Works by Sparks, Lauren M.

Results: 39

Exercise Response Variations in Skeletal Muscle PCr Recovery Rate and Insulin Sensitivity Relate to Muscle Epigenomic Profiles in Individuals With Type 2 Diabetes.

Published in:

2018

By:

Stephens, Natalie A.;
Brouwers, Bram;
Fanchao Yi;
Cornnell, Heather H.;
Meyer, Christian;
Goodpaster, Bret H.;
Pratley, Richard E.;
Smith, Steven R.;
Sparks, Lauren M.;
Eroshkin, Alexey M.;
Yi, Fanchao

Publication type:

journal article

A Metabolomic Signature of Glucagon Action in Healthy Individuals With Overweight/Obesity.

Published in:

Journal of the Endocrine Society, 2021, v. 5, n. 9, p. 1, doi. 10.1210/jendso/bvab118

By:

Vega, Rick B;
Whytock, Katie L;
Gassenhuber, Johan;
Goebel, Britta;
Tillner, Joachim;
Agueusop, Inoncent;
Truax, Agnieszka D;
Yu, Gongxin;
Carnero, Elvis;
Kapoor, Nidhi;
Gardell, Stephen;
Sparks, Lauren M;
Smith, Steven R

Publication type:

Article

Optimized RNA sequencing deconvolution illustrates the impact of obesity and weight loss on cell composition of human adipose tissue.

Published in:

Obesity (19307381), 2025, v. 33, n. 5, p. 936, doi. 10.1002/oby.24264

By:

Ahn, Cheehoon;
Divoux, Adeline;
Zhou, Mingqi;
Seldin, Marcus M.;
Sparks, Lauren M.;
Whytock, Katie L.

Publication type:

Article

Associations between regional adipose tissue distribution and skeletal muscle bioenergetics in older men and women.

Published in:

Obesity (19307381), 2024, v. 32, n. 6, p. 1125, doi. 10.1002/oby.24008

By:

Brennan, Andrea M.;
Coen, Paul M.;
Mau, Theresa;
Hetherington‐Rauth, Megan;
Toledo, Frederico G. S.;
Kershaw, Erin E.;
Cawthon, Peggy M.;
Kramer, Philip A.;
Ramos, Sofhia V.;
Newman, Anne B.;
Cummings, Steven R.;
Forman, Daniel E.;
Yeo, Reichelle X.;
Distefano, Giovanna;
Miljkovic, Iva;
Justice, Jamie N.;
Molina, Anthony J. A.;
Jurczak, Michael J.;
Sparks, Lauren M.;
Kritchevsky, Stephen B.

Publication type:

Article

Prolonged Glucagon Infusion Does Not Affect Energy Expenditure in Individuals with Overweight/Obesity: A Randomized Trial.

Published in:

2021

By:

Whytock, Katie L.;
Carnero, Elvis A.;
Vega, Rick B.;
Tillner, Joachim;
Bock, Christopher;
Chivukula, Karthik;
Yi, Fanchao;
Meyer, Christian;
Smith, Steven R.;
Sparks, Lauren M.

Publication type:

journal article

Genetic Markers of Brown Adipose Tissue Identity and In Vitro Brown Adipose Tissue Activity in Humans.

Published in:

2018

By:

Nascimento, Emmani B. M.;
Sparks, Lauren M.;
Divoux, Adeline;
van Gisbergen, Marike W.;
Broeders, Evie P. M.;
Jörgensen, Johanna A.;
Schaart, Gert;
Bouvy, Nicole D.;
van Marken Lichtenbelt, Wouter D.;
Schrauwen, Patrick

Publication type:

journal article

Active individuals have high mitochondrial content and oxidative markers in their abdominal subcutaneous adipose tissue.

Published in:

2016

By:

Pino, Maria F.;
Parsons, Stephanie A.;
Smith, Steven R.;
Sparks, Lauren M.

Publication type:

journal article

Low Macrophage Accumulation in Skeletal Muscle of Obese Type 2 Diabetics and Elderly Subjects.

Published in:

Obesity (19307381), 2012, v. 20, n. 7, p. 1530, doi. 10.1038/oby.2012.24

By:

Tam, Charmaine S.;
Sparks, Lauren M.;
Johannsen, Darcy L.;
Covington, Jeffrey D.;
Church, Timothy S.;
Ravussin, Eric

Publication type:

Article

Transcriptional Metabolic Inflexibility in Skeletal Muscle Among Individuals With Increasing Insulin Resistance.

Published in:

Obesity (19307381), 2011, v. 19, n. 11, p. 2158, doi. 10.1038/oby.2011.149

By:

Jans, Anneke;
Sparks, Lauren M.;
van Hees, Anneke M.J.;
Gjelstad, Ingrid M.F.;
Tierney, Audrey C.;
Risérus, Ulf;
Drevon, Christian A.;
Roche, Helen M.;
Schrauwen, Patrick;
Blaak, Ellen E.

Publication type:

Article

PGC1α –1 Nucleosome Position and Splice Variant Expression and Cardiovascular Disease Risk in Overweight and Obese Individuals.

Published in:

PPAR Research, 2014, p. 1, doi. 10.1155/2014/895734

By:

Henagan, Tara M.;
Stewart, Laura K.;
Forney, Laura A.;
Sparks, Lauren M.;
Johannsen, Neil;
Church, Timothy S.

Publication type:

Article

Myokine Secretion following an Aerobic Exercise Intervention in Individuals with Type 2 Diabetes with or without Exercise Resistance.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 9, p. 4889, doi. 10.3390/ijms25094889

By:

Garneau, Léa;
Mulvihill, Erin E.;
Smith, Steven R.;
Sparks, Lauren M.;
Aguer, Céline

Publication type:

Article

Skeletal Muscle Composition, Power, and Mitochondrial Energetics in Older Men and Women With Knee Osteoarthritis.

Published in:

Arthritis & Rheumatology, 2024, v. 76, n. 12, p. 1764, doi. 10.1002/art.42953

By:

Distefano, Giovanna;
Harrison, Stephanie;
Lynch, John;
Link, Thomas M.;
Kramer, Philip A.;
Ramos, Sofhia V.;
Mau, Theresa;
Coen, Paul M.;
Sparks, Lauren M.;
Goodpaster, Bret H.;
Cawthon, Peggy M.;
Cauley, Jane A.;
Lane, Nancy E.

Publication type:

Article

Resistance training to improve type 2 diabetes: working toward a prescription for the future.

Published in:

Nutrition & Metabolism, 2017, v. 14, p. 1, doi. 10.1186/s12986-017-0173-7

By:

Pesta, Dominik H.;
Goncalves, Renata L. S.;
Madiraju, Anila K.;
Strasser, Barbara;
Sparks, Lauren M.

Publication type:

Article

Effects of 12 Months of Caloric Restriction on Muscle Mitochondrial Function in Healthy Individuals.

Published in:

Journal of Clinical Endocrinology & Metabolism, 2017, v. 102, n. 1, p. 111, doi. 10.1210/jc.2016-3211

By:

Sparks, Lauren M.;
Redman, Leanne M.;
Conley, Kevin E.;
Harper, Mary-Ellen;
Yi, Fanchao;
Hodges, Andrew;
Eroshkin, Alexey;
Costford, Sheila R.;
Gabriel, Meghan E.;
Shook, Cherie;
Cornnell, Heather H.;
Ravussin, Eric;
Smith, Steven R.

Publication type:

Article

Effects of 12 Months of Caloric Restriction on Muscle Mitochondrial Function in Healthy Individuals.

Published in:

2016

By:

Sparks, Lauren Marie;
Redman, Leanne M;
Conley, Kevin E;
Harper, Mary-Ellen;
Yi, Fanchao;
Hodges, Andrew;
Eroshkin, Alexey;
Costford, Sheila R;
Gabriel, Meghan E;
Shook, Cherie;
Cornnell, Heather H;
Ravussin, Eric;
Smith, Steven R;
Sparks, Lauren M

Publication type:

journal article

Differences in Mitochondrial Coupling Reveal a Novel Signature of Mitohormesis in Muscle of Healthy Individuals.

Published in:

2016

By:

Sparks, Lauren M;
Redman, Leanne M;
Conley, Kevin E;
Harper, Mary-Ellen;
Hodges, Andrew;
Eroshkin, Alexey;
Costford, Sheila R;
Gabriel, Meghan E;
Fanchao Yi;
Shook, Cherie;
Cornnell, Heather H;
Ravussin, Eric;
Smith, Steven R

Publication type:

journal article

Resistance to the beneficial effects of exercise in type 2 diabetes: are some individuals programmed to fail?

Published in:

2015

By:

Stephens, Natalie A;
Sparks, Lauren M

Publication type:

Journal Article

Increased oxygen consumption in human adipose tissue from the "brown adipose tissue" region.

Published in:

2013

By:

Vijgen, Guy H E J;
Sparks, Lauren M;
Bouvy, Nicole D;
Schaart, Gert;
Hoeks, Joris;
van Marken Lichtenbelt, Wouter D;
Schrauwen, Patrick

Publication type:

journal article

Nine months of combined training improves ex vivo skeletal muscle metabolism in individuals with type 2 diabetes.

Published in:

2013

By:

Sparks, Lauren M;
Johannsen, Neil M;
Church, Timothy S;
Earnest, Conrad P;
Moonen-Kornips, Esther;
Moro, Cedric;
Hesselink, Matthijs K C;
Smith, Steven R;
Schrauwen, Patrick

Publication type:

journal article

Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men.

Published in:

2008

By:

Donkor, Jimmy;
Sparks, Lauren M;
Xie, Hui;
Smith, Steven R;
Reue, Karen

Publication type:

journal article

Twenty-four hour assessments of substrate oxidation reveal differences in metabolic flexibility in type 2 diabetes that are improved with aerobic training.

Published in:

Diabetologia, 2021, v. 64, n. 10, p. 2322, doi. 10.1007/s00125-021-05535-y

By:

Carnero, Elvis A.;
Bock, Christopher P.;
Distefano, Giovanna;
Corbin, Karen D.;
Stephens, Natalie A.;
Pratley, Richard E.;
Smith, Steven R.;
Goodpaster, Bret H.;
Sparks, Lauren M.

Publication type:

Article

Percutaneous biopsies of skeletal muscle and adipose tissue in individuals older than 70: methods and outcomes in the Study of Muscle, Mobility and Aging (SOMMA).

Published in:

GeroScience, 2024, v. 46, n. 3, p. 3419, doi. 10.1007/s11357-024-01087-2

By:

Zamora, Zeke;
Lui, Li-Yung;
Sparks, Lauren M.;
Justice, Jamie;
Lyles, Mary;
Gentle, Landon;
Gregory, Heather;
Yeo, Reichelle X.;
Kershaw, Erin E.;
Stefanovic-Racic, Maja;
Newman, Anne B.;
Kritchevsky, Stephen;
Toledo, Frederico G. S.

Publication type:

Article

Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary.

Published in:

GeroScience, 2023, v. 45, n. 1, p. 569, doi. 10.1007/s11357-022-00668-3

By:

Erickson, Melissa L.;
Allen, Jacob M.;
Beavers, Daniel P.;
Collins, Linda M.;
Davidson, Karina W.;
Erickson, Kirk I.;
Esser, Karyn A.;
Hesselink, Matthijs K. C.;
Moreau, Kerrie L.;
Laber, Eric B.;
Peterson, Charlotte A.;
Peterson, Courtney M.;
Reusch, Jane E.;
Thyfault, John P.;
Youngstedt, Shawn D.;
Zierath, Juleen R.;
Goodpaster, Bret H.;
LeBrasseur, Nathan K.;
Buford, Thomas W.;
Sparks, Lauren M.

Publication type:

Article

Targeting White Adipose Tissue with Exercise or Bariatric Surgery as Therapeutic Strategies in Obesity.

Published in:

Biology (2079-7737), 2019, v. 8, n. 1, p. 16, doi. 10.3390/biology8010016

By:

Giolo De Carvalho, Flávia;
Sparks, Lauren M.

Publication type:

Article

Individual Response Variation in the Effects of Weight Loss and Exercise on Insulin Sensitivity and Cardiometabolic Risk in Older Adults.

Published in:

Frontiers in Endocrinology, 2020, v. 11, p. N.PAG, doi. 10.3389/fendo.2020.00632

By:

Brennan, Andrea M.;
Standley, Robert A.;
Yi, Fanchao;
Carnero, Elvis A.;
Sparks, Lauren M.;
Goodpaster, Bret H.

Publication type:

Article

Adipose Tissue Quality in Aging: How Structural and Functional Aspects of Adipose Tissue Impact Skeletal Muscle Quality.

Published in:

Nutrients, 2019, v. 11, n. 11, p. 2553, doi. 10.3390/nu11112553

By:

De Carvalho, Flavia G.;
Justice, Jamie N.;
Freitas, Ellen C. de;
Kershaw, Erin E.;
Sparks, Lauren M.

Publication type:

Article

Plasma Myokine Concentrations After Acute Exercise in Non-obese and Obese Sedentary Women.

Published in:

Frontiers in Physiology, 2020, p. 1, doi. 10.3389/fphys.2020.00018

By:

Garneau, Léa;
Parsons, Stephanie A.;
Smith, Steven R.;
Mulvihill, Erin E.;
Sparks, Lauren M.;
Aguer, Céline

Publication type:

Article

Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.

Published in:

2015

By:

van de Weijer, Tineke;
Phielix, Esther;
Bilet, Lena;
Williams, Evan G;
Ropelle, Eduardo R;
Bierwagen, Alessandra;
Livingstone, Roshan;
Nowotny, Peter;
Sparks, Lauren M;
Paglialunga, Sabina;
Szendroedi, Julia;
Havekes, Bas;
Moullan, Norman;
Pirinen, Eija;
Hwang, Jong-Hee;
Schrauwen-Hinderling, Vera B;
Hesselink, Matthijs K C;
Auwerx, Johan;
Roden, Michael;
Schrauwen, Patrick

Publication type:

journal article

Evidence for a Direct Effect of the NAD<sup>+</sup> Precursor Acipimox on Muscle Mitochondrial Function in Humans.

Published in:

Diabetes, 2015, v. 64, n. 4, p. 1193, doi. 10.2337/db14-0667

By:

van de Weijer, Tineke;
Phielix, Esther;
Bilet, Lena;
Williams, Evan G.;
Ropelle, Eduardo R.;
Bierwagen, Alessandra;
Livingstone, Roshan;
Nowotny, Peter;
Sparks, Lauren M.;
Paglialunga, Sabina;
Szendroedi, Julia;
Havekes, Bas;
Moullan, Norman;
Pirinen, Eija;
Jong-Hee Hwang;
Schrauwen-Hinderling, Vera B.;
Hesselink, Matthijs K. C.;
Auwerx, Johan;
Roden, Michael;
Schrauwen, Patrick

Publication type:

Article

Reduced Incorporation of Fatty Acids Into Triacylglycerol in Myotubes From Obese Individuals With Type 2 Diabetes.

Published in:

Diabetes, 2014, v. 63, n. 5, p. 1583, doi. 10.2337/db13-1123

By:

Sparks, Lauren M.;
Bosma, Madeleen;
Brouwers, Bram;
van de Weijer, Tineke;
Bilet, Lena;
Schaart, Gert;
Moonen-Kornips, Esther;
Eichmann, Thomas O.;
Lass, Achim;
Hesselink, Matthijs K. C.;
Schrauwen, Patrick

Publication type:

Article

Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels.

Published in:

Diabetes, 2012, v. 61, n. 11, p. 2679, doi. 10.2337/db11-1402

By:

Bosma, Madeleen;
Hesselink, Matthijs K. C.;
Sparks, Lauren M.;
Timmers, Silvie;
Ferraz, Maria João;
Mattijssen, Frits;
van Beurden, Denis;
Schaart, Gert;
de Baets, Marc H.;
Verheyen, Fons K.;
Kersten, Sander;
Schrauwen, Patrick

Publication type:

Article

A High-Fat Diet Coordinately Downregulates Genes Required for Mitochondrial Oxidative Phosphorylation in Skeletal Muscle.

Published in:

Diabetes, 2005, v. 54, n. 7, p. 1926, doi. 10.2337/diabetes.54.7.1926

By:

Sparks, Lauren M.;
Xie, Hui;
Koza, Robert A.;
Mynatt, Randall;
Hulver, Matthew W.;
Bray, George A.;
Smith, Steven R.

Publication type:

Article

Editorial: Exercise intervention for prevention and management of type 2 diabetes.

Published in:

Frontiers in Physiology, 2023, p. 1, doi. 10.3389/fphys.2023.1320101

By:

Aguer, Céline;
Snigdha, Smiti;
Sparks, Lauren M.

Publication type:

Article

Determinants of the Changes in Glycemic Control with Exercise Training in Type 2 Diabetes: A Randomized Trial.

Published in:

PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0062973

By:

Johannsen, Neil M.;
Sparks, Lauren M.;
Zhang, Zhengyu;
Earnest, Conrad P.;
Smith, Steven R.;
Church, Timothy S.;
Ravussin, Eric

Publication type:

Article

Remodeling Lipid Metabolism and Improving Insulin Responsiveness in Human Primary Myotubes.

Published in:

PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0021068

By:

Sparks, Lauren M.;
Moro, Cedric;
Ukropcova, Barbara;
Bajpeyi, Sudip;
Civitarese, Anthony E.;
Hulver, Matthew W.;
Thoresen, G. Hege;
Rustan, Arild C.;
Smith, Steven R.

Publication type:

Article

An improvement in skeletal muscle mitochondrial capacity with short‐term aerobic training is associated with changes in Tribbles 1 expression.

Published in:

Physiological Reports, 2020, v. 8, n. 12, p. 1, doi. 10.14814/phy2.14416

By:

Vega, Rick B.;
Brouwers, Bram;
Parsons, Stephanie A.;
Stephens, Natalie A.;
Pino, Maria F.;
Hodges, Andrew;
Yi, Fanchao;
Yu, Gongxin;
Pratley, Richard E.;
Smith, Steven R.;
Sparks, Lauren M.

Publication type:

Article

Muscle Mitochondrial Bioenergetic Capacities Are Associated With Multimorbidity Burden in Older Adults: The Study of Muscle, Mobility and Aging.

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2024, v. 79, n. 7, p. 1, doi. 10.1093/gerona/glae101

By:

Mau, Theresa;
Blackwell, Terri L;
Cawthon, Peggy M;
Molina, Anthony J A;
Coen, Paul M;
Distefano, Giovanna;
Kramer, Philip A;
Ramos, Sofhia V;
Forman, Daniel E;
Goodpaster, Bret H;
Toledo, Frederico G S;
Duchowny, Kate A;
Sparks, Lauren M;
Newman, Anne B;
Kritchevsky, Stephen B;
Cummings, Steven R

Publication type:

Article

Mitochondrial energetics in skeletal muscle are associated with leg power and cardiorespiratory fitness in the Study of Muscle, Mobility, and Aging (SOMMA).

Published in:

Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2023, v. 78, n. 8, p. 1367, doi. 10.1093/gerona/glac238

By:

Mau, Theresa;
Lui, Li-Yung;
Distefano, Giovanna;
Kramer, Philip A;
Ramos, Sofhia V;
Toledo, Frederico G S;
Santanasto, Adam J;
Shankland, Eric G;
Marcinek, David J;
Jurczak, Michael J;
Sipula, Ian;
Bello, Fiona M;
Duchowny, Kate A;
Molina, Anthony J A;
Sparks, Lauren M;
Goodpaster, Bret H;
Hepple, Russell T;
Kritchevsky, Stephen B;
Newman, Anne B;
Cawthon, Peggy M

Publication type:

Article

Elevated Nicotinamide Phosphoribosyl Transferase in Skeletal Muscle Augments Exercise Performance and Mitochondrial Respiratory Capacity Following Exercise Training.

Published in:

Frontiers in Physiology, 2018, p. 1, doi. 10.3389/fphys.2018.00704

By:

Brouwers, Bram;
Stephens, Natalie A.;
Costford, Sheila R.;
Hopf, Meghan E.;
Ayala, Julio E.;
Fanchao Yi;
Hui Xie;
Jian-Liang Li;
Gardell, Stephen J.;
Sparks, Lauren M.;
Smith, Steven R.;
Wataru Aoi;
Sakuma, Kunihiro;
Siu, Parco M.

Publication type:

Article