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Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion.
Published in:
Physiological Reports, 2020, v. 8, n. 8, p. 1, doi. 10.14814/phy2.14420
By:
- Ferdaoussi, Mourad;
- Smith, Nancy;
- Lin, Haopeng;
- Bautista, Austin;
- Spigelman, Aliya F.;
- Lyon, James;
- Dai, XiaoQing;
- Manning Fox, Jocelyn E.;
- MacDonald, Patrick E.
Publication type:
Article
CK2 activity is crucial for proper glucagon expression.
Published in:
Diabetologia, 2024, v. 67, n. 7, p. 1368, doi. 10.1007/s00125-024-06128-1
By:
- Ampofo, Emmanuel;
- Pack, Mandy;
- Wrublewsky, Selina;
- Boewe, Anne S.;
- Spigelman, Aliya F.;
- Koch, Hanna;
- MacDonald, Patrick E.;
- Laschke, Matthias W.;
- Montenarh, Mathias;
- Götz, Claudia
Publication type:
Article
Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression.
Published in:
Diabetologia, 2023, v. 66, n. 4, p. 674, doi. 10.1007/s00125-022-05856-6
By:
- Mattis, Katia K.;
- Krentz, Nicole A. J.;
- Metzendorf, Christoph;
- Abaitua, Fernando;
- Spigelman, Aliya F.;
- Sun, Han;
- Ikle, Jennifer M.;
- Thaman, Swaraj;
- Rottner, Antje K.;
- Bautista, Austin;
- Mazzaferro, Eugenia;
- Perez-Alcantara, Marta;
- Manning Fox, Jocelyn E.;
- Torres, Jason M.;
- Wesolowska-Andersen, Agata;
- Yu, Grace Z.;
- Mahajan, Anubha;
- Larsson, Anders;
- MacDonald, Patrick E.;
- Davies, Benjamin
Publication type:
Article
Loss of tetraspanin‐7 expression reduces pancreatic β‐cell exocytosis Ca<sup>2+</sup> sensitivity but has limited effect on systemic metabolism.
Published in:
Diabetic Medicine, 2022, v. 39, n. 12, p. 1, doi. 10.1111/dme.14984
By:
- McLaughlin, Kerry;
- Acreman, Samuel;
- Nawaz, Sameena;
- Cutteridge, Joseph;
- Clark, Anne;
- Knudsen, Jakob G.;
- Denwood, Geoffrey;
- Spigelman, Aliya F.;
- Manning Fox, Jocelyn E.;
- Singh, Sumeet Pal;
- MacDonald, Patrick E.;
- Hastoy, Benoit;
- Zhang, Quan
Publication type:
Article
Modulation of insulin secretion by RBFOX2-mediated alternative splicing.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43605-4
By:
- Moss, Nicole D.;
- Wells, Kristen L.;
- Theis, Alexandra;
- Kim, Yong-Kyung;
- Spigelman, Aliya F.;
- Liu, Xiong;
- MacDonald, Patrick E.;
- Sussel, Lori
Publication type:
Article
Arginine- vasopressin mediates counterregulatory glucagon release and is diminished in type 1 diabetes.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.72919
By:
- Kim, Angela;
- Knudsen, Jakob G.;
- Madara, Joseph C.;
- Benrick, Anna;
- Hill, Thomas G.;
- Kadir, Lina Abdul;
- Kellard, Joely A.;
- Mellander, Lisa;
- Miranda, Caroline;
- Haopeng Lin;
- James, Timothy;
- Suba, Kinga;
- Spigelman, Aliya F.;
- Yanling Wu;
- MacDonald, Patrick E.;
- Asterholm, Ingrid Wernstedt;
- Magnussen, Tore;
- Christensen, Mikkel;
- Vilsbøll, Tina;
- Salem, Victoria
Publication type:
Article
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.
Published in:
2015
By:
- Ferdaoussi, Mourad;
- Xiaoqing Dai;
- Jensen, Mette V.;
- Runsheng Wang;
- Peterson, Brett S.;
- Chao Huang;
- Ilkayeva, Olga;
- Smith, Nancy;
- Miller, Nathanael;
- Hajmrle, Catherine;
- Spigelman, Aliya F.;
- Wright, Robert C.;
- Plummer, Gregory;
- Kunimasa Suzuki;
- Mackay, James P.;
- van de Bunt, Martijn;
- Gloyn, Anna L.;
- Ryan, Terence E.;
- Norquay, Lisa D.;
- Brosnan, M. Julia
Publication type:
journal article
SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells.
Published in:
Journal of Physiology, 2014, v. 592, n. 17, p. 3715, doi. 10.1113/jphysiol.2014.274084
By:
- Dai, Xiao‐Qing;
- Spigelman, Aliya F.;
- Khan, Shara;
- Braun, Matthias;
- Manning Fox, Jocelyn E.;
- MacDonald, Patrick E.
Publication type:
Article
MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation.
Published in:
Nucleic Acids Research, 2024, v. 52, n. W1, p. W398, doi. 10.1093/nar/gkae253
By:
- Pang, Zhiqiang;
- Lu, Yao;
- Zhou, Guangyan;
- Hui, Fiona;
- Xu, Lei;
- Viau, Charles;
- Spigelman, Aliya F;
- MacDonald, Patrick E;
- Wishart, David S;
- Li, Shuzhao;
- Xia, Jianguo
Publication type:
Article
Yield, cell composition, and function of islets isolated from different ages of neonatal pigs.
Published in:
Frontiers in Endocrinology, 2022, v. 13, p. 1, doi. 10.3389/fendo.2022.1032906
By:
- Arefanian, Hossein;
- Ramji, Qahir;
- Gupta, Nancy;
- Spigelman, Aliya F.;
- Grynoch, Donald;
- MacDonald, Patrick E.;
- Mueller, Thomas F.;
- Gazda, Lawrence S.;
- Rajotte, Ray V.;
- Rayat, Gina R.
Publication type:
Article
β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet-Fed Mice.
Published in:
2021
By:
- Lin, Haopeng;
- Smith, Nancy;
- Spigelman, Aliya F.;
- Suzuki, Kunimasa;
- Ferdaoussi, Mourad;
- Alghamdi, Tamadher A.;
- Lewandowski, Sophie L.;
- Jin, Yaxing;
- Bautista, Austin;
- Wang, Ying Wayne;
- Manning Fox, Jocelyn E.;
- Merrins, Matthew J.;
- Buteau, Jean;
- MacDonald, Patrick E.
Publication type:
journal article
In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking.
Published in:
Diabetes, 2012, v. 61, n. 7, p. 1708, doi. 10.2337/db11-1344
By:
- Cai, Erica P.;
- Casimir, Marina;
- Schroer, Stephanie A.;
- Luk, Cynthia T.;
- Shi, Sally Yu;
- Choi, Diana;
- Xiao Qing Dai;
- Hajmrle, Catherine;
- Spigelman, Aliya F.;
- Zhu, Dan;
- Gaisano, Herbert Y.;
- MacDonald, Patrick E.;
- Woo, Minna
Publication type:
Article

Found: 12