Works matching AU Somsák, László

Results: 44

Dual-Target Compounds against Type 2 Diabetes Mellitus : Proof of Concept for Sodium Dependent Glucose Transporter (SGLT) and Glycogen Phosphorylase (GP) Inhibitors.

Published in:

Pharmaceuticals (14248247), 2021, v. 14, n. 4, p. 364, doi. 10.3390/ph14040364

By:

Sipos, Ádám;
Szennyes, Eszter;
Hajnal, Nikolett Éva;
Kun, Sándor;
Szabó, Katalin E.;
Uray, Karen;
Somsák, László;
Docsa, Tibor;
Bokor, Éva

Publication type:

Article

Glycogen phosphorylase inhibitor, 2,3‐bis[(2E)‐3‐(4‐hydroxyphenyl)prop‐2‐enamido] butanedioic acid (BF142), improves baseline insulin secretion of MIN6 insulinoma cells.

Published in:

PLoS ONE, 2020, v. 15, n. 9, p. 1, doi. 10.1371/journal.pone.0236081

By:

Nagy, Lilla;
Béke, Ferenc;
Juhász, László;
Kovács, Tünde;
Juhász-Tóth, Éva;
Docsa, Tibor;
Tóth, Attila;
Gergely, Pál;
Somsák, László;
Bai, Péter

Publication type:

Article

C‐Glycosyl Styrene Type Compounds by Pd‐Catalyzed Cross‐Coupling Reactions of Anhydro‐Aldose Tosylhydrazones with Benzyl Bromides.

Published in:

Advanced Synthesis & Catalysis, 2019, v. 361, n. 1, p. 105, doi. 10.1002/adsc.201801059

By:

Kaszás, Tímea;
Tóth, Marietta;
Langer, Peter;
Somsák, László

Publication type:

Article

Synthesis, In Silico and Kinetics Evaluation of N -(β-d-glucopyranosyl)-2-arylimidazole-4(5)-carboxamides and N -(β-d-glucopyranosyl)-4(5)-arylimidazole-2-carboxamides as Glycogen Phosphorylase Inhibitors.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 9, p. 4591, doi. 10.3390/ijms25094591

By:

Homolya, Levente;
Mathomes, Rachel T.;
Varga, Luca;
Docsa, Tibor;
Juhász, László;
Hayes, Joseph M.;
Somsák, László

Publication type:

Article

2-Acetamido-2-deoxy-d-glucono-1,5-lactone Sulfonylhydrazones: Synthesis and Evaluation as Inhibitors of Human OGA and HexB Enzymes.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 3, p. 1037, doi. 10.3390/ijms23031037

By:

Kiss, Mariann;
Timári, István;
Barna, Teréz;
Mészáros, Zuzana;
Slámová, Kristýna;
Bojarová, Pavla;
Křen, Vladimír;
Hayes, Joseph M.;
Somsák, László

Publication type:

Article

Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 2, p. 813, doi. 10.3390/ijms23020813

By:

Kacsir, István;
Sipos, Adrienn;
Bényei, Attila;
Janka, Eszter;
Buglyó, Péter;
Somsák, László;
Bai, Péter;
Bokor, Éva

Publication type:

Article

Ruthenium Half-Sandwich Type Complexes with Bidentate Monosaccharide Ligands Show Antineoplastic Activity in Ovarian Cancer Cell Models through Reactive Oxygen Species Production.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 19, p. 10454, doi. 10.3390/ijms221910454

By:

Kacsir, István;
Sipos, Adrienn;
Ujlaki, Gyula;
Buglyó, Péter;
Somsák, László;
Bai, Péter;
Bokor, Éva

Publication type:

Article

Stereoselective Synthesis of Carbon-Sulfur-Bridged Glycomimetics by Photoinitiated Thiol-Ene Coupling Reactions.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 2, p. 1, doi. 10.3390/ijms21020573

By:

Csávás, Magdolna;
Eszenyi, Dániel;
Mező, Erika;
Lázár, László;
Debreczeni, Nóra;
Tóth, Marietta;
Somsák, László;
Borbás, Anikó

Publication type:

Article

Glycogen phosphorylase inhibition improves beta cell function.

Published in:

2018

By:

Nagy, Lilla;
Márton, Judit;
Vida, András;
Kis, Gréta;
Bokor, Éva;
Kun, Sándor;
Gönczi, Mónika;
Docsa, Tibor;
Tóth, Attila;
Antal, Miklós;
Gergely, Pál;
Csóka, Balázs;
Pacher, Pal;
Somsák, László;
Bai, Péter

Publication type:

journal article

[2+2] Cycloadditions of Methylene exo‐Glycals: Synthesis of Glycopyranosylidene‐Spiro‐Azetidine‐2‐ones (β‐Lactams) and Cyclobutanones.

Published in:

European Journal of Organic Chemistry, 2023, v. 26, n. 12, p. 1, doi. 10.1002/ejoc.202201488

By:

József, János;
Somsák, László;
Tóth, Marietta;
Juhász, László

Publication type:

Article

Coupling of N‐Tosylhydrazones with Tetrazoles: A Regioselective Synthesis of 2,5‐Disubstituted‐2H‐Tetrazoles.

Published in:

European Journal of Organic Chemistry, 2022, v. 2022, n. 42, p. 1, doi. 10.1002/ejoc.202201103

By:

Kaszás, Tímea;
Szakács, Bence;
Juhász‐Tóth, Éva;
Cservenyák, Ivett;
Kovács, Tamara;
Juhász, László;
Somsák, László;
Tóth, Marietta

Publication type:

Article

Mass spectrometric studies of anomeric glycopyranosyl azides.

Published in:

Journal of Mass Spectrometry, 2001, v. 36, n. 2, p. 211, doi. 10.1002/jms.112

By:

Dinya, Zoltán;
Benke, Péter;
Györgydeák, Zoltán;
Somsák, László;
Jekö, József;
Pintér, István;
Kuszman, János;
Praly, Jean-Pierre

Publication type:

Article

New syntheses towards C-glycosyl type glycomimetics.

Published in:

Pure & Applied Chemistry, 2019, v. 91, n. 7, p. 1159, doi. 10.1515/pac-2019-0208

By:

Somsák, László;
Bokor, Éva;
Juhász, László;
Kun, Sándor;
Lázár, László;
Juhász-Tóth, Éva;
Tóth, Marietta

Publication type:

Article

Electrochemical Bromination of Peracetylated Glycals.

Published in:

Advanced Synthesis & Catalysis, 2008, v. 350, n. 1, p. 29, doi. 10.1002/adsc.200700310

By:

Čolović, Marija;
Vukićević, Mirjana;
Šegan, Dejan;
Manojlović, Dragan;
Sojic, Neso;
Somsák, László;
Vukićević, Rastko D.

Publication type:

Article

A Simple Method for the Synthesis of Acylated Pyranoid Glycals Under Aprotic Conditions.

Published in:

Journal of Carbohydrate Chemistry, 1993, v. 12, n. 4/5, p. 679, doi. 10.1080/07328309308019417

By:

Somsák, László;
Németh, Ildikó

Publication type:

Article

Estimation of the Anomeric Effect of the Cyano Group.

Published in:

Journal of Carbohydrate Chemistry, 1990, v. 9, n. 5, p. 755, doi. 10.1080/07328309008543869

By:

Somsák, László;
Szabó, Mátyás

Publication type:

Article

Cover Picture: Structure-Activity Relationships of Glycogen Phosphorylase Inhibitor FR258900 and Its Analogues: A Combined Synthetic, Enzyme Kinetics, and Computational Study (ChemPlusChem 11/2014).

Published in:

ChemPlusChem, 2014, v. 79, n. 11, p. 1535, doi. 10.1002/cplu.201402403

By:

Juhász, László;
Varga, Gergely;
Sztankovics, Andrea;
Béke, Ferenc;
Docsa, Tibor;
Kiss‐Szikszai, Attila;
Gergely, Pál;
Kóňa, Juraj;
Tvaroška, Igor;
Somsák, László

Publication type:

Article

Structure-Activity Relationships of Glycogen Phosphorylase Inhibitor FR258900 and Its Analogues: A Combined Synthetic, Enzyme Kinetics, and Computational Study.

Published in:

2014

By:

Juhász, László;
Varga, Gergely;
Sztankovics, Andrea;
Béke, Ferenc;
Docsa, Tibor;
Kiss‐Szikszai, Attila;
Gergely, Pál;
Kóňa, Juraj;
Tvaroška, Igor;
Somsák, László

Publication type:

Other

Structure-Activity Relationships of Glycogen Phosphorylase Inhibitor FR258900 and Its Analogues: A Combined Synthetic, Enzyme Kinetics, and Computational Study.

Published in:

ChemPlusChem, 2014, v. 79, n. 11, p. 1558, doi. 10.1002/cplu.201402181

By:

Juhász, László;
Varga, Gergely;
Sztankovics, Andrea;
Béke, Ferenc;
Docsa, Tibor;
Kiss‐Szikszai, Attila;
Gergely, Pál;
Kóňa, Juraj;
Tvaroška, Igor;
Somsák, László

Publication type:

Article

Glycogen Phosphorylase Inhibitor N-(3,5-Dimethyl-Benzoyl)-N’-(β-D-Glucopyranosyl)Urea Improves Glucose Tolerance under Normoglycemic and Diabetic Conditions and Rearranges Hepatic Metabolism.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0069420

By:

Nagy, Lilla;
Docsa, Tibor;
Szántó, Magdolna;
Brunyánszki, Attila;
Hegedűs, Csaba;
Márton, Judit;
Kónya, Bálint;
Virág, László;
Somsák, László;
Gergely, Pál;
Bai, Péter

Publication type:

Article

Zinc- N -Base Mediated Synthesis of Pyranoid Glycals Mechanistic Studies.

Published in:

Journal of Carbohydrate Chemistry, 1997, v. 16, n. 7, p. 1075, doi. 10.1080/07328309708005738

By:

Somsák, László;
Madaj, Janusz;
Wisniewski, Andrzej

Publication type:

Article

Half-Sandwich Type Platinum-Group Metal Complexes of C -Glucosaminyl Azines: Synthesis and Antineoplastic and Antimicrobial Activities.

Published in:

Molecules, 2023, v. 28, n. 7, p. 3058, doi. 10.3390/molecules28073058

By:

Kacsir, István;
Sipos, Adrienn;
Major, Evelin;
Bajusz, Nikolett;
Bényei, Attila;
Buglyó, Péter;
Somsák, László;
Kardos, Gábor;
Bai, Péter;
Bokor, Éva

Publication type:

Article

Design and Synthesis of 3-(β-d-Glucopyranosyl)-4-amino/4-guanidino Pyrazole Derivatives and Analysis of Their Glycogen Phosphorylase Inhibitory Potential.

Published in:

Molecules, 2023, v. 28, n. 7, p. 3005, doi. 10.3390/molecules28073005

By:

Kun, Sándor;
Mathomes, Rachel T.;
Docsa, Tibor;
Somsák, László;
Hayes, Joseph M.

Publication type:

Article

First Synthesis of 3-Glycopyranosyl-1,2,4-Triazines and Some Cycloadditions Thereof.

Published in:

Molecules, 2022, v. 27, n. 22, p. 7801, doi. 10.3390/molecules27227801

By:

Bokor, Éva;
Ferenczi, Attila;
Hashimov, Mahir;
Juhász-Tóth, Éva;
Götz, Zsófia;
Zaki, Alshimaa Ibrahim;
Somsák, László

Publication type:

Article

Glycopyranosylidene-Spiro-Morpholinones: Evaluation of the Synthetic Possibilities Based on Glyculosonamide Derivatives and a New Method for the Construction of the Morpholine Ring.

Published in:

Molecules, 2022, v. 27, n. 22, p. 7785, doi. 10.3390/molecules27227785

By:

Kánya, Nándor;
Kun, Sándor;
Somsák, László

Publication type:

Article

Coupling Reactions of Anhydro-Aldose Tosylhydrazones with Boronic Acids.

Published in:

Molecules, 2022, v. 27, n. 6, p. 1795, doi. 10.3390/molecules27061795

By:

Kaszás, Tímea;
Baráth, Balázs Áron;
Balázs, Bernadett;
Blága, Tekla;
Juhász, László;
Somsák, László;
Tóth, Marietta

Publication type:

Article

Resources and Methods for Engineering "Designer" Glycan-Binding Proteins.

Published in:

Molecules, 2021, v. 26, n. 2, p. 380, doi. 10.3390/molecules26020380

By:

Warkentin, Ruben;
Kwan, David H.;
Somsák, László

Publication type:

Article

Plant Xyloglucan Xyloglucosyl Transferases and the Cell Wall Structure: Subtle but Significant.

Published in:

Molecules, 2020, v. 25, n. 23, p. 5619, doi. 10.3390/molecules25235619

By:

Stratilová, Barbora;
Kozmon, Stanislav;
Stratilová, Eva;
Hrmova, Maria;
Somsák, László

Publication type:

Article

Synthesis, Kinetic and Conformational Studies of 2-Substituted-5-(β-d-glucopyranosyl)-pyrimidin-4-ones as Potential Inhibitors of Glycogen Phosphorylase.

Published in:

Molecules, 2020, v. 25, n. 22, p. 5463, doi. 10.3390/molecules25225463

By:

Mavreas, Konstantinos F.;
Neofytos, Dionysios D.;
Chrysina, Evangelia D.;
Venturini, Alessandro;
Gimisis, Thanasis;
Muñoz-Torrero, Diego;
Somsák, László

Publication type:

Article

Synthetic Route to Glycosyl β-1C-(phosphino)-phosphonates as Unprecedented Stable Glycosyl Diphosphate Analogs and Their Preliminary Biological Evaluation.

Published in:

Molecules, 2020, v. 25, n. 21, p. 4969, doi. 10.3390/molecules25214969

By:

Bosco, Michaël;
Paik, Su-Jin;
Busca, Patricia;
Moore, Stuart E. H.;
Gravier-Pelletier, Christine;
Somsák, László

Publication type:

Article

N -Alkylated Iminosugar Based Ligands: Synthesis and Inhibition of Human Lysosomal β-Glucocerebrosidase.

Published in:

Molecules, 2020, v. 25, n. 20, p. 4618, doi. 10.3390/molecules25204618

By:

Wolfsgruber, Andreas;
Thonhofer, Martin;
Weber, Patrick;
Nasseri, Seyed A.;
Fischer, Roland;
Schalli, Michael;
Stütz, Arnold E.;
Withers, Stephen G.;
Wrodnigg, Tanja M.;
Somsák, László

Publication type:

Article

Synthesis of Fucose Derivatives with Thiol Motifs towards Suicide Inhibition of Helicobacter pylori.

Published in:

Molecules, 2020, v. 25, n. 18, p. 4281, doi. 10.3390/molecules25184281

By:

Reihill, Mark;
Guazzelli, Lorenzo;
Remaut, Han;
Oscarson, Stefan;
Somsák, László

Publication type:

Article

The Glycan Structure of T. cruzi mucins Depends on the Host. Insights on the Chameleonic Galactose.

Published in:

Molecules, 2020, v. 25, n. 17, p. 3913, doi. 10.3390/molecules25173913

By:

Giorgi, María Eugenia;
Lederkremer, Rosa M. de;
Somsák, László

Publication type:

Article

Mechanistic Insights into the Chaperoning of Human Lysosomal-Galactosidase Activity: Highly Functionalized Aminocyclopentanes and C-5a-Substituted Derivatives of 4-epi-Isofagomine.

Published in:

Molecules, 2020, v. 25, n. 17, p. 4025, doi. 10.3390/molecules25174025

By:

Weber, Patrick;
Thonhofer, Martin;
Averill, Summer;
Davies, Gideon J.;
Santana, Andres Gonzalez;
Müller, Philipp;
Nasseri, Seyed A.;
Offen, Wendy A.;
Pabst, Bettina M.;
Paschke, Eduard;
Schalli, Michael;
Torvisco, Ana;
Tschernutter, Marion;
Tysoe, Christina;
Windischhofer, Werner;
Withers, Stephen G.;
Wolfsgruber, Andreas;
Wrodnigg, Tanja M.;
Stütz, Arnold E.;
Somsák, László

Publication type:

Article

Intracellular Hydrolysis of Small-Molecule O-Linked N-Acetylglucosamine Transferase Inhibitors Differs among Cells and Is Not Required for Its Inhibition.

Published in:

Molecules, 2020, v. 25, n. 15, p. 3381, doi. 10.3390/molecules25153381

By:

Loi, Elena Maria;
Weiss, Matjaž;
Pajk, Stane;
Gobec, Martina;
Tomašič, Tihomir;
Pieters, Roland J.;
Anderluh, Marko;
Somsák, László

Publication type:

Article

Synthesis of Highly Oxygenated Bicyclic Carbasugars. Remarkable Difference in the Reactivity of the d-gluco and d-xylo- Derived Trienes.

Published in:

Molecules, 2020, v. 25, n. 15, p. 3357, doi. 10.3390/molecules25153357

By:

Witkowski, Grzegorz;
Potopnyk, Mykhaylo A.;
Tiara, Karolina;
Osuch-Kwiatkowska, Anna;
Jarosz, Sławomir;
Somsák, László

Publication type:

Article

Selectins—The Two Dr. Jekyll and Mr. Hyde Faces of Adhesion Molecules—A Review.

Published in:

Molecules, 2020, v. 25, n. 12, p. 2835, doi. 10.3390/molecules25122835

By:

Tvaroška, Igor;
Selvaraj, Chandrabose;
Koča, Jaroslav;
McPhee, Derek J.;
Somsák, László

Publication type:

Article

Esters of Glucose-2-Phosphate: Occurrence and Chemistry.

Published in:

Molecules, 2020, v. 25, n. 12, p. 2829, doi. 10.3390/molecules25122829

By:

Zhang, Qiang;
Li, Si-Zhe;
Ahmar, Mohammed;
Soulère, Laurent;
Queneau, Yves;
Somsák, László

Publication type:

Article

Synthesis of New Series of 2-C-(β-D-glucopyranosyl)-Pyrimidines and Their Evaluation as Inhibitors of Some Glycoenzymes.

Published in:

Molecules, 2020, v. 25, n. 3, p. 701, doi. 10.3390/molecules25030701

By:

Szennyes, Eszter;
Gyémánt, Gyöngyi;
Somsák, László;
Bokor, Éva;
Nicolotti, Orazio

Publication type:

Article

d-Mannose Treatment neither Affects Uropathogenic Escherichia coli Properties nor Induces Stable FimH Modifications.

Published in:

Molecules, 2020, v. 25, n. 2, p. 316, doi. 10.3390/molecules25020316

By:

Scribano, Daniela;
Sarshar, Meysam;
Prezioso, Carla;
Lucarelli, Marco;
Angeloni, Antonio;
Zagaglia, Carlo;
Palamara, Anna Teresa;
Ambrosi, Cecilia;
Somsák, László

Publication type:

Article

Unsymmetrical Spiroalkanedithiols Having Mixed Fluorinated and Alkyl Tailgroups of Varying Length: Film Structure and Interfacial Properties.

Published in:

Molecules, 2018, v. 23, n. 10, p. 2632, doi. 10.3390/molecules23102632

By:

Chinwangso, Pawilai;
St. Hill, Lydia R.;
Marquez, Maria D.;
Lee, T. Randall;
Somsák, László;
Burke, Anthony J.

Publication type:

Article

Utilizing a Spiro Core with Acridine- and Phenothiazine-Based New Hole Transporting Materials for Highly Efficient Green Phosphorescent Organic Light-Emitting Diodes.

Published in:

Molecules, 2018, v. 23, n. 4, p. 713, doi. 10.3390/molecules23040713

By:

Braveenth, Ramanaskanda;
Bae, Il-Ji;
Han, Ji-Hun;
Qiong, Wu;
Seon, Guk;
Raagulan, Kanthasamy;
Yang, Kihun;
Park, Young Hee;
Kim, Miyoung;
Chai, Kyu Yun;
Somsák, László

Publication type:

Article

Synthesis of New C- and N-β-d-Glucopyranosyl Derivatives of Imidazole, 1,2,3-Triazole and Tetrazole, and Their Evaluation as Inhibitors of Glycogen Phosphorylase.

Published in:

Molecules, 2018, v. 23, n. 3, p. 666, doi. 10.3390/molecules23030666

By:

Kun, Sándor;
Bokor, Éva;
Sipos, Ádám;
Docsa, Tibor;
Somsák, László

Publication type:

Article

Glucopyranosylidene-Spiro-Thiazolinones: Synthetic Studies and Determination of Absolute Configuration by TDDFT-ECD Calculations.

Published in:

Molecules, 2017, v. 22, n. 10, p. 1760, doi. 10.3390/molecules22101760

By:

Szabó, Katalin E.;
Kun, Sándor;
Mándi, Attila;
Kurtán, Tibor;
Somsák, László

Publication type:

Article