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Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein.
Published in:
NPJ Parkinson's Disease, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41531-022-00322-x
By:
- Patterson, Joseph R.;
- Hirst, Warren D.;
- Howe, Jacob W.;
- Russell, Christopher P.;
- Cole-Strauss, Allyson;
- Kemp, Christopher J.;
- Duffy, Megan F.;
- Lamp, Jared;
- Umstead, Andrew;
- Kubik, Michael;
- Stoll, Anna C.;
- Vega, Irving E.;
- Steece-Collier, Kathy;
- Chen, Yi;
- Campbell, Anne C.;
- Nezich, Catherine L.;
- Glajch, Kelly E.;
- Sortwell, Caryl E.
Publication type:
Article
Synucleinopathy-associated pathogenesis in Parkinson's disease and the potential for brain-derived neurotrophic factor.
Published in:
NPJ Parkinson's Disease, 2021, v. 7, n. 1, p. 1, doi. 10.1038/s41531-021-00179-6
By:
- Miller, Kathryn M.;
- Mercado, Natosha M.;
- Sortwell, Caryl E.
Publication type:
Article
Next-Generation Diamond Electrodes for Neurochemical Sensing: Challenges and Opportunities.
Published in:
Micromachines, 2021, v. 12, n. 2, p. 128, doi. 10.3390/mi12020128
By:
- Purcell, Erin K.;
- Becker, Michael F.;
- Guo, Yue;
- Hara, Seth A.;
- Ludwig, Kip A.;
- McKinney, Collin J.;
- Monroe, Elizabeth M.;
- Rechenberg, Robert;
- Rusinek, Cory A.;
- Saxena, Akash;
- Siegenthaler, James R.;
- Sortwell, Caryl E.;
- Thompson, Cort H.;
- Trevathan, James K.;
- Witt, Suzanne;
- Li, Wen
Publication type:
Article
Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity.
Published in:
Frontiers in Molecular Neuroscience, 2018, p. 1, doi. 10.3389/fnmol.2018.00036
By:
- Benskey, Matthew J.;
- Sellnow, Rhyomi C.;
- Sandoval, Ivette M.;
- Sortwell, Caryl E.;
- Lipton, Jack W.;
- Manfredsson, Fredric P.
Publication type:
Article
High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine.
Published in:
PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0133957
By:
- Fischer, D. Luke;
- Collier, Timothy J.;
- Cole-Strauss, Allyson;
- Wohlgenant, Susan L.;
- Lipton, Jack W.;
- Steece-Collier, Kathy;
- Manfredsson, Fredric P.;
- Kemp, Christopher J.;
- Sortwell, Caryl E.
Publication type:
Article
The Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes.
Published in:
PLoS ONE, 2015, v. 10, n. 5, p. 1, doi. 10.1371/journal.pone.0127768
By:
- Kanaan, Nicholas M.;
- Collier, Timothy J.;
- Cole-Strauss, Allyson;
- Grabinski, Tessa;
- Mattingly, Zachary R.;
- Winn, Mary E.;
- Steece-Collier, Kathy;
- Sortwell, Caryl E.;
- Manfredsson, Fredric P.;
- Lipton, Jack W.
Publication type:
Article
Morphological and Behavioral Impact of AAV2/5-Mediated Overexpression of Human Wildtype Alpha-Synuclein in the Rat Nigrostriatal System.
Published in:
PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0081426
By:
- Gombash, Sara E.;
- Manfredsson, Fredric P.;
- Kemp, Christopher J.;
- Kuhn, Nathan C.;
- Fleming, Sheila M.;
- Egan, Ann E.;
- Grant, Laura M.;
- Ciucci, Michelle R.;
- MacKeigan, Jeffrey P.;
- Sortwell, Caryl E.
Publication type:
Article
Cellular Models to Study Dopaminergic Injury Responses.
Published in:
Annals of the New York Academy of Sciences, 2003, v. 991, n. 1, p. 140, doi. 10.1111/j.1749-6632.2003.tb07472.x
By:
- COLLIER, TIMOTHY J.;
- STEECE-COLLIER, KATHY;
- McGUIRE, SUSAN;
- SORTWELL, CARYL E.
Publication type:
Article
Behavioral phenotyping of a rat model of the BDNF Val66Met polymorphism reveals selective impairment of fear memory.
Published in:
Translational Psychiatry, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41398-022-01858-5
By:
- Jaehne, Emily J.;
- Kent, Jessica N.;
- Antolasic, Emily J.;
- Wright, Bradley J.;
- Spiers, Jereme G.;
- Creutzberg, Kerstin C.;
- De Rosa, Federico;
- Riva, Marco A.;
- Sortwell, Caryl E.;
- Collier, Timothy J.;
- van den Buuse, Maarten
Publication type:
Article
Co-grafted embryonic striatum increases the survival of grafted embryonic dopamine neurons.
Published in:
Journal of Comparative Neurology, 1998, v. 399, n. 4, p. 530, doi. 10.1002/(SICI)1096-9861(19981005)399:4<530::AID-CNE6>3.0.CO;2-2
By:
- Sortwell, Caryl E.;
- Collier, Timothy J.;
- Sladek, John R.
Publication type:
Article
Agonist-induced morphologic decrease in cellular d<sub>1A</sub> dopamine receptor staining.
Published in:
Synapse, 1997, v. 27, n. 4, p. 313, doi. 10.1002/(SICI)1098-2396(199712)27:4<313::AID-SYN5>3.0.CO;2-F
By:
- Ariano, Marjorie A.;
- Sortwell, Caryl E.;
- Ray, Mikelene;
- Altemus, Katharine L.;
- Sibley, David R.;
- Levine, Michael S.
Publication type:
Article
Alpha-synuclein inclusion responsive microglia are resistant to CSF1R inhibition.
Published in:
Journal of Neuroinflammation, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12974-024-03108-5
By:
- Stoll, Anna C.;
- Kemp, Christopher J.;
- Patterson, Joseph R.;
- Kubik, Michael;
- Kuhn, Nathan;
- Benskey, Matthew;
- Duffy, Megan F.;
- Luk, Kelvin C.;
- Sortwell, Caryl E.
Publication type:
Article
Chronic Amitriptyline Treatment Attenuates Nigrostriatal Degeneration and Significantly Alters Trophic Support in a Rat Model of Parkinsonism.
Published in:
Neuropsychopharmacology, 2015, v. 40, n. 4, p. 874, doi. 10.1038/npp.2014.262
By:
- Paumier, Katrina L;
- Sortwell, Caryl E;
- Madhavan, Lalitha;
- Terpstra, Brian;
- Celano, Stephanie L;
- Green, Joshua J;
- Imus, Nastassja M;
- Marckini, Nathan;
- Daley, Brian;
- Steece-Collier, Kathy;
- Collier, Timothy J
Publication type:
Article
Advancing age and the rs6265 BDNF SNP are permissive to graft-induced dyskinesias in parkinsonian rats.
Published in:
NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-024-00771-6
By:
- Mercado, Natosha M.;
- Szarowicz, Carlye;
- Stancati, Jennifer A.;
- Sortwell, Caryl E.;
- Boezwinkle, Samuel A.;
- Collier, Timothy J.;
- Caulfield, Margaret E.;
- Steece-Collier, Kathy
Publication type:
Article
Transcriptomic profiling of early synucleinopathy in rats induced with preformed fibrils.
Published in:
NPJ Parkinson's Disease, 2024, v. 10, n. 1, p. 1, doi. 10.1038/s41531-023-00620-y
By:
- Patterson, Joseph R.;
- Kochmanski, Joseph;
- Stoll, Anna C.;
- Kubik, Michael;
- Kemp, Christopher J.;
- Duffy, Megan F.;
- Thompson, Kajene;
- Howe, Jacob W.;
- Cole-Strauss, Allyson;
- Kuhn, Nathan C.;
- Miller, Kathryn M.;
- Nelson, Seth;
- Onyekpe, Christopher U.;
- Beck, John S.;
- Counts, Scott E.;
- Bernstein, Alison I.;
- Steece-Collier, Kathy;
- Luk, Kelvin C.;
- Sortwell, Caryl E.
Publication type:
Article
Deficits in basal and evoked striatal dopamine release following alpha‐synuclein preformed fibril injection: An in vivo microdialysis study.
Published in:
European Journal of Neuroscience, 2024, v. 59, n. 7, p. 1585, doi. 10.1111/ejn.16275
By:
- Centner, Ashley;
- Del Priore, Isabella;
- Chambers, Nicole;
- Cohen, Sophie R.;
- Terry, Michelle L.;
- Coyle, Michael;
- Glinski, John;
- Stoll, Anna C.;
- Patterson, Joseph R.;
- Kemp, Christopher J.;
- Miller, Kathryn M.;
- Kubik, Michael;
- Kuhn, Nathan;
- Luk, Kelvin C.;
- Sortwell, Caryl E.;
- Bishop, Christopher
Publication type:
Article
Interference with anoikis-induced cell death of dopamine neurons: Implications for augmenting embryonic graft survival in a rat model of Parkinson's disease.
Published in:
Journal of Comparative Neurology, 2003, v. 464, n. 2, p. 172, doi. 10.1002/cne.10785
By:
- Deanna M. Marchionini;
- Timothy J. Collier;
- Maria Camargo;
- Susan McGuire;
- Mark Pitzer;
- Caryl E. Sortwell
Publication type:
Article
Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: Feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease.
Published in:
Journal of Comparative Neurology, 2002, v. 442, n. 4, p. 320, doi. 10.1002/cne.10108
By:
- Collier, Timothy J.;
- Sortwell, Caryl E.;
- Elsworth, John D.;
- Taylor, Jane R.;
- Roth, Robert H.;
- Sladek, John R.;
- Redmond, D. Eugene
Publication type:
Article
Oligodendrocyte-type 2 astrocyte-derived trophic factors increase survival of developing dopamine neurons through the inhibition of apoptotic cell death.
Published in:
Journal of Comparative Neurology, 2000, v. 426, n. 1, p. 143, doi. 10.1002/1096-9861(20001009)426:1<143::AID-CNE10>3.0.CO;2-8
By:
- Sortwell, Caryl E.;
- Daley, Brian F.;
- Pitzer, Mark R.;
- McGuire, Susan O.;
- Sladek Jr., John R.;
- Collier, Timothy J.
Publication type:
Article
Cyclosporin A protects striatal neurons in vitro and in vivo from 3-nitropropionic acid toxicity.
Published in:
Journal of Comparative Neurology, 2000, v. 425, n. 4, p. 471, doi. 10.1002/1096-9861(20001002)425:4<471::AID-CNE1>3.0.CO;2-U
By:
- Leventhal, Liza;
- Sortwell, Caryl E.;
- Hanbury, Rose;
- Collier, Timothy J.;
- Kordower, Jeffrey H.;
- Palfi, Stéphane
Publication type:
Article
Can STN DBS protect both nigral somata and innervation of the striatum?
Published in:
2017
By:
- Fischer, D. Luke;
- Manfredsson, Fredric P.;
- Sortwell, Caryl E.
Publication type:
Letter
Failure of proteasome inhibitor administration to provide a model of Parkinson's disease in rats and monkeys.
Published in:
Annals of Neurology, 2006, v. 60, n. 2, p. 264
By:
- Jeffrey H. Kordower;
- Nicholas M. Kanaan;
- Yaping Chu;
- Rangasamy Suresh Babu;
- James Stansell;
- Brian T. Terpstra;
- Caryl E. Sortwell;
- Kathy Steece‐Collier;
- Timothy J. Collier
Publication type:
Article
Correction to: Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.
Published in:
2018
By:
- Duffy, Megan F.;
- Collier, Timothy J.;
- Patterson, Joseph R.;
- Kemp, Christopher J.;
- Luk, Kelvin C.;
- Tansey, Malú G.;
- Paumier, Katrina L.;
- Kanaan, Nicholas M.;
- Fischer, D. Luke;
- Polinski, Nicole K.;
- Barth, Olivia L.;
- Howe, Jacob W.;
- Vaikath, Nishant N.;
- Majbour, Nour K.;
- El-Agnaf, Omar M. A.;
- Sortwell, Caryl E.
Publication type:
corrected article
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration.
Published in:
2018
By:
- Patterson, Joseph R.;
- Kemp, Christopher J.;
- Barth, Olivia L.;
- Howe, Jacob W.;
- Duffy, Megan F.;
- Polinski, Nicole K.;
- Fischer, Luke D.;
- Collier, Timothy J.;
- Paumier, Katrina L.;
- Kanaan, Nicholas M.;
- Sortwell, Caryl E.;
- Luk, Kelvin C.;
- Tansey, Malú G.;
- Vaikath, Nishant N.;
- Majbour, Nour K.;
- El-Agnaf, Omar M. A.;
- Fischer, D Luke
Publication type:
journal article
Dopaminergic Positron Emission Tomography Imaging in the Alpha‐Synuclein Preformed Fibril Model Reveals Similarities to Early Parkinson's Disease.
Published in:
Movement Disorders, 2022, v. 37, n. 8, p. 1739, doi. 10.1002/mds.29051
By:
- Sossi, Vesna;
- Patterson, Joseph R.;
- McCormick, Siobhan;
- Kemp, Christopher J.;
- Miller, Kathryn M.;
- Stoll, Anna C.;
- Kuhn, Nathan;
- Kubik, Michael;
- Kochmanski, Joseph;
- Luk, Kelvin C.;
- Sortwell, Caryl E.
Publication type:
Article
Cell therapy for Parkinson's disease: Why it doesn't work every time.
Published in:
2019
By:
- Collier, Timothy J.;
- Sortwell, Caryl E.;
- Mercado, Natosha M.;
- Steece‐Collier, Kathy;
- Steece-Collier, Kathy
Publication type:
journal article
Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia.
Published in:
2019
By:
- Steece‐Collier, Kathy;
- Stancati, Jennifer A.;
- Collier, Nicholas J.;
- Sandoval, Ivette M.;
- Mercado, Natosha M.;
- Sortwell, Caryl E.;
- Collier, Timothy J.;
- Manfredsson, Fredric P.;
- Steece-Collier, Kathy
Publication type:
journal article
Striatal Pleiotrophin Overexpression Provides Functional and Morphological Neuroprotection in the 6-Hydroxydopamine Model.
Published in:
Molecular Therapy, 2012, v. 20, n. 3, p. 544, doi. 10.1038/mt.2011.216
By:
- Gombash, Sara E;
- Lipton, Jack W;
- Collier, Timothy J;
- Madhavan, Lalitha;
- Steece-Collier, Kathy;
- Cole-Strauss, Allyson;
- Terpstra, Brian T;
- Spieles-Engemann, Anne L;
- Daley, Brian F;
- Wohlgenant, Susan L;
- Thompson, Valerie B;
- Manfredsson, Fredric P;
- Mandel, Ronald J;
- Sortwell, Caryl E
Publication type:
Article
Endogenous neural precursors influence grafted neural stem cells and contribute to neuroprotection in the parkinsonian rat.
Published in:
European Journal of Neuroscience, 2012, v. 35, n. 6, p. 883, doi. 10.1111/j.1460-9568.2012.08019.x
By:
- Madhavan, Lalitha;
- Daley, Brian F.;
- Sortwell, Caryl E.;
- Collier, Timothy J.
Publication type:
Article
Impact of dendritic spine preservation in medium spiny neurons on dopamine graft efficacy and the expression of dyskinesias in parkinsonian rats.
Published in:
European Journal of Neuroscience, 2010, v. 31, n. 3, p. 478, doi. 10.1111/j.1460-9568.2010.07077.x
By:
- Soderstrom, Katherine E.;
- O'Malley, Jennifer A.;
- Levine, Nathan D.;
- Sortwell, Caryl E.;
- Collier, Timothy J.;
- Steece‐Collier, Kathy
Publication type:
Article
Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS.
Published in:
Journal of Neuroscience, 2021, v. 41, n. 9, p. 2039, doi. 10.1523/JNEUROSCI.1952-20.2020
By:
- Miller, Kathryn M.;
- Patterson, Joseph R.;
- Kochmanski, Joseph;
- Kemp, Christopher J.;
- Stoll, Anna C.;
- Onyekpe, Christopher U.;
- Cole-Strauss, Allyson;
- Steece-Collier, Kathy;
- Howe, Jacob W.;
- Luk, Kelvin C.;
- Sortwell, Caryl E.
Publication type:
Article
Striatal Nurrl Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
Published in:
Journal of Neuroscience, 2020, v. 40, n. 18, p. 3675, doi. 10.1523/jneurosci.2936-19.2020
By:
- Sellnow, Rhyomi C.;
- Steece-Collier, Kathy;
- Altwal, Feras;
- Sandoval, Ivette M.;
- Kordower, Jeffrey H.;
- Collier, Timothy J.;
- Sortwell, Caryl E.;
- West, Anthony R.;
- Manfredsson, Fredric P.
Publication type:
Article
BDNF provides many routes toward STN DBS-mediated disease modification.
Published in:
2019
By:
- Fischer, D. Luke;
- Sortwell, Caryl E.
Publication type:
journal article
Developmental exposure to the Parkinson's disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice.
Published in:
Toxicological Sciences, 2023, v. 196, n. 1, p. 99, doi. 10.1093/toxsci/kfad086
By:
- Boyd, Sierra L;
- Kuhn, Nathan C;
- Patterson, Joseph R;
- Stoll, Anna C;
- Zimmerman, Sydney A;
- Kolanowski, Mason R;
- Neubecker, Joseph J;
- Luk, Kelvin C;
- Ramsson, Eric S;
- Sortwell, Caryl E;
- Bernstein, Alison I
Publication type:
Article
Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and L-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease.
Published in:
Journal of Neuroscience, 2015, v. 35, n. 45, p. 14983, doi. 10.1523/JNEUROSCI.2124-15.2015
By:
- Divito, Christopher B.;
- Steece-Collier, Kathy;
- Case, Daniel T.;
- Williams, Sean-Paul G.;
- Stancati, Jennifer A.;
- Lianteng Zhi;
- Rubio, Maria E.;
- Sortwell, Caryl E.;
- Collier, Timothy J.;
- Sulzer, David;
- Edwards, Robert H.;
- Hui Zhang;
- Seal, Rebecca P.
Publication type:
Article

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