Works by Spahn, Christian M. T.

Results: 30

EF-G and EF4: translocation and back-translocation on the bacterial ribosome.

Published in:

Nature Reviews Microbiology, 2014, v. 12, n. 2, p. 89, doi. 10.1038/nrmicro3176

By:

Yamamoto, Hiroshi;
Qin, Yan;
Achenbach, John;
Li, Chengmin;
Kijek, Jaroslaw;
Spahn, Christian M. T.;
Nierhaus, Knud H.

Publication type:

Article

The proline-rich antimicrobial peptide Api137 disrupts large ribosomal subunit assembly and induces misfolding.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-55836-8

By:

Lauer, Simon Malte;
Gasse, Jakob;
Krizsan, Andor;
Reepmeyer, Maren;
Sprink, Thiemo;
Nikolay, Rainer;
Spahn, Christian M. T.;
Hoffmann, Ralf

Publication type:

Article

Protein translation rate determines neocortical neuron fate.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49198-w

By:

Borisova, Ekaterina;
Newman, Andrew G.;
Couce Iglesias, Marta;
Dannenberg, Rike;
Schaub, Theres;
Qin, Bo;
Rusanova, Alexandra;
Brockmann, Marisa;
Koch, Janina;
Daniels, Marieatou;
Turko, Paul;
Jahn, Olaf;
Kaplan, David R.;
Rosário, Marta;
Iwawaki, Takao;
Spahn, Christian M. T.;
Rosenmund, Christian;
Meierhofer, David;
Kraushar, Matthew L.;
Tarabykin, Victor

Publication type:

Article

Ribosomal protein L2 is involved in the association of the ribosomal subunits, tRNA binding to A and P sites and peptidyl transfer.

Published in:

EMBO Journal, 2000, v. 19, n. 19, p. 5241, doi. 10.1093/emboj/19.19.5241

By:

Diedrich, Gundo;
Spahn, Christian M. T.;
Stelzl, Ulrich;
Schäfer, Markus A.;
Wooten, Tammy;
Bochkariov, Dmirty E.;
Cooperman, Barry S.;
Traut, Robert R.;
Nierhaus, Knud H.

Publication type:

Article

Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 Å resolution.

Published in:

EMBO Journal, 2000, v. 19, n. 11, p. 2710, doi. 10.1093/emboj/19.11.2710

By:

Gomez-Lorenzo, Maria G.;
Spahn, Christian M. T.;
Agrawal, Rajendra K.;
Grassucci, Robert A.;
Ballesta, Pawel P. G.;
Chakraburtty, Kalpana;
Ballesta, Juan P. G.;
Lavandera, Jose L.;
Garcia-Bustos, Jose F.;
Frank, Joachim

Publication type:

Article

Structure of eEF3 and the mechanism of transfer RNA release from the E-site.

Published in:

Nature, 2006, v. 443, n. 7112, p. 663, doi. 10.1038/nature05126

By:

Andersen, Christian B. F.;
Becker, Thomas;
Blau, Michael;
Anand, Monika;
Halic, Mario;
Balar, Bharvi;
Mielke, Thorsten;
Boesen, Thomas;
Pedersen, Jan Skov;
Spahn, Christian M. T.;
Kinzy, Terri Goss;
Andersen, Gregers R.;
Beckmann, Roland

Publication type:

Article

Structural basis for the binding of IRES RNAs to the head of the ribosomal 40S subunit.

Published in:

Nucleic Acids Research, 2011, v. 39, n. 12, p. 5264, doi. 10.1093/nar/gkr114

By:

Muhs, Margarita;
Yamamoto, Hiroshi;
Ismer, Jochen;
Takaku, Hiroaki;
Nashimoto, Masayuki;
Uchiumi, Toshio;
Nakashima, Nobuhiko;
Mielke, Thorsten;
Hildebrand, Peter W.;
Nierhaus, Knud H.;
Spahn, Christian M. T.

Publication type:

Article

An Unbiased cDNA Library Prepared from Isolated Aplysia Sensory Neuron Processes Is Enriched for Cytoskeletal and Translational mRNAs.

Published in:

Journal of Neuroscience, 2003, v. 23, n. 28, p. 9409, doi. 10.1523/JNEUROSCI.23-28-09409.2003

By:

Moccia, Robert;
Chen, Dillon;
Lyles, Vlasta;
Kapuya, Estreya;
E, Yaping;
Kalachikov, Sergey;
Spahn, Christian M. T.;
Frank, Joachim;
Kandel, Eric R.;
Barad, Mark;
Martin, Kelsey C.

Publication type:

Article

Translatomics: The Global View of Translation.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 1, p. 212, doi. 10.3390/ijms20010212

By:

Zhao, Jing;
Qin, Bo;
Nikolay, Rainer;
Spahn, Christian M. T.;
Zhang, Gong

Publication type:

Article

Cryo-electron tomography reveals structural insights into the membrane remodeling mode of dynamin-like EHD filaments.

Published in:

Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-35164-x

By:

Melo, Arthur A.;
Sprink, Thiemo;
Noel, Jeffrey K.;
Vázquez-Sarandeses, Elena;
van Hoorn, Chris;
Mohd, Saif;
Loerke, Justus;
Spahn, Christian M. T.;
Daumke, Oliver

Publication type:

Article

Cryo-EM structure of the Shigella type III needle complex.

Published in:

PLoS Pathogens, 2020, v. 16, n. 2, p. 1, doi. 10.1371/journal.ppat.1008263

By:

Lunelli, Michele;
Kamprad, Antje;
Bürger, Jörg;
Mielke, Thorsten;
Spahn, Christian M. T.;
Kolbe, Michael

Publication type:

Article

Effects of Antisense DNA Against the α-Sarcin Stem-Loop Structure of the Ribosomal 23S rRNA.

Published in:

Nucleic Acids Research, 1996, v. 24, n. 20, p. 3996, doi. 10.1093/nar/24.20.3996

By:

Meyer, Hellmuth-Alexander;
Triana-Alonso, Francisco;
Spahn, Christian M. T.;
Twardowski, Tomasz;
Sobkiewicz, Andrzej;
Nierhaus, Knud H.

Publication type:

Article

Multimodal binding and inhibition of bacterial ribosomes by the antimicrobial peptides Api137 and Api88.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48027-4

By:

Lauer, Simon M.;
Reepmeyer, Maren;
Berendes, Ole;
Klepacki, Dorota;
Gasse, Jakob;
Gabrielli, Sara;
Grubmüller, Helmut;
Bock, Lars V.;
Krizsan, Andor;
Nikolay, Rainer;
Spahn, Christian M. T.;
Hoffmann, Ralf

Publication type:

Article

Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46092-3

By:

Flügel, Timo;
Schacherl, Magdalena;
Unbehaun, Anett;
Schroeer, Birgit;
Dabrowski, Marylena;
Bürger, Jörg;
Mielke, Thorsten;
Sprink, Thiemo;
Diebolder, Christoph A.;
Guillén Schlippe, Yollete V.;
Spahn, Christian M. T.

Publication type:

Article

Transient disome complex formation in native polysomes during ongoing protein synthesis captured by cryo-EM.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-46092-3

By:

Flügel, Timo;
Schacherl, Magdalena;
Unbehaun, Anett;
Schroeer, Birgit;
Dabrowski, Marylena;
Bürger, Jörg;
Mielke, Thorsten;
Sprink, Thiemo;
Diebolder, Christoph A.;
Guillén Schlippe, Yollete V.;
Spahn, Christian M. T.

Publication type:

Article

Visualizing the modification landscape of the human 60S ribosomal subunit at close to atomic resolution.

Published in:

Nucleic Acids Research, 2025, v. 53, n. 1, p. 1, doi. 10.1093/nar/gkae1191

By:

Wiechert, Franziska;
Unbehaun, Anett;
Sprink, Thiemo;
Seibel, Helena;
Bürger, Jörg;
Loerke, Justus;
Mielke, Thorsten;
Diebolder, Christoph A;
Schacherl, Magdalena;
Spahn, Christian M T

Publication type:

Article

GTPase activation of elongation factor EF-Tu by the ribosome during decoding.

Published in:

EMBO Journal, 2009, v. 28, n. 6, p. 755, doi. 10.1038/emboj.2009.26

By:

Schuette, Jan-Christian;
Murphy, Frank V.;
Kelley, Ann C.;
Weir, John R.;
Giesebrecht, Jan;
Connell, Sean R.;
Loerke, Justus;
Mielke, Thorsten;
Wei Zhang;
Penczek, Pawel A.;
Ramakrishnan, V.;
Spahn, Christian M. T.

Publication type:

Article

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation.

Published in:

EMBO Journal, 2004, v. 23, n. 5, p. 1008, doi. 10.1038/sj.emboj.7600102

By:

Christian M. T. Spahn, Stanley J.;
Gomez- Lorenzo, Maria G.;
Grassucci, Robert A.;
Rene Jørgensen, Robert A.;
Andersen, Gregers R.;
Beckmann, Roland;
Penczek, Pawel A.;
Ballesta, Juan P. G.;
Joachim Frank

Publication type:

Article

Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA.

Published in:

Nature Structural & Molecular Biology, 2014, v. 21, n. 8, p. 721, doi. 10.1038/nsmb.2859

By:

Yamamoto, Hiroshi;
Unbehaun, Anett;
Loerke, Justus;
Behrmann, Elmar;
Collier, Marianne;
Bürger, Jörg;
Mielke, Thorsten;
Spahn, Christian M T

Publication type:

Article

A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 9, p. 910, doi. 10.1038/nsmb.1469

By:

Connell, Sean R.;
Topf, Maya;
Yan Qin;
Wilson, Daniel N.;
Mielke, Thorsten;
Fucini, Paola;
Nierhaus, Knud H.;
Spahn, Christian M. T.

Publication type:

Article

Structure of the ribosome-bound cricket paralysis virus IRES RNA.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 12, p. 1092, doi. 10.1038/nsmb1177

By:

Schüler, Martin;
Connell, Sean R.;
Lescoute, Aurelie;
Giesebrecht, Jan;
Dabrowski, Marylena;
Schroeer, Birgit;
Mielke, Thorsten;
Penczek, Pawel A.;
Westhof, Eric;
Spahn, Christian M. T.

Publication type:

Article

Localization and dynamic behavior of ribosomal protein L30e.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 5, p. 467, doi. 10.1038/nsmb933

By:

Halic, Mario;
Becker, Thomas;
Frank, Joachim;
Spahn, Christian M. T.;
Beckmann, Roland

Publication type:

Article

Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 10, p. 957, doi. 10.1038/nsmb822

By:

Sengupta, Jayati;
Nilsson, Jakob;
Gursky, Richard;
Spahn, Christian M. T.;
Nissen, Poul;
Frank, Joachim

Publication type:

Article

Divergent architecture of the heterotrimeric NatC complex explains N-terminal acetylation of cognate substrates.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-19321-8

By:

Grunwald, Stephan;
Hopf, Linus V. M.;
Bock-Bierbaum, Tobias;
Lally, Ciara C. M.;
Spahn, Christian M. T.;
Daumke, Oliver

Publication type:

Article

The complex of tmRNA-SmpB and EF-G on translocating ribosomes.

Published in:

Nature, 2012, v. 485, n. 7399, p. 526, doi. 10.1038/nature11006

By:

Ramrath, David J. F.;
Yamamoto, Hiroshi;
Rother, Kristian;
Wittek, Daniela;
Pech, Markus;
Mielke, Thorsten;
Loerke, Justus;
Scheerer, Patrick;
Ivanov, Pavel;
Teraoka, Yoshika;
Shpanchenko, Olga;
Nierhaus, Knud H.;
Spahn, Christian M. T.

Publication type:

Article

The crystal structure of an oxygen-tolerant hydrogenase uncovers a novel iron-sulphur centre.

Published in:

Nature, 2011, v. 479, n. 7372, p. 249, doi. 10.1038/nature10505

By:

Fritsch, Johannes;
Scheerer, Patrick;
Frielingsdorf, Stefan;
Kroschinsky, Sebastian;
Friedrich, Bärbel;
Lenz, Oliver;
Spahn, Christian M. T.

Publication type:

Article

Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.

Published in:

Nature, 2010, v. 468, n. 7324, p. 713, doi. 10.1038/nature09547

By:

Ratje, Andreas H.;
Loerke, Justus;
Mikolajka, Aleksandra;
Brünner, Matthias;
Hildebrand, Peter W.;
Starosta, Agata L.;
Dönhöfer, Alexandra;
Connell, Sean R.;
Fucini, Paola;
Mielke, Thorsten;
Whitford, Paul C.;
Onuchic, José N.;
Yanan Yu;
Sanbonmatsu, Karissa Y.;
Hartmann, Roland K.;
Penczek, Pawel A.;
Wilson, Daniel N.;
Spahn, Christian M. T.

Publication type:

Article

Ribosomal tRNA Binding Sites: Three-Site Models of Translation.

Published in:

Critical Reviews in Biochemistry & Molecular Biology, 1998, v. 33, n. 2, p. 95, doi. 10.1080/10409239891204189

By:

Burkhardt, Nils;
Jünemann, Ralf;
Spahn, Christian M. T.;
Nierhaus, Knud H.

Publication type:

Article

Structural insights into Cullin4-RING ubiquitin ligase remodelling by Vpr from simian immunodeficiency viruses.

Published in:

PLoS Pathogens, 2021, v. 17, n. 8, p. 1, doi. 10.1371/journal.ppat.1009775

By:

Banchenko, Sofia;
Krupp, Ferdinand;
Gotthold, Christine;
Bürger, Jörg;
Graziadei, Andrea;
O'Reilly, Francis J.;
Sinn, Ludwig;
Ruda, Olga;
Rappsilber, Juri;
Spahn, Christian M. T.;
Mielke, Thorsten;
Taylor, Ian A.;
Schwefel, David

Publication type:

Article

Multifaceted Stoichiometry Control of Bacterial Operons Revealed by Deep Proteome Quantification.

Published in:

Frontiers in Genetics, 2019, p. 1, doi. 10.3389/fgene.2019.00473

By:

Zhao, Jing;
Zhang, Hong;
Qin, Bo;
Nikolay, Rainer;
He, Qing-Yu;
Spahn, Christian M. T.;
Zhang, Gong

Publication type:

Article