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DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-33394-7
By:
- Shireby, Gemma;
- Dempster, Emma L.;
- Policicchio, Stefania;
- Smith, Rebecca G.;
- Pishva, Ehsan;
- Chioza, Barry;
- Davies, Jonathan P.;
- Burrage, Joe;
- Lunnon, Katie;
- Seiler Vellame, Dorothea;
- Love, Seth;
- Thomas, Alan;
- Brookes, Keeley;
- Morgan, Kevin;
- Francis, Paul;
- Hannon, Eilis;
- Mill, Jonathan
Publication type:
Article
Parallel profiling of DNA methylation and hydroxymethylation highlights neuropathology-associated epigenetic variation in Alzheimer's disease.
Published in:
Clinical Epigenetics, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13148-019-0636-y
By:
- Smith, Adam R.;
- Smith, Rebecca G.;
- Pishva, Ehsan;
- Hannon, Eilis;
- Roubroeks, Janou A. Y.;
- Burrage, Joe;
- Troakes, Claire;
- Al-Sarraj, Safa;
- Sloan, Carolyn;
- Mill, Jonathan;
- van den Hove, Daniel L.;
- Lunnon, Katie
Publication type:
Article
Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue.
Published in:
Clinical Epigenetics, 2017, v. 9, p. 1, doi. 10.1186/s13148-017-0337-3
By:
- Devall, Matthew;
- Smith, Rebecca G.;
- Jeffries, Aaron;
- Hannon, Eilis;
- Davies, Matthew N.;
- Schalkwyk, Leonard;
- Mill, Jonathan;
- Weedon, Michael;
- Lunnon, Katie
Publication type:
Article
Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex.
Published in:
2020
By:
- Shireby, Gemma L;
- Davies, Jonathan P;
- Francis, Paul T;
- Burrage, Joe;
- Walker, Emma M;
- Neilson, Grant W A;
- Dahir, Aisha;
- Thomas, Alan J;
- Love, Seth;
- Smith, Rebecca G;
- Lunnon, Katie;
- Kumari, Meena;
- Schalkwyk, Leonard C;
- Morgan, Kevin;
- Brookes, Keeley;
- Hannon, Eilis;
- Mill, Jonathan
Publication type:
journal article
Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF‐AD study.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 10, p. 6722, doi. 10.1002/alz.14098
By:
- Smith, Rebecca G.;
- Pishva, Ehsan;
- Kouhsar, Morteza;
- Imm, Jennifer;
- Dobricic, Valerija;
- Johannsen, Peter;
- Wittig, Michael;
- Franke, Andre;
- Vandenberghe, Rik;
- Schaeverbeke, Jolien;
- Freund‐Levi, Yvonne;
- Frölich, Lutz;
- Scheltens, Philip;
- Teunissen, Charlotte E.;
- Frisoni, Giovanni;
- Blin, Olivier;
- Richardson, Jill C.;
- Bordet, Régis;
- Engelborghs, Sebastiaan;
- de Roeck, Ellen
Publication type:
Article
Blood‐based multivariate methylation risk score for cognitive impairment and dementia.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 10, p. 6682, doi. 10.1002/alz.14061
By:
- Koetsier, Jarno;
- Cavill, Rachel;
- Reijnders, Rick;
- Harvey, Joshua;
- Homann, Jan;
- Kouhsar, Morteza;
- Deckers, Kay;
- Köhler, Sebastian;
- Eijssen, Lars M. T.;
- van den Hove, Daniel L. A.;
- Demuth, Ilja;
- Düzel, Sandra;
- Smith, Rebecca G.;
- Smith, Adam R.;
- Burrage, Joe;
- Walker, Emma M.;
- Shireby, Gemma;
- Hannon, Eilis;
- Dempster, Emma;
- Frayling, Tim
Publication type:
Article
Blood DNA methylomic signatures associated with CSF biomarkers of Alzheimer's disease in the EMIF‐AD Multimodal Biomarker Discovery study.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080072
By:
- Smith, Rebecca G.;
- Imm, Jennifer L;
- Dobricic, Valerija;
- Sommerer, Yasmine;
- Bos, Isabelle;
- Vos, Stephanie J. B.;
- Verhey, Frans R.J.;
- Scheltens, Philip;
- Engelborgs, Sebastiaan;
- Frisoni, Giovanni B;
- Blin, Olivier;
- Richardson, Jill C;
- Bordet, Régis;
- Tsolaki, Magda;
- Popp, Julius;
- Martinez‐Lage, Pablo;
- Lleo, Alberto;
- Johannsen, Peter;
- Freund‐Levi, Yvonne;
- Lutz, Frölich
Publication type:
Article
A transcriptome‐wide analysis of Alzheimer's disease brain during systemic inflammation.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077446
By:
- Pegoraro, Giulia;
- Smith, Rebecca G.;
- MacBean, Lachlan Ford;
- Smith, Adam R.;
- Boche, Delphine;
- Pishva, Ehsan;
- Lunnon, Katie
Publication type:
Article
Targeted bisulfite sequencing analysis of Alzheimer's disease candidate genes reveals differential methylation across neurofibrillary tangle burden in the prefrontal cortex.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079525
By:
- Wheildon, Greg;
- Smith, Adam R.;
- Soanes, Darren;
- Smith, Rebecca G.;
- Moore, Karen;
- O'Neill, Paul;
- Morgan, Kevin;
- Thomas, Alan J;
- Love, Seth;
- Francis, Paul T;
- Mill, Jonathan;
- Pishva, Ehsan;
- Lunnon, Katie
Publication type:
Article
Targeted bisulfite sequencing analysis of Alzheimer's disease candidate genes reveals differential methylation across neurofibrillary tangle burden in the prefrontal cortex.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079525
By:
- Wheildon, Greg;
- Smith, Adam R.;
- Soanes, Darren;
- Smith, Rebecca G.;
- Moore, Karen;
- O'Neill, Paul;
- Morgan, Kevin;
- Thomas, Alan J;
- Love, Seth;
- Francis, Paul T;
- Mill, Jonathan;
- Pishva, Ehsan;
- Lunnon, Katie
Publication type:
Article
An integrated systems‐level analysis of the molecular changes resulting from systemic infections in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.069193
By:
- MacBean, Lachlan Ford;
- Smith, Adam R.;
- Smith, Rebecca G.;
- Lunnon, Katie
Publication type:
Article
Investigating the molecular consequences of co‐morbidites in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.069267
By:
- MacBean, Lachlan Ford;
- Smith, Adam R.;
- Smith, Rebecca G.;
- Lunnon, Katie
Publication type:
Article
An epigenome wide association study of sub‐phenotypes in Parkinson's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.069252
By:
- Harvey, Joshua;
- Smith, Adam R.;
- Weymouth, Luke Stephen;
- Smith, Rebecca G.;
- Hubbard, Leon;
- Bresner, Kate;
- Pishva, Ehsan;
- Williams, Nigel;
- Lunnon, Katie;
- Creese, Byron
Publication type:
Article
Targeted bisulfite sequencing analysis of candidate genes associated with Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.067703
By:
- Wheildon, Greg;
- Smith, Adam R.;
- Soanes, Darren;
- Smith, Rebecca G.;
- Moore, Karen;
- O'Neill, Paul;
- Morgan, Kevin;
- Thomas, Alan J;
- Francis, Paul T;
- Love, Seth;
- Mill, Jonathan;
- Pishva, Ehsan;
- Lunnon, Katie
Publication type:
Article
DNA methylation profiling across brain regions in Huntington's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.067590
By:
- Wheildon, Greg;
- Weymouth, Luke Stephen;
- Smith, Adam R.;
- Smith, Rebecca G.;
- Troakes, Claire;
- Al‐Sarraj, Safa;
- Lunnon, Katie
Publication type:
Article
An integrated systems‐level analysis of the molecular changes resulting from systemic inflammation and amyloid‐beta immunisation in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.060320
By:
- MacBean, Lachlan Ford;
- Smith, Adam R.;
- Smith, Rebecca G.;
- Boche, Delphine;
- Lunnon, Katie
Publication type:
Article
Targeted bisulfite sequencing analysis of candidate genes associated with Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.052829
By:
- Wheildon, Greg;
- Smith, Adam R.;
- Smith, Rebecca G.;
- Lunnon, Katie
Publication type:
Article
An integrated systems‐level analysis of the molecular changes resulting from systemic inflammation in Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.051373
By:
- MacBean, Lachlan F;
- Smith, Rebecca G.;
- Smith, Adam R.;
- Nicoll, James AR;
- Boche, Delphine;
- Lunnon, Katie
Publication type:
Article
DNA methylation differences associated with peripheral biomarkers in the EMIF‐AD cohort: Biomarkers (non‐neuroimaging) / Novel biomarkers.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045853
By:
- Smith, Rebecca G.;
- Bos, Isabelle;
- Vos, Stephanie J.B.;
- Verhey, Frans R.J.;
- Scheltens, Philip;
- Engelborghs, Sebastiaan;
- Frisoni, Giovanni B.;
- Blin, Olivier;
- Richardson, Jill;
- Bordet, Régis;
- Tsolaki, Magda;
- Popp, Julius;
- Martinez‐Lage, Pablo;
- Lleó, Alberto;
- Johannsen, Peter;
- Freund, Yvonne;
- Frölich, Lutz;
- Vandenberghe, Rik;
- Lovestone, Simon;
- Streffer, Johannes
Publication type:
Article
Epigenomic features related to microglia are associated with attenuated effect of APOE ε4 on Alzheimer's disease risk in humans: Human neuropathology: AD neuropathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.043533
By:
- Ma, Yiyi;
- Yu, Lei;
- Olah, Marta;
- Smith, Rebecca G.;
- Pishva, Ehsan;
- Menon, Vilas;
- Lunnon, Katie;
- Bennett, David A.;
- Klein, Hans‐Ulrich;
- De Jager, Philip L.
Publication type:
Article
O4‐10‐06: INTEGRATED GENETIC‐EPIGENETIC ANALYSES OF ALZHEIMER'S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1261, doi. 10.1016/j.jalz.2019.06.4799
By:
- Smith, Rebecca G.;
- Pishva, Ehsan;
- Shireby, Gemma;
- Smith, Adam R.;
- Hannon, Eilis;
- Sharp, Andrew J.;
- f Mastroeni, Diego;
- Schalkwyk, Leonard C.;
- Haroutunian, Vahram;
- Coleman, Paul D.;
- Bennett, David A.;
- van den Hove, Daniel L.A.;
- De Jager, Philip L.;
- Mill, Jonathan;
- Lunnon, Katie
Publication type:
Article
Elevated DNA methylation across a 48‐kb region spanning the HOXA gene cluster is associated with Alzheimer's disease neuropathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, n. 12, p. 1580, doi. 10.1016/j.jalz.2018.01.017
By:
- Smith, Rebecca G.;
- Hannon, Eilis;
- De Jager, Philip L.;
- Chibnik, Lori;
- Lott, Simon J.;
- Condliffe, Daniel;
- Smith, Adam R.;
- Haroutunian, Vahram;
- Troakes, Claire;
- Al‐Sarraj, Safa;
- Bennett, David A.;
- Powell, John;
- Lovestone, Simon;
- Schalkwyk, Leonard;
- Mill, Jonathan;
- Lunnon, Katie
Publication type:
Article
P2‐143: PSYCHOSIS‐ASSOCIATED EPIGENETIC VARIATION IN PATIENTS WITH ALZHEIMER'S DISEASE ACROSS CORTICAL BRAIN REGIONS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P723, doi. 10.1016/j.jalz.2018.06.829
By:
- Creese, Byron;
- Pishva, Ehsan;
- Proitsi, Petroula;
- Smith, Rebecca G.;
- Ballard, Clive;
- van den Hove, Daniel L.A.;
- Mill, Jonathan;
- Lunnon, Katie
Publication type:
Article
F1‐02‐04: GENOMICS AND EPIGENOMICS ANALYSES IN THE EMIF‐AD MULTIMODAL BIOMARKER DISCOVERY STUDY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P204, doi. 10.1016/j.jalz.2018.06.2310
By:
- Hong, Shengjun;
- Dobricic, Valerija;
- Smith, Rebecca G.;
- Küçükali, Fahri;
- Kilpert, Fabian;
- Bos, Isabelle;
- Vos, Stephanie J.B.;
- Vandenberghe, Rik;
- Scheltens, Philip;
- Engelborghs, Sebastiaan;
- Frisoni, Giovanni B.;
- Blin, Olivier;
- Richardson, Jill;
- Bordet, Régis;
- Tsolaki, Magda;
- Verhey, Frans R.J.;
- Popp, Julius;
- Martinez-Lage, Pablo;
- Lleó, Alberto;
- Johannsen, Peter
Publication type:
Article
Integrating computer-based instruction and peer tutoring.
Published in:
Intervention in School & Clinic, 1997, v. 33, n. 1, p. 65, doi. 10.1177/105345129703300114
By:
- Smith, Rebecca G.
Publication type:
Article
Neonatal DNA methylation and early-onset conduct problems: A genome-wide, prospective study.
Published in:
Development & Psychopathology, 2018, v. 30, n. 2, p. 383, doi. 10.1017/S095457941700092X
By:
- Cecil, Charlotte A. M.;
- Walton, Esther;
- Jaffee, Sara R.;
- O'Connor, Tom;
- Maughan, Barbara;
- Relton, Caroline L.;
- Smith, Rebecca G.;
- McArdle, Wendy;
- Gaunt, Tom R.;
- Ouellet-Morin, Isabelle;
- Barker, Edward D.
Publication type:
Article
A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-23243-4
By:
- Smith, Rebecca G.;
- Pishva, Ehsan;
- Shireby, Gemma;
- Smith, Adam R.;
- Roubroeks, Janou A. Y.;
- Hannon, Eilis;
- Wheildon, Gregory;
- Mastroeni, Diego;
- Gasparoni, Gilles;
- Riemenschneider, Matthias;
- Giese, Armin;
- Sharp, Andrew J.;
- Schalkwyk, Leonard;
- Haroutunian, Vahram;
- Viechtbauer, Wolfgang;
- van den Hove, Daniel L. A.;
- Weedon, Michael;
- Brokaw, Danielle;
- Francis, Paul T.;
- Thomas, Alan J.
Publication type:
Article
Genetic polymorphisms and their association with brain and behavioural measures in heterogeneous stock mice.
Published in:
Scientific Reports, 2017, p. 41204, doi. 10.1038/srep41204
By:
- Janecka, Magdalena;
- Marzi, Sarah J.;
- Parsons, Michael J.;
- Liu, Lin;
- Paya-Cano, Jose L.;
- Smith, Rebecca G.;
- Fernandes, Cathy;
- Schalkwyk, Leonard C.
Publication type:
Article
Advancing Paternal Age Is Associated with Deficits in Social and Exploratory Behaviors in the Offspring: A Mouse Model.
Published in:
PLoS ONE, 2009, v. 4, n. 12, p. 1, doi. 10.1371/journal.pone.0008456
By:
- Smith, Rebecca G.;
- Kember, Rachel L.;
- Mill, Jonathan;
- Fernandes, Cathy;
- Schalkwyk, Leonard C.;
- Buxbaum, Joseph D.;
- Reichenberg, Abraham
Publication type:
Article
Variation in 5-hydroxymethylcytosine across human cortex and cerebellum.
Published in:
Genome Biology, 2016, v. 17, p. 1, doi. 10.1186/s13059-016-0871-x
By:
- Lunnon, Katie;
- Hannon, Eilis;
- Smith, Rebecca G.;
- Dempster, Emma;
- Wong, Chloe;
- Burrage, Joe;
- Troakes, Claire;
- Al-Sarraj, Safa;
- Kepa, Agnieszka;
- Schalkwyk, Leonard;
- Mill, Jonathan
Publication type:
Article
Epigenetics and DNA methylomic profiling in Alzheimer's disease and other neurodegenerative diseases.
Published in:
Journal of Neurochemistry, 2017, v. 143, n. 2, p. 158, doi. 10.1111/jnc.14148
By:
- Roubroeks, Janou A. Y.;
- Smith, Rebecca G.;
- Hove, Daniel L. A.;
- Lunnon, Katie
Publication type:
Article
Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue.
Published in:
Human Molecular Genetics, 2019, v. 28, n. 13, p. 2201, doi. 10.1093/hmg/ddz052
By:
- Wong, Chloe C Y;
- Smith, Rebecca G;
- Hannon, Eilis;
- Ramaswami, Gokul;
- Parikshak, Neelroop N;
- Assary, Elham;
- Troakes, Claire;
- Poschmann, Jeremie;
- Schalkwyk, Leonard C;
- Sun, Wenjie;
- Prabhakar, Shyam;
- Geschwind, Daniel H;
- Mill, Jonathan
Publication type:
Article
Alzheimer's disease-associated (hydroxy)methylomic changes in the brain and blood.
Published in:
Clinical Epigenetics, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13148-019-0755-5
By:
- Lardenoije, Roy;
- Roubroeks, Janou A. Y.;
- Pishva, Ehsan;
- Leber, Markus;
- Wagner, Holger;
- Iatrou, Artemis;
- Smith, Adam R.;
- Smith, Rebecca G.;
- Eijssen, Lars M. T.;
- Kleineidam, Luca;
- Kawalia, Amit;
- Hoffmann, Per;
- Luck, Tobias;
- Riedel-Heller, Steffi;
- Jessen, Frank;
- Maier, Wolfgang;
- Wagner, Michael;
- Hurlemann, René;
- Kenis, Gunter;
- Ali, Muhammad
Publication type:
Article
DNA methylation at the Igf2/H19 imprinting control region is associated with cerebellum mass in outbred mice.
Published in:
Molecular Brain, 2012, v. 5, n. 1, p. 42, doi. 10.1186/1756-6606-5-42
By:
- Pidsley, Ruth;
- Fernandes, Cathy;
- Viana, Joana;
- Paya-Cano, Jose L.;
- Lin Liu;
- Smith, Rebecca G.;
- Schalkwyk, Leonard C.;
- Mill, Jonathan
Publication type:
Article
Altered DNA methylation profiles in blood from patients with sporadic Creutzfeldt–Jakob disease.
Published in:
Acta Neuropathologica, 2020, v. 140, n. 6, p. 863, doi. 10.1007/s00401-020-02224-9
By:
- Dabin, Luke C.;
- Guntoro, Fernando;
- Campbell, Tracy;
- Bélicard, Tony;
- Smith, Adam R.;
- Smith, Rebecca G.;
- Raybould, Rachel;
- Schott, Jonathan M.;
- Lunnon, Katie;
- Sarkies, Peter;
- Collinge, John;
- Mead, Simon;
- Viré, Emmanuelle
Publication type:
Article
Genome-wide characterization of mitochondrial DNA methylation in human brain.
Published in:
Frontiers in Endocrinology, 2023, v. 13, p. 1, doi. 10.3389/fendo.2022.1059120
By:
- Devall, Matthew;
- Soanes, Darren M.;
- Smith, Adam R.;
- Dempster, Emma L.;
- Smith, Rebecca G.;
- Burrage, Joe;
- Iatrou, Artemis;
- Hannon, Eilis;
- Troakes, Claire;
- Moore, Karen;
- O’Neill, Paul;
- Al-Sarraj, Safa;
- Schalkwyk, Leonard;
- Mill, Jonathan;
- Weedon, Michael;
- Lunnon, Katie
Publication type:
Article

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