Works by Sterner, Reinhard

Results: 47

Generation of a Stand‐Alone Tryptophan Synthase α‐Subunit by Mimicking an Evolutionary Blueprint.

Published in:

ChemBioChem, 2019, v. 20, n. 21, p. 2747, doi. 10.1002/cbic.201900323

By:

Schupfner, Michael;
Busch, Florian;
Wysocki, Vicki H.;
Sterner, Reinhard

Publication type:

Article

Artificial Light Regulation of an Allosteric Bienzyme Complex by a Photosensitive Ligand.

Published in:

ChemBioChem, 2018, v. 19, n. 16, p. 1750, doi. 10.1002/cbic.201800219

By:

Kneuttinger, Andrea C.;
Winter, Martin;
Simeth, Nadja A.;
Heyn, Kristina;
Merkl, Rainer;
König, Burkhard;
Sterner, Reinhard

Publication type:

Article

Aufklärung der Funktion eines Enzyms mit der Fähigkeit zur Synthese eines Archaea-typischen Lipids in Bacteria.

Published in:

Angewandte Chemie, 2011, v. 123, n. 35, p. 8338, doi. 10.1002/ange.201101832

By:

Guldan, Harald;
Matysik, Frank-Michael;
Bocola, Marco;
Sterner, Reinhard;
Babinger, Patrick

Publication type:

Article

Towards Photochromic Azobenzene‐Based Inhibitors for Tryptophan Synthase.

Published in:

Chemistry - A European Journal, 2021, v. 27, n. 7, p. 2439, doi. 10.1002/chem.202004061

By:

Simeth, Nadja A.;
Kinateder, Thomas;
Rajendran, Chitra;
Nazet, Julian;
Merkl, Rainer;
Sterner, Reinhard;
König, Burkhard;
Kneuttinger, Andrea C.

Publication type:

Article

Regulation of the hetero-octameric ATP phosphoribosyl transferase complex fromThermotoga maritimaby a tRNA synthetase-like subunit.

Published in:

Molecular Microbiology, 2005, v. 55, n. 3, p. 675, doi. 10.1111/j.1365-2958.2004.04422.x

By:

Vega, M. Cristina;
Zou, Peijian;
Fernandez, Francisco J.;
Murphy, Gavin E.;
Sterner, Reinhard;
Popov, Alexander;
Wilmanns, Matthias

Publication type:

Article

Molecular basis for the allosteric activation mechanism of the heterodimeric imidazole glycerol phosphate synthase complex.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22968-6

By:

Wurm, Jan Philip;
Sung, Sihyun;
Kneuttinger, Andrea Christa;
Hupfeld, Enrico;
Sterner, Reinhard;
Wilmanns, Matthias;
Sprangers, Remco

Publication type:

Article

Rosetta:MSF: a modular framework for multi-state computational protein design.

Published in:

2017

By:

Löffler, Patrick;
Schmitz, Samuel;
Hupfeld, Enrico;
Sterner, Reinhard;
Merkl, Rainer

Publication type:

Product Review

Highlight issue: protein design.

Published in:

Biological Chemistry, 2017, v. 398, n. 1, p. 1, doi. 10.1515/hsz-2016-0322

By:

Sterner, Reinhard;
Höcker, Birte;
Kolmar, Harald

Publication type:

Article

Ancestral protein reconstruction: techniques and applications.

Published in:

Biological Chemistry, 2016, v. 397, n. 1, p. 1, doi. 10.1515/hsz-2015-0158

By:

Merkl, Rainer;
Sterner, Reinhard

Publication type:

Article

Hyperthermostable acetyl xylan esterase.

Published in:

Microbial Biotechnology, 2010, v. 3, n. 1, p. 84, doi. 10.1111/j.1751-7915.2009.00150.x

By:

Drzewiecki, Katharina;
Angelov, Angel;
Ballschmiter, Meike;
Tiefenbach, Klaus-Jürgen;
Sterner, Reinhard;
Liebl, Wolfgang

Publication type:

Article

Functional Assignment of an Enzyme that Catalyzes the Synthesis of an Archaea-Type Ether Lipid in Bacteria.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 35, p. 8188, doi. 10.1002/anie.201101832

By:

Guldan, Harald;
Matysik, Frank-Michael;
Bocola, Marco;
Sterner, Reinhard;
Babinger, Patrick

Publication type:

Article

Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 20, p. 5106, doi. 10.3390/ijms20205106

By:

Kneuttinger, Andrea C.;
Zwisele, Stefanie;
Straub, Kristina;
Bruckmann, Astrid;
Busch, Florian;
Kinateder, Thomas;
Gaim, Barbara;
Wysocki, Vicki H.;
Merkl, Rainer;
Sterner, Reinhard

Publication type:

Article

Improving enzyme functional annotation by integrating in vitro and in silico approaches: The example of histidinol phosphate phosphatases.

Published in:

Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 2, p. 1, doi. 10.1002/pro.4899

By:

Kinateder, Thomas;
Mayer, Carina;
Nazet, Julian;
Sterner, Reinhard

Publication type:

Article

Experimental and computational analysis of the ancestry of an evolutionary young enzyme from histidine biosynthesis.

Published in:

Protein Science: A Publication of the Protein Society, 2023, v. 32, n. 1, p. 1, doi. 10.1002/pro.4536

By:

Kinateder, Thomas;
Drexler, Lukas;
Straub, Kristina;
Merkl, Rainer;
Sterner, Reinhard

Publication type:

Article

The interaction of ammonia and xenon with the imidazole glycerol phosphate synthase from Thermotoga maritima as detected by NMR spectroscopy.

Published in:

Protein Science: A Publication of the Protein Society, 2010, v. 19, n. 9, p. 1774, doi. 10.1002/pro.463

By:

Liebold, Christoph;
List, Felix;
Kalbitzer, Hans Robert;
Sterner, Reinhard;
Brunner, Eike

Publication type:

Article

Long-Term Persistence of Bi-functionality Contributes to the Robustness of Microbial Life through Exaptation.

Published in:

PLoS Genetics, 2016, v. 12, n. 1, p. 1, doi. 10.1371/journal.pgen.1005836

By:

Plach, Maximilian G.;
Reisinger, Bernd;
Sterner, Reinhard;
Merkl, Rainer

Publication type:

Article

Establishing catalytic activity on an artificial (βα)<sub>8</sub>-barrel protein designed from identical half-barrels.

Published in:

FEBS Letters, 2013, v. 587, n. 17, p. 2798, doi. 10.1016/j.febslet.2013.06.022

By:

Sperl, Josef M.;
Rohweder, Bettina;
Rajendran, Chitra;
Sterner, Reinhard

Publication type:

Article

Prediction of quaternary structure by analysis of hot spot residues in protein‐protein interfaces: the case of anthranilate phosphoribosyltransferases.

Published in:

Proteins, 2019, v. 87, n. 10, p. 815, doi. 10.1002/prot.25744

By:

Schlee, Sandra;
Straub, Kristina;
Schwab, Thomas;
Kinateder, Thomas;
Merkl, Rainer;
Sterner, Reinhard

Publication type:

Article

Combining ancestral sequence reconstruction with protein design to identify an interface hotspot in a key metabolic enzyme complex.

Published in:

Proteins, 2017, v. 85, n. 2, p. 312, doi. 10.1002/prot.25225

By:

Holinski, Alexandra;
Heyn, Kristina;
Merkl, Rainer;
Sterner, Reinhard

Publication type:

Article

Corrigendum: Dimerization Determines Substrate Specificity of a Bacterial Prenyltransferase.

Published in:

ChemBioChem, 2012, v. 13, n. 12, p. 1710, doi. 10.1002/cbic.201200473

By:

Peterhoff, David;
Zellner, Hermann;
Guldan, Harald;
Merkl, Rainer;
Sterner, Reinhard;
Babinger, Patrick

Publication type:

Article

Dimerization Determines Substrate Specificity of a Bacterial Prenyltransferase.

Published in:

ChemBioChem, 2012, v. 13, n. 9, p. 1297, doi. 10.1002/cbic.201200127

By:

Peterhoff, David;
Zellner, Hermann;
Guldan, Harald;
Merkl, Rainer;
Sterner, Reinhard;
Babinger, Patrick

Publication type:

Article

Related (βα).

Published in:

ChemBioChem, 2011, v. 12, n. 10, p. 1487, doi. 10.1002/cbic.201100082

By:

List, Felix;
Sterner, Reinhard;
Wilmanns, Matthias

Publication type:

Article

Stabilization of a Metabolic Enzyme by Library Selection in Thermus thermophilus.

Published in:

ChemBioChem, 2011, v. 12, n. 10, p. 1581, doi. 10.1002/cbic.201000770

By:

Schwab, Thomas;
Sterner, Reinhard

Publication type:

Article

A Fast and Precise Approach for Computational Saturation Mutagenesis and its Experimental Validation by Using an Artificial (βα).

Published in:

ChemBioChem, 2011, v. 12, n. 10, p. 1544, doi. 10.1002/cbic.201100051

By:

Fischer, Andre;
Seitz, Tobias;
Lochner, Adriane;
Sterner, Reinhard;
Merkl, Rainer;
Bocola, Marco

Publication type:

Article

Editorial: Directed Evolution: A Powerful Approach to Optimising and Understanding Enzymes.

Published in:

ChemBioChem, 2011, v. 12, n. 10, p. 1439, doi. 10.1002/cbic.201100285

By:

Sterner, Reinhard

Publication type:

Article

A Robust Protein Host for Anchoring Chelating Ligands and Organocatalysts.

Published in:

ChemBioChem, 2008, v. 9, n. 4, p. 552, doi. 10.1002/cbic.200700413

By:

Reetz, Manfred T.;
Rentzsch, Martin;
Pletsch, Andreas;
Taglieber, Andreas;
Hollmann, Frank;
Mondière, Régis J. G.;
Dickmann, Norbert;
Höcker, Birte;
Cerrone, Simona;
Haeger, Michaela C.;
Sterner, Reinhard

Publication type:

Article

Book Review: Directed Molecular Evolution of Proteins or How to Improve Enzymes for Biocatalysis. Edited by Susanne Brakmann and Kai Johnsson.

Published in:

ChemBioChem, 2003, v. 4, n. 1, p. 119, doi. 10.1002/cbic.200390005

By:

Sterner, Reinhard

Publication type:

Article

Mapping key amino acid residues for the epimerase efficiency and stereospecificity of the sex pheromone biosynthetic short-chain dehydrogenases/reductases of Nasonia.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-37200-7

By:

Semmelmann, Florian;
Hofferberth, John;
Ruther, Joachim;
Sterner, Reinhard

Publication type:

Article

A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization.

Published in:

Molecular Microbiology, 2014, v. 92, n. 4, p. 885, doi. 10.1111/mmi.12596

By:

Peterhoff, David;
Beer, Barbara;
Rajendran, Chitra;
Kumpula, Esa‐Pekka;
Kapetaniou, Evangelia;
Guldan, Harald;
Wierenga, Rik K.;
Sterner, Reinhard;
Babinger, Patrick

Publication type:

Article

Protein Design at the Crossroads of Biotechnology, Chemistry, Theory, and Evolution.

Published in:

2003

By:

Jaenicke, Rainer;
Sterner, Reinhard

Publication type:

Other

Random mutagenesis suggests that sequence errors are not a major cause of variation in the activity of individual molecules of β-galactosidase.

Published in:

Biochemistry & Cell Biology, 2012, v. 90, n. 4, p. 540, doi. 10.1139/o2012-006

By:

Craig, Douglas B.;
Schwab, Thomas;
Sterner, Reinhard

Publication type:

Article

Dissection of a (βα)<sub>8</sub>-barrel enzyme into two folded halves.

Published in:

Nature Structural Biology, 2001, v. 8, n. 1, p. 32

By:

Höcker, Birte;
Beismann-Driemeyer, Silke;
Hettwer, Stefan;
Lustig, Ariel;
Sterner, Reinhard

Publication type:

Article

TransCent: Computational enzyme design by transferring active sites and considering constraints relevant for catalysis.

Published in:

BMC Bioinformatics, 2009, v. 10, p. 1, doi. 10.1186/1471-2105-10-54

By:

Fischer, André;
Enkler, Nils;
Neudert, Gerd;
Bocola, Marco;
Sterner, Reinhard;
Merkl, Rainer

Publication type:

Article

Umwandlung einer Anthranilatsynthase in eine Isochorismatsynthase: Implikationen für die Evolution von Chorismat-umsetzenden Enzymen.

Published in:

Angewandte Chemie, 2015, v. 127, n. 38, p. 11423, doi. 10.1002/ange.201505063

By:

Plach, Maximilian G.;
Löffler, Patrick;
Merkl, Rainer;
Sterner, Reinhard

Publication type:

Article

Nutzung natürlicher Proteinsymmetrie zum Design lichtschaltbarer Enzyminhibitoren.

Published in:

Angewandte Chemie, 2014, v. 126, n. 2, p. 606, doi. 10.1002/ange.201307207

By:

Reisinger, Bernd;
Kuzmanovic, Natascha;
Löffler, Patrick;
Merkl, Rainer;
König, Burkhard;
Sterner, Reinhard

Publication type:

Article

Characterisation of a thermoalkali-stable cyclodextrin glycosyltransferase from the anaerobic thermoalkaliphilic bacteriumAnaerobranca gottschalkii.

Published in:

Archives of Microbiology, 2004, v. 182, n. 2/3, p. 226, doi. 10.1007/s00203-004-0717-x

By:

Thiemann, Volker;
Dönges, Catharina;
Prowe, Steffen G.;
Sterner, Reinhard;
Antranikian, Garabed

Publication type:

Article

Activation of a Chimeric Rpb5/RpoH Subunit Using Library Selection.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0087485

By:

Sommer, Bettina;
Waege, Ingrid;
Pöllmann, David;
Seitz, Tobias;
Thomm, Michael;
Sterner, Reinhard;
Hausner, Winfried

Publication type:

Article

Conversion of Anthranilate Synthase into Isochorismate Synthase: Implications for the Evolution of Chorismate-Utilizing Enzymes.

Published in:

Angewandte Chemie International Edition, 2015, v. 54, n. 38, p. 11270, doi. 10.1002/anie.201505063

By:

Plach, Maximilian G.;
Löffler, Patrick;
Merkl, Rainer;
Sterner, Reinhard

Publication type:

Article

Exploiting Protein Symmetry To Design Light-Controllable Enzyme Inhibitors.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 2, p. 595, doi. 10.1002/anie.201307207

By:

Reisinger, Bernd;
Kuzmanovic, Natascha;
Löffler, Patrick;
Merkl, Rainer;
König, Burkhard;
Sterner, Reinhard

Publication type:

Article

A common evolutionary origin of two elementary enzyme folds

Published in:

FEBS Letters, 2002, v. 510, n. 3, p. 133, doi. 10.1016/S0014-5793(01)03232-X

By:

Höcker, Birte;
Schmidt, Steffen;
Sterner, Reinhard

Publication type:

Article

Improving thermal and detergent stability of Bacillus stearothermophilus neopullulanase by rational enzyme design.

Published in:

PEDS: Protein Engineering, Design & Selection, 2015, v. 28, p. 147, doi. 10.1093/protein/gzv001

By:

Ece, Selin;
Evran, Serap;
Janda, Jan-Oliver;
Merkl, Rainer;
Sterner, Reinhard

Publication type:

Article

Improving thermal and detergent stability of Bacillus stearothermophilus neopullulanase by rational enzyme design.

Published in:

PEDS: Protein Engineering, Design & Selection, 2015, v. 28, n. 6, p. 147, doi. 10.1093/protein/gzv001

By:

Ece, Selin;
Evran, Serap;
Janda, Jan-Oliver;
Merkl, Rainer;
Sterner, Reinhard

Publication type:

Article

A sugar isomerization reaction established on various (βα)8-barrel scaffolds is based on substrate-assisted catalysis†.

Published in:

PEDS: Protein Engineering, Design & Selection, 2012, v. 25, n. 11, p. 751, doi. 10.1093/protein/gzs080

By:

Reisinger, Bernd;
Bocola, Marco;
List, Felix;
Claren, Jörg;
Rajendran, Chitra;
Sterner, Reinhard

Publication type:

Article

Directed evolution of (βα)8-barrel enzymes: establishing phosphoribosylanthranilate isomerisation activity on the scaffold of the tryptophan synthase α-subunit.

Published in:

PEDS: Protein Engineering, Design & Selection, 2012, v. 25, n. 6, p. 285, doi. 10.1093/protein/gzs015

By:

Evran, Serap;
Telefoncu, Azmi;
Sterner, Reinhard

Publication type:

Article

A naturally occurring standalone TrpB enzyme provides insights into allosteric communication within tryptophan synthase.

Published in:

Protein Science: A Publication of the Protein Society, 2025, v. 34, n. 4, p. 1, doi. 10.1002/pro.70103

By:

Kinateder, Thomas;
Drexler, Lukas;
Duran, Cristina;
Osuna, Sílvia;
Sterner, Reinhard

Publication type:

Article

Thermophilic adaptation of proteins

Published in:

Critical Reviews in Biochemistry & Molecular Biology, 2001, v. 36, n. 1, p. 39

By:

Liebl, Wolfgang;
Sterner, Reinhard

Publication type:

Article

Epimerisation of chiral hydroxylactones by short-chain dehydrogenases/reductases accounts for sex pheromone evolution in Nasonia.

Published in:

Scientific Reports, 2016, p. 34697, doi. 10.1038/srep34697

By:

Ruther, Joachim;
Hagström, Åsa K.;
Brandstetter, Birgit;
Hofferberth, John;
Bruckmann, Astrid;
Semmelmann, Florian;
Fink, Michaela;
Lowack, Helena;
Laberer, Sabine;
Niehuis, Oliver;
Deutzmann, Rainer;
Löfstedt, Christer;
Sterner, Reinhard

Publication type:

Article