Works by Sondek, John

Results: 28

Crystal structure of the multifunctional Gβ5–RGS9 complex.

Published in:

Nature Structural & Molecular Biology, 2008, v. 15, n. 2, p. 155, doi. 10.1038/nsmb.1377

By:

Cheever, Matthew L.;
Snyder, Jason T.;
Gershburg, Svetlana;
Siderovski, David P.;
Harden, T. Kendall;
Sondek, John

Publication type:

Article

Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.

Published in:

Nature Structural & Molecular Biology, 2007, v. 14, n. 9, p. 814, doi. 10.1038/nsmb1290

By:

Mitin, Natalia;
Betts, Laurie;
Yohe, Marielle E.;
Der, Channing J.;
Sondek, John;
Rossman, Kent L.

Publication type:

Article

Crystal structure of Rac1 bound to its effector phospholipase C-β2.

Published in:

Nature Structural & Molecular Biology, 2006, v. 13, n. 12, p. 1135, doi. 10.1038/nsmb1175

By:

Jezyk, Mark R.;
Snyder, Jason T.;
Gershberg, Svetlana;
Worthylake, David K.;
Harden, T. Kendall;
Sondek, John

Publication type:

Article

Correction: Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction.

Published in:

2007

By:

Desveaux, Darrell;
Singer, Alex U.;
Ai-Jiuan Wu;
McNulty, Brian C.;
Musslewhite, Laura;
Nimchuk, Zachary;
Sondek, John;
Dangl, Jeffrey L.

Publication type:

Correction Notice

Type III Effector Activation via Nucleotide Binding, Phosphorylation, and Host Target Interaction.

Published in:

PLoS Pathogens, 2007, v. 3, n. 3, p. 0456, doi. 10.1371/journal.ppat.0030048

By:

Desveaux, Darrell;
Singer, Alex U.;
Ai-Jiuan Wu;
McNulty, Brian C.;
Musselwhite, Laura;
Nimchuk, Zachary;
Sondek, John;
Dangl, Jeffery L.

Publication type:

Article

AvrRpm1 Missense Mutations Weakly Activate RPS2-Mediated Immune Response in Arabidopsis thaliana.

Published in:

PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0042633

By:

Cherkis, Karen A.;
Temple, Brenda R. S.;
Eui-Hwan Chung;
Sondek, John;
Dangl, Jeffery L.;
Hozbor, Daniela Flavia

Publication type:

Article

PH domain of ELMO functions in trans to regulate Rac activation via Dock180.

Published in:

Nature Structural & Molecular Biology, 2004, v. 11, n. 8, p. 756, doi. 10.1038/nsmb800

By:

Lu, Mingjian;
Kinchen, Jason M.;
Rossman, Kent L.;
Grimsley, Cynthia;
DeBakker, Colin;
Brugnera, Enrico;
Tosello-Trampont, Annie-Carole;
Haney, Lisa B.;
Klingele, Doris;
Sondek, John;
Hengartner, Michael O.;
Ravichandran, Kodi S.

Publication type:

Article

A target enablement package for modulating the activity of PLCγ2 as a therapeutic strategy for the treatment of Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.074712

By:

Clayton, Brent;
Bissel, Stephanie J;
Richardson, Timothy I;
Massey, Steven M;
Beck, Daniel E;
Putt, Karson S;
Bedford, Logan M;
Utsuki, Tada;
Visvanathan, Ramya;
Mesecar, Andrew D;
Lendy, Emma K;
Kaiser, Bridget L;
Chu, Shaoyou;
Mason, Emily R;
Quinney, Sara K;
Kandasamy, Murugesh;
Masters, Andrea R;
Lamb, Bruce T;
Palkowitz, Alan D;
Sondek, John

Publication type:

Article

Structural and energetic differences between insertions and substitutions in staphylococcal nuclease.

Published in:

Proteins, 1992, v. 13, n. 2, p. 132, doi. 10.1002/prot.340130206

By:

Sondek, John;
Shortle, David

Publication type:

Article

Accommodation of single amino acid insertions by the native state of staphylococcal nuclease.

Published in:

Proteins, 1990, v. 7, n. 4, p. 299, doi. 10.1002/prot.340070402

By:

Sondek, John;
Shortle, David

Publication type:

Article

Crystal structure of a GA protein betagamma at 2.1 A resolution.

Published in:

Nature, 1996, v. 379, n. 6563, p. 369, doi. 10.1038/379369a0

By:

Sondek, John;
Bohm, Andrew

Publication type:

Article

The 2.0 A crystal structure of a heterotrimeric G protein.

Published in:

Nature, 1996, v. 379, n. 6563, p. 311, doi. 10.1038/379311a0

By:

Lambright, David G.;
Sondek, John

Publication type:

Article

GTPase mechanism of Gproteins from the 1.7-angstrom crystal structure of transducin alpha-GDP-AIF4-.

Published in:

Nature, 1994, v. 372, n. 6503, p. 276, doi. 10.1038/372276a0

By:

Sondek, John;
Lambright, David G.

Publication type:

Article

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.

Published in:

EMBO Journal, 2002, v. 21, n. 6, p. 1315, doi. 10.1093/emboj/21.6.1315

By:

Rossman, Kent L.;
Worthylake, David K.;
Snyder, Jason T.;
Siderovski, David P.;
Campbell, Sharon L.;
Sondek, John

Publication type:

Article

Functional relevance of the disulfide-linked complex of the N-terminal PDZ domain of InaD with NorpA.

Published in:

EMBO Journal, 2001, v. 20, n. 16, p. 4414, doi. 10.1093/emboj/20.16.4414

By:

Kimple, Michelle E.;
Siderovski, David P.;
Sondek, John

Publication type:

Article

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.

Published in:

Nature Structural Biology, 2002, v. 9, n. 6, p. 468, doi. 10.1038/nsb796

By:

Snyder, Jason T.;
Worthylake, David K.;
Rossman, Kent L.;
Betts, Laurie;
Pruitt, Wendy M.;
Siderovski, David P.;
Der, Channing J.;
Sondek, John

Publication type:

Article

A unique fold of phospholipase C-β mediates dimerization and interaction with Gαq.

Published in:

Nature Structural Biology, 2002, v. 9, n. 1, p. 32, doi. 10.1038/nsb731

By:

Singer, Alex U.;
Waldo, Gary L.;
Harden, T. Kendall;
Sondek, John

Publication type:

Article

Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.

Published in:

Nature Structural Biology, 2001, v. 8, n. 12, p. 1037, doi. 10.1038/nsb719

By:

Karnoub, Antoine E.;
Worthylake, David K.;
Rossman, Kent L.;
Pruitt, Wendy Morse;
Campbell, Sharon L.;
Sondek, John;
Der, Channing J.

Publication type:

Article

Inhibition of NF-ΚB Activity by IΚBβ in Association with ΚB-Ras.

Published in:

Molecular & Cellular Biology, 2004, v. 24, n. 7, p. 3048, doi. 10.1128/MCB.24.7.3048-3056.2004

By:

Yi Chen;
Vallee, Sebastein;
Wu, Joann;
Don Vu;
Sondek, John;
Ghosh, Gourisankar

Publication type:

Article

Spatiotemporal dynamics of GEF-H1 activation controlled by microtubule- and Src-mediated pathways.

Published in:

Journal of Cell Biology, 2019, v. 218, n. 9, p. 3077, doi. 10.1083/jcb.201812073

By:

Azoitei, Mihai L.;
Noh, Jungsik;
Marston, Daniel J.;
Roudot, Philippe;
Marshall, Christopher B.;
Daugird, Timothy A.;
Lisanza, Sidney L.;
Sand, María-José;
Ikura, Mitsu;
Sondek, John;
Rottapel, Robert;
Hahn, Klaus M.;
Danuser, Gaudenz

Publication type:

Article

Electrostatic and Functional Analysis of the Seven-Bladed WD β-Propellers.

Published in:

Evolutionary Bioinformatics, 2008, n. 4, p. 203, doi. 10.4137/EBO.S743

By:

Valeyev, Najl V.;
Downing, A. Kristina;
Sondek, John;
Deane, Charlotte

Publication type:

Article

Structual determinants for GoLoco-induced inhibition of nucleotide release by Gα subunits.

Published in:

Nature, 2002, v. 416, n. 6883, p. 878, doi. 10.1038/416878a

By:

Kimple, Randall J.;
Kimple, Michelle E.;
Betts, Laurie;
Sondek, John;
Siderovski, David P.

Publication type:

Article

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1.

Published in:

Nature, 2000, v. 408, n. 6813, p. 682, doi. 10.1038/35047014

By:

Worthylake, David K.;
Rossman, Kent L.;
Sondek, John

Publication type:

Article

Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes.

Published in:

eLife, 2022, p. 1, doi. 10.7554/eLife.77809

By:

Siraliev-Perez, Edhriz;
Stariha, Jordan T. B.;
Hoffmann, Reece M.;
Temple, Brenda R. S.;
Qisheng Zhang;
Hajicek, Nicole;
Jenkins, Meredith L.;
Burke, John E.;
Sondek, John

Publication type:

Article

Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation.

Published in:

Oncogene, 2004, v. 23, n. 58, p. 9369, doi. 10.1038/sj.onc.1208182

By:

Singh, Anurag;
Karnoub, Antoine E.;
Palmby, Todd R.;
Lengyel, Ernst;
Sondek, John;
Der, Channing J.

Publication type:

Article

GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.

Published in:

Nature Reviews Molecular Cell Biology, 2005, v. 6, n. 2, p. 167, doi. 10.1038/nrm1587

By:

Rossman, Kent L.;
Der, Channing J.;
Sondek, John

Publication type:

Article

De novo design of stable proteins that efficaciously inhibit oncogenic G proteins.

Published in:

Protein Science: A Publication of the Protein Society, 2023, v. 32, n. 8, p. 1, doi. 10.1002/pro.4713

By:

Cummins, Matthew C.;
Tripathy, Ashutosh;
Sondek, John;
Kuhlman, Brian

Publication type:

Article

Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.

Published in:

Nature Cell Biology, 2002, v. 4, n. 8, p. 621, doi. 10.1038/ncb833

By:

Lambert, John M.;
Lambert, Que T.;
Reuther, Gary W.;
Malliri, Angeliki;
Siderovski, David P.;
Sondek, John;
Collard, John G.;
Der, Channing J.

Publication type:

Article