Works by Southall, Noel


Results: 69
    1

    COPI Complex Is a Regulator of Lipid Homeostasis.

    Published in:
    PLoS Biology, 2008, v. 6, n. 11, p. e292, doi. 10.1371/journal.pbio.0060292
    By:
    • Beller, Mathias;
    • Sztalryd, Carole;
    • Southall, Noel;
    • Bell, Ming;
    • Jäckle, Herbert;
    • Auld, Douglas S.;
    • Oliver, Brian
    Publication type:
    Article
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    Predicting liver cytosol stability of small molecules.

    Published in:
    Journal of Cheminformatics, 2020, v. 12, n. 1, p. 1, doi. 10.1186/s13321-020-00426-7
    By:
    • Shah, Pranav;
    • Siramshetty, Vishal B.;
    • Zakharov, Alexey V.;
    • Southall, Noel T.;
    • Xu, Xin;
    • Nguyen, Dac-Trung
    Publication type:
    Article
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    Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening.

    Published in:
    Environmental Health Perspectives, 2008, v. 116, n. 3, p. 284, doi. 10.1289/ehp.10727
    By:
    • Menghang Xia;
    • Ruili Huang;
    • Witt, Kristine L.;
    • Southall, Noel;
    • Fostel, Jennifer;
    • Ming-Hsuang Cho;
    • Jadhav, Ajit;
    • Smith, Cynthia S.;
    • Inglese, James;
    • Portier, Christopher J.;
    • Tice, Raymond R.;
    • Austin, Christopher P.
    Publication type:
    Article
    10

    Efficacy and Mechanism of Action of Low Dose Emetine against Human Cytomegalovirus.

    Published in:
    PLoS Pathogens, 2016, v. 12, n. 6, p. 1, doi. 10.1371/journal.ppat.1005717
    By:
    • Mukhopadhyay, Rupkatha;
    • Roy, Sujayita;
    • Venkatadri, Rajkumar;
    • Su, Yu-Pin;
    • Ye, Wenjuan;
    • Barnaeva, Elena;
    • Mathews Griner, Lesley;
    • Southall, Noel;
    • Hu, Xin;
    • Wang, Amy Q.;
    • Xu, Xin;
    • Dulcey, Andrés E.;
    • Marugan, Juan J.;
    • Ferrer, Marc;
    • Arav-Boger, Ravit
    Publication type:
    Article
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    Machine intelligence in healthcare—perspectives on trustworthiness, explainability, usability, and transparency.

    Published in:
    NPJ Digital Medicine, 2020, v. 3, n. 1, p. 1, doi. 10.1038/s41746-020-0254-2
    By:
    • Cutillo, Christine M.;
    • Sharma, Karlie R.;
    • Foschini, Luca;
    • Kundu, Shinjini;
    • Mackintosh, Maxine;
    • Mandl, Kenneth D.;
    • MI in Healthcare Workshop Working Group;
    • Beck, Tyler;
    • Collier, Elaine;
    • Colvis, Christine;
    • Gersing, Kenneth;
    • Gordon, Valery;
    • Jensen, Roxanne;
    • Shabestari, Behrouz;
    • Southall, Noel
    Publication type:
    Article
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    A Novel Brain Penetrant NPS Receptor Antagonist, NCGC00185684, Blocks Alcohol-Induced ERK-Phosphorylation in the Central Amygdala and Decreases Operant Alcohol Self-Administration in Rats.

    Published in:
    Journal of Neuroscience, 2013, v. 33, n. 24, p. 10132, doi. 10.1523/JNEUROSCI.4742-12.2013
    By:
    • Thorsell, Annika;
    • Tapocik, Jenica D.;
    • Ke Liu;
    • Zook, Michelle;
    • Bell, Lauren;
    • Flanigan, Meghan;
    • Patnaik, Samarjit;
    • Marugan, Juan;
    • Damadzic, Ruslan;
    • Dehdashti, Seameen J.;
    • Schwandt, Melanie L.;
    • Southall, Noel;
    • Austin, Christopher P.;
    • Eskay, Robert;
    • Ciccocioppo, Roberto;
    • Wei Zheng;
    • Heilig, Markus
    Publication type:
    Article
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    Progress toward a universal biomedical data translator.

    Published in:
    CTS: Clinical & Translational Science, 2022, v. 15, n. 8, p. 1838, doi. 10.1111/cts.13301
    By:
    • Fecho, Karamarie;
    • Thessen, Anne E.;
    • Baranzini, Sergio E.;
    • Bizon, Chris;
    • Hadlock, Jennifer J.;
    • Huang, Sui;
    • Roper, Ryan T.;
    • Southall, Noel;
    • Ta, Casey;
    • Watkins, Paul B.;
    • Williams, Mark D.;
    • Xu, Hao;
    • Byrd, William;
    • Dančík, Vlado;
    • Duby, Marc P.;
    • Dumontier, Michel;
    • Glusman, Gustavo;
    • Harris, Nomi L.;
    • Hinderer, Eugene W.;
    • Hyde, Greg
    Publication type:
    Article
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    Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-Kras<sup>G12D/+</sup>;Tp53<sup>R172H/+</sup> (KPC) mice, a genetically engineered model of pancreatic cancer.

    Published in:
    2018
    By:
    • Vilimas, Tomas;
    • Wang, Amy Q.;
    • Patnaik, Samarjit;
    • Hughes, Emma A.;
    • Singleton, Marc D.;
    • Knotts, Zachary;
    • Li, Dandan;
    • Frankowski, Kevin;
    • Schlomer, Jerome J.;
    • Guerin, Theresa M.;
    • Springer, Stephanie;
    • Drennan, Catherine;
    • Dextras, Christopher;
    • Wang, Chen;
    • Gilbert, Debra;
    • Southall, Noel;
    • Ferrer, Marc;
    • Huang, Sui;
    • Kozlov, Serguei;
    • Marugan, Juan
    Publication type:
    journal article
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    Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

    Published in:
    Science Translational Medicine, 2018, v. 10, n. 441, p. 1, doi. 10.1126/scitranslmed.aap8307
    By:
    • Frankowski, Kevin J.;
    • Wang, Chen;
    • Patnaik, Samarjit;
    • Schoenen, Frank J.;
    • Southall, Noel;
    • Li, Dandan;
    • Teper, Yaroslav;
    • Sun, Wei;
    • Kandela, Irawati;
    • Hu, Deqing;
    • Dextras, Christopher;
    • Knotts, Zachary;
    • Bian, Yansong;
    • Norton, John;
    • Titus, Steve;
    • Lewandowska, Marzena A.;
    • Wen, Yiping;
    • Farley, Katherine I.;
    • Griner, Lesley Mathews;
    • Sultan, Jamey
    Publication type:
    Article
    28

    The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases - recommendations of the IRDiRC Data Mining and Repurposing Task Force.

    Published in:
    2019
    By:
    • Southall, Noel T;
    • Natarajan, Madhusudan;
    • Lau, Lilian Pek Lian;
    • Jonker, Anneliene Hechtelt;
    • Deprez, Benoît;
    • Guilliams, Tim;
    • Hunter, Lawrence;
    • Rademaker, Carin MA;
    • Hivert, Virginie;
    • Ardigò, Diego;
    • on behalf of the IRDiRC Data Mining and Repurposing Task Force;
    • Cavalla, David;
    • Colvis, Christine;
    • Hettne, Kristina;
    • 't-Hoen, Peter-Bram;
    • Kant, Caroline;
    • Krischer, Jeffrey;
    • Marin, Frédéric;
    • Quintana, Jordi;
    • Rademaker, Carin MA
    Publication type:
    journal article
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    Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2.

    Published in:
    Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-04143-9
    By:
    • Esteban-Lopez, Maria;
    • Wilson, Kenneth J.;
    • Myhr, Courtney;
    • Kaftanovskaya, Elena M.;
    • Henderson, Mark J.;
    • Southall, Noel T.;
    • Xu, Xin;
    • Wang, Amy;
    • Hu, Xin;
    • Barnaeva, Elena;
    • Ye, Wenjuan;
    • George, Emmett R.;
    • Sherrill, John T.;
    • Ferrer, Marc;
    • Morello, Roy;
    • Agoulnik, Irina U.;
    • Marugan, Juan J.;
    • Agoulnik, Alexander I.
    Publication type:
    Article
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    DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation.

    Published in:
    Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-36144-2
    By:
    • Rojas, Camilo;
    • Barnaeva, Elena;
    • Thomas, Ajit G.;
    • Hu, Xin;
    • Southall, Noel;
    • Marugan, Juan;
    • Chaudhuri, Amrita Datta;
    • Yoo, Seung-Wan;
    • Hin, Niyada;
    • Stepanek, Ondrej;
    • Wu, Ying;
    • Zimmermann, Sarah C.;
    • Gadiano, Alexandra G.;
    • Tsukamoto, Takashi;
    • Rais, Rana;
    • Haughey, Norman;
    • Ferrer, Marc;
    • Slusher, Barbara S.
    Publication type:
    Article
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    Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules.

    Published in:
    Nature Communications, 2013, v. 4, n. 6, p. 2044, doi. 10.1038/ncomms3044
    By:
    • Childs-Disney, Jessica L.;
    • Stepniak-Konieczna, Ewa;
    • Tran, Tuan;
    • Yildirim, Ilyas;
    • Park, HaJeung;
    • Chen, Catherine Z.;
    • Hoskins, Jason;
    • Southall, Noel;
    • Marugan, Juan J.;
    • Patnaik, Samarjit;
    • Zheng, Wei;
    • Austin, Chris P.;
    • Schatz, George C.;
    • Sobczak, Krzysztof;
    • Thornton, Charles A.;
    • Disney, Matthew D.
    Publication type:
    Article
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    High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines.

    Published in:
    Human Molecular Genetics, 2014, v. 23, n. 6, p. 1551, doi. 10.1093/hmg/ddt542
    By:
    • Ketley, Ami;
    • Chen, Catherine Z.;
    • Li, Xin;
    • Arya, Sukrat;
    • Robinson, Thelma E.;
    • Granados-Riveron, Javier;
    • Udosen, Inyang;
    • Morris, Glenn E.;
    • Holt, Ian;
    • Furling, Denis;
    • Chaouch, Soraya;
    • Haworth, Ben;
    • Southall, Noel;
    • Shinn, Paul;
    • Zheng, Wei;
    • Austin, Christopher P.;
    • Hayes, Christopher J.;
    • Brook, J. David
    Publication type:
    Article
    44

    Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays.

    Published in:
    PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0130796
    By:
    • Lee, Jonathan A.;
    • Shinn, Paul;
    • Jaken, Susan;
    • Oliver, Sarah;
    • Willard, Francis S.;
    • Heidler, Steven;
    • Peery, Robert B.;
    • Oler, Jennifer;
    • Chu, Shaoyou;
    • Southall, Noel;
    • Dexheimer, Thomas S.;
    • Smallwood, Jeffrey;
    • Huang, Ruili;
    • Guha, Rajarshi;
    • Jadhav, Ajit;
    • Cox, Karen;
    • Austin, Christopher P.;
    • Simeonov, Anton;
    • Sittampalam, G. Sitta;
    • Husain, Saba
    Publication type:
    Article
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