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Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase.
Published in:
Biochemical Journal, 2022, v. 479, n. 5, p. 661, doi. 10.1042/BCJ20220019
By:
- Zhuoyao Chen;
- Jinwei Zhang;
- Murillo-de-Ozores, Adrián R.;
- Castañeda-Bueno, María;
- D'Amico, Francesca;
- Heilig, Raphael;
- Manning, Charlotte E.;
- Sorrell, Fiona J.;
- D'Angiolella, Vincenzo;
- Fischer, Roman;
- Mulder, Monique P. C.;
- Gamba, Gerardo;
- Alessi, Dario R.;
- Bullock, Alex N.
Publication type:
Article
Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.
Published in:
Biochemical Journal, 2019, v. 476, n. 7, p. 1037, doi. 10.1042/BCJ20180867
By:
- Sorrell, Fiona J.;
- Kilian, Lena Marie;
- Elkins, Jonathan M.
Publication type:
Article
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases.
Published in:
Biochemical Journal, 2017, v. 474, n. 22, p. 3747, doi. 10.1042/BCJ20170527
By:
- Pinkas, Daniel M.;
- Sanvitale, Caroline E.;
- Bufton, Joshua C.;
- Sorrell, Fiona J.;
- Solcan, Nicolae;
- Chalk, Rod;
- Doutch, James;
- Bullock, Alex N.
Publication type:
Article
Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.
Published in:
Biochemical Journal, 2014, v. 460, n. 2, p. 237, doi. 10.1042/BJ20140153
By:
- SCHUMACHER, Frances-Rose;
- SORRELL, Fiona J.;
- ALESSI, Dario R.;
- BULLOCK, Alex N.;
- KURZ, Thimo
Publication type:
Article
Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design.
Published in:
ChemMedChem, 2023, v. 18, n. 8, p. 1, doi. 10.1002/cmdc.202200615
By:
- Krieger, Johannes;
- Sorrell, Fiona J.;
- Wegener, Ansgar A.;
- Leuthner, Birgitta;
- Machrouhi‐Porcher, Fouzia;
- Hecht, Martin;
- Leibrock, Eva M.;
- Müller, Juliane E.;
- Eisert, Jonathan;
- Hartung, Ingo V.;
- Schlesiger, Sarah
Publication type:
Article
Identification and Characterization of a Small-Molecule Inhibitor of Death-Associated Protein Kinase 1.
Published in:
ChemBioChem, 2015, v. 16, n. 1, p. 59, doi. 10.1002/cbic.201402512
By:
- Wilbek, Theis S.;
- Skovgaard, Tine;
- Sorrell, Fiona J.;
- Knapp, Stefan;
- Berthelsen, Jens;
- Strømgaard, Kristian
Publication type:
Article
Structure-Activity Relationship Refinement and Further Assessment of Indole-3-glyoxylamides as a Lead Series against Prion Disease.
Published in:
ChemMedChem, 2011, v. 6, n. 1, p. 115, doi. 10.1002/cmdc.201000383
By:
- Thompson, Mark J.;
- Louth, Jennifer C.;
- Ferrara, Steven;
- Sorrell, Fiona J.;
- Irving, Benjamin J.;
- Cochrane, Edward J.;
- Meijer, Anthony J. H. M.;
- Chen, Beining
Publication type:
Article
Inside Cover: Improved 2,4-Diarylthiazole-Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency (ChemMedChem 9/2010).
Published in:
ChemMedChem, 2010, v. 5, n. 9, p. 1406, doi. 10.1002/cmdc.201090037
By:
- Thompson, Mark J.;
- Louth, Jennifer C.;
- Greenwood, Gemma K.;
- Sorrell, Fiona J.;
- Knight, Sandra G.;
- Adams, Nathan B. P.;
- Chen, Beining
Publication type:
Article
Improved 2,4-Diarylthiazole-Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency.
Published in:
ChemMedChem, 2010, v. 5, n. 9, p. 1476, doi. 10.1002/cmdc.201000217
By:
- Thompson, Mark J.;
- Louth, Jennifer C.;
- Greenwood, Gemma K.;
- Sorrell, Fiona J.;
- Knight, Sandra G.;
- Adams, Nathan B. P.;
- Chen, Beining
Publication type:
Article

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