Works by Spinella, Michael J

Results: 33

G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer.

Published in:

Cell Cycle, 2017, v. 16, n. 21, p. 2146, doi. 10.1080/15384101.2017.1371884

By:

Yim, Christina Y.;
Bikorimana, Emmanuel;
Khan, Ema;
Warzecha, Joshua M.;
Shin, Leah;
Rodriguez, Jennifer;
Dmitrovsky, Ethan;
Freemantle, Sarah J.;
Spinella, Michael J.

Publication type:

Article

Reciprocal epigenetic remodeling controls testicular cancer hypersensitivity to hypomethylating agents and chemotherapy.

Published in:

Molecular Oncology, 2022, v. 16, n. 3, p. 683, doi. 10.1002/1878-0261.13096

By:

Singh, Ratnakar;
Fazal, Zeeshan;
Bikorimana, Emmanuel;
Boyd, Raya I.;
Yerby, Cliff;
Tomlin, Megan;
Baldwin, Hannah;
Shokry, Doha;
Corbet, Andrea K.;
Shahid, Khadeeja;
Hattab, Aleyah;
Freemantle, Sarah J.;
Spinella, Michael J.

Publication type:

Article

A Dynamic Shift in Estrogen Receptor Expression During Granulosa Cell Differentiation in the Ovary.

Published in:

Endocrinology, 2025, v. 166, n. 2, p. 1, doi. 10.1210/endocr/bqaf006

By:

Park, Chan Jin;
Oh, Ji-Eun;
Lin, PoChing;
Zhou, Sherry;
Bunnell, Mary;
Bikorimana, Emmanuel;
Spinella, Michael J;
Lim, Hyunjung Jade;
Ko, CheMyong J

Publication type:

Article

A phase 1 study of combined guadecitabine and cisplatin in platinum refractory germ cell cancer.

Published in:

Cancer Medicine, 2021, v. 10, n. 1, p. 156, doi. 10.1002/cam4.3583

By:

Albany, Costantine;
Fazal, Zeeshan;
Singh, Ratnakar;
Bikorimana, Emmanuel;
Adra, Nabil;
Hanna, Nasser H.;
Einhorn, Lawrence H.;
Perkins, Susan M.;
Sandusky, George E.;
Christensen, Brock C.;
Keer, Harold;
Fang, Fang;
Nephew, Kenneth P.;
Spinella, Michael J.

Publication type:

Article

Perfluorooctanesulfonic Acid Alters Pro-Cancer Phenotypes and Metabolic and Transcriptional Signatures in Testicular Germ Cell Tumors.

Published in:

Toxics, 2024, v. 12, n. 4, p. 232, doi. 10.3390/toxics12040232

By:

Boyd, Raya I.;
Shokry, Doha;
Fazal, Zeeshan;
Rennels, Brayden C.;
Freemantle, Sarah J.;
La Frano, Michael R.;
Prins, Gail S.;
Madak Erdogan, Zeynep;
Irudayaraj, Joseph;
Singh, Ratnakar;
Spinella, Michael J.

Publication type:

Article

The Relationship between Typical Environmental Endocrine Disruptors and Kidney Disease.

Published in:

Toxics, 2023, v. 11, n. 1, p. 32, doi. 10.3390/toxics11010032

By:

Zhang, Xing;
Flaws, Jodi A.;
Spinella, Michael J.;
Irudayaraj, Joseph

Publication type:

Article

Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review.

Published in:

2018

By:

Chovanec, Michal;
Taza, Fadi;
Kalra, Maitri;
Hahn, Noah;
Nephew, Kenneth P.;
Spinella, Michael J.;
Albany, Costantine

Publication type:

journal article

Headway and Hurdles in the Clinical Development of Dietary Phytochemicals for Cancer Therapy and Prevention: Lessons Learned from Vitamin A Derivatives.

Published in:

AAPS Journal, 2014, v. 16, n. 2, p. 281, doi. 10.1208/s12248-014-9562-2

By:

Yim, Christina Y.;
Mao, Pingping;
Spinella, Michael J.

Publication type:

Article

All-trans-retinoic acid antagonizes the hedgehog pathway by inducing patched.

Published in:

Cancer Biology & Therapy, 2014, v. 15, n. 4, p. 463, doi. 10.4161/cbt.27821

By:

Busch, Alexander M.;
Galimberti, Fabrizio;
Nehls, Kristen E.;
Roengvoraphoj, Monic;
Sekula, David;
Bin Li;
Yongli Guo;
Direnzo, James;
Fiering, Steven N.;
Spinella, Michael J.;
Robbins, David J.;
Memoli, Vincent A.;
Freemantle, Sarah J.;
Dmitrovsky, Ethan

Publication type:

Article

Selective repression of retinoic acid target genes by RIP140 during induced tumor cell differentiation of pluripotent human embryonal carcinoma cells.

Published in:

Molecular Cancer, 2007, v. 6, p. 57, doi. 10.1186/1476-4598-6-57

By:

Heim, Kelly C.;
White, Kristina A.;
Deng, Dexin;
Tomlinson, Craig R.;
Moore, Jason H.;
Freemantle, Sarah J.;
Spinella, Michael J.

Publication type:

Article

FGF4 dissociates anti-tumorigenic from differentiation signals of retinoic acid in human embryonal carcinomas.

Published in:

Oncogene, 1998, v. 17, n. 6, p. 761, doi. 10.1038/sj.onc.1201992

By:

Maerz, Wolfgang J;
Baselga, Jose;
Reuter, Victor E;
Mellado, Begona;
Myers, Michael L;
Bosl, George J;
Spinella, Michael J;
Dmitrovsky, Ethan

Publication type:

Article

Specific retinoid receptors cooperate to signal growth suppression and maturation of human embryonal carcinoma cells.

Published in:

Oncogene, 1998, v. 16, n. 26, p. 3471, doi. 10.1038/sj.onc.1201876

By:

Spinella, Michael J;
Kitareewan, Sutisak;
Mellado, Begonia;
Sekula, David;
Khoo, Kei-Siong;
Dmitrovsky, Ethan

Publication type:

Article

Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors.

Published in:

Cancers, 2019, v. 11, n. 6, p. 796, doi. 10.3390/cancers11060796

By:

Singh, Ratnakar;
Fazal, Zeeshan;
Corbet, Andrea K.;
Bikorimana, Emmanuel;
Rodriguez, Jennifer C.;
Khan, Ema M.;
Shahid, Khadeeja;
Freemantle, Sarah J.;
Spinella, Michael J.

Publication type:

Article

Refractory testicular germ cell tumors are highly sensitive to the targeting of polycomb pathway demethylases KDM6A and KDM6B.

Published in:

Cell Communication & Signaling, 2024, v. 22, n. 1, p. 1, doi. 10.1186/s12964-024-01912-3

By:

Shokry, Doha;
Khan, Mehwish W.;
Powell, Christine;
Johnson, Samantha;
Rennels, Brayden C.;
Boyd, Raya I.;
Sun, Zhengyang;
Fazal, Zeeshan;
Freemantle, Sarah J.;
Parker, Maryanna H.;
Vieson, Miranda D.;
Samuelson, Jonathan P.;
Spinella, Michael J.;
Singh, Ratnakar

Publication type:

Article

Per- and Polyfluoroalkyl Substance Exposure Combined with High-Fat Diet Supports Prostate Cancer Progression.

Published in:

Nutrients, 2021, v. 13, n. 11, p. 3902, doi. 10.3390/nu13113902

By:

Imir, Ozan Berk;
Kaminsky, Alanna Zoe;
Zuo, Qian-Ying;
Liu, Yu-Jeh;
Singh, Ratnakar;
Spinella, Michael J.;
Irudayaraj, Joseph;
Hu, Wen-Yang;
Prins, Gail S.;
Madak Erdogan, Zeynep

Publication type:

Article

Cyclin Proteolysis as a Retinoid Cancer Prevention Mechanism.

Published in:

Annals of the New York Academy of Sciences, 2001, v. 952, n. 1, p. 13, doi. 10.1111/j.1749-6632.2001.tb02724.x

By:

DRAGNEV, KONSTANTIN H.;
FREEMANTLE, SARAH J.;
SPINELLA, MICHAEL J.;
DMITROVSKY, ETHAN

Publication type:

Article

Retinoids in cancer therapy and chemoprevention: promise meets resistance.

Published in:

Oncogene, 2003, v. 22, n. 47, p. 7305, doi. 10.1038/sj.onc.1206936

By:

Freemantle, Sarah J;
Spinella, Michael J;
Dmitrovsky, Ethan

Publication type:

Article

Developmentally-related candidate retinoic acid target genes regulated early during neuronal differentiation of human embryonal carcinoma.

Published in:

Oncogene, 2002, v. 21, n. 18, p. 2880, doi. 10.1038/sj.onc.1205408

By:

Freemantle, Sarah J.;
Kerley, Joanna S.;
Olsen, Shannon L.;
Gross, Robert H.;
Spinella, Michael J.

Publication type:

Article

Retinoic acid activates p53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of p53 transactivation function.

Published in:

Oncogene, 2001, v. 20, n. 20, p. 2559, doi. 10.1038/sj.onc.1204370

By:

Curtin, Joshua C;
Dragnev, Konstantin H;
Sekula, David;
Christie, Allison J;
Dmitrovsky, Ethan;
Spinella, Michael J

Publication type:

Article

4HPR triggers apoptosis but not differentiation in retinoid sensitive and resistant human embryonal carcinoma cells through an RARγ independent pathway.

Published in:

Oncogene, 1999, v. 18, n. 42, p. 5747, doi. 10.1038/sj.onc.1202981

By:

Kitareewan, Sutisak;
Spinella, Michael J;
Allopenna, Janet;
Reczek, Peter R;
Dmitrovsky, Ethan

Publication type:

Article

Toward a Mechanistic Understanding of Poly- and Perfluoroalkylated Substances and Cancer.

Published in:

Cancers, 2022, v. 14, n. 12, p. 2919, doi. 10.3390/cancers14122919

By:

Boyd, Raya I.;
Ahmad, Saeed;
Singh, Ratnakar;
Fazal, Zeeshan;
Prins, Gail S.;
Madak Erdogan, Zeynep;
Irudayaraj, Joseph;
Spinella, Michael J.

Publication type:

Article

Targeting Cancer Stem Cells with Differentiation Agents as an Alternative to Genotoxic Chemotherapy for the Treatment of Malignant Testicular Germ Cell Tumors.

Published in:

Cancers, 2021, v. 13, n. 9, p. 2045, doi. 10.3390/cancers13092045

By:

Loehr, Amanda R.;
Pierpont, Timothy M.;
Gelsleichter, Eric;
Galang, Anabella Maria D.;
Fernandez, Irma R.;
Moore, Elizabeth S.;
Guo, Matthew Z.;
Miller, Andrew D.;
Weiss, Robert S.;
Spinella, Michael J.;
Freemantle, Sarah J.;
Fazal, Zeeshan;
Singh, Ratnakar

Publication type:

Article

Between a Rock and a Hard Place: An Epigenetic-Centric View of Testicular Germ Cell Tumors.

Published in:

Cancers, 2021, v. 13, n. 7, p. 1506, doi. 10.3390/cancers13071506

By:

Singh, Ratnakar;
Fazal, Zeeshan;
Freemantle, Sarah J.;
Spinella, Michael J.;
Köberle, Beate;
Di Lorenzo, Giuseppe

Publication type:

Article

The Potential of Artificial Intelligence to Detect Lymphovascular Invasion in Testicular Cancer.

Published in:

Cancers, 2021, v. 13, n. 6, p. 1325, doi. 10.3390/cancers13061325

By:

Ghosh, Abhisek;
Sirinukunwattana, Korsuk;
Khalid Alham, Nasullah;
Browning, Lisa;
Colling, Richard;
Protheroe, Andrew;
Protheroe, Emily;
Jones, Stephanie;
Aberdeen, Alan;
Rittscher, Jens;
Verrill, Clare;
Spinella, Michael J.;
Freemantle, Sarah J.;
Fazal, Zeeshan;
Singh, Ratnakar

Publication type:

Article

Nephrotoxicity of perfluorooctane sulfonate (PFOS)—effect on transcription and epigenetic factors.

Published in:

Environmental Epigenetics (2058-5888), 2022, v. 8, n. 1, p. 1, doi. 10.1093/eep/dvac010

By:

Wen, Yi;
Rashid, Faizan;
Fazal, Zeeshan;
Singh, Ratnakar;
Spinella, Michael J;
Irudayaraj, Joseph

Publication type:

Article

Serine/Threonine Kinase 17A Is a Novel Candidate for Therapeutic Targeting in Glioblastoma.

Published in:

PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0081803

By:

Mao, Pingping;
Hever-Jardine, Mary P.;
Rahme, Gilbert J.;
Yang, Eric;
Tam, Janice;
Kodali, Anita;
Biswal, Bijesh;
Fadul, Camilo E.;
Gaur, Arti;
Israel, Mark A.;
Spinella, Michael J.

Publication type:

Article

Acute Hypersensitivity of Pluripotent Testicular Cancer- Derived Embryonal Carcinoma to Low-Dose 5-Aza Deoxycytidine Is Associated with Global DNA Damage- Associated p53 Activation, Anti-Pluripotency and DNA Demethylation.

Published in:

PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0053003

By:

Biswal, Bijesh K.;
Beyrouthy, Maroun J.;
Hever-Jardine, Mary P.;
Armstrong, David;
Tomlinson, Craig R.;
Christensen, Brock C.;
Marsit, Carmen J.;
Spinella, Michael J.

Publication type:

Article

Retinoic Acid Mediates Long-Paced Oscillations in Retinoid Receptor Activity: Evidence for a Potential Role for RIP140.

Published in:

PLoS ONE, 2009, v. 4, n. 10, p. 1, doi. 10.1371/journal.pone.0007639

By:

Heim, Kelly C.;
Gamsby, Joshua J.;
Hever, Mary P.;
Freemantle, Sarah J.;
Loros, Jennifer J.;
Dunlap, Jay C.;
Spinella, Michael J.

Publication type:

Article

Modulation of Clock Gene Expression by the Transcriptional Coregulator Receptor Interacting Protein 140 (RIP140).

Published in:

Journal of Biological Rhythms, 2011, v. 26, n. 3, p. 187, doi. 10.1177/0748730411401579

By:

Poliandri, Ariel H. B.;
Gamsby, Joshua J.;
Christian, Mark;
Spinella, Michael J.;
Loros, Jennifer J.;
Dunlap, Jay C.;
Parker, Malcolm G.

Publication type:

Article

Aberrant retinoid signaling and breast cancer: the view from outside the nucleus.

Published in:

2000

By:

Spinella, Michael J.;
Dmitrovsky, Ethan;
Spinella, M J;
Dmitrovsky, E

Publication type:

commentary

A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embyronal carcinoma.

Published in:

Oncogene, 2005, v. 24, n. 40, p. 6090, doi. 10.1038/sj.onc.1208755

By:

Kerley-Hamilton, Joanna S.;
Pike, Aimee M.;
Na Li;
DiRenzo, James;
Spinella, Michael J.

Publication type:

Article

p53 in human embryonal carcinoma: identification of a transferable, transcriptional repression domain in the N-terminal region of p53.

Published in:

Oncogene, 2005, v. 24, n. 9, p. 1481, doi. 10.1038/sj.onc.1208130

By:

Curtin, Joshua C.;
Spinella, Michael J.

Publication type:

Article

Hypermethylation and global remodelling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumours.

Published in:

Epigenetics, 2021, v. 16, n. 10, p. 1071, doi. 10.1080/15592294.2020.1834926

By:

Fazal, Zeeshan;
Singh, Ratnakar;
Fang, Fang;
Bikorimana, Emmanuel;
Baldwin, Hannah;
Corbet, Andrea;
Tomlin, Megan;
Yerby, Cliff;
Adra, Nabil;
Albany, Costantine;
Lee, Sarah;
Freemantle, Sarah J.;
Nephew, Kenneth P;
Christensen, Brock C;
Spinella, Michael J.

Publication type:

Article