Works by Stienen, Ger J. M.

Results: 32

Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk‐related rat model of heart failure with preserved ejection fraction.

Published in:

Acta Physiologica, 2020, v. 228, n. 3, p. 1, doi. 10.1111/apha.13378

By:

Miranda‐Silva, Daniela;
Wüst, Rob C. I.;
Conceição, Glória;
Gonçalves‐Rodrigues, Patrícia;
Gonçalves, Nádia;
Gonçalves, Alexandre;
Kuster, Diederik W. D.;
Leite‐Moreira, Adelino F.;
van der Velden, Jolanda;
de Sousa Beleza, Jorge M.;
Magalhães, José;
Stienen, Ger J. M.;
Falcão‐Pires, Inês

Publication type:

Article

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.

Published in:

2017

By:

van den Berg, Marloes;
Hooijman, Pleuni E.;
Beishuizen, Albertus;
de Waard, Monique C.;
Paul, Marinus A.;
Hartemink, Koen J.;
van Hees, Hieronymus W. H.;
Lawlor, Michael W.;
Brocca, Lorenza;
Bottinelli, Roberto;
Pellegrino, Maria A.;
Stienen, Ger J. M.;
Heunks, Leo M. A.;
Wüst, Rob C. I.;
Ottenheijm, Coen A. C.

Publication type:

journal article

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients.

Published in:

2015

By:

Hooijman, Pleuni E;
Beishuizen, Albertus;
Witt, Christian C;
de Waard, Monique C;
Girbes, Armand R J;
Spoelstra-de Man, Angelique M E;
Niessen, Hans W M;
Manders, Emmy;
van Hees, Hieronymus W H;
van den Brom, Charissa E;
Silderhuis, Vera;
Lawlor, Michael W;
Labeit, Siegfried;
Stienen, Ger J M;
Hartemink, Koen J;
Paul, Marinus A;
Heunks, Leo M A;
Ottenheijm, Coen A C

Publication type:

journal article

Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2015, v. 191, n. 10, p. 1126, doi. 10.1164/rccm.201412-2214OC

By:

Hooijman, Pleuni E.;
Beishuizen, Albertus;
Witt, Christian C.;
de Waard, Monique C.;
Girbes, Armand R. J.;
Spoelstra-de Man, Angelique M. E.;
Niessen, Hans W. M.;
Manders, Emmy;
van Hees, Hieronymus W. H.;
van den Brom, Charissa E.;
Silderhuis, Vera;
Lawlor, Michael W.;
Labeit, Siegfried;
Stienen, Ger J. M.;
Hartemink, Koen J.;
Paul, Marinus A.;
Heunks, Leo M. A.;
Ottenheijm, Coen A. C.

Publication type:

Article

DIAPHRAGM MUSCLE FIBER WEAKNESS AND UBIQUITIN-PROTEASOME ACTIVATION IN CRITICALLY ILL PATIENTS.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2015, v. 191, n. 10, p. E1, doi. 10.1164/rccm.201412-2214oc

By:

Hooijman, Pleuni E.;
Beishuizen, Albertus;
Witt, Christian C.;
de Waard, Monique C.;
Girbes, Armand R. J.;
Spoelstra-de Man, Angelique M. E.;
Niessen, Hans W. M.;
Manders, E.;
van Hees, Hieronymus W. H.;
van den Brom, Charissa E.;
Silderhuis, Vera;
Lawlor, Michael W.;
Labeit, Siegfried;
Stienen, Ger J. M.;
Hartemink, Koen J.;
Paul, Marinus A.;
Heunks, Leo M. A.;
Ottenheijm, Coen A. C.

Publication type:

Article

Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure.

Published in:

Cardiovascular Research, 2016, v. 111, n. 4, p. 362, doi. 10.1093/cvr/cvw176

By:

Wüst, Rob C.I.;
de Vries, Heder J.;
Wintjes, Liesbeth T.;
Rodenburg, Richard J.;
Niessen, Hans W. M.;
Stienen, Ger J. M.

Publication type:

Article

Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium.

Published in:

Journal of Physiology, 2007, v. 582, n. 2, p. 695, doi. 10.1113/jphysiol.2007.134486

By:

Lamberts, Regis R.;
Hamdani, Nazha;
Soekhoe, Tenoedj W.;
Boontje, Nicky M.;
Zaremba, Ruud;
Walker, Lori A.;
de Tombe, Pieter P.;
van der Velden, Jolanda;
Stienen, Ger J. M.

Publication type:

Article

Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator.

Published in:

2014

By:

Hooijman, Pleuni E;
Beishuizen, Albertus;
de Waard, Monique C;
de Man, Frances S;
Vermeijden, J W;
Steenvoorde, Pascal;
Bouwman, R Arthur;
Lommen, Wies;
van Hees, Hieronymus W H;
Heunks, Leo M A;
Dickhoff, Chris;
van der Peet, Donald L;
Girbes, Armand R J;
Jasper, Jeff R;
Malik, Fady I;
Stienen, Ger J M;
Hartemink, Koen J;
Paul, Marinus A;
Ottenheijm, Coen A C

Publication type:

Letter

Diaphragm Fiber Strength Is Reduced in Critically Ill Patients and Restored by a Troponin Activator.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2014, v. 189, n. 7, p. 863, doi. 10.1164/rccm.201312-2260le

By:

Hooijman, Pleuni E.;
Beishuizen, Albertus;
de Waard, Monique C.;
de Man, Frances S.;
Vermeijden, J. W.;
Steenvoorde, Pascal;
Arthur Bouwman, R.;
Lommen, Wies;
van Hees, Hieronymus W. H.;
Heunks, Leo M. A.;
Dickhoff, Chris;
van der Peet, Donald L.;
Girbes, Armand R. J.;
Jasper, Jeff R.;
Malik, Fady I.;
Stienen, Ger J. M.;
Hartemink, Koen J.;
Paul, Marinus A.;
Ottenheijm, Coen A. C.

Publication type:

Article

Diaphragm Muscle Fiber Weakness in Pulmonary Hypertension.

Published in:

American Journal of Respiratory & Critical Care Medicine, 2011, v. 183, n. 10, p. 1411, doi. 10.1164/rccm.201003-0354OC

By:

de Man, Frances S.;
van Hees, Hieronymus W. H.;
Handoko, M. Louis;
Niessen, Hans W.;
Schalij, Ingrid;
Humbert, Marc;
Dorfmüller, Peter;
Mercier, Olaf;
Bogaard, Harm-Jan;
Postmus, Piet E.;
Westerhof, Nico;
Stienen, Ger J. M.;
van der Laarse, Willem J.;
Vonk-Noordegraaf, Anton;
Ottenheijm, Coen A. C.

Publication type:

Article

More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease.

Published in:

Journal of Muscle Research & Cell Motility, 2010, v. 31, n. 4, p. 289, doi. 10.1007/s10974-010-9231-8

By:

Hamdani, Nazha;
Borbély, Attila;
Veenstra, Sophie P. G. R.;
Kooij, Viola;
Vrydag, Wim;
Zaremba, Ruud;
dos Remedios, Cris;
Niessen, Hans W. M.;
Michel, Martin C.;
Paulus, Walter J.;
Stienen, Ger J. M.;
van der Velden, Jolanda

Publication type:

Article

A piece of the human heart: variance of protein phosphorylation in left ventricular samples from end-stage primary cardiomyopathy patients.

Published in:

Journal of Muscle Research & Cell Motility, 2009, v. 30, n. 7/8, p. 299, doi. 10.1007/s10974-010-9205-x

By:

Van Dijk, Sabine J.;
Holewijn, Rozemarije A.;
Tebeest, Anouk;
Dos Remedios, Cris;
Stienen, Ger J. M.;
Van der Velden, Jolanda

Publication type:

Article

Expression of cTnI-R145G affects shortening properties of adult rat cardiomyocytes.

Published in:

Pflügers Archiv: European Journal of Physiology, 2008, v. 457, n. 1, p. 17, doi. 10.1007/s00424-008-0487-4

By:

Reis, Stephanie;
Littwitz, Christoph;
Preilowski, Sebastian;
Mügge, Andreas;
Stienen, Ger J. M.;
Pott, Lutz;
Jaquet, Kornelia

Publication type:

Article

The force and stiffness of myosin motors in the isometric twitch of a cardiac trabecula and the effect of the extracellular calcium concentration.

Published in:

Journal of Physiology, 2018, v. 596, n. 13, p. 2581, doi. 10.1113/JP275579

By:

Pinzauti, Francesca;
Pertici, Irene;
Reconditi, Massimo;
Narayanan, Theyencheri;
Stienen, Ger J. M.;
Piazzesi, Gabriella;
Lombardi, Vincenzo;
Linari, Marco;
Caremani, Marco

Publication type:

Article

Rapid frequency-dependent changes in free mitochondrial calcium concentration in rat cardiac myocytes.

Published in:

Journal of Physiology, 2017, v. 595, n. 6, p. 2001, doi. 10.1113/JP273589

By:

Wüst, Rob C. I.;
Helmes, Michiel;
Martin, Jody L.;
der Wardt, Thomas J. T.;
Musters, René J. P.;
der Velden, Jolanda;
Stienen, Ger J. M.

Publication type:

Article

Synergistic role of ADP and Ca2+ in diastolic myocardial stiffness.

Published in:

Journal of Physiology, 2015, v. 593, n. 17, p. 3899, doi. 10.1113/JP270354

By:

Sequeira, Vasco;
Najafi, Aref;
McConnell, Mark;
Fowler, Ewan D.;
Bollen, Ilse A. E.;
Wüst, Rob C. I.;
dos Remedios, Cris;
Helmes, Michiel;
White, Ed;
Stienen, Ger J. M.;
Tardiff, Jil;
Kuster, Diederik W. D.;
der Velden, Jolanda

Publication type:

Article

Rapid changes in NADH and flavin autofluorescence in rat cardiac trabeculae reveal large mitochondrial complex II reserve capacity.

Published in:

Journal of Physiology, 2015, v. 593, n. 8, p. 1829, doi. 10.1113/jphysiol.2014.286153

By:

Wüst, Rob C. I.;
Helmes, Michiel;
Stienen, Ger J. M.

Publication type:

Article

Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation.

Published in:

Journal of Physiology, 2014, v. 592, n. 15, p. 3257, doi. 10.1113/jphysiol.2014.274571

By:

Witjas‐Paalberends, E. Rosalie;
Ferrara, Claudia;
Scellini, Beatrice;
Piroddi, Nicoletta;
Montag, Judith;
Tesi, Chiara;
Stienen, Ger J. M.;
Michels, Michelle;
Ho, Carolyn Y.;
Kraft, Theresia;
Poggesi, Corrado;
Velden, Jolanda

Publication type:

Article

Training one type of striated muscle to counteract failure of another type.

Published in:

Journal of Physiology, 2012, v. 590, n. 6, p. 1307, doi. 10.1113/jphysiol.2012.228569

By:

Stienen, Ger J. M.;
Ottenheijm, Coen A. C.

Publication type:

Article

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.

Published in:

Skeletal Muscle, 2015, v. 5, n. 1, p. 1, doi. 10.1186/s13395-015-0037-7

By:

de Winter, Josine M.;
Joureau, Barbara;
Sequeira, Vasco;
Clarke, Nigel F.;
van der Velden, Jolanda;
Stienen, Ger J. M.;
Granzier, Henk;
Beggs, Alan H.;
Ottenheijm, Coen A. C.

Publication type:

Article

A 3D diffusional-compartmental model of the calcium dynamics in cytosol, sarcoplasmic reticulum and mitochondria of murine skeletal muscle fibers.

Published in:

PLoS ONE, 2018, v. 13, n. 7, p. 1, doi. 10.1371/journal.pone.0201050

By:

Marcucci, Lorenzo;
Canato, Marta;
Protasi, Feliciano;
Stienen, Ger J. M.;
Reggiani, Carlo

Publication type:

Article

Protein kinase C α and ε phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium.

Published in:

Basic Research in Cardiology, 2010, v. 105, n. 2, p. 289, doi. 10.1007/s00395-009-0053-z

By:

Kooij, Viola;
Boontje, Nicky;
Zaremba, Ruud;
Jaquet, Kornelia;
dos Remedios, Cris;
Stienen, Ger J. M.;
Velden, Jolanda van der

Publication type:

Article

Effects of contractile protein phosphorylation on force development in permeabilized rat cardiac myocytes.

Published in:

Basic Research in Cardiology, 2007, v. 102, n. 6, p. 476, doi. 10.1007/s00395-007-0663-2

By:

Verduyn, S. Cora;
Zaremba, Ruud;
Velden, Jolanda van der;
Stienen, Ger J. M.

Publication type:

Article

Right ventricular hypertrophy causes impairment of left ventricular diastolic function in the rat.

Published in:

Basic Research in Cardiology, 2007, v. 102, n. 1, p. 19, doi. 10.1007/s00395-006-0620-5

By:

Lamberts, Regis R.;
Vaessen, Rob J.;
Westerhof, Nico;
Stienen, Ger J. M.

Publication type:

Article

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.

Published in:

Brain: A Journal of Neurology, 2013, v. 136, n. 6, p. 1718, doi. 10.1093/brain/awt113

By:

Ottenheijm, Coen A. C.;
Buck, Danielle;
de Winter, Josine M.;
Ferrara, Claudia;
Piroddi, Nicoletta;
Tesi, Chiara;
Jasper, Jeffrey R.;
Malik, Fady I.;
Meng, Hui;
Stienen, Ger J. M.;
Beggs, Alan H.;
Labeit, Siegfried;
Poggesi, Corrado;
Lawlor, Michael W.;
Granzier, Henk

Publication type:

Article

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3).

Published in:

2018

By:

Joureau, Barbara;
de Winter, Josine Marieke;
Conijn, Stefan;
Bogaards, Sylvia J. P.;
Kovacevic, Igor;
Kalganov, Albert;
Persson, Malin;
Lindqvist, Johan;
Stienen, Ger J. M.;
Irving, Thomas C.;
Ma, Weikang;
Yuen, Michaela;
Clarke, Nigel F.;
Rassier, Dilson E.;
Malfatti, Edoardo;
Romero, Norma B.;
Beggs, Alan H.;
Ottenheijm, Coen A. C.

Publication type:

journal article

Mutation-specific effects on thin filament length in thin filament myopathy.

Published in:

2016

By:

Winter, Josine M. de;
Joureau, Barbara;
Lee, Eun‐Jeong;
Kiss, Balázs;
Yuen, Michaela;
Gupta, Vandana A.;
Pappas, Christopher T.;
Gregorio, Carol C.;
Stienen, Ger J. M.;
Edvardson, Simon;
Wallgren‐Pettersson, Carina;
Lehtokari, Vilma‐Lotta;
Pelin, Katarina;
Malfatti, Edoardo;
Romero, Norma B.;
Engelen, Baziel G. van;
Voermans, Nicol C.;
Donkervoort, Sandra;
Bönnemann, C. G.;
Clarke, Nigel F.

Publication type:

journal article

Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies.

Published in:

Proteomics - Clinical Applications, 2007, v. 1, n. 10, p. 1285, doi. 10.1002/prca.200600891

By:

Zaremba, Ruud;
Merkus, Daphne;
Hamdani, Nazha;
Lamers, Jos M. J.;
Paulus, Walter J.;
dos Remedios, Cris;
Duncker, Dirk J.;
Stienen, Ger J. M.;
van der Velden, Jolanda

Publication type:

Article

Mitochondrial Ca2+-Handling in Fast Skeletal Muscle Fibers from Wild Type and Calsequestrin-Null Mice.

Published in:

PLoS ONE, 2013, v. 8, n. 10, p. 1, doi. 10.1371/journal.pone.0074919

By:

Scorzeto, Michele;
Giacomello, Marta;
Toniolo, Luana;
Canato, Marta;
Blaauw, Bert;
Paolini, Cecilia;
Protasi, Feliciano;
Reggiani, Carlo;
Stienen, Ger J. M.

Publication type:

Article

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol.

Published in:

BMC Neurology, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-2377-13-144

By:

Lassche, Saskia;
Ottenheijm, Coen A. C.;
Voermans, Nicol C.;
Westeneng, Henk-Jan;
Janssen, Barbara H.;
van der Maarel, Silvère M.;
Hopman, Maria T.;
Padberg, George W.;
Stienen, Ger J. M.;
van Engelen, Baziel G. M.

Publication type:

Article

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol.

Published in:

2013

By:

Lassche, Saskia;
Ottenheijm, Coen Ac;
Voermans, Nicol C;
Westeneng, Henk-Jan;
Janssen, Barbara H;
van der Maarel, Silvère M;
Hopman, Maria T;
Padberg, George W;
Stienen, Ger Jm;
van Engelen, Baziel Gm;
Ottenheijm, Coen A C;
Stienen, Ger J M;
van Engelen, Baziel G M

Publication type:

journal article

The development of familial hypertrophic cardiomyopathy: from mutation to bedside.

Published in:

European Journal of Clinical Investigation, 2011, v. 41, n. 5, p. 568, doi. 10.1111/j.1365-2362.2010.02439.x

By:

Brouwer, Wessel P.;
van Dijk, Sabine J.;
Stienen, Ger J. M.;
van Rossum, Albert C.;
van der Velden, Jolanda;
Germans, Tjeerd

Publication type:

Article

Works by Stienen, Ger J. M.

Disturbed cardiac mitochondrial and cytosolic calcium handling in a metabolic risk‐related rat model of heart failure with preserved ejection fraction.

Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.

Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients.

Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients.

DIAPHRAGM MUSCLE FIBER WEAKNESS AND UBIQUITIN-PROTEASOME ACTIVATION IN CRITICALLY ILL PATIENTS.

Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure.

Frequency-dependent myofilament Ca<sup>2+</sup> desensitization in failing rat myocardium.

Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator.

Diaphragm Fiber Strength Is Reduced in Critically Ill Patients and Restored by a Troponin Activator.

Diaphragm Muscle Fiber Weakness in Pulmonary Hypertension.

More severe cellular phenotype in human idiopathic dilated cardiomyopathy compared to ischemic heart disease.

A piece of the human heart: variance of protein phosphorylation in left ventricular samples from end-stage primary cardiomyopathy patients.

Expression of cTnI-R145G affects shortening properties of adult rat cardiomyocytes.

The force and stiffness of myosin motors in the isometric twitch of a cardiac trabecula and the effect of the extracellular calcium concentration.

Rapid frequency-dependent changes in free mitochondrial calcium concentration in rat cardiac myocytes.

Synergistic role of ADP and Ca<sup>2+</sup> in diastolic myocardial stiffness.

Rapid changes in NADH and flavin autofluorescence in rat cardiac trabeculae reveal large mitochondrial complex II reserve capacity.

Faster cross-bridge detachment and increased tension cost in human hypertrophic cardiomyopathy with the R403Q MYH7 mutation.

Training one type of striated muscle to counteract failure of another type.

Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.

A 3D diffusional-compartmental model of the calcium dynamics in cytosol, sarcoplasmic reticulum and mitochondria of murine skeletal muscle fibers.

Protein kinase C α and ε phosphorylation of troponin and myosin binding protein C reduce Ca<sup>2+</sup> sensitivity in human myocardium.

Effects of contractile protein phosphorylation on force development in permeabilized rat cardiac myocytes.

Right ventricular hypertrophy causes impairment of left ventricular diastolic function in the rat.

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.

Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3).

Mutation-specific effects on thin filament length in thin filament myopathy.

Quantitative analysis of myofilament protein phosphorylation in small cardiac biopsies.

Mitochondrial Ca<sup>2+</sup>-Handling in Fast Skeletal Muscle Fibers from Wild Type and Calsequestrin-Null Mice.

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol.

Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol.

The development of familial hypertrophic cardiomyopathy: from mutation to bedside.