Works by Swietach, Pawel

Results: 52

Targeting of Evolutionarily Acquired Cancer Cell Phenotype by Exploiting pHi-Metabolic Vulnerabilities.

Published in:

Cancers, 2021, v. 13, n. 1, p. 64, doi. 10.3390/cancers13010064

By:

Ordway, Bryce;
Tomaszewski, Michal;
Byrne, Samantha;
Abrahams, Dominique;
Swietach, Pawel;
Gillies, Robert J.;
Damaghi, Mehdi

Publication type:

Article

Autoregulation of H+/lactate efflux prevents monocarboxylate transport (MCT) inhibitors from reducing glycolytic lactic acid production.

Published in:

2022

By:

Blaszczak, Wiktoria;
Williams, Hannah;
Swietach, Pawel

Publication type:

journal article

Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo.

Published in:

2018

By:

Lee, Shen-Han;
McIntyre, Dominick;
Honess, Davina;
Hulikova, Alzbeta;
Pacheco-Torres, Jesús;
Cerdán, Sebastián;
Swietach, Pawel;
Harris, Adrian L.;
Griffiths, John R.

Publication type:

journal article

Proton export upregulates aerobic glycolysis.

Published in:

BMC Biology, 2022, v. 20, n. 1, p. 1, doi. 10.1186/s12915-022-01340-0

By:

Russell, Shonagh;
Xu, Liping;
Kam, Yoonseok;
Abrahams, Dominique;
Ordway, Bryce;
Lopez, Alex S.;
Bui, Marilyn M.;
Johnson, Joseph;
Epstein, Tamir;
Ruiz, Epifanio;
Lloyd, Mark C.;
Swietach, Pawel;
Verduzco, Daniel;
Wojtkowiak, Jonathan;
Gillies, Robert J.

Publication type:

Article

Evidence-based guidelines for controlling pH in mammalian live-cell culture systems.

Published in:

Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-019-0393-7

By:

Michl, Johanna;
Park, Kyung Chan;
Swietach, Pawel

Publication type:

Article

Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays.

Published in:

Chemosensors, 2021, v. 9, n. 6, p. 139, doi. 10.3390/chemosensors9060139

By:

Blaszczak, Wiktoria;
Tan, Zhengchu;
Swietach, Pawel

Publication type:

Article

Optimal thinning of MCMC output.

Published in:

Journal of the Royal Statistical Society: Series B (Statistical Methodology), 2022, v. 84, n. 4, p. 1059, doi. 10.1111/rssb.12503

By:

Riabiz, Marina;
Chen, Wilson Ye;
Cockayne, Jon;
Swietach, Pawel;
Niederer, Steven A.;
Mackey, Lester;
Oates, Chris. J.

Publication type:

Article

SGLT2 inhibitors and the cardiac Na+/H+ exchanger-1: the plot thickens.

Published in:

Cardiovascular Research, 2021, v. 117, n. 14, p. 2702, doi. 10.1093/cvr/cvab184

By:

Chung, Yu Jin;
Park, Kyung Chan;
Tokar, Sergiy;
Eykyn, Thomas R;
Fuller, William;
Pavlovic, Davor;
Swietach, Pawel;
Shattock, Michael J

Publication type:

Article

Off-target effects of sodium-glucose co-transporter 2 blockers: empagliflozin does not inhibit Na+/H+ exchanger-1 or lower [Na+]i in the heart.

Published in:

Cardiovascular Research, 2021, v. 117, n. 14, p. 2794, doi. 10.1093/cvr/cvaa323

By:

Chung, Yu Jin;
Park, Kyung Chan;
Tokar, Sergiy;
Eykyn, Thomas R;
Fuller, William;
Pavlovic, Davor;
Swietach, Pawel;
Shattock, Michael J

Publication type:

Article

Nitric oxide modulates cardiomyocyte pH control through a biphasic effect on sodium/hydrogen exchanger-1.

Published in:

Cardiovascular Research, 2020, v. 116, n. 12, p. 1958, doi. 10.1093/cvr/cvz311

By:

Richards, Mark A;
Simon, Jillian N;
Ma, Ruichong;
Loonat, Aminah A;
Crabtree, Mark J;
Paterson, David J;
Fahlman, Richard P;
Casadei, Barbara;
Fliegel, Larry;
Swietach, Pawel

Publication type:

Article

Common inhibitors of membrane H+-transport also inhibit carbonic anhydrase.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1284, doi. 10.1096/fasebj.21.6.a1284

By:

Villafuerte, Francisco C.;
Swietach, Pawel;
Vaughan-Jones., Richard O.

Publication type:

Article

H+-extrusion by Na+-H+ exchange is localised at the surface sarcolemma in rat ventricular myocytes.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A1282

By:

Therese HUC, Laurence;
Swietach, Pawel;
Lira, Gregory;
Simmonds, Lucy;
Vaughan-Jones, Richard David

Publication type:

Article

Carbonic anhydrase IX unifies spatial pH1 regulation in large cellclusters.

Published in:

FASEB Journal, 2007, v. 21, n. 6, p. A926, doi. 10.1096/fasebj.21.6.a926-b

By:

Swietach, Pawel;
Wigfield, Simon;
Supuran, Claudiu;
Harris, Adrian L.;
Vaughan-Jones, Richard D.

Publication type:

Article

Regulation of intracellular pH in cancer cell lines under normoxia and hypoxia.

Published in:

Journal of Cellular Physiology, 2013, v. 228, n. 4, p. 743, doi. 10.1002/jcp.24221

By:

Hulikova, Alzbeta;
Harris, Adrian L.;
Vaughan‐Jones, Richard D.;
Swietach, Pawel

Publication type:

Article

Alkaline nucleoplasm facilitates contractile gene expression in the mammalian heart.

Published in:

Basic Research in Cardiology, 2022, v. 117, n. 1, p. 1, doi. 10.1007/s00395-022-00924-9

By:

Hulikova, Alzbeta;
Park, Kyung Chan;
Loonat, Aminah A.;
Gunadasa-Rohling, Mala;
Curtis, M. Kate;
Chung, Yu Jin;
Wilson, Abigail;
Carr, Carolyn A.;
Trafford, Andrew W.;
Fournier, Marjorie;
Moshnikova, Anna;
Andreev, Oleg A.;
Reshetnyak, Yana K.;
Riley, Paul R.;
Smart, Nicola;
Milne, Thomas A.;
Crump, Nicholas T.;
Swietach, Pawel

Publication type:

Article

A Barter Economy in Tumors: Exchanging Metabolites through Gap Junctions.

Published in:

Cancers, 2019, v. 11, n. 1, p. 117, doi. 10.3390/cancers11010117

By:

Swietach, Pawel;
Monterisi, Stefania

Publication type:

Article

The release of GLP‐1 from gut L cells is inhibited by low extracellular pH.

Published in:

Obesity (19307381), 2024, v. 32, n. 10, p. 1819, doi. 10.1002/oby.24125

By:

Garbutt, Philippa;
Cyranka, Malgorzata;
Michl, Johanna;
Maejima, Yuko;
Vedovato, Natascia;
Shimomura, Kenju;
Swietach, Pawel;
de Wet, Heidi

Publication type:

Article

Regional acidosis locally inhibits but remotely stimulates Ca2+ waves in ventricular myocytes.

Published in:

Cardiovascular Research, 2017, v. 113, n. 8, p. 984, doi. 10.1093/cvr/cvx033

By:

Ford, Kerrie L.;
Moorhouse, Emma L.;
Bortolozzi, Mario;
Richards, Mark A.;
Swietach, Pawel;
Vaughan-Jones, Richard D.

Publication type:

Article

Intracellular tortuosity underlies slow cAMP diffusion in adult ventricular myocytes.

Published in:

Cardiovascular Research, 2016, v. 110, n. 3, p. 395, doi. 10.1093/cvr/cvw080

By:

Richards, Mark;
Lomas, Oliver;
Jalink, Kees;
Ford, Kerrie L.;
Vaughan-Jones, Richard D.;
Lefkimmiatis, Konstantinos;
Swietach, Pawel

Publication type:

Article

Na+ ions as spatial intracellular messengers for co-ordinating Ca2+ signals during pH heterogeneity in cardiomyocytes.

Published in:

Cardiovascular Research, 2015, v. 105, n. 2, p. 171, doi. 10.1093/cvr/cvu251

By:

Swietach, Pawel;
Spitzer, Kenneth W.;
Vaughan-Jones, Richard D.

Publication type:

Article

Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study.

Published in:

Cardiovascular Research, 2010, v. 86, n. 1, p. 82, doi. 10.1093/cvr/cvp396

By:

Schroeder, Marie A.;
Swietach, Pawel;
Atherton, Helen J.;
Gallagher, Ferdia A.;
Lee, Phillip;
Radda, George K.;
Clarke, Kieran;
Tyler, Damian J.

Publication type:

Article

Spatial regulation of intracellular pH in multicellular strands of neonatal rat cardiomyocytes.

Published in:

Cardiovascular Research, 2010, v. 85, n. 4, p. 729, doi. 10.1093/cvr/cvp343

By:

Swietach, Pawel;
Camelliti, Patrizia;
Hulikova, Alzbeta;
Kohl, Peter;
Vaughan-Jones, Richard D.

Publication type:

Article

Detection of Intravascular Hemolysis in Newborn Infants Using Urinary Carbonic Anhydrase I Immunoreactivity.

Published in:

Journal of Applied Laboratory Medicine, 2020, v. 5, n. 5, p. 921, doi. 10.1093/jalm/jfaa051

By:

Hulikova, Alzbeta;
Kramer, Holger;
Khan, Hammad;
Swietach, Pawel

Publication type:

Article

Hydrogen ion dynamics in human red blood cells.

Published in:

Journal of Physiology, 2010, v. 588, n. 24, p. 4995, doi. 10.1113/jphysiol.2010.197392

By:

Swietach, Pawel;
Tiffert, Teresa;
Mauritz, Jakob M. A.;
Seear, Rachel;
Esposito, Alessandro;
Kaminski, Clemens F.;
Lew, Virgilio L.;
Vaughan-Jones, Richard D.

Publication type:

Article

Relationship between intracellular pH and proton mobility in rat and guinea-pig ventricular myocytes.

Published in:

Journal of Physiology, 2005, v. 566, n. 3, p. 793, doi. 10.1113/jphysiol.2005.086165

By:

Swietach, Pawel;
Vaughan-Jones, Richard D.

Publication type:

Article

Functional diversity of electrogenic Na+–HCO3− cotransport in ventricular myocytes from rat, rabbit and guinea pig.

Published in:

Journal of Physiology, 2005, v. 562, n. 2, p. 455, doi. 10.1113/jphysiol.2004.071068

By:

Yamamoto, Taku;
Swietach, Pawel;
Rossini, Alessandra;
Shih-Hurng Loh;
Vaughan-Jones, Richard D.;
Spitzer, Kenneth W.

Publication type:

Article

Temperature dependence of Na[sup+]-H[sup+] exchange, Na[sup+]-HCO[sub3, sup-] co-transport, intracellular buffering and intracellular pH in guinea-pig ventricular myocytes.

Published in:

Journal of Physiology, 2003, v. 552, n. 3, p. 715, doi. 10.1113/jphysiol.2003.051888

By:

Ch'en, Frederick F.-T.;
Dilworth, Emma;
Swietach, Pawel;
Goddard, Ruth S.;
Vaughan-Jones, Richard D.

Publication type:

Article

Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.78425

By:

Monterisi, Stefania;
Michl, Johanna;
Hulikova, Alzbeta;
Koth, Jana;
Bridges, Esther M.;
Hill, Amaryllis E.;
Abdullayeva, Gulnar;
Bodmer, Walter F.;
Swietach, Pawel

Publication type:

Article

Single‐cell oxygen saturation imaging shows that gas exchange by red blood cells is not impaired in COVID‐19 patients.

Published in:

British Journal of Haematology, 2020, v. 190, n. 4, p. e229, doi. 10.1111/bjh.17025

By:

Park, Kyung Chan;
Donovan, Killian;
McKechnie, Stuart;
Ramamurthy, Narayan;
Klenerman, Paul;
Swietach, Pawel

Publication type:

Article

Spatial Regulation of Intracellular pH in the Ventricular Myocyte.

Published in:

Annals of the New York Academy of Sciences, 2005, v. 1047, n. 1, p. 271, doi. 10.1196/annals.1341.024

By:

SWIETACH, PAWEL;
VAUGHAN‐JONES, RICHARD D.

Publication type:

Article

What do cellular responses to acidity tell us about cancer?

Published in:

Cancer & Metastasis Reviews, 2021, v. 40, n. 4, p. 1159, doi. 10.1007/s10555-021-10005-3

By:

Blaszczak, Wiktoria;
Swietach, Pawel

Publication type:

Article

What is pH regulation, and why do cancer cells need it?

Published in:

Cancer & Metastasis Reviews, 2019, v. 38, n. 1/2, p. 5, doi. 10.1007/s10555-018-09778-x

By:

Swietach, Pawel

Publication type:

Article

Regulation of tumor pH and the role of carbonic anhydrase 9.

Published in:

Cancer & Metastasis Reviews, 2007, v. 26, n. 2, p. 299, doi. 10.1007/s10555-007-9064-0

By:

Pawel Swietach;
Richard Vaughan-Jones;
Adrian Harris

Publication type:

Article

Defining the ionic mechanisms of optogenetic control of vascular tone by channelrhodopsin-2.

Published in:

2018

By:

Rorsman, Nils J G;
Ta, Chau M;
Garnett, Hannah;
Swietach, Pawel;
Tammaro, Paolo

Publication type:

journal article

Red blood cell thickness is evolutionarily constrained by slow, hemoglobin-restricted diffusion in cytoplasm.

Published in:

Scientific Reports, 2016, p. 36018, doi. 10.1038/srep36018

By:

Richardson, Sarah L.;
Swietach, Pawel

Publication type:

Article

Cancer-associated, hypoxia-inducible carbonic anhydrase IX facilitates CO2 diffusion.

Published in:

BJU International, 2008, v. 101, p. 22, doi. 10.1111/j.1464-410X.2008.07644.x

By:

Swietach, Pawel;
Wigfield, Simon;
Supuran, Claudiu T.;
Harris, Adrian L.;
Vaughan-Jones, Richard D.

Publication type:

Article

T-cells produce acidic niches in lymph nodes to suppress their own effector functions.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-17756-7

By:

Wu, Hao;
Estrella, Veronica;
Beatty, Matthew;
Abrahams, Dominique;
El-Kenawi, Asmaa;
Russell, Shonagh;
Ibrahim-Hashim, Arig;
Longo, Dario Livio;
Reshetnyak, Yana K.;
Moshnikova, Anna;
Andreev, Oleg A.;
Luddy, Kimberly;
Damaghi, Mehdi;
Kodumudi, Krithika;
Pillai, Smitha R.;
Enriquez-Navas, Pedro;
Pilon-Thomas, Shari;
Swietach, Pawel;
Gillies, Robert J.

Publication type:

Article

Importance of Intracellular pH in Determining the Uptake and Efficacy of the Weakly Basic Chemotherapeutic Drug, Doxorubicin.

Published in:

PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035949

By:

Swietach, Pawel;
Hulikova, Alzbeta;
Patiar, Shalini;
Vaughan-Jones, Richard D.;
Harris, Adrian L.

Publication type:

Article

Recovery from hypoxia‐induced internalization of cardiac Na+/H + exchanger 1 requires an adequate intracellular store of antioxidants.

Published in:

Journal of Cellular Physiology, 2019, v. 234, n. 4, p. 4681, doi. 10.1002/jcp.27268

By:

Şimşek, Gül;
Vaughan‐Jones, Richard D.;
Swietach, Pawel;
Kandilci, H. Burak

Publication type:

Article

Channelling protons out of the heart.

Published in:

Journal of Physiology, 2022, v. 600, n. 11, p. 2551, doi. 10.1113/JP283250

By:

Swietach, Pawel;
Despa, Sanda

Publication type:

Article

Rebuttal from Pawel Swietach, Richard D. Vaughan-Jones, Alzbeta Hulikova and Steven A. Niederer.

Published in:

Journal of Physiology, 2015, v. 593, n. 23, p. 5035, doi. 10.1113/JP271240

By:

Swietach, Pawel;
Vaughan‐Jones, Richard D.;
Hulikova, Alzbeta;
Niederer, Steven A.

Publication type:

Article

CrossTalk opposing view: Physiological CO2 exchange does not normally depend on membrane channels.

Published in:

Journal of Physiology, 2015, v. 593, n. 23, p. 5029, doi. 10.1113/JP270013

By:

Hulikova, Alzbeta;
Vaughan‐Jones, Richard D.;
Niederer, Steven A.;
Swietach, Pawel

Publication type:

Article

Pumping Ca2+ up H+ gradients: a Ca2+-H+ exchanger without a membrane.

Published in:

Journal of Physiology, 2014, v. 592, n. 15, p. 3179, doi. 10.1113/jphysiol.2013.265959

By:

Swietach, Pawel;
Leem, Chae‐Hun;
Spitzer, Kenneth W.;
Vaughan‐Jones, Richard D.

Publication type:

Article

Facilitation by intracellular carbonic anhydrase of Na+-HCO3− co-transport but not Na+/H+ exchange activity in the mammalian ventricular myocyte.

Published in:

Journal of Physiology, 2014, v. 592, n. 5, p. 991, doi. 10.1113/jphysiol.2013.265439

By:

Villafuerte, Francisco C.;
Swietach, Pawel;
Youm, Jae‐Boum;
Ford, Kerrie;
Cardenas, Rosa;
Supuran, Claudiu T.;
Cobden, Philip M.;
Rohling, Mala;
Vaughan‐Jones, Richard D.

Publication type:

Article

Sarcolemmal localisation of Na+/H+ exchange and Na+-HCO3− co-transport influences the spatial regulation of intracellular pH in rat ventricular myocytes.

Published in:

Journal of Physiology, 2013, v. 591, n. 9, p. 2287, doi. 10.1113/jphysiol.2012.249664

By:

Garciarena, Carolina D.;
Ma, Yu‐ling;
Swietach, Pawel;
Huc, Laurence;
Vaughan‐Jones, Richard D.

Publication type:

Article

pH-Regulated Na+ Influx into the Mammalian Ventricular Myocyte: The Relative Role of Na+-H+ Exchange and Na+-HCO3− Co-Transport.

Published in:

Journal of Cardiovascular Electrophysiology, 2006, v. 17, p. S134, doi. 10.1111/j.1540-8167.2006.00394.x

By:

VAUGHAN‐JONES, RICHARD D.;
VILLAFUERTE, FRANCISCO C.;
SWIETACH, PAWEL;
YAMAMOTO, TAKU;
ROSSINI, ALESSANDRA;
SPITZER, KENNETH W.

Publication type:

Article

Normoxic cells remotely regulate the acid-base balance of cells at the hypoxic core of connexin-coupled tumor growths.

Published in:

FASEB Journal, 2018, v. 32, p. 83, doi. 10.1096/fj.201700480R

By:

Dovmark, Tobias H.;
Hulikova, Alzbeta;
Niederer, Steven A.;
Vaughan-Jones, Richard D.;
Swietach, Pawel

Publication type:

Article

Distinct moieties underlie biphasic H+ gating of connexin43 channels, producing a pH optimum for intercellular communication.

Published in:

FASEB Journal, 2018, v. 32, n. 4, p. 1969, doi. 10.1096/fj.201700876R

By:

Garciarena, Carolina D.;
Malik, Akif;
Swietach, Pawel;
Moreno, Alonso P.;
Vaughan-Jones, Richard D.

Publication type:

Article

Normoxic cells remotely regulate the acid‐base balance of cells at the hypoxic core of connexin‐coupled tumor growths.

Published in:

FASEB Journal, 2018, v. 32, n. 1, p. 83, doi. 10.1096/fj.201700480r

By:

H. Dovmark, Tobias;
Hulikova, Alzbeta;
A. Niederer, Steven;
D. Vaughan‐Jones, Richard;
Swietach, Pawel

Publication type:

Article

Normoxic cells remotely regulate the acid-base balance of cells at the hypoxic core of connexin-coupled tumor growths.

Published in:

FASEB Journal, 2018, v. 32, n. 1, p. 83, doi. 10.1096/fj.201700480R

By:

Dovmark, Tobias H.;
Hulikova, Alzbeta;
Niederer, Steven A.;
Vaughan-Jones, Richard D.;
Swietach, Pawel

Publication type:

Article