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Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10-2474.
- Published in:
- 2020
- By:
- Publication type:
- journal article
Safety Profile of Eslicarbazepine Acetate as Add-On Therapy in Adults with Refractory Focal-Onset Seizures: From Clinical Studies to 6 Years of Post-Marketing Experience.
- Published in:
- 2017
- By:
- Publication type:
- journal article
Effect of zamicastat on blood pressure and heart rate response to cold pressor test: A double‐blind, randomized, placebo‐controlled study in healthy subjects.
- Published in:
- British Journal of Clinical Pharmacology, 2024, v. 90, n. 11, p. 2781, doi. 10.1111/bcp.16167
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- Publication type:
- Article
A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5-carboxamide derivatives in mouse plasma and brain tissue: Eslicarbazepine acetate, carbamazepine and main metabolites.
- Published in:
- Journal of Separation Science, 2011, v. 34, n. 12, p. 1391, doi. 10.1002/jssc.201100099
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- Publication type:
- Article
In-vivo evaluation of prolonged release bilayer tablets of anti-Parkinson drugs in Göttingen minipigs.
- Published in:
- Journal of Pharmacy & Pharmacology, 2011, v. 63, n. 6, p. 780, doi. 10.1111/j.2042-7158.2011.01278.x
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- Publication type:
- Article
Opicapone pharmacokinetics and pharmacodynamics comparison between healthy Japanese and matched white subjects.
- Published in:
- Clinical Pharmacology in Drug Development, 2016, v. 5, n. 2, p. 150, doi. 10.1002/cpdd.213
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- Publication type:
- Article
Effect of 3 Single-Dose Regimens of Opicapone on Levodopa Pharmacokinetics, Catechol- O-Methyltransferase Activity and Motor Response in Patients With Parkinson Disease.
- Published in:
- Clinical Pharmacology in Drug Development, 2016, v. 5, n. 3, p. 232, doi. 10.1002/cpdd.217
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- Publication type:
- Article
Evaluation of opicapone on cardiac repolarization in a thorough QT/QTc study.
- Published in:
- Clinical Pharmacology in Drug Development, 2015, v. 4, n. 6, p. 454, doi. 10.1002/cpdd.188
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- Publication type:
- Article
Bioequivalence of Eslicarbazepine Acetate from Two Different Sources of its Active Product Ingredient in Healthy Subjects.
- Published in:
- Drugs in R&D, 2013, v. 13, n. 2, p. 137, doi. 10.1007/s40268-013-0016-6
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- Publication type:
- Article
Dosage Form Proportionality and Food Effect of the Final Tablet Formulation of Eslicarbazepine Acetate: Randomized, Open-Label, Crossover, Single-Centre Study in Healthy Volunteers.
- Published in:
- Drugs in R&D, 2008, v. 9, n. 6, p. 447, doi. 10.2165/0126839-200809060-00007
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- Publication type:
- Article
Pharmacokinetic-Pharmacodynamic Interaction between Nebicapone, a Novel Catechol-O-Methyltransferase Inhibitor, and Controlled-Release Levodopa/Carbidopa 200 mg/50 mg Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Subjects.
- Published in:
- Drugs in R&D, 2008, v. 9, n. 6, p. 435, doi. 10.2165/0126839-200809060-00006
- By:
- Publication type:
- Article
Pooled efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: Data from four double-blind placebo-controlled pivotal phase III clinical studies.
- Published in:
- CNS Neuroscience & Therapeutics, 2017, v. 23, n. 12, p. 961, doi. 10.1111/cns.12765
- By:
- Publication type:
- Article
Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug.
- Published in:
- Brain: A Journal of Neurology, 2015, v. 138, n. 2, p. 371, doi. 10.1093/brain/awu339
- By:
- Publication type:
- Article
Eslicarbazepine acetate as adjunctive therapy in patients with uncontrolled partial-onset seizures: Results of a phase III, double-blind, randomized, placebo-controlled trial.
- Published in:
- Epilepsia (Series 4), 2015, v. 56, n. 2, p. 244, doi. 10.1111/epi.12894
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- Publication type:
- Article
Pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine at steady state in healthy volunteers.
- Published in:
- Epilepsia (Series 4), 2013, v. 54, n. 8, p. 1453, doi. 10.1111/epi.12242
- By:
- Publication type:
- Article
Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers.
- Published in:
- Epilepsia (Series 4), 2013, v. 54, n. 1, p. 108, doi. 10.1111/j.1528-1167.2012.03595.x
- By:
- Publication type:
- Article
Efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures: Integrated analysis of pooled data from double-blind phase III clinical studies.
- Published in:
- Epilepsia (Series 4), 2013, v. 54, n. 1, p. 98, doi. 10.1111/j.1528-1167.2012.03605.x
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- Publication type:
- Article
Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across mouse small intestine by the Ussing chamber technique.
- Published in:
- Epilepsia (Series 4), 2012, v. 53, n. 3, p. 529, doi. 10.1111/j.1528-1167.2012.03409.x
- By:
- Publication type:
- Article
Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: A randomized, double-blind, placebo-controlled, parallel-group phase III study.
- Published in:
- Epilepsia (Series 4), 2009, v. 50, n. 3, p. 454, doi. 10.1111/j.1528-1167.2008.01946.x
- By:
- Publication type:
- Article
Eslicarbazepine Acetate: A Double-blind, Add-on, Placebo-controlled Exploratory Trial in Adult Patients with Partial-onset Seizures.
- Published in:
- Epilepsia (Series 4), 2007, v. 48, n. 3, p. 497, doi. 10.1111/j.1528-1167.2007.00984.x
- By:
- Publication type:
- Article
Long-term Effect of Convulsive Behavior on the Density of Adenosine A<sub>1</sub> and A<sub>2A</sub> Receptors in the Rat Cerebral Cortex.
- Published in:
- Epilepsia (Series 4), 2005, v. 46, p. 159, doi. 10.1111/j.1528-1167.2005.01026.x
- By:
- Publication type:
- Article
Opicapone versus placebo in the treatment of Parkinson's disease patients with end-of-dose motor fluctuation-associated pain: rationale and design of the randomised, double-blind OCEAN (OpiCapone Effect on motor fluctuations and pAiN) trial.
- Published in:
- 2022
- By:
- Publication type:
- journal article
Overexpression of Non-Functional LAT1/4F2hc in Renal Proximal Tubular Epithelial Cells from the Spontaneous Hypertensive Rat.
- Published in:
- Cellular Physiology & Biochemistry (Karger AG), 2007, v. 20, n. 5, p. 535, doi. 10.1159/000107537
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- Publication type:
- Article
Dopamine D<sub>1</sub>-like Receptor-Mediated Inhibition of Cl/HCO<sub>3</sub><sup>-</sup> Exchanger Activity in Rat Intestinal Epithelial IEC-6 Cells is Regulated by G Protein-Coupled Receptor Kinase 6 (GRK 6).
- Published in:
- Cellular Physiology & Biochemistry (Karger AG), 2006, v. 18, n. 6, p. 347, doi. 10.1159/000097612
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- Publication type:
- Article
Distinct Signalling Cascades Downstream to G<sub>s</sub>α Coupled Dopamine D<sub>1</sub>-like NHE3 Inhibition in Rat and Opossum Renal Epithelial Cells.
- Published in:
- Cellular Physiology & Biochemistry (Karger AG), 2004, v. 14, n. 1/2, p. 91, doi. 10.1159/000076930
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- Publication type:
- Article
Dopamine D<sub>3</sub> receptor-mediated inhibition of Na<sup>+</sup>/H<sup>+</sup> exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.
- Published in:
- British Journal of Pharmacology, 2004, v. 142, n. 8, p. 1343, doi. 10.1038/sj.bjp.0705893
- By:
- Publication type:
- Article
Intestinal Na<sup>+</sup>–K<sup>+</sup>–ATPase activity and molecular events downstream of interferon-γ receptor stimulation.
- Published in:
- British Journal of Pharmacology, 2004, v. 142, n. 8, p. 1281, doi. 10.1038/sj.bjp.0705895
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- Publication type:
- Article
A Double-Blind, Randomized, Placebo and Active-Controlled Study of Nebicapone for the Treatment of Motor Fluctuations in Parkinson's Disease J. J. Ferreira et al. Nebicapone for the Treatment of Motor Fluctuations in Parkinson's Disease.
- Published in:
- CNS Neuroscience & Therapeutics, 2010, v. 16, n. 6, p. 337, doi. 10.1111/j.1755-5949.2010.00145.x
- By:
- Publication type:
- Article
Discovery of a Potent, Long‐Acting, and CNS‐Active Inhibitor (BIA 10‐2474) of Fatty Acid Amide Hydrolase.
- Published in:
- ChemMedChem, 2018, v. 13, n. 20, p. 2177, doi. 10.1002/cmdc.201800393
- By:
- Publication type:
- Article
Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.
- Published in:
- Analytical & Bioanalytical Chemistry, 2010, v. 397, n. 4, p. 1605, doi. 10.1007/s00216-010-3673-0
- By:
- Publication type:
- Article
Contemporary Options for the Management of Motor Complications in Parkinson's Disease: Updated Clinical Review.
- Published in:
- Drugs, 2019, v. 79, n. 6, p. 593, doi. 10.1007/s40265-019-01098-w
- By:
- Publication type:
- Article
The Added Benefit of Opicapone When Used Early in Parkinson's Disease Patients With Levodopa-Induced Motor Fluctuations: A Post-hoc Analysis of BIPARK-I and -II.
- Published in:
- Frontiers in Neurology, 2021, v. 12, p. 1, doi. 10.3389/fneur.2021.754016
- By:
- Publication type:
- Article
Acute salt loading induces sympathetic nervous system overdrive in mice lacking salt-inducible kinase 1 (SIK1).
- Published in:
- Hypertension Research, 2019, v. 42, n. 8, p. 1114, doi. 10.1038/s41440-019-0249-z
- By:
- Publication type:
- Article
Blood pressure decrease in spontaneously hypertensive rats folowing renal denervation or dopamine β-hydroxylase inhibition with etamicastat.
- Published in:
- Hypertension Research, 2015, v. 38, n. 9, p. 605, doi. 10.1038/hr.2015.50
- By:
- Publication type:
- Article
Blood pressure-decreasing effect of etamicastat alone and in combination with antihypertensive drugs in the spontaneously hypertensive rat.
- Published in:
- Hypertension Research, 2015, v. 38, n. 1, p. 30, doi. 10.1038/hr.2014.143
- By:
- Publication type:
- Article
Stereoselective disposition of S- and R-licarbazepine in mice.
- Published in:
- Chirality, 2008, v. 20, n. 6, p. 796, doi. 10.1002/chir.20546
- By:
- Publication type:
- Article
BIA 3-202, a Novel Catechol-O-Methyltransferase Inhibitor, Reduces the Peripheral O-Methylation of L-DOPA and Enhances Its Availability to the Brain.
- Published in:
- Pharmacology, 2003, v. 68, n. 1, p. 29, doi. 10.1159/000068730
- By:
- Publication type:
- Article
Absorption, metabolism and excretion of opicapone in human healthy volunteers.
- Published in:
- British Journal of Clinical Pharmacology, 2022, v. 88, n. 10, p. 4540, doi. 10.1111/bcp.15383
- By:
- Publication type:
- Article
Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics.
- Published in:
- British Journal of Clinical Pharmacology, 2017, v. 83, n. 3, p. 540, doi. 10.1111/bcp.13156
- By:
- Publication type:
- Article
Opicapone: a short lived and very long acting novel catechol- O-methyltransferase inhibitor following multiple dose administration in healthy subjects.
- Published in:
- British Journal of Clinical Pharmacology, 2013, v. 76, n. 5, p. 763, doi. 10.1111/bcp.12081
- By:
- Publication type:
- Article
Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus.
- Published in:
- BMC Neuroscience, 2014, v. 15, n. 1, p. 22, doi. 10.1186/s12868-014-0134-2
- By:
- Publication type:
- Article
Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus.
- Published in:
- 2014
- By:
- Publication type:
- journal article
Inactivation Mechanism of the Fatty Acid Amide Hydrolase Inhibitor BIA 10‐2474.
- Published in:
- ChemBioChem, 2022, v. 23, n. 20, p. 1, doi. 10.1002/cbic.202200166
- By:
- Publication type:
- Article
Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate.
- Published in:
- Epilepsia Open, 2023, v. 8, n. 3, p. 1190, doi. 10.1002/epi4.12735
- By:
- Publication type:
- Article
Opicapone Use in Clinical Practice across Germany: A Sub-Analysis of the OPTIPARK Study in Parkinson's Disease Patients with Motor Fluctuations.
- Published in:
- European Neurology, 2022, v. 85, n. 5, p. 389, doi. 10.1159/000523771
- By:
- Publication type:
- Article
Complex effects of eslicarbazepine on inhibitory micro networks in chronic experimental epilepsy.
- Published in:
- Epilepsia (Series 4), 2021, v. 62, n. 2, p. 542, doi. 10.1111/epi.16808
- By:
- Publication type:
- Article
Long‐term efficacy and safety of eslicarbazepine acetate monotherapy for adults with newly diagnosed focal epilepsy: An open‐label extension study.
- Published in:
- Epilepsia (Series 4), 2020, v. 61, n. 10, p. 2129, doi. 10.1111/epi.16666
- By:
- Publication type:
- Article
Effects of eslicarbazepine on slow inactivation processes of sodium channels in dentate gyrus granule cells.
- Published in:
- Epilepsia (Series 4), 2018, v. 59, n. 8, p. 1492, doi. 10.1111/epi.14504
- By:
- Publication type:
- Article
Response: Comparing the dosages of lacosamide, eslicarbazepine acetate, and controlled‐release carbamazepine in noninferiority epilepsy monotherapy trials: How much “fair” is “fair”.
- Published in:
- 2018
- By:
- Publication type:
- Letter to the Editor
Efficacy and safety of eslicarbazepine acetate versus controlled‐release carbamazepine monotherapy in newly diagnosed epilepsy: A phase III double‐blind, randomized, parallel‐group, multicenter study.
- Published in:
- Epilepsia (Series 4), 2018, v. 59, n. 2, p. 479, doi. 10.1111/epi.13993
- By:
- Publication type:
- Article