2020, v. 11, p. 1, doi. 10.3389/fphys.2020.00728

By:

Moss, Fraser J.;
Mahinthichaichan, Paween;
Lodowski, David T.;
Kowatz, Thomas;
Tajkhorshid, Emad;
Engel, Andreas;
Boron, Walter F.;
Vahedi-Faridi, Ardeschir

Publication type:

Article

Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF-κB.

Published in:

Molecular & Cellular Biology, 2010, v. 30, n. 9, p. 2170, doi. 10.1128/MCB.01343-09

By:

Yang, Xiao-Dong;
Tajkhorshid, Emad;
Chen, Lin-Feng

Publication type:

Article

Interplay of mechanical and binding properties of Fibronectin type I.

Published in:

Theoretical Chemistry Accounts: Theory, Computation, & Modeling, 2010, v. 125, n. 3-6, p. 397, doi. 10.1007/s00214-009-0677-y

By:

Diao, Jiankuai;
Maniotis, Andrew J.;
Folberg, Robert;
Tajkhorshid, Emad

Publication type:

Article

Efficient Exploration of Membrane-Associated Phenomena at Atomic Resolution.

Published in:

Journal of Membrane Biology, 2015, v. 248, n. 3, p. 563, doi. 10.1007/s00232-015-9806-9

By:

Vermaas, Josh;
Baylon, Javier;
Arcario, Mark;
Muller, Melanie;
Wu, Zhe;
Pogorelov, Taras;
Tajkhorshid, Emad

Publication type:

Article

Structural mechanism of plant aquaporin gating.

Published in:

Nature, 2006, v. 439, n. 7077, p. 688, doi. 10.1038/nature04316

By:

Törnroth-Horsefield, Susanna;
Yi Wang;
Hedfalk, Kristina;
Johanson, Urban;
Karlsson, Maria;
Tajkhorshid, Emad;
Neutze, Richard;
Kjellbom, Per

Publication type:

Article

Knockout of VDAC1 in H9c2 Cells Promotes Oxidative Stress-Induced Cell Apoptosis through Decreased Mitochondrial Hexokinase II Binding and Enhanced Glycolytic Stress.

Published in:

Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2020, v. 54, n. 5, p. 853, doi. 10.33594/000000274

By:

Meiying Yang;
Jie Sun;
Stowe, David F.;
Tajkhorshid, Emad;
Wai-Meng Kwok;
Camara, Amadou K. S.

Publication type:

Article

WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.

Published in:

Nucleic Acids Research, 2024, v. 52, n. 9, p. 4969, doi. 10.1093/nar/gkae161

By:

Zhang, Jie;
Yu, Yuanyuan;
Zou, Xiuqun;
Du, Yaning;
Liang, Qiankun;
Gong, Mengyao;
He, Yurong;
Luo, Junqi;
Wu, Dandan;
Jiang, Xiaoli;
Sinclair, Matt;
Tajkhorshid, Emad;
Chen, Hong-Zhuan;
Hou, Zhaoyuan;
Zheng, Yuejuan;
Chen, Lin-Feng;
Yang, Xiao-Dong

Publication type:

Article

Mitochondrial VDAC1: A Key Gatekeeper as Potential Therapeutic Target.

Published in:

Frontiers in Physiology, 2017, p. 1, doi. 10.3389/fphys.2017.00460

By:

Camara, Amadou K. S.;
YiFan Zhou;
Po-Chao Wen;
Tajkhorshid, Emad;
Wai-Meng Kwok

Publication type:

Article

An Activity‐Based Sensing Approach for the Detection of Cyclooxygenase‐2 in Live Cells.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 8, p. 3307, doi. 10.1002/anie.201914845

By:

Yadav, Anuj K.;
Reinhardt, Christopher J.;
Arango, Andres S.;
Huff, Hannah C.;
Dong, Liang;
Malkowski, Michael G.;
Das, Aditi;
Tajkhorshid, Emad;
Chan, Jefferson

Publication type:

Article

A Chalcogen‐Bonding Cascade Switch for Planarizable Push–Pull Probes.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 44, p. 15752, doi. 10.1002/anie.201909741

By:

Macchione, Mariano;
Goujon, Antoine;
Strakova, Karolina;
Humeniuk, Heorhii V.;
Licari, Giuseppe;
Tajkhorshid, Emad;
Sakai, Naomi;
Matile, Stefan

Publication type:

Article

Conformational changes in the nucleotide‐binding domains of P‐glycoprotein induced by ATP hydrolysis.

Published in:

FEBS Letters, 2021, v. 595, n. 6, p. 735, doi. 10.1002/1873-3468.13992

By:

Dehghani‐Ghahnaviyeh, Sepehr;
Kapoor, Karan;
Tajkhorshid, Emad

Publication type:

Article

Microscopic Characterization of GRP1 PH Domain Interaction with Anionic Membranes.

Published in:

Journal of Computational Chemistry, 2020, v. 41, n. 6, p. 489, doi. 10.1002/jcc.26109

By:

Pant, Shashank;
Tajkhorshid, Emad

Publication type:

Article

Restricted Surface Diffusion of Cytochromes on Bioenergetic Membranes with Anionic Lipids.

Published in:

Membranes, 2025, v. 15, n. 4, p. 124, doi. 10.3390/membranes15040124

By:

Chan, Aaron;
Tajkhorshid, Emad

Publication type:

Article

The Role of Protein–Lipid Interactions in Priming the Bacterial Translocon.

Published in:

Membranes, 2024, v. 14, n. 12, p. 249, doi. 10.3390/membranes14120249

By:

Sinclair, Matt;
Tajkhorshid, Emad

Publication type:

Article

Anti-inflammatory dopamine- and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-20946-6

By:

Arnold, William R.;
Carnevale, Lauren N.;
Xie, Zili;
Baylon, Javier L.;
Tajkhorshid, Emad;
Hu, Hongzhen;
Das, Aditi

Publication type:

Article

Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-20032-3

By:

Jia, Ruyu;
Martens, Chloe;
Shekhar, Mrinal;
Pant, Shashank;
Pellowe, Grant A.;
Lau, Andy M.;
Findlay, Heather E.;
Harris, Nicola J.;
Tajkhorshid, Emad;
Booth, Paula J.;
Politis, Argyris

Publication type:

Article

Aβ(1-42) tetramer and octamer structures reveal edge conductivity pores as a mechanism for membrane damage.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16566-1

By:

Ciudad, Sonia;
Puig, Eduard;
Botzanowski, Thomas;
Meigooni, Moeen;
Arango, Andres S.;
Do, Jimmy;
Mayzel, Maxim;
Bayoumi, Mariam;
Chaignepain, Stéphane;
Maglia, Giovanni;
Cianferani, Sarah;
Orekhov, Vladislav;
Tajkhorshid, Emad;
Bardiaux, Benjamin;
Carulla, Natàlia

Publication type:

Article

Integrating hydrogen–deuterium exchange mass spectrometry with molecular dynamics simulations to probe lipid-modulated conformational changes in membrane proteins.

Published in:

Nature Protocols, 2019, v. 14, n. 11, p. 3183, doi. 10.1038/s41596-019-0219-6

By:

Martens, Chloe;
Shekhar, Mrinal;
Lau, Andy M.;
Tajkhorshid, Emad;
Politis, Argyris

Publication type:

Article

Rapid parameterization of small molecules using the force field toolkit.

Published in:

Journal of Computational Chemistry, 2013, v. 34, n. 32, p. 2757, doi. 10.1002/jcc.23422

By:

Mayne, Christopher G.;
Saam, Jan;
Schulten, Klaus;
Tajkhorshid, Emad;
Gumbart, James C.

Publication type:

Article

Scalable molecular dynamics with NAMD.

Published in:

Journal of Computational Chemistry, 2005, v. 26, n. 16, p. 1781, doi. 10.1002/jcc.20289

By:

Phillips, James C.;
Braun, Rosemary;
Wei Wang;
Gumbart, James;
Tajkhorshid, Emad;
Villa, Elizabeth;
Chipot, Christophe;
Skeel, Robert D.;
Kale, Laxmikant;
Schulten, Klaus

Publication type:

Article

Classical force field parameters for the heme prosthetic group of cytochrome c.

Published in:

Journal of Computational Chemistry, 2004, v. 25, n. 13, p. 1613, doi. 10.1002/jcc.20079

By:

Autenrieth, Felix;
Tajkhorshid, Emad;
Baudry, Jerome;
Luthey-Schulten, Zaida

Publication type:

Article

The mechanism of proton exclusion in aquaporin channels.

Published in:

Proteins, 2004, v. 55, n. 2, p. 223, doi. 10.1002/prot.20038

By:

Ilan, Boaz;
Tajkhorshid, Emad;
Schulten, Klaus;
Voth, Gregory A.

Publication type:

Article

Generating Concentration Gradients across Membranes for Molecular Dynamics Simulations of Periodic Systems.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 7, p. 3616, doi. 10.3390/ijms25073616

By:

Shinn, Eric Joon;
Tajkhorshid, Emad

Publication type:

Article

Modeling and Dynamics of the Inward-Facing State of a Na+/Cl- Dependent Neurotransmitter Transporter Homologue.

Published in:

PLoS Computational Biology, 2010, v. 6, n. 8, p. 1, doi. 10.1371/journal.pcbi.1000905

By:

Shaikh, Saher Afshan;
Tajkhorshid, Emad

Publication type:

Article

An Activity‐Based Sensing Approach for the Detection of Cyclooxygenase‐2 in Live Cells.

Published in:

Angewandte Chemie, 2020, v. 132, n. 8, p. 3333, doi. 10.1002/ange.201914845

By:

Yadav, Anuj K.;
Reinhardt, Christopher J.;
Arango, Andres S.;
Huff, Hannah C.;
Dong, Liang;
Malkowski, Michael G.;
Das, Aditi;
Tajkhorshid, Emad;
Chan, Jefferson

Publication type:

Article

A Chalcogen‐Bonding Cascade Switch for Planarizable Push–Pull Probes.

Published in:

Angewandte Chemie, 2019, v. 131, n. 44, p. 15899, doi. 10.1002/ange.201909741

By:

Macchione, Mariano;
Goujon, Antoine;
Strakova, Karolina;
Humeniuk, Heorhii V.;
Licari, Giuseppe;
Tajkhorshid, Emad;
Sakai, Naomi;
Matile, Stefan

Publication type:

Article

Structural basis for the reaction cycle of DASS dicarboxylate transporters.

Published in:

eLife, 2020, p. 1, doi. 10.7554/eLife.61350

By:

Sauer, David B.;
Trebesch, Noah;
Marden, Jennifer J.;
Cocco, Nicolette;
Jinmei Song;
Akiko Koide;
Shohei Koide;
Tajkhorshid, Emad;
Da-Neng Wang

Publication type:

Article

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.12792

By:

Fanning, Sean W.;
Mayne, Christopher G.;
Dharmarajan, Venkatasubramanian;
Carlson, Kathryn E.;
Martin, Teresa A.;
Novick, Scott J.;
Weiyi Toy;
Green, Bradley;
Panchamukhi, Srinivas;
Katzenellenbogen, Benita S.;
Tajkhorshid, Emad;
Griffin, Patrick R.;
Yang Shen;
Chandarlapaty, Sarat;
Katzenellenbogen, John A.;
Greene, Geoffrey L.

Publication type:

Article

Revealing an outward-facing open conformational state in a CLC Cl–/H+ exchange transporter.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.11189

By:

Khantwal, Chandra M.;
Abraham, Sherwin J.;
Wei Han;
Tao Jiang;
Chavan, Tanmay S.;
Cheng, Ricky C.;
Elvington, Shelley M.;
Liu, Corey W.;
Mathews, Irimpan I.;
Stein, Richard A.;
Mchaourab, Hassane S.;
Tajkhorshid, Emad;
Maduke, Merritt

Publication type:

Article

Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-07477-3

By:

Infield, Daniel T.;
Matulef, Kimberly;
Galpin, Jason D.;
Lam, Kin;
Tajkhorshid, Emad;
Ahern, Christopher A.;
Valiyaveetil, Francis I.

Publication type:

Article

Direct protein-lipid interactions shape the conformational landscape of secondary transporters.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06704-1

By:

Martens, Chloe;
Shekhar, Mrinal;
Borysik, Antoni J.;
Lau, Andy M.;
Reading, Eamonn;
Tajkhorshid, Emad;
Booth, Paula J.;
Politis, Argyris

Publication type:

Article

Interaction of the α2A domain of integrin with small collagen fragments.

Published in:

Protein & Cell, 2010, v. 1, n. 4, p. 393, doi. 10.1007/s13238-010-0038-6

By:

Siebert, Hans-Christian;
Burg-Roderfeld, Monika;
Eckert, Thomas;
Stötzel, Sabine;
Kirch, Ulrike;
Diercks, Tammo;
Humphries, Martin;
Frank, Martin;
Wechselberger, Rainer;
Tajkhorshid, Emad;
Oesser, Steffen

Publication type:

Article

Nitric oxide conduction by the brain aquaporin AQP4.

Published in:

Proteins, 2010, v. 78, n. 3, p. 661, doi. 10.1002/prot.22595

By:

Wang, Yi;
Tajkhorshid, Emad

Publication type:

Article

Cryo‐EM structures of human ABCA7 provide insights into its phospholipid translocation mechanisms.

Published in:

EMBO Journal, 2023, v. 42, n. 3, p. 1, doi. 10.15252/embj.2022111065

By:

Le, Le Thi My;
Thompson, James Robert;
Dehghani‐Ghahnaviyeh, Sepehr;
Pant, Shashank;
Dang, Phuoc Xuan;
French, Jarrod Bradley;
Kanikeyo, Takahisa;
Tajkhorshid, Emad;
Alam, Amer

Publication type:

Article

Structural basis for iron piracy by pathogenic Neisseria.

Published in:

Nature, 2012, v. 483, n. 7387, p. 53, doi. 10.1038/nature10823

By:

Noinaj, Nicholas;
Easley, Nicole C.;
Oke, Muse;
Mizuno, Naoko;
Gumbart, James;
Boura, Evzen;
Steere, Ashley N.;
Zak, Olga;
Aisen, Philip;
Tajkhorshid, Emad;
Evans, Robert W.;
Gorringe, Andrew R.;
Mason, Anne B.;
Steven, Alasdair C.;
Buchanan, Susan K.

Publication type:

Article

Identifying mutation hotspots reveals pathogenetic mechanisms of KCNQ2 epileptic encephalopathy.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-61697-6

By:

Zhang, Jiaren;
Kim, Eung Chang;
Chen, Congcong;
Procko, Erik;
Pant, Shashank;
Lam, Kin;
Patel, Jaimin;
Choi, Rebecca;
Hong, Mary;
Joshi, Dhruv;
Bolton, Eric;
Tajkhorshid, Emad;
Chung, Hee Jung

Publication type:

Article

Locking Two Rigid-body Bundles in an Outward-Facing Conformation: The Ion-coupling Mechanism in a LeuT-fold Transporter.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-55722-6

By:

Li, Jing;
Zhao, Zhiyu;
Tajkhorshid, Emad

Publication type:

Article

Binding partner- and force-promoted changes in αE-catenin conformation probed by native cysteine labeling.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-51816-3

By:

Terekhova, Ksenia;
Pokutta, Sabine;
Kee, Yee S.;
Li, Jing;
Tajkhorshid, Emad;
Fuller, Gerald;
Dunn, Alexander R.;
Weis, William I.

Publication type:

Article

Inside Cover: Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction (Angew. Chem. Int. Ed. 13/2016).

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 13, p. 4104, doi. 10.1002/anie.201601641

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 13, p. 4252, doi. 10.1002/anie.201510557

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

Innentitelbild: Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction (Angew. Chem. 13/2016).

Published in:

Angewandte Chemie, 2016, v. 128, n. 13, p. 4174, doi. 10.1002/ange.201601641

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction.

Published in:

Angewandte Chemie, 2016, v. 128, n. 13, p. 4324, doi. 10.1002/ange.201510557

By:

Speltz, Thomas E.;
Fanning, Sean W.;
Mayne, Christopher G.;
Fowler, Colin;
Tajkhorshid, Emad;
Greene, Geoffrey L.;
Moore, Terry W.

Publication type:

Article

The structures of secretory and dimeric immunoglobulin A.

Published in:

eLife, 2020, p. 1, doi. 10.7554/eLife.56098

By:

Bharathkar, Sonya Kumar;
Parker, Benjamin W.;
Malyutin, Andrey G.;
Haloi, Nandan;
Huey-Tubman, Kathryn E.;
Tajkhorshid, Emad;
Stadtmueller, Beth M.

Publication type:

Article

Determination of structural and functional overlap/divergence of five proto-type galectins by analysis of the growth-regulatory interaction with ganglioside GM.

Published in:

International Journal of Cancer, 2005, v. 114, n. 1, p. 46, doi. 10.1002/ijc.20699

By:

André, Sabine;
Kaltner, Herbert;
Lensch, Martin;
Russwurm, Roland;
Siebert, Hans-Christian;
Fallsehr, Christine;
Tajkhorshid, Emad;
Heck, Albert J.R.;
von Knebel Doeberitz, Magnus;
Gabius, Hans-Joachim;
Kopitz, Juergen

Publication type:

Article

Editorial: Mitochondrial Exchangers and Transporters in Cell Survival and Death.

Published in:

Frontiers in Physiology, 2021, v. 12, p. 1, doi. 10.3389/fphys.2021.745353

By:

Kwok, Wai-Meng;
Tajkhorshid, Emad;
Camara, Amadou K. S.

Publication type:

Article

PIP2-dependent coupling of voltage sensor and pore domains in Kv7.2 channel.

Published in:

Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-021-02729-3

By:

Pant, Shashank;
Zhang, Jiaren;
Kim, Eung Chang;
Lam, Kin;
Chung, Hee Jung;
Tajkhorshid, Emad

Publication type:

Article