Works by Soni, Aashish

Results: 19

The p97-Ufd1-NpI4 ATPase complex ensures robustness of the G2/M checkpoint by facilitating CDC25A degradation.

Published in:

Cell Cycle, 2014, v. 13, n. 6, p. 919, doi. 10.4161/cc.27779

By:

Riemer, Anne;
Dobrynin, Grzegorz;
Dressler, Alina;
Bremer, Sebastian;
Soni, Aashish;
Iliakis, George;
Meyer, Hemmo

Publication type:

Article

Low CDK Activity and Enhanced Degradation by APC/C CDH1 Abolishes CtIP Activity and Alt-EJ in Quiescent Cells.

Published in:

Cells (2073-4409), 2023, v. 12, n. 11, p. 1530, doi. 10.3390/cells12111530

By:

Li, Fanghua;
Mladenov, Emil;
Sun, Yanjie;
Soni, Aashish;
Stuschke, Martin;
Timmermann, Beate;
Iliakis, George

Publication type:

Article

The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G 2 -Checkpoint Activation in Cells Exposed to Ionizing Radiation.

Published in:

Cells (2073-4409), 2023, v. 12, n. 10, p. 1387, doi. 10.3390/cells12101387

By:

Luo, Daxian;
Mladenov, Emil;
Soni, Aashish;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Increased Resection at DSBs in G 2 -Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ.

Published in:

Cells (2073-4409), 2022, v. 11, n. 13, p. N.PAG, doi. 10.3390/cells11132099

By:

Xiao, Huaping;
Li, Fanghua;
Mladenov, Emil;
Soni, Aashish;
Mladenova, Veronika;
Pan, Bing;
Dueva, Rositsa;
Stuschke, Martin;
Timmermann, Beate;
Iliakis, George

Publication type:

Article

PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 21, p. 12876, doi. 10.3390/ijms232112876

By:

Pei, Xile;
Mladenov, Emil;
Soni, Aashish;
Li, Fanghua;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 14, p. 7506, doi. 10.3390/ijms23147506

By:

Soni, Aashish;
Duan, Xiaolu;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 20, p. 10957, doi. 10.3390/ijms222010957

By:

Krieger, Lisa Marie;
Mladenov, Emil;
Soni, Aashish;
Demond, Marilen;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

Deregulated BCL-2 family proteins impact on repair of DNA double-strand breaks and are targets to overcome radioresistance in lung cancer.

Published in:

Journal of Cancer Research & Clinical Oncology, 2017, v. 143, n. 9, p. 1733, doi. 10.1007/s00432-017-2427-1

By:

Wieczorek, Sarah;
Breitenbuecher, Frank;
Soni, Aashish;
Paul-Konietzko, Katja;
Ziegler, Sophie;
Sak, Ali;
Iliakis, George;
Schuler, Martin

Publication type:

Article

DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G2-checkpoint in S-phase irradiated cells.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-51071-6

By:

Mladenov, Emil;
Fan, Xiaoxiang;
Paul-Konietzko, Katja;
Soni, Aashish;
Iliakis, George

Publication type:

Article

Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G2-phase.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-44771-6

By:

Mladenov, Emil;
Fan, Xiaoxiang;
Dueva, Rositsa;
Soni, Aashish;
Iliakis, George

Publication type:

Article

NGS Detects Extensive Genomic Alterations in Survivors of Irradiated Normal Human Fibroblast Cells.

Published in:

Radiation Research, 2025, v. 203, n. 1, p. 37, doi. 10.1667/RADE-24-00094.1

By:

Soni, Aashish;
Beisser, Daniela;
Mladenov, Emil;
Höller, Matthias;
Wohlers, Inken;
Nikolov, Vladimir;
Magin, Simon;
Mussfeldt, Tamara;
Klein-Hitpass, Ludger;
Cornforth, Michael N.;
Loucas, Bradford D.;
Rahmann, Sven;
Iliakis, George

Publication type:

Article

DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.

Published in:

Frontiers in Oncology, 2013, v. 3, p. 1, doi. 10.3389/fonc.2013.00113

By:

Mladenov, Emil;
Magin, Simon;
Soni, Aashish;
Iliakis, George

Publication type:

Article

DNA Double-Strand Break Repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.

Published in:

Frontiers in Oncology, 2013, p. 1, doi. 10.3389/fonc.2013.00113

By:

Mladenov, Emil;
Magin, Simon;
Soni, Aashish;
Iliakis, George

Publication type:

Article

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52.

Published in:

Nucleic Acids Research, 2020, v. 48, n. 4, p. 1905, doi. 10.1093/nar/gkz1167

By:

Mladenov, Emil;
Staudt, Christian;
Soni, Aashish;
Murmann-Konda, Tamara;
Siemann-Loekes, Maria;
Iliakis, George

Publication type:

Article

Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment.

Published in:

Nucleic Acids Research, 2016, v. 44, n. 16, p. 7673, doi. 10.1093/nar/gkw487

By:

Schipler, Agnes;
Mladenova, Veronika;
Soni, Aashish;
Nikolov, Vladimir;
Saha, Janapriya;
Mladenov, Emil;
Iliakis, George

Publication type:

Article

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining.

Published in:

Nucleic Acids Research, 2014, v. 42, n. 10, p. 6380, doi. 10.1093/nar/gku298

By:

Soni, Aashish;
Siemann, Maria;
Grabos, Martha;
Murmann, Tamara;
Pantelias, Gabriel E.;
Iliakis, George

Publication type:

Article

BMN673 Is a PARP Inhibitor with Unique Radiosensitizing Properties: Mechanisms and Potential in Radiation Therapy.

Published in:

Cancers, 2022, v. 14, n. 22, p. 5619, doi. 10.3390/cancers14225619

By:

Soni, Aashish;
Lin, Xixi;
Mladenov, Emil;
Mladenova, Veronika;
Stuschke, Martin;
Iliakis, George

Publication type:

Article

NTRK1/TrkA Activation Overrides the G 2 /M-Checkpoint upon Irradiation.

Published in:

Cancers, 2021, v. 13, n. 23, p. 6023, doi. 10.3390/cancers13236023

By:

Hassiepen, Christina;
Soni, Aashish;
Rudolf, Ines;
Boron, Vivian;
Oeck, Sebastian;
Iliakis, George;
Schramm, Alexander

Publication type:

Article

DEFINED BIOLOGICAL MODELS OF HIGH-LET RADIATION LESIONS.

Published in:

Radiation Protection Dosimetry, 2019, v. 183, n. 1/2, p. 60, doi. 10.1093/rpd/ncy248

By:

Iliakis, George;
Mladenova, Veronika;
Sharif, Mortoga;
Chaudhary, Shipra;
Mavragani, Ifigeneia V;
Soni, Aashish;
Saha, Janapriya;
Schipler, Agnes;
Mladenov, Emil

Publication type:

Article

Works by Soni, Aashish

The p97-Ufd1-NpI4 ATPase complex ensures robustness of the G<sub>2</sub>/M checkpoint by facilitating CDC25A degradation.

Low CDK Activity and Enhanced Degradation by APC/C CDH1 Abolishes CtIP Activity and Alt-EJ in Quiescent Cells.

The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G 2 -Checkpoint Activation in Cells Exposed to Ionizing Radiation.

Increased Resection at DSBs in G 2 -Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ.

PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination.

ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions.

Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA.

Deregulated BCL-2 family proteins impact on repair of DNA double-strand breaks and are targets to overcome radioresistance in lung cancer.

DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G<sub>2</sub>-checkpoint in S-phase irradiated cells.

Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G<sub>2</sub>-phase.

NGS Detects Extensive Genomic Alterations in Survivors of Irradiated Normal Human Fibroblast Cells.

DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.

DNA Double-Strand Break Repair as determinant of cellular radiosensitivity to killing and target in radiation therapy.

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52.

Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment.

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining.

BMN673 Is a PARP Inhibitor with Unique Radiosensitizing Properties: Mechanisms and Potential in Radiation Therapy.

NTRK1/TrkA Activation Overrides the G 2 /M-Checkpoint upon Irradiation.

DEFINED BIOLOGICAL MODELS OF HIGH-LET RADIATION LESIONS.