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693 - Efficacy and safety of orismilast, a potent PDE4B/D inhibitor, in adults with moderate-to-severe atopic dermatitis: a phase 2b randomized, double-blind, placebo-controlled clinical trial (ADESOS).
- Published in:
- British Journal of Dermatology, 2024, v. 191, p. 1, doi. 10.1093/bjd/ljae266.067
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- Publication type:
- Article
Next Generation PDE4 Inhibitors that Selectively Target PDE4B/D Subtypes: A Narrative Review.
- Published in:
- Dermatology & Therapy, 2023, v. 13, n. 12, p. 3031, doi. 10.1007/s13555-023-01054-3
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- Publication type:
- Article
Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy.
- Published in:
- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-39365-2
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- Publication type:
- Article
Candida expansion in the gut of lung cancer patients associates with an ecological signature that supports growth under dysbiotic conditions.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38058-8
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- Publication type:
- Article
Oral orismilast: Efficacy and safety in moderate-to-severe psoriasis and development of modified release tablets.
- Published in:
- Journal of the European Academy of Dermatology & Venereology, 2023, v. 37, n. 4, p. 711, doi. 10.1111/jdv.18812
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- Publication type:
- Article
Pharmacology of orismilast, a potent and selective PDE4 inhibitor.
- Published in:
- Journal of the European Academy of Dermatology & Venereology, 2023, v. 37, n. 4, p. 721, doi. 10.1111/jdv.18818
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- Publication type:
- Article
High-quality genome-scale metabolic network reconstruction of probiotic bacterium Escherichia coli Nissle 1917.
- Published in:
- BMC Bioinformatics, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s12859-022-05108-9
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- Publication type:
- Article
Comparison of non-invasive Staphylococcus aureus sampling methods on lesional skin in patients with atopic dermatitis.
- Published in:
- European Journal of Clinical Microbiology & Infectious Diseases, 2022, v. 41, n. 2, p. 245, doi. 10.1007/s10096-021-04365-5
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- Publication type:
- Article
Human milk oligosaccharides induce acute yet reversible compositional changes in the gut microbiota of conventional mice linked to a reduction of butyrate levels.
- Published in:
- MicroLife, 2022, v. 3, p. N.PAG, doi. 10.1093/femsml/uqac006
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- Publication type:
- Article
Niclosamide shows strong antiviral activity in a human airway model of SARS-CoV-2 infection and a conserved potency against the Alpha (B.1.1.7), Beta (B.1.351) and Delta variant (B.1.617.2).
- Published in:
- PLoS ONE, 2021, v. 16, n. 12, p. 1, doi. 10.1371/journal.pone.0260958
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- Publication type:
- Article
The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity.
- Published in:
- PLoS Biology, 2021, v. 19, n. 10, p. 1, doi. 10.1371/journal.pbio.3001428
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- Publication type:
- Article
Forecasting the dissemination of antibiotic resistance genes across bacterial genomes.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22757-1
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- Publication type:
- Article
The evolutionary trajectories of P. aeruginosa in biofilm and planktonic growth modes exposed to ciprofloxacin: beyond selection of antibiotic resistance.
- Published in:
- NPJ Biofilms & Microbiomes, 2020, v. 6, n. 1, p. 1, doi. 10.1038/s41522-020-00138-8
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- Publication type:
- Article
Global responses to oxytetracycline treatment in tetracycline-resistant Escherichia coli.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-64995-1
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- Publication type:
- Article
Predictable modulation of cancer treatment outcomes by the gut microbiota.
- Published in:
- Microbiome, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40168-020-00811-2
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- Publication type:
- Article
Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15080-8
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- Publication type:
- Article
Overcoming genetic heterogeneity in industrial fermentations.
- Published in:
- Nature Biotechnology, 2019, v. 37, n. 8, p. 869, doi. 10.1038/s41587-019-0171-6
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- Publication type:
- Article
Rapid diagnosis of lung infections.
- Published in:
- Nature Biotechnology, 2019, v. 37, n. 7, p. 725, doi. 10.1038/s41587-019-0174-3
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- Publication type:
- Article
Collateral sensitivity constrains resistance evolution of the CTX-M-15 β-lactamase.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-08529-y
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- Publication type:
- Article
Diverse genetic error modes constrain large-scale bio-based production.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03232-w
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- Publication type:
- Article
Biochemical mechanisms determine the functional compatibility of heterologous genes.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-02944-3
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- Publication type:
- Article
Transfer and Persistence of a Multi-Drug Resistance Plasmid in situ of the Infant Gut Microbiota in the Absence of Antibiotic Treatment.
- Published in:
- Frontiers in Microbiology, 2017, p. 1, doi. 10.3389/fmicb.2017.01852
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- Publication type:
- Article
A versatile one-step CRISPR-Cas9 based approach to plasmid-curing.
- Published in:
- Microbial Cell Factories, 2017, v. 16, p. 1, doi. 10.1186/s12934-017-0748-z
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- Publication type:
- Article
Dissemination of antibiotic resistance genes from antibiotic producers to pathogens.
- Published in:
- Nature Communications, 2017, v. 8, n. 6, p. 1, doi. 10.1038/ncomms15784
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- Publication type:
- Article
Time-Resolved Tracking of Mutations Reveals Diverse Allele Dynamics during Escherichia coli Antimicrobial Adaptive Evolution to Single Drugs and Drug Pairs.
- Published in:
- Frontiers in Microbiology, 2017, v. 8, p. 1, doi. 10.3389/fmicb.2017.00893
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- Publication type:
- Article
Adaptive Laboratory Evolution of Antibiotic Resistance Using Different Selection Regimes Lead to Similar Phenotypes and Genotypes.
- Published in:
- Frontiers in Microbiology, 2017, v. 8, p. 1, doi. 10.3389/fmicb.2017.00816
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- Publication type:
- Article
Rapid resistome mapping using nanopore sequencing.
- Published in:
- Nucleic Acids Research, 2017, v. 45, n. 8, p. 1, doi. 10.1093/nar/gkw1328
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- Publication type:
- Article
Sponge Microbiota Are a Reservoir of Functional Antibiotic Resistance Genes.
- Published in:
- Frontiers in Microbiology, 2016, v. 7, p. 1, doi. 10.3389/fmicb.2016.01848
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- Publication type:
- Article
Survival and Evolution of a Large Multidrug Resistance Plasmid in New Clinical Bacterial Hosts.
- Published in:
- Molecular Biology & Evolution, 2016, v. 33, n. 11, p. 2860, doi. 10.1093/molbev/msw163
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- Publication type:
- Article
Adaptive responses to cefotaxime treatment in ESBL-producing Escherichia coli and the possible use of significantly regulated pathways as novel secondary targets.
- Published in:
- 2016
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- Publication type:
- journal article
Relation between tetR and tetA expression in tetracycline resistant Escherichia coli.
- Published in:
- BMC Microbiology, 2016, v. 16, p. 1, doi. 10.1186/s12866-016-0649-z
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- Publication type:
- Article
Transient overexpression of DNA adenine methylase enables efficient and mobile genome engineering with reduced off-target effects.
- Published in:
- Nucleic Acids Research, 2016, v. 44, n. 4, p. 1, doi. 10.1093/nar/gkv1090
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- Publication type:
- Article
Simulating Serial-Target Antibacterial Drug Synergies Using Flux Balance Analysis.
- Published in:
- PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0147651
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- Publication type:
- Article
CRMAGE: CRISPR Optimized MAGE Recombineering.
- Published in:
- Scientific Reports, 2016, p. 19452, doi. 10.1038/srep19452
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- Publication type:
- Article
Limited dissemination of the wastewater treatment plant core resistome.
- Published in:
- Nature Communications, 2015, v. 6, n. 9, p. 8452, doi. 10.1038/ncomms9452
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- Publication type:
- Article
Collateral Resistance and Sensitivity Modulate Evolution of High-Level Resistance to Drug Combination Treatment in Staphylococcus aureus.
- Published in:
- Molecular Biology & Evolution, 2015, v. 32, n. 5, p. 1175, doi. 10.1093/molbev/msv006
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- Publication type:
- Article
Extended spectrum β-lactamase-producing Escherichia coli forms filaments as an initial response to cefotaxime treatment.
- Published in:
- BMC Microbiology, 2015, v. 15, n. 1, p. 1, doi. 10.1186/s12866-015-0399-3
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- Publication type:
- Article
Prediction of resistance development against drug combinations by collateral responses to component drugs.
- Published in:
- Science Translational Medicine, 2014, v. 6, n. 262, p. 1, doi. 10.1126/scitranslmed.3009940
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- Publication type:
- Article
Improving biotech education through gamified laboratory simulations.
- Published in:
- Nature Biotechnology, 2014, v. 32, n. 7, p. 694, doi. 10.1038/nbt.2955
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- Publication type:
- Article
Human Intestinal Cells Modulate Conjugational Transfer of Multidrug Resistance Plasmids between Clinical <i>Escherichia coli</i> Isolates.
- Published in:
- PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100739
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- Publication type:
- Article
MICROBIOLOGY: Barriers to the spread of resistance.
- Published in:
- Nature, 2014, v. 509, n. 7502, p. 567, doi. 10.1038/nature13342
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- Publication type:
- Article
Use of Collateral Sensitivity Networks to Design Drug Cycling Protocols That Avoid Resistance Development.
- Published in:
- Science Translational Medicine, 2013, v. 5, n. 204, p. 1, doi. 10.1126/scitranslmed.3006609
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- Publication type:
- Article
Crystallizing proteins on the basis of their precipitation diagram determined using a microfluidic formulator.
- Published in:
- 2005
- By:
- Publication type:
- Other