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Perturbation of TM6SF2 Expression Alters Lipid Metabolism in a Human Liver Cell Line.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 18, p. 9758, doi. 10.3390/ijms22189758
By:
- Pant, Asmita;
- Chen, Yue;
- Kuppa, Annapurna;
- Du, Xiaomeng;
- Halligan, Brian D.;
- Speliotes, Elizabeth K.
Publication type:
Article
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Published in:
2011
By:
- Heid, Iris M;
- Jackson, Anne U;
- Randall, Joshua C;
- Winkler, Thomas W;
- Qi, Lu;
- Steinthorsdottir, Valgerdur;
- Thorleifsson, Gudmar;
- Zillikens, M Carola;
- Speliotes, Elizabeth K;
- Mägi, Reedik;
- Workalemahu, Tsegaselassie;
- White, Charles C;
- Bouatia-Naji, Nabila;
- Harris, Tamara B;
- Berndt, Sonja I;
- Ingelsson, Erik;
- Willer, Cristen J;
- Weedon, Michael N;
- Luan, Jian'an;
- Vedantam, Sailaja
Publication type:
Correction Notice
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Published in:
Nature Genetics, 2010, v. 42, n. 11, p. 949, doi. 10.1038/ng.685
By:
- Heid, Iris M.;
- Jackson, Anne U.;
- Randall, Joshua C.;
- Winkler, Thomas W.;
- Lu Qi;
- Steinthorsdottir, Valgerdur;
- Thorleifsson, Gudmar;
- Zillikens, M. Carola;
- Speliotes, Elizabeth K.;
- Mägi, Reedik;
- Workalemahu, Tsegaselassie;
- White, Charles C.;
- Bouatia-Naji, Nabila;
- Harris, Tamara B.;
- Berndt, Sonja I.;
- Ingelsson, Erik;
- Willer, Cristen J.;
- Weedon, Michael N.;
- Luan, Jian'an;
- Vedantam, Sailaja
Publication type:
Article
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Published in:
Nature Genetics, 2010, v. 42, n. 11, p. 937, doi. 10.1038/ng.686
By:
- Speliotes, Elizabeth K.;
- Willer, Cristen J.;
- Berndt, Sonja I.;
- Monda, Keri L.;
- Thorleifsson, Gudmar;
- Jackson, Anne U.;
- Allen, Hana Lango;
- Lindgren, Cecilia M.;
- Luan, Jian'an;
- Mägi, Reedik;
- Randall, Joshua C.;
- Vedantam, Sailaja;
- Winkler, Thomas W.;
- Lu Qi;
- Workalemahu, Tsegaselassie;
- Heid, Iris M.;
- Steinthorsdottir, Valgerdur;
- Stringham, Heather M.;
- Weedon, Michael N.;
- Wheeler, Eleanor
Publication type:
Article
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
Published in:
Nature Genetics, 2009, v. 41, n. 1, p. 25, doi. 10.1038/ng.287
By:
- Willer, Cristen J.;
- Speliotes, Elizabeth K.;
- Loos, Ruth J. F.;
- Shengxu Li;
- Lindgren, Cecilia M.;
- Heid, Iris M.;
- Berndt, Sonja I.;
- Elliott, Amanda L.;
- Jackson, Anne U.;
- Lamina, Claudia;
- Lettre, Guillaume;
- Lim, Noha;
- Lyon, Helen N.;
- McCarroll, Steven A.;
- Papadakis, Konstantinos;
- Lu Qi;
- Randall, Joshua C.;
- Roccasecca, Rosa Maria;
- Sanna, Serena;
- Scheet, Paul
Publication type:
Article
Author Correction: Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.
Published in:
2023
By:
- Chen, Vincent L.;
- Du, Xiaomeng;
- Chen, Yanhua;
- Kuppa, Annapurna;
- Handelman, Samuel K.;
- Vohnoutka, Rishel B.;
- Peyser, Patricia A.;
- Palmer, Nicholette D.;
- Bielak, Lawrence F.;
- Halligan, Brian;
- Speliotes, Elizabeth K.
Publication type:
Correction Notice
A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS).
Published in:
PLoS ONE, 2015, v. 10, n. 11, p. 1, doi. 10.1371/journal.pone.0134649
By:
- Gao, Chuan;
- Wang, Nan;
- Guo, Xiuqing;
- Ziegler, Julie T.;
- Taylor, Kent D.;
- Xiang, Anny H.;
- Hai, Yang;
- Kridel, Steven J.;
- Nadler, Jerry L.;
- Kandeel, Fouad;
- Raffel, Leslie J.;
- Chen, Yii-Der I.;
- Norris, Jill M.;
- Rotter, Jerome I.;
- Watanabe, Richard M.;
- Wagenknecht, Lynne E.;
- Bowden, Donald W.;
- Speliotes, Elizabeth K.;
- Goodarzi, Mark O.;
- Langefeld, Carl D.
Publication type:
Article
Genetic variants that associate with cirrhosis have pleiotropic effects on human traits.
Published in:
Liver International, 2020, v. 40, n. 2, p. 405, doi. 10.1111/liv.14321
By:
- Chen, Vincent L.;
- Chen, Yanhua;
- Du, Xiaomeng;
- Handelman, Samuel K.;
- Speliotes, Elizabeth K.
Publication type:
Article
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Published in:
Nature, 2010, v. 467, n. 7317, p. 832, doi. 10.1038/nature09410
By:
- Lango Allen, Hana;
- Estrada, Karol;
- Lettre, Guillaume;
- Berndt, Sonja I.;
- Weedon, Michael N.;
- Rivadeneira, Fernando;
- Willer, Cristen J.;
- Jackson, Anne U.;
- Vedantam, Sailaja;
- Raychaudhuri, Soumya;
- Ferreira, Teresa;
- Wood, Andrew R.;
- Weyant, Robert J.;
- Segrè, Ayellet V.;
- Speliotes, Elizabeth K.;
- Wheeler, Eleanor;
- Soranzo, Nicole;
- Ju-Hyun Park;
- Jian Yang;
- Gudbjartsson, Daniel
Publication type:
Article
Association of Nonalcoholic Fatty Liver Disease With Lower Brain Volume in Healthy Middle-aged Adults in the Framingham Study.
Published in:
JAMA Neurology, 2018, v. 75, n. 1, p. 97, doi. 10.1001/jamaneurol.2017.3229
By:
- Weinstein, Galit;
- Zelber-Sagi, Shira;
- Preis, Sarah R.;
- Beiser, Alexa S.;
- DeCarli, Charles;
- Speliotes, Elizabeth K.;
- Satizabal, Claudia L.;
- Vasan, Ramachandran S.;
- Seshadri, Sudha
Publication type:
Article
Biological interpretation of genome-wide association studies using predicted gene functions.
Published in:
Nature Communications, 2015, v. 6, n. 1, p. 5890, doi. 10.1038/ncomms6890
By:
- Pers, Tune H.;
- Karjalainen, Juha M.;
- Chan, Yingleong;
- Westra, Harm-Jan;
- Wood, Andrew R.;
- Yang, Jian;
- Lui, Julian C.;
- Vedantam, Sailaja;
- Gustafsson, Stefan;
- Esko, Tonu;
- Frayling, Tim;
- Speliotes, Elizabeth K.;
- Boehnke, Michael;
- Raychaudhuri, Soumya;
- Fehrmann, Rudolf S. N.;
- Hirschhorn, Joel N.;
- Franke, Lude
Publication type:
Article
Adipose Tissue Depots and Their Cross-Sectional Associations With Circulating Biomarkers of Metabolic Regulation.
Published in:
2016
By:
- Lee, Jane J.;
- Britton, Kathryn A.;
- Pedley, Alison;
- Massaro, Joseph M.;
- Speliotes, Elizabeth K.;
- Murabito, Joanne M.;
- Hoffmann, Udo;
- Ingram, Cheryl;
- Keaney, John F.;
- Vasan, Ramachandran S.;
- Fox, Caroline S.;
- Keaney, John F Jr
Publication type:
journal article
Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity.
Published in:
Human Molecular Genetics, 2015, v. 24, n. 23, p. 6849, doi. 10.1093/hmg/ddv379
By:
- Hägg, Sara;
- Ganna, Andrea;
- Van Der Laan, Sander W.;
- Esko, Tonu;
- Pers, Tune H.;
- Locke, Adam E.;
- Berndt, Sonja I.;
- Justice, Anne E.;
- Kahali, Bratati;
- Siemelink, Marten A.;
- Pasterkamp, Gerard;
- Strachan, David P.;
- Speliotes, Elizabeth K.;
- North, Kari E.;
- Loos, Ruth J. F.;
- Hirschhorn, Joel N.;
- Pawitan, Yudi;
- Ingelsson, Erik
Publication type:
Article
Independent markers of nonalcoholic fatty liver disease in a gentrifying population-based Chinese cohort.
Published in:
2019
By:
- Zhou, Xianghai;
- Li, Yufeng;
- Zhang, Xiuying;
- Guan, Ying Ying;
- Puentes, Yindra;
- Zhang, Fang;
- Speliotes, Elizabeth K.;
- Ji, Linong
Publication type:
journal article
FTO genotype is associated with phenotypic variability of body mass index.
Published in:
Nature, 2012, v. 490, n. 7419, p. 267, doi. 10.1038/nature11401
By:
- Yang, Jian;
- Loos, Ruth J. F.;
- Powell, Joseph E.;
- Medland, Sarah E.;
- Speliotes, Elizabeth K.;
- Chasman, Daniel I.;
- Rose, Lynda M.;
- Thorleifsson, Gudmar;
- Steinthorsdottir, Valgerdur;
- Mägi, Reedik;
- Waite, Lindsay;
- Vernon Smith, Albert;
- Yerges-Armstrong, Laura M.;
- Monda, Keri L.;
- Hadley, David;
- Mahajan, Anubha;
- Li, Guo;
- Kapur, Karen;
- Vitart, Veronique;
- Huffman, Jennifer E.
Publication type:
Article
Comparison of the Potency of Competitive NMDA Antagonists Against the Neurotoxicity of Glutamate and NMDA.
Published in:
Journal of Neurochemistry, 1994, v. 63, n. 3, p. 879, doi. 10.1046/j.1471-4159.1994.63030879.x
By:
- Speliotes, Elizabeth K.;
- Hartnett, Karen A.;
- Blitzblau, Rachel C.;
- Aizenman, Elias;
- Rosenberg, Paul A.
Publication type:
Article
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits.
Published in:
PLoS Genetics, 2011, v. 7, n. 3, p. 1
By:
- Speliotes, Elizabeth K.;
- Yerges-Armstrong, Laura M.;
- Wu, Jun;
- Hernaez, Ruben;
- Kim, Lauren J.;
- Palmer, Cameron D.;
- Gudnason, Vilmundur;
- Eiriksdottir, Gudny;
- Garcia, Melissa E.;
- Launer, Lenore J.;
- Nalls, Michael A.;
- Clark, Jeanne M.;
- Mitchell, Braxton D.;
- Shuldiner, Alan R.;
- Butler, Johannah L.;
- Tomas, Marta;
- Hoffmann, Udo;
- Hwang, Shih-Jen;
- Massaro, Joseph M.;
- O'Donnell, Christopher J.
Publication type:
Article
Common body mass index-associated variants confer risk of extreme obesity.
Published in:
Human Molecular Genetics, 2010, v. 19, n. 18, p. 3690
By:
- Cotsapas, Chris;
- Speliotes, Elizabeth K.;
- Hatoum, Ida J.;
- Greenawalt, Danielle M.;
- Dobrin, Radu;
- Lum, Pek Y.;
- Suver, Christine;
- Chudin, Eugene;
- Kemp, Daniel;
- Reitman, Marc;
- Voight, Benjamin F.;
- Neale, Benjamin M.;
- Schadt, Eric E.;
- Hirschhorn, Joel N.;
- Kaplan, Lee M.;
- Daly, Mark J.
Publication type:
Article
Common body mass index-associated variants confer risk of extreme obesity.
Published in:
Human Molecular Genetics, 2009, v. 18, n. 18, p. 3502
By:
- Cotsapas, Chris;
- Speliotes, Elizabeth K.;
- Hatoum, Ida J.;
- Greenawalt, Danielle M.;
- Dobrin, Radu;
- Lum, Pek Y.;
- Suver, Christine;
- Chudin, Eugene;
- Kemp, Daniel;
- Reitman, Marc;
- Voight, Benjamin F.;
- Neale, Benjamin M.;
- Schadt, Eric E.;
- Hirschhorn, Joel N.;
- Kaplan, Lee M.;
- Daly, Mark J.
Publication type:
Article
Genome-Wide Family-Based Linkage Analysis of Exome Chip Variants and Cardiometabolic Risk.
Published in:
Genetic Epidemiology, 2014, v. 38, n. 4, p. 345, doi. 10.1002/gepi.21801
By:
- Hellwege, Jacklyn N.;
- Palmer, Nicholette D.;
- Raffield, Laura M.;
- Ng, Maggie C.Y.;
- Hawkins, Gregory A.;
- Long, Jirong;
- Lorenzo, Carlos;
- Norris, Jill M.;
- Ida Chen, Y.‐D.;
- Speliotes, Elizabeth K.;
- Rotter, Jerome I.;
- Langefeld, Carl D.;
- Wagenknecht, Lynne E.;
- Bowden, Donald W.
Publication type:
Article
Genome-Wide Study of Subcutaneous and Visceral Adipose Tissue Reveals Novel Sex-Specific Adiposity Loci in Mexican Americans.
Published in:
2018
By:
- Gao, Chuan;
- Langefeld, Carl D.;
- Ziegler, Julie T.;
- Taylor, Kent D.;
- Norris, Jill M.;
- Chen, Yii‐Der I.;
- Hellwege, Jacklyn N.;
- Guo, Xiuqing;
- Allison, Matthew A.;
- Speliotes, Elizabeth K.;
- Rotter, Jerome I.;
- Bowden, Donald W.;
- Wagenknecht, Lynne E.;
- Palmer, Nicholette D.;
- Chen, Yii-Der I
Publication type:
journal article
Liver fat is reproducibly measured using computed tomography in the Framingham Heart Study.
Published in:
Journal of Gastroenterology & Hepatology, 2008, v. 23, n. 6, p. 894, doi. 10.1111/j.1440-1746.2008.05420.x
By:
- Speliotes, Elizabeth K.;
- Massaro, Joseph M.;
- Hoffmann, Udo;
- Foster, Meredith C.;
- Sahani, Dushyant V.;
- Hirschhorn, Joel N.;
- O'Donnell, Christopher J.;
- Fox, Caroline S.
Publication type:
Article
Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20870-1
By:
- Chen, Vincent L.;
- Du, Xiaomeng;
- Chen, Yanhua;
- Kuppa, Annapurna;
- Handelman, Samuel K.;
- Vohnoutka, Rishel B.;
- Peyser, Patricia A.;
- Palmer, Nicholette D.;
- Bielak, Lawrence F.;
- Halligan, Brian;
- Speliotes, Elizabeth K.
Publication type:
Article
Non-Alcoholic Fatty Liver Disease and Vitamin D in the UK Biobank: A Two-Sample Bidirectional Mendelian Randomisation Study.
Published in:
Nutrients, 2023, v. 15, n. 6, p. 1442, doi. 10.3390/nu15061442
By:
- Zhang, Zixuan;
- Burrows, Kimberley;
- Fuller, Harriett;
- Speliotes, Elizabeth K.;
- Abeysekera, Kushala W. M.;
- Thorne, James L.;
- Lewis, Sarah J.;
- Zulyniak, Michael A.;
- Moore, J. Bernadette
Publication type:
Article
A Peripheral Blood DNA Methylation Signature of Hepatic Fat Reveals a Potential Causal Pathway for Nonalcoholic Fatty Liver Disease.
Published in:
2019
By:
- Ma, Jiantao;
- Nano, Jana;
- Ding, Jingzhong;
- Zheng, Yinan;
- Hennein, Rachel;
- Liu, Chunyu;
- Speliotes, Elizabeth K;
- Huan, Tianxiao;
- Song, Ci;
- Mendelson, Michael M;
- Joehanes, Roby;
- Long, Michelle T;
- Liang, Liming;
- Smith, Jennifer A;
- Reynolds, Lindsay M;
- Ghanbari, Mohsen;
- Muka, Taulant;
- van Meurs, Joyce B J;
- Alferink, Louise J M;
- Franco, Oscar H
Publication type:
journal article

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