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Soluble GC stimulators and activators: Past, present and future.
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- British Journal of Pharmacology, 2024, v. 181, n. 21, p. 4130, doi. 10.1111/bph.15698
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- Article
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential.
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- 2006
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- Publication type:
- journal article
Nitric Oxide-Independent Soluble Guanylate Cyclase Activation Improves Vascular Function and Cardiac Remodeling in Sickle Cell Disease.
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- American Journal of Respiratory Cell & Molecular Biology, 2018, v. 58, n. 5, p. 636, doi. 10.1165/rcmb.2017-0292OC
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- Article
The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems.
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- 2013
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- Abstract
Increases survival by apo-sGC activation via post-stroke blood brain barrier stabilisation and anti-inflammation.
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- 2013
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- Abstract
Chronic activation of heme free soluble guanylate cyclase leads to cardio-renal protection in experimental hypertension.
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- 2013
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- Abstract
Urinary cGMP concentrations after exposure to radio-contrast media in patient at risk for contrast media induced nephropathy (CIN) predicts 90-day morbidity and mortality.
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- 2013
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- Abstract
The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators.
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- Angewandte Chemie International Edition, 2013, v. 52, n. 36, p. 9442, doi. 10.1002/anie.201302588
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- Article
Cover Picture: The Chemistry and Biology of Soluble Guanylate Cyclase Stimulators and Activators / Nicotinic Acetylcholine Receptor Agonists: A Milestone for Modern Crop Protection / Polyurethanes: Versatile Materials and Sustainable Problem Solvers for Today's Challenges (Angew. Chem. Int. Ed. 36/2013)
- Published in:
- Angewandte Chemie International Edition, 2013, v. 52, n. 36, p. 9333, doi. 10.1002/anie.201306066
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- Publication type:
- Article
Inhibition of the TGFβ signalling pathway by cGMP and cGMP-dependent kinase I in renal fibrosis.
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- FEBS Open Bio, 2017, v. 7, n. 4, p. 550, doi. 10.1002/2211-5463.12202
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- Article
Humoral and Hemodynamic Responses After Left Ventricular Assist Device Implantation and Heart Transplantation.
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- Experimental Biology & Medicine, 2006, v. 231, n. 6, p. 861, doi. 10.3181/00379727-231-2310861
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- Article
Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart.
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- Hypertension Research, 2009, v. 32, n. 7, p. 597, doi. 10.1038/hr.2009.64
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- Article
Soluble guanylate cyclase: a potential therapeutic target for heart failure.
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- Heart Failure Reviews, 2013, v. 18, n. 2, p. 123, doi. 10.1007/s10741-012-9323-1
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- Publication type:
- Article
Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema.
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- American Journal of Respiratory & Critical Care Medicine, 2014, v. 189, n. 11, p. E1, doi. 10.1164/rccm.201311-2037oc
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- Publication type:
- Article
Stimulation of Soluble Guanylate Cyclase Prevents Cigarette Smoke-induced Pulmonary Hypertension and Emphysema.
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- American Journal of Respiratory & Critical Care Medicine, 2014, v. 189, n. 11, p. 1359, doi. 10.1164/rccm.201311-2037OC
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- Publication type:
- Article
Identification and characterization of the new generation soluble guanylate cyclase stimulator BAY‐747 designed for the treatment of resistant hypertension.
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- British Journal of Pharmacology, 2023, v. 180, n. 19, p. 2500, doi. 10.1111/bph.16142
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- Article
Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice.
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- Nature Communications, 2015, v. 6, n. 10, p. 8482, doi. 10.1038/ncomms9482
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- Article
Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue.
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- Nature Communications, 2015, v. 6, n. 5, p. 7235, doi. 10.1038/ncomms8235
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- Article
Riociguat Reduces Infarct Size and Post-Infarct Heart Failure in Mouse Hearts: Insights from MRI/PET Imaging.
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- PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0083910
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- Article
Effects of Different Pulmonary Vasodilators on Arterial Saturation in a Model of Pulmonary Hypertension.
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- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0073502
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- Publication type:
- Article
The Soluble Guanylate Cyclase Activator BAY 58-2667 Protects against Morbidity and Mortality in Endotoxic Shock by Recoupling Organ Systems.
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- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0072155
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- Publication type:
- Article
The Soluble Guanylyl Cyclase Activator Bay 58-2667 Selectively Limits Cardiomyocyte Hypertrophy.
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- PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0044481
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- Article
The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats.
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- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043433
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- Article
Effects of Stimulation of Soluble Guanylate Cyclase on Diabetic Nephropathy in Diabetic eNOS Knockout Mice on Top of Angiotensin II Receptor Blockade.
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- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042623
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- Article
Fluorescence Dequenching Makes Haem-Free Soluble Guanylate Cyclase Detectable in Living Cells.
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- PLoS ONE, 2011, v. 6, n. 8, p. 1, doi. 10.1371/journal.pone.0023596
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- Article
Soluble Guanylate Cyclase Stimulation Prevents Fibrotic Tissue Remodeling and Improves Survival in Salt- Sensitive Dahl Rats.
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- PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0021853
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- Article
Kynurenine is an endothelium-derived relaxing factor produced during inflammation.
- Published in:
- 2010
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- Correction notice
Kynurenine is an endothelium-derived relaxing factor produced during inflammation.
- Published in:
- Nature Medicine, 2010, v. 16, n. 3, p. 279, doi. 10.1038/nm.2092
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- Article
Improvement of right heart structure and function by BAY 41-8543 in pulmonary artery banded mice.
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- 2011
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- Abstract
Evidence for two catalytic centers and Mn<sup>2+</sup> as physiological cofactor of soluble guanylyl cyclase.
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- 2011
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- Abstract
Comparison of different vasodilators, endothelin antagonist, PDE5 inhibitior and sGC stimulators, in an animal model of secondary pulmonary hypertension: effects on "desaturation".
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- 2011
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- Abstract
The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.
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- 2011
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- Abstract
Effects of riociguat in severe experimental pulmonary hypertension.
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- 2011
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- Abstract
Biomarkers in two different animal models of pulmonary arterial hypertension (PAH) under treatment with a cGMP enhancing substance.
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- 2011
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- Abstract
Riociguat prevents fibrotic tissue remodelling and improves survival in salt-sensitive Dahl rats.
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- 2011
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- Abstract
Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC mice.
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- 2011
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- Abstract
Additional stimulation of sGC on top of standard treatment with ARB's may offer a new therapeutic approach for the treatment of diabetic nephropathy resistant to ARB treatment alone.
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- 2011
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- Abstract
Nitric oxide-independent stimulation of soluble guanylate cyclase attenuates pulmonary fibrosis.
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- 2011
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- Abstract
Activation of heme-free soluble guanylate cyclase with cinaciguat has beneficial cardiorenal actions when added to furosemide in experimental heart failure.
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- 2011
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- Abstract
Structural insights into sGC activation by different activators.
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- 2011
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- Abstract
Targeting heme-oxidized soluble guanylate cyclase with BAY 58-2667 in experimental heart failure.
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- 2007
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- Abstract
Increased mesangial cGMP levels prevent mesangial cell proliferation and matrix expansion in experimental glomerulonephritis.
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- 2007
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- Abstract
Design and synthesis of the first NO- and haem-independent sGC activator BAY 58-2667 for the treatment of acute decompensated heart failure.
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- 2007
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- Abstract
Beyond NO and heme: biochemical and pharmacological opportunities.
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- 2005
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- Abstract
Inhaled NO and the guanylate cyclase stimulator Bay 41-2272 oleic acid induced acute lung injury in rabbits.
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- 2005
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- Abstract
Co-activation of soluble and particulate guanylate cyclase by BAY 58-2667 and BNP enhances cardiorenal function in experimental heart failure.
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- 2005
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- Abstract
Residues stabilizing the heme moiety of the NO sensor soluble guanylate cyclase.
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- 2005
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- Abstract
Formation of quasi-covalent sGC α<sub>1</sub>/β<sub>1</sub>-heterodimers by ODQ-induced oxidation of the prosthetic heme moiety.
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- 2005
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- Abstract
Beneficial effect of soluble guanylate cyclase stimulator BAY 41-2272 on cardiovascular remodeling in angiotensin II-induced hypertensive rats.
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- 2005
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- Abstract
Antifibrotic effects of an sGC activator in rat models of liver fibrosis.
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- 2005
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- Abstract