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Polypharmacy: the whys, the so whats and the what nexts.
Published in:
British Journal of Hospital Medicine (17508460), 2020, v. 81, n. 5, p. 1, doi. 10.12968/hmed.2019.0383
By:
- Bennett, Frances;
- Sofat, Reecha
Publication type:
Article
Incidence, morbidity, mortality and disparities in dementia: A population linked electronic health records study of 4.3 million individuals.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 1, p. 123, doi. 10.1002/alz.12635
By:
- Chung, Sheng‐Chia;
- Providencia, Rui;
- Sofat, Reecha;
- Pujades‐Rodriguez, Mar;
- Torralbo, Ana;
- Fatemifar, Ghazaleh;
- Fitzpatrick, Natalie K.;
- Taylor, Julie;
- Li, Ken;
- Dale, Caroline;
- Rossor, Martin;
- Acosta‐Mena, Dionisio;
- Whittaker, John;
- Denaxas, Spiros
Publication type:
Article
Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25731-z
By:
- Gordillo-Marañón, María;
- Zwierzyna, Magdalena;
- Charoen, Pimphen;
- Drenos, Fotios;
- Chopade, Sandesh;
- Shah, Tina;
- Engmann, Jorgen;
- Chaturvedi, Nishi;
- Papacosta, Olia;
- Wannamethee, Goya;
- Wong, Andrew;
- Sofat, Reecha;
- Kivimaki, Mika;
- Price, Jackie F.;
- Hughes, Alun D.;
- Gaunt, Tom R.;
- Lawlor, Deborah A.;
- Gaulton, Anna;
- Hingorani, Aroon D.;
- Schmidt, Amand F.
Publication type:
Article
Bleeding in cardiac patients prescribed antithrombotic drugs: electronic health record phenotyping algorithms, incidence, trends and prognosis.
Published in:
2019
By:
- Pasea, Laura;
- Chung, Sheng-Chia;
- Pujades-Rodriguez, Mar;
- Shah, Anoop D.;
- Alvarez-Madrazo, Samantha;
- Allan, Victoria;
- Teo, James T.;
- Bean, Daniel;
- Sofat, Reecha;
- Dobson, Richard;
- Banerjee, Amitava;
- Patel, Riyaz S.;
- Timmis, Adam;
- Denaxas, Spiros;
- Hemingway, Harry
Publication type:
journal article
Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium.
Published in:
PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071345
By:
- Shah, Tina;
- Engmann, Jorgen;
- Dale, Caroline;
- Shah, Sonia;
- White, Jon;
- Giambartolomei, Claudia;
- McLachlan, Stela;
- Zabaneh, Delilah;
- Cavadino, Alana;
- Finan, Chris;
- Wong, Andrew;
- Amuzu, Antoinette;
- Ong, Ken;
- Gaunt, Tom;
- Holmes, Michael V.;
- Warren, Helen;
- Davies, Teri-Louise;
- Drenos, Fotios;
- Cooper, Jackie;
- Sofat, Reecha
Publication type:
Article
The urgent need to move upstream in caring for people with rheumatic and musculoskeletal diseases.
Published in:
2022
By:
- Bouraoui, Aicha;
- Rutter, Megan;
- Williamson, Luke;
- Fisher, Corinne;
- Sofat, Reecha;
- Sen, Debajit
Publication type:
Editorial
Effectiveness of biosimilar adoption within a UK tertiary hospital: 6‐year follow‐up.
Published in:
British Journal of Clinical Pharmacology, 2023, v. 89, n. 10, p. 2944, doi. 10.1111/bcp.15859
By:
- Barron, Andrew;
- Chung, Jennifer;
- Ferner, Robin E.;
- Leandro, Maria;
- Maru, Saloni;
- Scourfield, Andrew;
- Urquhart, Robert;
- Sofat, Reecha
Publication type:
Article
How to assess pharmacogenomic tests for implementation in the NHS in England.
Published in:
British Journal of Clinical Pharmacology, 2023, v. 89, n. 9, p. 2649, doi. 10.1111/bcp.15820
By:
- Sanghvi, Sonali;
- Ferner, Robin E.;
- Scourfield, Andrew;
- Urquhart, Robert;
- Amin, Sejal;
- Hingorani, Aroon D.;
- Sofat, Reecha
Publication type:
Article
Are high‐cost drug funding mechanisms fit for purpose? A retrospective study of individual funding requests in an NHS tertiary hospital.
Published in:
British Journal of Clinical Pharmacology, 2023, v. 89, n. 1, p. 11, doi. 10.1111/bcp.14409
By:
- Sanghvi, Sonali;
- Allen, Rachel;
- Cho, Steven;
- Ferner, Robin E.;
- Urquhart, Robert;
- Sofat, Reecha
Publication type:
Article
Pharmacogenomic alerts: Developing guidance for use by healthcare professionals.
Published in:
British Journal of Clinical Pharmacology, 2022, v. 88, n. 7, p. 3201, doi. 10.1111/bcp.15234
By:
- Carter, John‐Paul L.;
- Critchlow, James;
- Jackson, Sarah;
- Sanghvi, Sonali;
- Feger, Helene;
- Chaudhry, Afzal;
- Foley, Lorraine;
- Sofat, Reecha
Publication type:
Article
Free‐of‐charge medicine schemes in the NHS: A local and regional drug and therapeutic committee's experience.
Published in:
British Journal of Clinical Pharmacology, 2022, v. 88, n. 6, p. 2571, doi. 10.1111/bcp.15094
By:
- O'Callaghan, Simon;
- Ferner, Robin E.;
- Barron, Andrew;
- Saxby, Katherine;
- Sofat, Reecha
Publication type:
Article
Beyond dexamethasone, emerging immuno‐thrombotic therapies for COVID‐19.
Published in:
British Journal of Clinical Pharmacology, 2021, v. 87, n. 3, p. 845, doi. 10.1111/bcp.14540
By:
- Jensen, Melanie Peta;
- George, Marc;
- Gilroy, Derek;
- Sofat, Reecha
Publication type:
Article
Overprescribing and rational therapeutics: Barriers to change and opportunities to improve.
Published in:
British Journal of Clinical Pharmacology, 2021, v. 87, n. 1, p. 34, doi. 10.1111/bcp.14291
By:
- Bennett, Frances;
- Ferner, Robin;
- Sofat, Reecha
Publication type:
Article
Drug and therapeutics committees as guardians of safe and rational medicines use.
Published in:
British Journal of Clinical Pharmacology, 2020, v. 86, n. 1, p. 10, doi. 10.1111/bcp.14088
By:
- Sofat, Reecha;
- Cremers, Serge;
- Ferner, R.E.
Publication type:
Article
A novel approach to support implementation of biosimilars within a UK tertiary hospital.
Published in:
British Journal of Clinical Pharmacology, 2020, v. 86, n. 1, p. 23, doi. 10.1111/bcp.14150
By:
- Saxby, Katherine;
- Sanghvi, Sonali;
- Bodalia, Pritesh N.;
- Ferner, Robin E.;
- Leandro, Maria;
- Urquhart, Robert;
- Sofat, Reecha
Publication type:
Article
Comparative efficacy and tolerability of anti-epileptic drugs for refractory focal epilepsy: systematic review and network meta-analysis reveals the need for long term comparator trials.
Published in:
British Journal of Clinical Pharmacology, 2013, v. 76, n. 5, p. 649, doi. 10.1111/bcp.12083
By:
- Bodalia, Pritesh N.;
- Grosso, Anthony M.;
- Sofat, Reecha;
- MacAllister, Raymond J.;
- Smeeth, Liam;
- Dhillon, Soraya;
- Casas, Juan ‐ Pablo;
- Wonderling, David;
- Hingorani, Aroon D.
Publication type:
Article
Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.
Published in:
European Heart Journal, 2012, v. 33, n. 3, p. 393, doi. 10.1093/eurheartj/ehr225
By:
- Angelakopoulou, Aspasia;
- Shah, Tina;
- Sofat, Reecha;
- Shah, Sonia;
- Berry, Diane J.;
- Cooper, Jackie;
- Palmen, Jutta;
- Tzoulaki, Ioanna;
- Wong, Andrew;
- Jefferis, Barbara J.;
- Maniatis, Nikolas;
- Drenos, Fotios;
- Gigante, Bruna;
- Hardy, Rebecca;
- Laxton, Ross C.;
- Leander, Karin;
- Motterle, Anna;
- Simpson, Iain A.;
- Smeeth, Liam;
- Thomson, Andy
Publication type:
Article
Drug‐induced orthostatic hypotension: Cluster analysis of co‐prescription patterns in older people in UK primary care.
Published in:
Pharmacoepidemiology & Drug Safety, 2024, v. 33, n. 1, p. 1, doi. 10.1002/pds.5730
By:
- Bhanu, Cini;
- Petersen, Irene;
- Orlu, Mine;
- Davis, Daniel;
- Sofat, Reecha;
- Bazo‐Alvarez, Juan Carlos;
- Walters, Kate
Publication type:
Article
Directly Acting Oral Anticoagulants for the Prevention of Stroke in Atrial Fibrillation in England and Wales: Cost-Effectiveness Model and Value of Information Analysis.
Published in:
MDM Policy & Practice, 2019, v. 4, n. 2, p. N.PAG, doi. 10.1177/2381468319866828
By:
- Thom, Howard H. Z.;
- Hollingworth, Will;
- Sofat, Reecha;
- Wang, Zhenru;
- Fang, Wei;
- Bodalia, Pritesh N.;
- Bryden, Peter A.;
- Davies, Philippa A.;
- Caldwell, Deborah M.;
- Dias, Sofia;
- Eaton, Diane;
- Higgins, Julian P. T.;
- Hingorani, Aroon D.;
- Lopez-Lopez, Jose A.;
- Okoli, George N.;
- Richards, Alison;
- Salisbury, Chris;
- Savović, Jelena;
- Stephens-Boal, Annya;
- Sterne, Jonathan A. C.
Publication type:
Article
24-Hour vs. Spot Urinary Sodium and Potassium Measurements in Adult Hypertensive Patients: A Cohort Validation Study.
Published in:
American Journal of Hypertension, 2019, v. 32, n. 10, p. 983, doi. 10.1093/ajh/hpz104
By:
- Wan, Elizabeth R;
- Cross, Jennifer;
- Sofat, Reecha;
- Walsh, Stephen B
Publication type:
Article
Association of Smoking, Alcohol Consumption, Blood Pressure, Body Mass Index, and Glycemic Risk Factors With Age-Related Macular Degeneration: A Mendelian Randomization Study.
Published in:
2021
By:
- Kuan, Valerie;
- Warwick, Alasdair;
- Hingorani, Aroon;
- Tufail, Adnan;
- Cipriani, Valentina;
- Burgess, Stephen;
- Sofat, Reecha;
- International AMD Genomics Consortium (IAMDGC)
Publication type:
journal article
Association of C-Reactive Protein Genetic Polymorphisms With Late Age-Related Macular Degeneration.
Published in:
2017
By:
- Cipriani, Valentina;
- Hogg, Ruth E.;
- Sofat, Reecha;
- Moore, Anthony T.;
- Webster, Andrew R.;
- Yates, John R. W.;
- Fletcher, Astrid E.;
- European Eye (EUREYE) Study Group
Publication type:
journal article
Improving the odds of drug development success through human genomics: modelling study.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-54849-w
By:
- Hingorani, Aroon D.;
- Kuan, Valerie;
- Finan, Chris;
- Kruger, Felix A.;
- Gaulton, Anna;
- Chopade, Sandesh;
- Sofat, Reecha;
- MacAllister, Raymond J.;
- Overington, John P.;
- Hemingway, Harry;
- Denaxas, Spiros;
- Prieto, David;
- Casas, Juan Pablo
Publication type:
Article
Genetic Variants Associated with von Willebrand Factor Levels in Healthy Men and Women Identified Using the HumanCVD BeadChip.
Published in:
Annals of Human Genetics, 2011, v. 75, n. 4, p. 456, doi. 10.1111/j.1469-1809.2011.00654.x
By:
- Zabaneh, Delilah;
- Gaunt, Tom R.;
- Kumari, Meena;
- Drenos, Fotios;
- Shah, Sonia;
- Berry, Diane;
- Power, Chris;
- Hypponen, Elina;
- Shah, Tina;
- Palmen, Jutta;
- Pallas, Jacky;
- Talmud, Philippa J.;
- Casas, Juan Pablo;
- Sofat, Reecha;
- Lowe, Gordon;
- Rumley, Ann;
- Morris, Richard W.;
- Whincup, Peter H.;
- Rodriguez, Santiago;
- Ebrahim, Shah
Publication type:
Article
An informatics consult approach for generating clinical evidence for treatment decisions.
Published in:
2021
By:
- Lai, Alvina G.;
- Chang, Wai Hoong;
- Parisinos, Constantinos A.;
- Katsoulis, Michail;
- Blackburn, Ruth M.;
- Shah, Anoop D.;
- Nguyen, Vincent;
- Denaxas, Spiros;
- Davey Smith, George;
- Gaunt, Tom R.;
- Nirantharakumar, Krishnarajah;
- Cox, Murray P.;
- Forde, Donall;
- Asselbergs, Folkert W.;
- Harris, Steve;
- Richardson, Sylvia;
- Sofat, Reecha;
- Dobson, Richard J. B.;
- Hingorani, Aroon;
- Patel, Riyaz
Publication type:
journal article
Cross-talk between iNKT cells and monocytes triggers an atheroprotective immune response in SLE patients with asymptomatic plaque.
Published in:
Science Immunology, 2016, v. 1, n. 6, p. 1, doi. 10.1126/sciimmunol.aah4081
By:
- Smith, Edward;
- Croca, Sara;
- Waddington, Kirsty E.;
- Sofat, Reecha;
- Griffin, Maura;
- Nicolaides, Andrew;
- Isenberg, David A.;
- Torra, Ines Pineda;
- Rahman, Anisur;
- Jury, Elizabeth C.
Publication type:
Article
Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson's disease.
Published in:
2018
By:
- Kia, Demis A.;
- Noyce, Alastair J.;
- White, Jon;
- Speed, Doug;
- Nicolas, Aude;
- IPDGC collaborators;
- Burgess, Stephen;
- Lawlor, Debbie A.;
- Davey Smith, George;
- Singleton, Andrew;
- Nalls, Mike A.;
- Sofat, Reecha;
- Wood, Nicholas W.
Publication type:
journal article
Genetic Determinants of Thiazide‐Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances – A Genome‐Wide Evaluation of the UK Biobank.
Published in:
Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 6, p. 1408, doi. 10.1002/cpt.3229
By:
- Asiimwe, Innocent G.;
- Walker, Lauren;
- Sofat, Reecha;
- Jorgensen, Andrea L.;
- Pirmohamed, Munir
Publication type:
Article
RBCK1‐related disease: A rare multisystem disorder with polyglucosan storage, auto‐inflammation, recurrent infections, skeletal, and cardiac myopathy—Four additional patients and a review of the current literature.
Published in:
Journal of Inherited Metabolic Disease, 2020, v. 43, n. 5, p. 1002, doi. 10.1002/jimd.12234
By:
- Phadke, Rahul;
- Hedberg‐Oldfors, Carola;
- Scalco, Renata S.;
- Lowe, David M.;
- Ashworth, Michael;
- Novelli, Marco;
- Vara, Roshni;
- Merwick, Aine;
- Amer, Halima;
- Sofat, Reecha;
- Sugarman, Max;
- Jovanovic, Ana;
- Roberts, Mark;
- Nakou, Vasiliki;
- King, Andrew;
- Bodi, Istvan;
- Jungbluth, Heinz;
- Oldfors, Anders;
- Murphy, Elaine
Publication type:
Article
Data-driven identification of ageing-related diseases from electronic health records.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-82459-y
By:
- Kuan, Valerie;
- Fraser, Helen C.;
- Hingorani, Melanie;
- Denaxas, Spiros;
- Gonzalez-Izquierdo, Arturo;
- Direk, Kenan;
- Nitsch, Dorothea;
- Mathur, Rohini;
- Parisinos, Constantinos A.;
- Lumbers, R. Thomas;
- Sofat, Reecha;
- Wong, Ian C. K.;
- Casas, Juan P.;
- Thornton, Janet M.;
- Hemingway, Harry;
- Partridge, Linda;
- Hingorani, Aroon D.
Publication type:
Article
Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial.
Published in:
2019
By:
- Hobbs, Adrian J.;
- Moyes, Amie J.;
- Baliga, Reshma S.;
- Ghedia, Dipa;
- Ochiel, Rachel;
- Sylvestre, Yvonne;
- Doré, Caroline J.;
- Chowdhury, Kashfia;
- Maclagan, Kate;
- Quartly, Harriet L.;
- Sofat, Reecha;
- Smit, Angelique;
- Schreiber, Benjamin E.;
- Coghlan, Gerry J.;
- MacAllister, Raymond J.
Publication type:
journal article
Circulating Apolipoprotein E Concentration and Cardiovascular Disease Risk: Meta-analysis of Results from Three Studies.
Published in:
2016
By:
- Sofat, Reecha;
- Cooper, Jackie A.;
- Kumari, Meena;
- Casas, Juan P.;
- Mitchell, Jacqueline P.;
- Acharya, Jayshree;
- Thom, Simon;
- Hughes, Alun D.;
- Humphries, Steve E.;
- Hingorani, Aroon D.
Publication type:
journal article
Evidence of association of APOE with age-related macular degeneration - a pooled analysis of 15 studies.
Published in:
Human Mutation, 2011, v. 32, n. 12, p. 1407, doi. 10.1002/humu.21577
By:
- McKay, Gareth J.;
- Patterson, Chris C.;
- Chakravarthy, Usha;
- Dasari, Shilpa;
- Klaver, Caroline C.;
- Vingerling, Johannes R.;
- Ho, Lintje;
- de Jong, Paulus T.V.M.;
- Fletcher, Astrid E.;
- Young, Ian S.;
- Seland, Johan H.;
- Rahu, Mati;
- Soubrane, Gisele;
- Tomazzoli, Laura;
- Topouzis, Fotis;
- Vioque, Jesus;
- Hingorani, Aroon D.;
- Sofat, Reecha;
- Dean, Michael;
- Sawitzke, Julie
Publication type:
Article
Budget impact analysis of a pilot polypharmacy clinic.
Published in:
British Journal of Healthcare Management, 2022, v. 28, n. 4, p. 1, doi. 10.12968/bjhc.2021.0016
By:
- Bennett, Frances;
- Barron, Andrew;
- Shah, Neha;
- Webb, David J;
- Sofat, Reecha
Publication type:
Article
Metabolic profiles of socio-economic position: a multi-cohort analysis.
Published in:
2021
By:
- Robinson, Oliver;
- Carter, Alice R;
- Ala-Korpela, Mika;
- Casas, Juan P;
- Chaturvedi, Nishi;
- Engmann, Jorgen;
- Howe, Laura D;
- Hughes, Alun D;
- Järvelin, Marjo-Riitta;
- Kähönen, Mika;
- Karhunen, Ville;
- Kuh, Diana;
- Shah, Tina;
- Ben-Shlomo, Yoav;
- Sofat, Reecha;
- Lau, Chung-Ho E;
- Lehtimäki, Terho;
- Menon, Usha;
- Raitakari, Olli;
- Ryan, Andy
Publication type:
journal article
Selecting instruments for Mendelian randomization in the wake of genome-wide association studies.
Published in:
2016
By:
- Swerdlow, Daniel I.;
- Kuchenbaecker, Karoline B.;
- Shah, Sonia;
- Sofat, Reecha;
- Holmes, Michael V.;
- White, Jon;
- Mindell, Jennifer S.;
- Kivimaki, Mika;
- Brunner, Eric J.;
- Whittaker, John C.;
- Casas, Juan P.;
- Hingorani, Aroon D.
Publication type:
journal article
Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype.
Published in:
International Journal of Epidemiology, 2012, v. 41, n. 1, p. 250, doi. 10.1093/ije/dyr204
By:
- Sofat, Reecha;
- Casas, Juan P;
- Webster, Andrew R;
- Bird, Alan C;
- Mann, Samantha S;
- Yates, John RW;
- Moore, Anthony T;
- Sepp, Tiina;
- Cipriani, Valentina;
- Bunce, Catey;
- Khan, Jane C;
- Shahid, Humma;
- Swaroop, Anand;
- Abecasis, Gonçalo;
- Branham, Kari E H;
- Zareparsi, Sepideh;
- Bergen, Arthur A;
- Klaver, Caroline CW;
- Baas, Dominique C;
- Zhang, Kang
Publication type:
Article
Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts.
Published in:
International Journal of Epidemiology, 2009, v. 38, n. 1, p. 217, doi. 10.1093/ije/dyn217
By:
- Tina Shah;
- Juan P Casas;
- Jackie A Cooper;
- Ioanna Tzoulaki;
- Reecha Sofat;
- Valerie McCormack;
- Liam Smeeth;
- John E Deanfield;
- Gordon D Lowe;
- Ann Rumley;
- F Gerald R Fowkes;
- Steve E Humphries;
- Aroon D Hingorani
Publication type:
Article
Influence of common genetic variation on blood lipid levels, cardiovascular risk, and coronary events in two British prospective cohort studies.
Published in:
European Heart Journal, 2013, v. 34, n. 13, p. 972, doi. 10.1093/eurheartj/ehs243
By:
- Shah, Sonia;
- Casas, Juan P.;
- Gaunt, Tom R.;
- Cooper, Jackie;
- Drenos, Fotios;
- Zabaneh, Delilah;
- Swerdlow, Daniel I.;
- Shah, Tina;
- Sofat, Reecha;
- Palmen, Jutta;
- Kumari, Meena;
- Kivimaki, Mika;
- Ebrahim, Shah;
- Smith, George Davey;
- Lawlor, Debbie A.;
- Talmud, Philippa J.;
- Whittaker, John;
- Day, Ian N.M.;
- Hingorani, Aroon D.;
- Humphries, Steve E.
Publication type:
Article
Is it important to measure or reduce C-reactive protein in people at risk of cardiovascular disease?
Published in:
European Heart Journal, 2012, v. 33, n. 18, p. 2258, doi. 10.1093/eurheartj/ehs168
By:
- Hingorani, Aroon D.;
- Sofat, Reecha;
- Morris, Richard W.;
- Whincup, Peter;
- Lowe, Gordon D.;
- Mindell, Jennifer;
- Sattar, Naveed;
- Casas, Juan P.;
- Shah, Tina
Publication type:
Article
Association of a sequence variant in DAB2IP with coronary heart disease.
Published in:
European Heart Journal, 2012, v. 33, n. 7, p. 881, doi. 10.1093/eurheartj/ehr075
By:
- Harrison, Seamus C.;
- Cooper, Jackie A.;
- Li, Kawah;
- Talmud, Phillipa J.;
- Sofat, Reecha;
- Stephens, Jeffery W.;
- Hamsten, Anders;
- Sanders, Julie;
- Montgomery, Hugh;
- Neil, Andrew;
- Humphries, Steve E.
Publication type:
Article

Found: 41