Works matching AU Sohma, Youhei

Results: 36

A Cyclic KLVFF-Derived Peptide Aggregation Inhibitor Induces the Formation of Less-Toxic Off-Pathway Amyloid-β Oligomers.

Published in:

ChemBioChem, 2014, v. 15, n. 17, p. 2577, doi. 10.1002/cbic.201402430

By:

Arai, Tadamasa;
Sasaki, Daisuke;
Araya, Takushi;
Sato, Takeshi;
Sohma, Youhei;
Kanai, Motomu

Publication type:

Article

Titelbild: Design and Folding of [GluA4(OβThrB30)]Insulin ('Ester Insulin'): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin (Angew. Chem. 32/2010).

Published in:

Angewandte Chemie, 2010, v. 122, n. 32, p. 5517, doi. 10.1002/ange.201002659

By:

Sohma, Youhei;
Hua, Qing-Xin;
Whittaker, Jonathan;
Weiss, Michael A.;
Kent, Stephen B. H.

Publication type:

Article

Design and Folding of [GluA4(OβThrB30)]Insulin ('Ester Insulin'): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin.

Published in:

Angewandte Chemie, 2010, v. 122, n. 32, p. 5621, doi. 10.1002/ange.201001151

By:

Sohma, Youhei;
Hua, Qing-Xin;
Whittaker, Jonathan;
Weiss, Michael A.;
Kent, Stephen B. H.

Publication type:

Article

Amyloid-reoriented enzyme catalysis.

Published in:

Nature Communications, 2025, v. 16, n. 1, p. 1, doi. 10.1038/s41467-025-58536-5

By:

Sawazaki, Taka;
Murai, Fuma;
Yamamoto, Kai;
Sasaki, Daisuke;
Sohma, Youhei

Publication type:

Article

Photo-oxygenation of histidine residue inhibits α-synuclein aggregation.

Published in:

FASEB Journal, 2023, v. 37, n. 12, p. 1, doi. 10.1096/fj.202301533R

By:

Reito Nakamura;
Ikumi Tomizawa;
Atsushi Iwai;
Tetsuo Ikeda;
Kota Hirayama;
Yung Wen Chiu;
Takanobu Suzuki;
Airi Tarutani;
Tatsuo Mano;
Atsushi Iwata;
Tatsushi Toda;
Youhei Sohma;
Motomu Kanai;
Yukiko Hori;
Taisuke Tomita

Publication type:

Article

Synthesis of O-Acyl Isopeptides.

Published in:

Chemical Record, 2013, v. 13, n. 2, p. 218, doi. 10.1002/tcr.201200023

By:

Sohma, Youhei;
Kiso, Yoshiaki

Publication type:

Article

Modular synthetic strategy for N/C‐terminal protected amyloidogenic peptides.

Published in:

Journal of Peptide Science, 2024, v. 30, n. 3, p. 1, doi. 10.1002/psc.3546

By:

Sawazaki, Taka;
Sohma, Youhei

Publication type:

Article

O-Acyl isopeptide method: development of an O-acyl isodipeptide unit for Boc SPPS and its application to the synthesis of A β1-42 isopeptide.

Published in:

Journal of Peptide Science, 2014, v. 20, n. 9, p. 669, doi. 10.1002/psc.2662

By:

Yoshiya, Taku;
Uemura, Tsuyoshi;
Maruno, Takahiro;
Kubo, Shigeru;
Kiso, Yoshiaki;
Sohma, Youhei;
Kobayashi, Yuji;
Yoshizawa‐Kumagaye, Kumiko;
Nishiuchi, Yuji

Publication type:

Article

Synthesis of an O-acyl isopeptide by using native chemical ligation in an aqueous solvent system.

Published in:

Journal of Peptide Science, 2014, v. 20, n. 5, p. 361, doi. 10.1002/psc.2622

By:

Kawashima, Hiroyuki;
Kuruma, Tomomi;
Yamashita, Masayuki;
Sohma, Youhei;
Akaji, Kenichi

Publication type:

Article

Through the looking glass - a new world of proteins enabled by chemical synthesis.

Published in:

Journal of Peptide Science, 2012, v. 18, n. 7, p. 428, doi. 10.1002/psc.2421

By:

Kent, Stephen;
Sohma, Youhei;
Liu, Suhuai;
Bang, Duhee;
Pentelute, Brad;
Mandal, Kalyaneswar

Publication type:

Article

Epimerization-free synthesis of cyclic peptide by use of the O-acyl isopeptide method.

Published in:

Journal of Peptide Science, 2010, v. 16, n. 8, p. 437, doi. 10.1002/psc.1261

By:

Yoshiya, Taku;
Kawashima, Hiroyuki;
Hasegawa, Yuka;
Okamoto, Kazuhiro;
Kimura, Tooru;
Sohma, Youhei;
Kiso, Yoshiaki

Publication type:

Article

' O-Acyl isopeptide method' for peptide synthesis: Solvent effects in the synthesis of Aβ1-42 isopeptide using ' O-acyl isodipeptide unit'.

Published in:

Journal of Peptide Science, 2007, v. 13, n. 12, p. 868, doi. 10.1002/psc.905

By:

Taniguchi, Atsuhiko;
Yoshiya, Taku;
Abe, Naoko;
Fukao, Fukue;
Sohma, Youhei;
Kimura, Tooru;
Hayashi, Yoshio;
Kiso, Yoshiaki

Publication type:

Article

'Click peptide': a novel ' O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid β peptide analogues.

Published in:

Journal of Peptide Science, 2006, v. 12, n. 12, p. 823, doi. 10.1002/psc.817

By:

Sohma, Youhei;
Taniguchi, Atsuhiko;
Yoshiya, Taku;
Chiyomori, Yousuke;
Fukao, Fukue;
Nakamura, Setsuko;
Skwarczynski, Mariusz;
Okada, Takuma;
Ikeda, Keisuke;
Hayashi, Yoshio;
Kimura, Tooru;
Hirota, Shun;
Matsuzaki, Katsumi;
Kiso, Yoshiaki

Publication type:

Article

Design and Folding of [GluA4(OβThrB30)]Insulin ('Ester Insulin'): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin.

Published in:

Angewandte Chemie International Edition, 2010, v. 49, n. 32, p. 5489, doi. 10.1002/anie.201001151

By:

Sohma, Youhei;
Hua, Qing-Xin;
Whittaker, Jonathan;
Weiss, Michael A.;
Kent, Stephen B. H.

Publication type:

Article

Cover Picture: Design and Folding of [GluA4(OβThrB30)]Insulin ('Ester Insulin'): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin (Angew. Chem. Int. Ed. 32/2010).

Published in:

Angewandte Chemie International Edition, 2010, v. 49, n. 32, p. 5389, doi. 10.1002/anie.201002659

By:

Sohma, Youhei;
Hua, Qing-Xin;
Whittaker, Jonathan;
Weiss, Michael A.;
Kent, Stephen B. H.

Publication type:

Article

Comparative Properties of Insulin-like Growth Factor 1 (IGF-1) and [Gly7D-Ala]IGF-1 Prepared by Total Chemical Synthesis.

Published in:

Angewandte Chemie International Edition, 2008, v. 47, n. 6, p. 1102, doi. 10.1002/anie.200703521

By:

Sohma, Youhei;
Pentelute, Brad L.;
Whittaker, Jonathan;
Hua, Qin-xin;
Whittaker, Linda J.;
Weiss, Michael A.;
Kent, Stephen B. H.

Publication type:

Article

Click Peptide Concept: O-Acyl Isopeptide of Islet Amyloid Polypeptide as a Nonaggregative Precursor Molecule.

Published in:

ChemBioChem, 2011, v. 12, n. 8, p. 1216, doi. 10.1002/cbic.201100025

By:

Yoshiya, Taku;
Higa, Ayano;
Abe, Naoko;
Fukao, Fukue;
Kuruma, Tomomi;
Toda, Yuki;
Sohma, Youhei;
Kiso, Yoshiaki

Publication type:

Article

'Click Peptide': pH-Triggered in Situ Production and Aggregation of Monomer Aβ1-42.

Published in:

ChemBioChem, 2009, v. 10, n. 4, p. 710, doi. 10.1002/cbic.200800765

By:

Taniguchi, Atsuhiko;
Sohma, Youhei;
Hirayama, Yuta;
Mukai, Hidehito;
Kimura, Tooru;
Hayashi, Yoshio;
Matsuzaki, Katsumi;
Kiso, Yoshiaki

Publication type:

Article

Controlled Production of Amyloid β Peptide from a Photo-Triggered, Water-Soluble Precursor 'Click Peptide'.

Published in:

ChemBioChem, 2008, v. 9, n. 18, p. 3055, doi. 10.1002/cbic.200800503

By:

Taniguchi, Atsuhiko;
Skwarczynski, Mariusz;
Sohma, Youhei;
Okada, Takuma;
Ikeda, Keisuke;
Prakash, Halan;
Mukai, Hidehito;
Hayashi, Yoshio;
Kimura, Tooru;
Hirota, Shun;
Matsuzaki, Katsumi;
Kiso, Yoshiaki

Publication type:

Article

“Click Peptides”—Chemical Biology-Oriented Synthesis of Alzheimer's Disease-Related Amyloid β Peptide (Aβ) Analogues Based on the “O-Acyl Isopeptide Method”.

Published in:

ChemBioChem, 2006, v. 7, n. 10, p. 1549, doi. 10.1002/cbic.200600112

By:

Youhei Sohma;
Yoshiaki Kiso

Publication type:

Article

Photo-Oxygenation as a New Therapeutic Strategy for Neurodegenerative Proteinopathies by Enhancing the Clearance of Amyloid Proteins.

Published in:

Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.945017

By:

Tomizawa, Ikumi;
Nakagawa, Hanako;
Sohma, Youhei;
Kanai, Motomu;
Hori, Yukiko;
Tomita, Taisuke

Publication type:

Article

Rational Design and Identification of a Non-Peptidic Aggregation Inhibitor of Amyloid-_ Based on a Pharmacophore Motif Obtained from cyclo[-Lys-Leu-Val-Phe-Phe-].

Published in:

Angewandte Chemie, 2014, v. 126, n. 31, p. 8375, doi. 10.1002/ange.201405109

By:

Arai, Tadamasa;
Araya, Takushi;
Sasaki, Daisuke;
Taniguchi, Atsuhiko;
Sato, Takeshi;
Sohma, Youhei;
Kanai, Motomu

Publication type:

Article

Serine-Selective Aerobic Cleavage of Peptides and a Protein Using a Water-Soluble Copper-Organoradical Conjugate.

Published in:

Angewandte Chemie, 2014, v. 126, n. 25, p. 6619, doi. 10.1002/ange.201402618

By:

Seki, Yohei;
Tanabe, Kana;
Sasaki, Daisuke;
Sohma, Youhei;
Oisaki, Kounosuke;
Kanai, Motomu

Publication type:

Article

Attenuation of the Aggregation and Neurotoxicity of Amyloid-β Peptides by Catalytic Photooxygenation.

Published in:

Angewandte Chemie, 2014, v. 126, n. 5, p. 1406, doi. 10.1002/ange.201308001

By:

Taniguchi, Atsuhiko;
Sasaki, Daisuke;
Shiohara, Azusa;
Iwatsubo, Takeshi;
Tomita, Taisuke;
Sohma, Youhei;
Kanai, Motomu

Publication type:

Article

S-acyl isopeptide method: Use of allyl-type protective group for improved preparation of thioester-containing S-acyl isopeptides by Fmoc-based SPPS.

Published in:

Biopolymers, 2011, v. 96, n. 2, p. 228, doi. 10.1002/bip.21410

By:

Yoshiya, Taku;
Hasegawa, Yuka;
Kawamura, Wakana;
Kawashima, Hiroyuki;
Sohma, Youhei;
Kimura, Tooru;
Kiso, Yoshiaki

Publication type:

Article

Development of O-acyl isopeptide method.

Published in:

Biopolymers, 2007, v. 88, n. 2, p. 253, doi. 10.1002/bip.20683

By:

Sohma, Youhei;
Yoshiya, Taku;
Taniguchi, Atsuhiko;
Kimura, Tooru;
Hayashi, Yoshio;
Kiso, Yoshiaki

Publication type:

Article

ON intramolecular acyl migration reaction in the development of prodrugs and the synthesis of difficult sequence-containing bioactive peptides.

Published in:

Biopolymers, 2004, v. 76, n. 4, p. 344, doi. 10.1002/bip.20136

By:

Sohma, Youhei;
Hayashi, Yoshio;
Skwarczynski, Mariusz;
Hamada, Yoshio;
Sasaki, Masato;
Kimura, Tooru;
Kiso, Yoshiaki

Publication type:

Article

The ' O-acyl isopeptide method' for the synthesis of difficult sequence-containing peptides: application to the synthesis of Alzheimer's disease-related amyloid β peptide (Aβ) 1-42.

Published in:

Journal of Peptide Science, 2005, v. 11, n. 8, p. 441, doi. 10.1002/psc.649

By:

Sohma, Youhei;
Hayashi, Yoshio;
Kimura, Maiko;
Chiyomori, Yousuke;
Taniguchi, Atsuhiko;
Sasaki, Masato;
Kimura, Tooru;
Kiso, Yoshiaki

Publication type:

Article

Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in Alzheimer's disease mice.

Published in:

2021

By:

Ozawa, Shuta;
Hori, Yukiko;
Shimizu, Yusuke;
Taniguchi, Atsuhiko;
Suzuki, Takanobu;
Wang, Wenbo;
Chiu, Yung Wen;
Koike, Reiko;
Yokoshima, Satoshi;
Fukuyama, Tohru;
Takatori, Sho;
Sohma, Youhei;
Kanai, Motomu;
Tomita, Taisuke

Publication type:

journal article

Leuco Ethyl Violet as Self‐Activating Prodrug Photocatalyst for In Vivo Amyloid‐Selective Oxygenation.

Published in:

Advanced Science, 2024, v. 11, n. 26, p. 1, doi. 10.1002/advs.202401346

By:

Furuta, Masahiro;
Arii, Suguru;
Umeda, Hiroki;
Matsukawa, Ryota;
Shizu, Katsuyuki;
Kaji, Hironori;
Kawashima, Shigehiro A.;
Hori, Yukiko;
Tomita, Taisuke;
Sohma, Youhei;
Mitsunuma, Harunobu;
Kanai, Motomu

Publication type:

Article

Promotion in the Clearance of Aggregated Aβ In Vivo Using Amyloid Selective Photo-Oxygenation Technology.

Published in:

Neuroscience Insights, 2022, p. 1, doi. 10.1177/26331055221126179

By:

Hori, Yukiko;
Sohma, Youhei;
Kanai, Motomu;
Tomita, Taisuke

Publication type:

Article

Rational Design and Identification of a Non-Peptidic Aggregation Inhibitor of Amyloid-β Based on a Pharmacophore Motif Obtained from cyclo[-Lys-Leu-Val-Phe-Phe-].

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 31, p. 8236, doi. 10.1002/anie.201405109

By:

Arai, Tadamasa;
Araya, Takushi;
Sasaki, Daisuke;
Taniguchi, Atsuhiko;
Sato, Takeshi;
Sohma, Youhei;
Kanai, Motomu

Publication type:

Article

Serine-Selective Aerobic Cleavage of Peptides and a Protein Using a Water-Soluble Copper-Organoradical Conjugate.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 25, p. 6501, doi. 10.1002/anie.201402618

By:

Seki, Yohei;
Tanabe, Kana;
Sasaki, Daisuke;
Sohma, Youhei;
Oisaki, Kounosuke;
Kanai, Motomu

Publication type:

Article

Attenuation of the Aggregation and Neurotoxicity of Amyloid-β Peptides by Catalytic Photooxygenation.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 5, p. 1382, doi. 10.1002/anie.201308001

By:

Taniguchi, Atsuhiko;
Sasaki, Daisuke;
Shiohara, Azusa;
Iwatsubo, Takeshi;
Tomita, Taisuke;
Sohma, Youhei;
Kanai, Motomu

Publication type:

Article

P2‐059: PHOTOOXYGENATION BY BIOCOMPATIBLE CATALYST REDUCES THE Aβ LEVEL IN THE BRAINS OF ALZHEIMER DISEASE MODEL MICE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P594, doi. 10.1016/j.jalz.2019.06.2466

By:

Tomita, Taisuke;
Ozawa, Shuta;
Sohma, Youhei;
Kanai, Motomu;
Hori, Yukiko

Publication type:

Article

Semi-synthesis of TDP-43 reveals the effects of phosphorylation in N-terminal domain on self-association.

Published in:

Communications Chemistry, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42004-025-01522-1

By:

Sasaki, Daisuke;
Tenda, Mao;
Sohma, Youhei

Publication type:

Article

Works matching AU Sohma, Youhei

A Cyclic KLVFF-Derived Peptide Aggregation Inhibitor Induces the Formation of Less-Toxic Off-Pathway Amyloid-β Oligomers.

Titelbild: Design and Folding of [Glu<sup>A4</sup>(O<sup>β</sup>Thr<sup>B30</sup>)]Insulin ('Ester Insulin'): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin (Angew. Chem. 32/2010).

Design and Folding of [Glu<sup>A4</sup>(O<sup>β</sup>Thr<sup>B30</sup>)]Insulin ('Ester Insulin'): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin.

Amyloid-reoriented enzyme catalysis.

Photo-oxygenation of histidine residue inhibits α-synuclein aggregation.

Synthesis of O-Acyl Isopeptides.

Modular synthetic strategy for N/C‐terminal protected amyloidogenic peptides.

O-Acyl isopeptide method: development of an O-acyl isodipeptide unit for Boc SPPS and its application to the synthesis of A β1-42 isopeptide.

Synthesis of an O-acyl isopeptide by using native chemical ligation in an aqueous solvent system.

Through the looking glass - a new world of proteins enabled by chemical synthesis.

Epimerization-free synthesis of cyclic peptide by use of the O-acyl isopeptide method.

' O-Acyl isopeptide method' for peptide synthesis: Solvent effects in the synthesis of Aβ1-42 isopeptide using ' O-acyl isodipeptide unit'.

'Click peptide': a novel ' O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid β peptide analogues.

Design and Folding of [Glu<sup>A4</sup>(O<sup>β</sup>Thr<sup>B30</sup>)]Insulin ('Ester Insulin'): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin.

Cover Picture: Design and Folding of [Glu<sup>A4</sup>(O<sup>β</sup>Thr<sup>B30</sup>)]Insulin ('Ester Insulin'): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insulin (Angew. Chem. Int. Ed. 32/2010).

Comparative Properties of Insulin-like Growth Factor 1 (IGF-1) and [Gly7D-Ala]IGF-1 Prepared by Total Chemical Synthesis.

Click Peptide Concept: O-Acyl Isopeptide of Islet Amyloid Polypeptide as a Nonaggregative Precursor Molecule.

'Click Peptide': pH-Triggered in Situ Production and Aggregation of Monomer Aβ1-42.

Controlled Production of Amyloid β Peptide from a Photo-Triggered, Water-Soluble Precursor 'Click Peptide'.

“Click Peptides”—Chemical Biology-Oriented Synthesis of Alzheimer's Disease-Related Amyloid β Peptide (Aβ) Analogues Based on the “O-Acyl Isopeptide Method”.

Photo-Oxygenation as a New Therapeutic Strategy for Neurodegenerative Proteinopathies by Enhancing the Clearance of Amyloid Proteins.

Rational Design and Identification of a Non-Peptidic Aggregation Inhibitor of Amyloid-_ Based on a Pharmacophore Motif Obtained from cyclo[-Lys-Leu-Val-Phe-Phe-].

Serine-Selective Aerobic Cleavage of Peptides and a Protein Using a Water-Soluble Copper-Organoradical Conjugate.

Attenuation of the Aggregation and Neurotoxicity of Amyloid-β Peptides by Catalytic Photooxygenation.

S-acyl isopeptide method: Use of allyl-type protective group for improved preparation of thioester-containing S-acyl isopeptides by Fmoc-based SPPS.

Development of O-acyl isopeptide method.

ON intramolecular acyl migration reaction in the development of prodrugs and the synthesis of difficult sequence-containing bioactive peptides.

The ' O-acyl isopeptide method' for the synthesis of difficult sequence-containing peptides: application to the synthesis of Alzheimer's disease-related amyloid β peptide (Aβ) 1-42.

Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in Alzheimer's disease mice.

Leuco Ethyl Violet as Self‐Activating Prodrug Photocatalyst for In Vivo Amyloid‐Selective Oxygenation.

Promotion in the Clearance of Aggregated Aβ In Vivo Using Amyloid Selective Photo-Oxygenation Technology.

Rational Design and Identification of a Non-Peptidic Aggregation Inhibitor of Amyloid-β Based on a Pharmacophore Motif Obtained from cyclo[-Lys-Leu-Val-Phe-Phe-].

Serine-Selective Aerobic Cleavage of Peptides and a Protein Using a Water-Soluble Copper-Organoradical Conjugate.

Attenuation of the Aggregation and Neurotoxicity of Amyloid-β Peptides by Catalytic Photooxygenation.

P2‐059: PHOTOOXYGENATION BY BIOCOMPATIBLE CATALYST REDUCES THE Aβ LEVEL IN THE BRAINS OF ALZHEIMER DISEASE MODEL MICE.

Semi-synthesis of TDP-43 reveals the effects of phosphorylation in N-terminal domain on self-association.