Works by Tainer, John A.

Results: 134

Mobility and evolutionary variability factors in protein antigenicity (reply).

Published in:

Nature, 1985, v. 317, n. 6032, p. 90, doi. 10.1038/317090b0

By:

TAINER, JOHN A.;
GETZOFF, ELIZABETH D.;
ALEXANDER, HANNAH;
HOUGHTEN, RICHARD A.;
OLSON, ARTHUR J.;
LERNER, RICHARD A.

Publication type:

Article

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein.

Published in:

Nature, 1984, v. 312, n. 5990, p. 127, doi. 10.1038/312127a0

By:

Tainer, John A.;
Getzoff, Elizabeth D.;
Alexander, Hannah;
Houghten, Richard A.;
Olson, Arthur J.;
Lerner, Richard A.;
Hendrickson, Wayne A.

Publication type:

Article

A goldilocks computational protocol for inhibitor discovery targeting DNA damage responses including replication-repair functions.

Published in:

Frontiers in Molecular Biosciences, 2024, p. 1, doi. 10.3389/fmolb.2024.1442267

By:

Moiani, Davide;
Tainer, John A.

Publication type:

Article

Defining Antibody-Antigen Recognition: Towards Engineered Antibodies and Epitopes.

Published in:

International Reviews of Immunology, 1991, v. 7, n. 2, p. 165, doi. 10.3109/08830189109061773

By:

Tainer, John A.;
Deal, Carolyn D.;
Geysen, H. Mario;
Roberts, Victoria A.;
Getzoff, Elizabeth D.

Publication type:

Article

Unraveling the effect of changes in conformation and compactness at the antibody V<sub>L</sub>-V<sub>H</sub> interface upon antigen binding.

Published in:

Journal of Molecular Recognition, 1999, v. 12, n. 4, p. 267, doi. 10.1002/(SICI)1099-1352(199907/08)12:4<267::AID-JMR465>3.0.CO;2-9

By:

Pellequer, Jean-Luc;
Chen, Shu-wen W.;
Roberts, Victoria A.;
Tainer, John A.;
Getzoff, Elizabeth D.

Publication type:

Article

Molecular model of TFIIH recruitment to the transcription-coupled repair machinery.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-57593-0

By:

Paul, Tanmoy;
Yan, Chunli;
Yu, Jina;
Tsutakawa, Susan E.;
Tainer, John A.;
Wang, Dong;
Ivanov, Ivaylo

Publication type:

Article

Structure of a designed protein cage that self-assembles into a highly porous cube.

Published in:

Nature Chemistry, 2014, v. 6, n. 12, p. 1065, doi. 10.1038/nchem.2107

By:

Lai, Yen-Ting;
Reading, Eamonn;
Hura, Greg L.;
Tsai, Kuang-Lei;
Laganowsky, Arthur;
Asturias, Francisco J.;
Tainer, John A.;
Robinson, Carol V.;
Yeates, Todd O.

Publication type:

Article

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.

Published in:

EMBO Journal, 2000, v. 19, n. 7, p. 1719, doi. 10.1093/emboj/19.7.1719

By:

Daniels, Douglas S.;
Mol, Clifford D.;
Arvai, Andrew S.;
Kanugula, Sreenivas;
Pegg, Anthony E.;
Tainer, John A.

Publication type:

Article

Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.

Published in:

EMBO Journal, 2000, v. 19, n. 7, p. 1719, doi. 10.1093/emboj/19.7.1719

By:

Daniels, Douglas S.;
Mol, Clifford D.;
Arvai, Andrew S.;
Kanugula, Sreenivas;
Pegg, Anthony E.;
Tainer, John A.

Publication type:

Article

Inducible nitric oxide synthase: role of the N-terminal ß-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.

Published in:

EMBO Journal, 1999, v. 18, n. 22, p. 6260, doi. 10.1093/emboj/18.22.6260

By:

Ghosh, Dipak K.;
Crane, Brian R.;
Ghosh, Sanjay;
Wolan, Dennis;
Gachhui, Ratan;
Crooks, Carol;
Presta, Anthony;
Tainer, John A.;
Getzoff, Elizabeth D.;
Stuehr, Dennis J.

Publication type:

Article

N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.

Published in:

EMBO Journal, 1999, v. 18, n. 22, p. 6271, doi. 10.1093/emboj/18.22.6271

By:

Crane, Brian R.;
Rosenfeld, Robin J.;
Arvai, Andrew S.;
Ghosh, Dipak K.;
Ghosh, Sanjav;
Tainer, John A.;
Stuehr, Dennis J.;
Getzoff, Elizabeth D.

Publication type:

Article

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

Published in:

EMBO Journal, 1998, v. 17, n. 17, p. 5214, doi. 10.1093/emboj/17.17.5214

By:

Parikh, Sudip S.;
Mol, Clifford D.;
Slupphaug, Geir;
Bharati, Sangeeta;
Krokan, Hans E.;
Tainer, John A.

Publication type:

Article

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites.

Published in:

EMBO Journal, 1997, v. 16, n. 21, p. 6548, doi. 10.1093/emboj/16.21.6548

By:

Gorman, Michael A.;
Morera, Solange;
Rothwell, Dominic G.;
de la Fortelle, Eric;
Mol, Clifford D.;
Tainer, John A.;
Hickson, Ian D.;
Freemont, Paul S.

Publication type:

Article

A Phase‐Separating Molecular Tether for Lariat Debranching Enzyme is Defective in Non‐Photosensitive Trichothiodystrophy.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.02893

By:

Townley, Brittany;
Schmidt, Nicholas;
Holehouse, Alex;
Bacolla, Albino;
Srivatsan, Sridhar;
Walter, Matthew;
Tainer, John;
Mosammaparast, Nima

Publication type:

Article

Type IV pilus structure and bacterial pathogenicity.

Published in:

Nature Reviews Microbiology, 2004, v. 2, n. 5, p. 363, doi. 10.1038/nrmicro885

By:

Craig, Lisa;
Pique, Michael E.;
Tainer, John A.

Publication type:

Article

Replication-Based Rearrangements Are a Common Mechanism for SNCA Duplication in Parkinson's Disease.

Published in:

2020

By:

Seo, Soo Hyun;
Bacolla, Albino;
Yoo, Dallah;
Koo, Yoon Jung;
Cho, Sung Im;
Kim, Man Jin;
Seong, Moon‐Woo;
Kim, Han‐Joon;
Kim, Jong‐Min;
Tainer, John A.;
Park, Sung Sup;
Kim, Ji Yeon;
Jeon, Beomseok;
Seong, Moon-Woo;
Kim, Han-Joon;
Kim, Jong-Min

Publication type:

journal article

Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets.

Published in:

Nature, 1975, v. 257, n. 5528, p. 680, doi. 10.1038/257680a0

By:

TURNER, STEPHEN R.;
TAINER, JOHN A.;
LYNN, WILLIAM S.

Publication type:

Article

Crystallographic structure reveals phosphorylated pilin from Neisseria: phosphoserine sites modify type IV pilus surface chemistry and fibre morphology.

Published in:

Molecular Microbiology, 1999, v. 31, n. 3, p. 743, doi. 10.1046/j.1365-2958.1999.01184.x

By:

Forest, Katrina T;
Dunham, Steven A;
Koomey, Michael;
Tainer, John A

Publication type:

Article

Consequences of the loss of O-linked glycosylation of meningococcal type IV pilin on piliation...

Published in:

Molecular Microbiology, 1998, v. 27, n. 4, p. 705, doi. 10.1046/j.1365-2958.1998.00706.x

By:

Marceau, Michael;
Forest, Katrina;
Beretti, Jena-Luc;
Tainer, John;
Nassif, Xavier

Publication type:

Article

A new structural framework for integrating replication protein A into DNA processing machinery.

Published in:

Nucleic Acids Research, 2013, v. 41, n. 4, p. 2313, doi. 10.1093/nar/gks1332

By:

Brosey, Chris A.;
Yan, Chunli;
Tsutakawa, Susan E.;
Heller, William T.;
Rambo, Robert P.;
Tainer, John A.;
Ivanov, Ivaylo;
Chazin, Walter J.

Publication type:

Article

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 22, p. 11435, doi. 10.1093/nar/gks954

By:

Limbo, Oliver;
Moiani, Davide;
Kertokalio, Aryandi;
Wyman, Claire;
Tainer, John A.;
Russell, Paul

Publication type:

Article

Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 13, p. 6070, doi. 10.1093/nar/gks291

By:

Roberts, Victoria A.;
Pique, Michael E.;
Hsu, Simon;
Li, Sheng;
Slupphaug, Geir;
Rambo, Robert P.;
Jamison, Jonathan W.;
Liu, Tong;
Lee, Jun H.;
Tainer, John A.;
Ten Eyck, Lynn F.;
Woods, Virgil L.

Publication type:

Article

Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends.

Published in:

Nucleic Acids Research, 2012, v. 40, n. 10, p. 4507, doi. 10.1093/nar/gks051

By:

Patel, Nikesh;
Atack, John M.;
Finger, L. David;
Exell, Jack C.;
Thompson, Peter;
Tsutakawa, Susan;
Tainer, John A.;
Williams, David M.;
Grasby, Jane A.

Publication type:

Article

Mapping interactions between the RNA chaperone FinO and its RNA targets.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 10, p. 4450, doi. 10.1093/nar/gkr025

By:

Arthur, David C.;
Edwards, Ross A.;
Tsutakawa, Susan;
Tainer, John A.;
Frost, Laura S.;
Glover, J. N. Mark

Publication type:

Article

The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase.

Published in:

Nucleic Acids Research, 2007, v. 35, n. 5, p. 1624, doi. 10.1093/nar/gkm006

By:

Vijayakumar, Sangeetha;
Chapados, Brian R.;
Schmidt, Kristina H.;
Kolodner, Richard D.;
Tainer, John A.;
Tomkinson, Alan E.

Publication type:

Article

Proliferating cell nuclear antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 20, p. 6023, doi. 10.1093/nar/gkl744

By:

Ivanov, Ivaylo;
Chapados, Brian R.;
McCammon, J. Andrew;
Tainer, John A.

Publication type:

Article

Synthesis and characterization of oligonucleotides containing 2′-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction.

Published in:

Nucleic Acids Research, 2006, v. 34, n. 5, p. 1540, doi. 10.1093/nar/gkl061

By:

Doi, Yusuke;
Katafuchi, Atsushi;
Fujiwara, Yoshie;
Hitomi, Kenichi;
Tainer, John A.;
Ide, Hiroshi;
Iwai, Shigenori

Publication type:

Article

Structural and functional analysis of Mre11‐3.

Published in:

Nucleic Acids Research, 2004, v. 32, n. 6, p. 1886, doi. 10.1093/nar/gkh343

By:

Arthur, L. Matthew;
Gustausson, Karin;
Hopfner, Karl‐Peter;
Carson, Christian T.;
Stracker, Travis H.;
Karcher, Annette;
Felton, Diana;
Weitzman, Matthew D.;
Tainer, John;
Carney, James P.

Publication type:

Article

MDB: the Metalloprotein Database and Browser at The Scripps Research Institute.

Published in:

Nucleic Acids Research, 2002, v. 30, n. 1, p. 379, doi. 10.1093/nar/30.1.379

By:

Castagnetto, Jesus M.;
Hennessy, Sean W.;
Roberts, Victoria A.;
Getzoff, Elizabeth D.;
Tainer, John A.;
Pique, Michael E.

Publication type:

Article

Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum.

Published in:

Proteins, 2003, v. 51, n. 1, p. 137, doi. 10.1002/prot.10345

By:

Rosa M.F. Cardoso;
Douglas S. Daniels;
Christopher M. Bruns;
John A. Tainer

Publication type:

Article

Screening a Peptidyl Database for Potential Ligands to Proteins With Side-Chain Flexibility

Published in:

Proteins, 1998, v. 33, n. 1, p. 74

By:

Schnecke, Volker;
Swanson, Craig A.;
Getzoff, Elizabeth D.;
Tainer, John A.;
Kulm, Leslie A.

Publication type:

Article

Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human C u,Z n superoxide dismutase.

Published in:

Proteins, 1997, v. 29, n. 1, p. 103, doi. 10.1002/(SICI)1097-0134(199709)29:1<103::AID-PROT8>3.0.CO;2-G

By:

Fisher, Cindy L.;
Cabelli, Diane E.;
Hallewell, Robert A.;
Beroza, Paul;
Lo, Terence P.;
Getzoff, Elizabeth D.;
Tainer, John A.

Publication type:

Article

Atomic and residue hydrophilicity in the context of folded protein structures.

Published in:

Proteins, 1995, v. 23, n. 4, p. 536, doi. 10.1002/prot.340230408

By:

Kuhn, Leslie A.;
Swanson, Craig A.;
Pique, Michael E.;
Tainer, John A.;
Getzoff, Elizabeth D.

Publication type:

Article

Purification and crystallization of a schistosomal glutathione S-Transferase.

Published in:

Proteins, 1995, v. 22, n. 1, p. 55, doi. 10.1002/prot.340220108

By:

McTigue, Michele A.;
Bernstein, Susan L.;
Williams, DeWight R.;
Tainer, John A.

Publication type:

Article

Crystallization and preliminary crystallographic study of human CksHs1: A cell cycle regulatory protein.

Published in:

Proteins, 1995, v. 21, n. 1, p. 70, doi. 10.1002/prot.340210109

By:

Arvai, Andrew S.;
Bourne, Yves;
Williams, DeWight;
Reed, Steve I.;
Tainer, John A.

Publication type:

Article

Predicting molecular interactions and inducible complementarity: Fragment docking of fab-peptide complexes.

Published in:

Proteins, 1994, v. 20, n. 1, p. 15, doi. 10.1002/prot.340200104

By:

Friedman, Alan R.;
Roberts, Victoria A.;
Tainer, John A.

Publication type:

Article

The role of arginine 143 in the electrostatics and mechanism of Cu, Zn superoxide dismutase: Computational and experimental evaluation by mutational analysis.

Published in:

Proteins, 1994, v. 19, n. 1, p. 24, doi. 10.1002/prot.340190105

By:

Fisher, Cindy L.;
Cabelli, Diane E.;
Tainer, John A.;
Hallewell, Robert A.;
Getzoff, Elizabeth D.

Publication type:

Article

Evolution of CuZn superoxide dismutase and the Greek Key β-barrel structural motif.

Published in:

Proteins, 1989, v. 5, n. 4, p. 322, doi. 10.1002/prot.340050408

By:

Getzoff, Elizabeth D.;
Tainer, John A.;
Stempien, Michelle M.;
Bell, Graeme I.;
Hallewell, Robert A.

Publication type:

Article

Cancer, cadmium and genome integrity.

Published in:

Nature Genetics, 2003, v. 34, n. 3, p. 239, doi. 10.1038/ng0703-239

By:

McMurray, Cynthia T;
Tainer, John A

Publication type:

Article

SUMO-Targeted Ubiquitin Ligase, Rad60, and Nse2 SUMO Ligase Suppress Spontaneous Top1-Mediated DNA Damage and Genome Instability.

Published in:

PLoS Genetics, 2011, v. 7, n. 3, p. 1, doi. 10.1371/journal.pgen.1001320

By:

Heideker, Johanna;
Prudden, John;
Perry, J. Jefferson P.;
Tainer, John A.;
Boddy, Michael N.

Publication type:

Article

Stress Responses as Master Keys to Epigenomic Changes in Transcriptome and Metabolome for Cancer Etiology and Therapeutics.

Published in:

Molecular & Cellular Biology, 2022, v. 42, n. 1, p. 1, doi. 10.1128/MCB.00483-21

By:

Mondal, Atanu;
Bhattacharya, Apoorva;
Singh, Vipin;
Pandita, Shruti;
Bacolla, Albino;
Pandita, Raj K.;
Tainer, John A.;
Ramos, Kenneth S.;
Pandita, Tej K.;
Das, Chandrima

Publication type:

Article

Stress Responses as Master Keys to Epigenomic Changes in Transcriptome and Metabolome for Cancer Etiology and Therapeutics.

Published in:

Molecular & Cellular Biology, 2022, v. 42, n. 1, p. 1, doi. 10.1128/mcb.00483-21

By:

Mondal, Atanu;
Bhattacharya, Apoorva;
Singh, Vipin;
Pandita, Shruti;
Bacolla, Albino;
Pandita, Raj K.;
Tainer, John A.;
Ramos, Kenneth S.;
Pandita, Tej K.;
Das, Chandrima

Publication type:

Article

Autism-Associated Vigilin Depletion Impairs DNA Damage Repair.

Published in:

Molecular & Cellular Biology, 2021, v. 41, n. 7, p. 1, doi. 10.1128/MCB.00082-21

By:

Banday, Shahid;
Pandit, Raj K.;
Mushtaq, Arjamand;
Bacolla, Albino;
Mir, Ulfat Syed;
Singh, Dharmendra Kumar;
Jan, Sadaf;
Bhat, Krishna P.;
Hunt, Clayton R.;
Rao, Ganesh;
Charaka, Vijay K.;
Tainer, John A.;
Pandita, Tej K.;
Altaf, Mohammad

Publication type:

Article

Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development.

Published in:

Molecular & Cellular Biology, 2020, v. 40, n. 18, p. 1, doi. 10.1128/MCB.00232-20

By:

Singh, Mayank;
Bacolla, Albino;
Chaudhary, Shilpi;
Hunt, Clayton R.;
Pandita, Shruti;
Chauhan, Ravi;
Gupta, Ashna;
Tainer, John A.;
Pandita, Tej K.

Publication type:

Article

Identification of unique α4 chain structure and conserved antiangiogenic activity of α3NC1 type IV collagen in zebrafish.

Published in:

Developmental Dynamics, 2023, v. 252, n. 7, p. 1046, doi. 10.1002/dvdy.590

By:

LeBleu, Valerie S.;
Dai, Jianli;
Tsutakawa, Susan;
MacDonald, Brian A.;
Alge, Joseph L.;
Sund, Malin;
Xie, Liang;
Sugimoto, Hikaru;
Tainer, John;
Zon, Leonard I.;
Kalluri, Raghu

Publication type:

Article

Manganese superoxide dismutase induction during measles virus infection (M. Wang and J.M. Howell contributed equally to this submission.).

Published in:

Journal of Medical Virology, 2003, v. 70, n. 3, p. 470

By:

Michael Wang;
Joseph M. Howell;
Jane E. Libbey;
John A. Tainer;
Robert S. Fujinami

Publication type:

Article

Two novel SOD1 mutations in patients with familial amyotrophic lateral sclerosis.

Published in:

Human Molecular Genetics, 1995, v. 4, n. 6, p. 1113

By:

Deng, Han-Xiang;
Tainer, John A.;
Mitsumoto, Hiroshi;
Ohnishi, Akio;
He, Xiaoxuan;
Hung, Wu-Yen;
Zhao, Yaliang;
Juneja, Tony;
Hentati, Afif;
Siddique, Teepu

Publication type:

Article

Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38416-6

By:

Yu, Jina;
Yan, Chunli;
Dodd, Thomas;
Tsai, Chi-Lin;
Tainer, John A.;
Tsutakawa, Susan E.;
Ivanov, Ivaylo

Publication type:

Article

Design of a monomeric human glutathione transferase GSTP1, a structurally stable but catalytically inactive protein.

Published in:

Protein Engineering, 2002, v. 15, n. 10, p. 827, doi. 10.1093/protein/15.10.827

By:

Abdalla, Abdel-Monem;
Bruns, Christopher M.;
Tainer, John A.;
Mannervik, Bengt;
Stenberg, Gun

Publication type:

Article

Heparin-mediated dimerization of follistatin.

Published in:

Experimental Biology & Medicine, 2021, v. 246, n. 4, p. 467, doi. 10.1177/1535370220966296

By:

Walker, Ryan G;
Kattamuri, Chandramohan;
Goebel, Erich J;
Zhang, Fuming;
Hammel, Michal;
Tainer, John A;
Linhardt, Robert J;
Thompson, Thomas B

Publication type:

Article