Works by Sumbria, Rachita

Results: 35

Effects of Dabigatran in Mouse Models of Aging and Cerebral Amyloid Angiopathy.

Published in:

Frontiers in Neurology, 2019, p. 1, doi. 10.3389/fneur.2019.00966

By:

Michael, Neethu;
Grigoryan, Mher Mahoney;
Kilday, Kelley;
Sumbria, Rachita K.;
Vasilevko, Vitaly;
van Ryn, Joanne;
Cribbs, David H.;
Paganini-Hill, Annlia;
Fisher, Mark J.

Publication type:

Article

Tumor necrosis factor α Inhibition for Alzheimer's Disease.

Published in:

Journal of Central Nervous System Disease, 2017, n. 9, p. 1, doi. 10.1177/1179573517709278

By:

Chang, Rudy;
Kei-Lwun Yee;
Sumbria, Rachita K.

Publication type:

Article

Biologic TNF-α inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy.

Published in:

2021

By:

Ou, Weijun;
Yang, Joshua;
Simanauskaite, Juste;
Choi, Matthew;
Castellanos, Demi M.;
Chang, Rudy;
Sun, Jiahong;
Jagadeesan, Nataraj;
Parfitt, Karen D.;
Cribbs, David H.;
Sumbria, Rachita K.

Publication type:

journal article

Brain delivery of erythropoietin results in a significant reduction of brain Aβ and spatial memory deficits in the APP knock‐in mouse model.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. S6, p. 1, doi. 10.1002/alz.090625

By:

Chang, Rudy Tieu;
Chandrashekar, Devaraj V.;
Roules, Grace‐Ann Chuli;
Iwasaki, Emi;
Jagadeesan, Nataraj;
Sumbria, Rachita K.

Publication type:

Article

Chronic heavy alcohol intake and liver‐specific LRP‐1 reduction increase amyloidosis in Alzheimer's disease mice.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.087662

By:

Chandrashekar, Devaraj V.;
Roules, G. Chuli;
Steinberg, Ross A.;
Panchal, Urvashi R.;
Jagadeesan, Nataraj;
Oyegbesan, Adenike;
Roselyn, Trinh;
Yang, Joshua;
Bhagwat, Sharda R.;
Rakholia, Hiya;
Mevawala, Rutvi D.;
Roosan, Moom;
Han, Derick;
Sumbria, Rachita K.

Publication type:

Article

Modulation of hippocampal protein expression by a brain penetrant biologic TNF‐α inhibitor in the 3xTg Alzheimer's disease mice.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082686

By:

Jagadeesan, Nataraj;
Roules, Grace Anne Chuli;
Chandrashekar, Devaraj V;
Yang, Joshua;
Kolluru, Sanjana;
Sumbria, Rachita K

Publication type:

Article

P2‐165: HEMATOLOGIC SAFETY OF A BRAIN PENETRATING ERYTHROPOIETIN‐TRANSFERRIN RECEPTOR ANTIBODY FUSION PROTEIN IN A MOUSE MODEL OF ALZHEIMER'S DISEASE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P638, doi. 10.1016/j.jalz.2019.06.2572

By:

Sun, Jiahong;
Yang, Joshua;
Zhu, Charlene;
Whitman, Kathrine;
Martin, Jan Michelle;
Mody, Pavan;
Cribbs, David H.;
Boado, Ruben;
Pardridge, William M.;
Sumbria, Rachita K.

Publication type:

Article

P3‐057: THERAPEUTIC EFFECTS OF A BRAIN PENETRATING BISPECIFIC ERYTHROPOIETIN‐TRANSFERRIN RECEPTOR ANTIBODY FUSION PROTEIN IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER'S DISEASE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1086, doi. 10.1016/j.jalz.2018.06.1413

By:

Chang, Rudy;
Al Maghribi, Abrar;
Vanderpoel, Victoria;
Ing, Austin;
Vasilevko, Vitaly;
Cribbs, David H.;
Boado, Ruben;
Pardridge, William M.;
Sumbria, Rachita

Publication type:

Article

Chronic kidney disease promotes cerebral microhemorrhage formation.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02703-2

By:

Fang, Chuo;
Lau, Wei Ling;
Sun, Jiahong;
Chang, Rudy;
Vallejo, Adrian;
Lee, Donghy;
Liu, Jihua;
Liu, Han;
Hung, Yu-Han;
Zhao, Yitong;
Paganini-Hill, Annlia;
Sumbria, Rachita K.;
Cribbs, David H.;
Fisher, Mark

Publication type:

Article

Acute Depression of Energy Metabolism after Microdialysis Probe Implantation is Distinct from Ischemia-Induced Changes in Mouse Brain.

Published in:

Neurochemical Research, 2011, v. 36, n. 1, p. 109, doi. 10.1007/s11064-010-0276-2

By:

Sumbria, Rachita;
Klein, Jochen;
Bickel, Ulrich

Publication type:

Article

PROTECTIVE EFFECTS OF A BRAIN-PENETRATING BIOLOGIC TNF-ALPHA INHIBITOR IN A MOUSE MODEL OF ALZHEIMER’S DISEASE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1242, doi. 10.1016/j.jalz.2017.07.451

By:

Chang, Rudy;
Knox, Jillian;
Chang, Jae;
Woods, Jeffery;
Derbedrossian, Aram;
Vasilevko, Vitaly;
Cribbs, David H.;
Boado, Ruben;
Pardridge, William M.;
Sumbria, Rachita

Publication type:

Article

Brain protection from stroke with intravenous TNFα decoy receptor-Trojan horse fusion protein.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2012, v. 32, n. 10, p. 1933, doi. 10.1038/jcbfm.2012.97

By:

Sumbria, Rachita K;
Boado, Ruben J;
Pardridge, William M

Publication type:

Article

Erythrocyte–brain endothelial interactions induce microglial responses and cerebral microhemorrhages in vivo.

Published in:

Journal of Neuroinflammation, 2023, v. 20, n. 1, p. 1, doi. 10.1186/s12974-023-02932-5

By:

Zhang, Hai;
Sumbria, Rachita K.;
Chang, Rudy;
Sun, Jiahong;
Cribbs, David H.;
Holmes, Todd C.;
Fisher, Mark J.;
Xu, Xiangmin

Publication type:

Article

Effect of chronic alcohol feeding using the Lieber-DeCarli diet on Alzheimer's disease pathology in Tg2576 mice.

Published in:

Frontiers in Aging Neuroscience, 2025, p. 1, doi. 10.3389/fnagi.2025.1526571

By:

Chandrashekar, Devaraj V.;
Jagadeesan, Nataraj;
Abdullah, Tamara;
Chang, Rudy;
Steinberg, Ross A.;
Sanchez, Frankey;
Khal, Elias;
Yang, Joshua;
Cribbs, David H.;
Han, Derick;
Sumbria, Rachita K.

Publication type:

Article

Brain Endothelial Erythrophagocytosis and Hemoglobin Transmigration Across Brain Endothelium: Implications for Pathogenesis of Cerebral Microbleeds.

Published in:

Frontiers in Cellular Neuroscience, 2018, p. N.PAG, doi. 10.3389/fncel.2018.00279

By:

Chang, Rudy;
Castillo, Juan;
Zambon, Alexander C.;
Krasieva, Tatiana B.;
Fisher, Mark J.;
Sumbria, Rachita K.

Publication type:

Article

The Promises and Challenges of Erythropoietin for Treatment of Alzheimer's Disease.

Published in:

NeuroMolecular Medicine, 2019, v. 21, n. 1, p. 12, doi. 10.1007/s12017-019-08524-y

By:

Sun, Jiahong;
Martin, Jan Michelle;
Vanderpoel, Victoria;
Sumbria, Rachita K.

Publication type:

Article

The Effects of a Blood–Brain Barrier Penetrating Erythropoietin in a Mouse Model of Tauopathy.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 4, p. 558, doi. 10.3390/ph16040558

By:

Yang, Joshua;
Ou, Weijun;
Jagadeesan, Nataraj;
Simanauskaite, Juste;
Sun, Jiahong;
Castellanos, Demi;
Cribbs, David H.;
Sumbria, Rachita K.

Publication type:

Article

A murine model of inflammation-induced cerebral microbleeds.

Published in:

2016

By:

Sumbria, Rachita K.;
Grigoryan, Mher Mahoney;
Vasilevko, Vitaly;
Krasieva, Tatiana B.;
Scadeng, Miriam;
Dvornikova, Alexandra K.;
Paganini-Hill, Annlia;
Kim, Ronald;
Cribbs, David H.;
Fisher, Mark J.

Publication type:

journal article

The legacy of William M. Pardridge (1947–2024) on the science and fields concerned with the physiology of the blood-brain barrier and the transport of drugs to the brain.

Published in:

Fluids & Barriers of the CNS, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12987-025-00659-4

By:

Boado, Ruben J.;
Bickel, Ulrich;
Sumbria, Rachita K.

Publication type:

Article

Brain endothelial cells as phagocytes: mechanisms and implications.

Published in:

Fluids & Barriers of the CNS, 2025, v. 22, n. 1, p. 1, doi. 10.1186/s12987-025-00637-w

By:

Chang, Rudy T.;
Fisher, Mark J.;
Sumbria, Rachita K.

Publication type:

Article

Modulation of hepatic amyloid precursor protein and lipoprotein receptor-related protein 1 by chronic alcohol intake: Potential link between liver steatosis and amyloid-β.

Published in:

Frontiers in Physiology, 2022, v. 13, p. 1, doi. 10.3389/fphys.2022.930402

By:

Garcia, Jerome;
Chang, Rudy;
Steinberg, Ross A.;
Arce, Aldo;
Yang, Joshua;
Van Der Eb, Peter;
Abdullah, Tamara;
Chandrashekar, Devaraj V.;
Eck, Sydney M.;
Meza, Pablo;
Zhang-Xu Liu;
Cadenas, Enrique;
Cribbs, David H.;
Kaplowitz, Neil;
Sumbria, Rachita K.;
Han, Derick

Publication type:

Article

Elevated TNF-α Leads to Neural Circuit Instability in the Absence of Interferon Regulatory Factor 8.

Published in:

Journal of Neuroscience, 2022, v. 42, n. 32, p. 6171, doi. 10.1523/JNEUROSCI.0601-22.2022

By:

Feinberg, Philip A.;
Becker, Shannon C.;
Leeyup Chung;
Ferrari, Loris;
Stellwagen, David;
Anaclet, Christelle;
Durán-Laforet, Violeta;
Faust, Travis E.;
Sumbria, Rachita K.;
Schafer, Dorothy P.

Publication type:

Article

Alcohol as a Modifiable Risk Factor for Alzheimer's Disease—Evidence from Experimental Studies.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9492, doi. 10.3390/ijms24119492

By:

Chandrashekar, Devaraj V.;
Steinberg, Ross A.;
Han, Derick;
Sumbria, Rachita K.

Publication type:

Article

Hematologic safety of chronic brain‐penetrating erythropoietin dosing in APP/PS1 mice.

Published in:

Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2019, v. 5, n. 1, p. 627, doi. 10.1016/j.trci.2019.09.003

By:

Sun, Jiahong;
Yang, Joshua;
Whitman, Kathrine;
Zhu, Charlene;
Cribbs, David H.;
Boado, Ruben J.;
Pardridge, William M.;
Sumbria, Rachita K.

Publication type:

Article

Efficacy and Safety of a Brain-Penetrant Biologic TNF-α Inhibitor in Aged APP/PS1 Mice.

Published in:

Pharmaceutics, 2022, v. 14, n. 10, p. N.PAG, doi. 10.3390/pharmaceutics14102200

By:

Ou, Weijun;
Ohno, Yuu;
Yang, Joshua;
Chandrashekar, Devaraj V.;
Abdullah, Tamara;
Sun, Jiahong;
Murphy, Riley;
Roules, Chuli;
Jagadeesan, Nataraj;
Cribbs, David H.;
Sumbria, Rachita K.

Publication type:

Article

Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice.

Published in:

Pharmaceutics, 2020, v. 12, n. 9, p. 852, doi. 10.3390/pharmaceutics12090852

By:

Castellanos, Demi M.;
Sun, Jiahong;
Yang, Joshua;
Ou, Weijun;
Zambon, Alexander C.;
Pardridge, William M.;
Sumbria, Rachita K.

Publication type:

Article

Comparative studies between the murine immortalized brain endothelial cell line (bEnd.3) and induced pluripotent stem cell-derived human brain endothelial cells for paracellular transport.

Published in:

PLoS ONE, 2022, v. 17, n. 5, p. 1, doi. 10.1371/journal.pone.0268860

By:

Sun, Jiahong;
Ou, Weijun;
Han, Derick;
Paganini-Hill, Annlia;
Fisher, Mark J.;
Sumbria, Rachita K.

Publication type:

Article

Effects of PDE4 pathway inhibition in rat experimental stroke.

Published in:

2014

By:

Yang, Fan;
Sumbria, Rachita K;
Xue, Dong;
Yu, Chuanhui;
He, Dan;
Liu, Shuo;
Paganini-Hill, Annlia;
Fisher, Mark

Publication type:

journal article

Effects of PDE4 Pathway Inhibition in Rat Experimental Stroke.

Published in:

Journal of Pharmacy & Pharmaceutical Sciences, 2014, v. 17, n. 3, p. 362, doi. 10.18433/j3s02v

By:

Fan Yang;
Sumbria, Rachita K.;
Dong Xue;
Chuanhui Yu;
Dan He;
Shuo Liu;
Paganini-Hill, Annlia;
Fisher, Mark J.

Publication type:

Article

Ginkgo extract EGb761 confers neuroprotection by reduction of glutamate release in ischemic brain.

Published in:

2012

By:

Klein J;
Mdzinarishvili A;
Sambria RK;
Lang D;
Mdzinarishvili, Alexander;
Sumbria, Rachita;
Lang, Dorothee;
Klein, Jochen

Publication type:

journal article

Ginkgo Extract EGb761 Confers Neuroprotection by Reduction of Glutamate Release in Ischemic Brain.

Published in:

Journal of Pharmacy & Pharmaceutical Sciences, 2012, v. 15, n. 1, p. 94

By:

Mdzinarishvil, Alexander;
Sumbria, Rachita;
Lang, Dorothee;
Klein, Jochen

Publication type:

Article

Aging exacerbates development of cerebral microbleeds in a mouse model.

Published in:

2018

By:

Sumbria, Rachita K.;
Grigoryan, Mher Mahoney;
Vasilevko, Vitaly;
Paganini-Hill, Annlia;
Kilday, Kelley;
Kim, Ronald;
Cribbs, David H.;
Fisher, Mark J.

Publication type:

journal article

Effects of phosphodiesterase 3A modulation on murine cerebral microhemorrhages.

Published in:

2017

By:

Sumbria, Rachita K.;
Vasilevko, Vitaly;
Grigoryan, Mher Mahoney;
Paganini-Hill, Annlia;
Kim, Ronald;
Cribbs, David H.;
Fisher, Mark J.

Publication type:

journal article

Effects of phosphodiesterase 3A modulation on murine cerebral microhemorrhages.

Published in:

Journal of Neuroinflammation, 2017, v. 14, p. 1, doi. 10.1186/s12974-017-0885-7

By:

Sumbria, Rachita K.;
Vasilevko, Vitaly;
Grigoryan, Mher Mahoney;
Paganini-Hill, Annlia;
Kim, Ronald;
Cribbs, David H.;
Fisher, Mark J.

Publication type:

Article

Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor.

Published in:

Biotechnology & Bioengineering, 2013, v. 110, n. 5, p. 1456, doi. 10.1002/bit.24795

By:

Boado, Ruben J.;
Lu, Jeff Zhiqiang;
Hui, Eric K.‐W.;
Sumbria, Rachita K.;
Pardridge, William M.

Publication type:

Article