Works by Smirnovas, Vytautas

Results: 51

PROTEIN AGGREGATION AND NEURONAL LOSS IN EXPERIMENTAL MODELS OF NEURODEGENERATIVE DISORDERS.

Published in:

Neurologijos Seminarai, 2018, v. 22, n. 3, p. 238

By:

Borutaite, Vilmante;
Pampuscenko, Katryna;
Morkuniene, Ramune;
Smirnovas, Vytautas

Publication type:

Article

Cover Feature: Structure‐Activity Relationship of Fluorinated Benzenesulfonamides as Inhibitors of Amyloid‐β Aggregation (Chem. Eur. J. 58/2024).

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 58, p. 1, doi. 10.1002/chem.202485804

By:

Žvirblis, Mantas;
Sakalauskas, Andrius;
Ali Janvand, Saeid Hadi;
Dudutienė, Virginija;
Žiaunys, Mantas;
Sniečkutė, Rūta;
Otzen, Daniel E.;
Smirnovas, Vytautas;
Matulis, Daumantas

Publication type:

Article

Structure‐Activity Relationship of Fluorinated Benzenesulfonamides as Inhibitors of Amyloid‐β Aggregation.

Published in:

Chemistry - A European Journal, 2024, v. 30, n. 58, p. 1, doi. 10.1002/chem.202402330

By:

Žvirblis, Mantas;
Sakalauskas, Andrius;
Ali Janvand, Saeid Hadi;
Dudutienė, Virginija;
Žiaunys, Mantas;
Sniečkutė, Rūta;
Otzen, Daniel E.;
Smirnovas, Vytautas;
Matulis, Daumantas

Publication type:

Article

Protein Amyloidogenesis in the Context of Volume Fluctuations: A Case Study on Insulin.

Published in:

ChemPhysChem, 2006, v. 7, n. 5, p. 1046, doi. 10.1002/cphc.200500717

By:

Vytautas Smirnovas;
Roland Winter;
Theodor Funck;
Wojciech Dzwolak

Publication type:

Article

Study of Insulin Aggregation and Fibril Structure under Different Environmental Conditions.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 17, p. 9406, doi. 10.3390/ijms25179406

By:

Ziaunys, Mantas;
Mikalauskaite, Kamile;
Sakalauskas, Andrius;
Smirnovas, Vytautas

Publication type:

Article

ApoE Isoforms Inhibit Amyloid Aggregation of Proinflammatory Protein S100A9.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 4, p. 2114, doi. 10.3390/ijms25042114

By:

Ghosh, Shamasree;
Tamilselvi, Shanmugam;
Williams, Chloe;
Jayaweera, Sanduni W.;
Iashchishyn, Igor A.;
Šulskis, Darius;
Gilthorpe, Jonathan D.;
Olofsson, Anders;
Smirnovas, Vytautas;
Svedružić, Željko M.;
Morozova-Roche, Ludmilla A.

Publication type:

Article

The Stabilization of S100A9 Structure by Calcium Inhibits the Formation of Amyloid Fibrils.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 17, p. 13200, doi. 10.3390/ijms241713200

By:

Sanders, Ella;
Csondor, Rebecca;
Šulskis, Darius;
Baronaitė, Ieva;
Smirnovas, Vytautas;
Maheswaran, Luckshi;
Horrocks, Jack;
Munro, Rory;
Georgiadou, Christina;
Horvath, Istvan;
Morozova-Roche, Ludmilla A.;
Williamson, Philip T. F.

Publication type:

Article

Conformation-Specific Association of Prion Protein Amyloid Aggregates with Tau Protein Monomers.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9277, doi. 10.3390/ijms24119277

By:

Ziaunys, Mantas;
Mikalauskaite, Kamile;
Krasauskas, Lukas;
Smirnovas, Vytautas

Publication type:

Article

The Major Components of Cerebrospinal Fluid Dictate the Characteristics of Inhibitors against Amyloid-Beta Aggregation.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5991, doi. 10.3390/ijms24065991

By:

Sakalauskas, Andrius;
Ziaunys, Mantas;
Snieckute, Ruta;
Janoniene, Agne;
Veiveris, Dominykas;
Zvirblis, Mantas;
Dudutiene, Virginija;
Smirnovas, Vytautas

Publication type:

Article

Interactions between S100A9 and Alpha-Synuclein: Insight from NMR Spectroscopy.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 12, p. 6781, doi. 10.3390/ijms23126781

By:

Toleikis, Zigmantas;
Bobrovs, Raitis;
Janoniene, Agne;
Lends, Alons;
Ziaunys, Mantas;
Baronaite, Ieva;
Petrauskas, Vytautas;
Kitoka, Kristine;
Smirnovas, Vytautas;
Jaudzems, Kristaps

Publication type:

Article

Lysozyme Amyloid Fibril Structural Variability Dependence on Initial Protein Folding State.

Published in:

International Journal of Molecular Sciences, 2022, v. 23, n. 10, p. 5421, doi. 10.3390/ijms23105421

By:

Mikalauskaite, Kamile;
Ziaunys, Mantas;
Smirnovas, Vytautas

Publication type:

Article

Polymorphism of Alpha-Synuclein Amyloid Fibrils Depends on Ionic Strength and Protein Concentration.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 22, p. 12382, doi. 10.3390/ijms222212382

By:

Ziaunys, Mantas;
Sakalauskas, Andrius;
Mikalauskaite, Kamile;
Smirnovas, Vytautas

Publication type:

Article

Aggregation Condition–Structure Relationship of Mouse Prion Protein Fibrils.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 17, p. 9635, doi. 10.3390/ijms22179635

By:

Fridmanis, Jēkabs;
Toleikis, Zigmantas;
Sneideris, Tomas;
Ziaunys, Mantas;
Bobrovs, Raitis;
Smirnovas, Vytautas;
Jaudzems, Kristaps

Publication type:

Article

Co-Aggregation of S100A9 with DOPA and Cyclen-Based Compounds Manifested in Amyloid Fibril Thickening without Altering Rates of Self-Assembly.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 16, p. 8556, doi. 10.3390/ijms22168556

By:

Arabuli, Lili;
Iashchishyn, Igor A.;
Romanova, Nina V.;
Musteikyte, Greta;
Smirnovas, Vytautas;
Chaudhary, Himanshu;
Svedružić, Željko M.;
Morozova-Roche, Ludmilla A.

Publication type:

Article

S100A9 Alters the Pathway of Alpha-Synuclein Amyloid Aggregation.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 15, p. 7972, doi. 10.3390/ijms22157972

By:

Toleikis, Zigmantas;
Ziaunys, Mantas;
Baranauskiene, Lina;
Petrauskas, Vytautas;
Jaudzems, Kristaps;
Smirnovas, Vytautas

Publication type:

Article

Human Polymerase δ-Interacting Protein 2 (PolDIP2) Inhibits the Formation of Human Tau Oligomers and Fibrils.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 11, p. 5768, doi. 10.3390/ijms22115768

By:

Kasho, Kazutoshi;
Krasauskas, Lukas;
Smirnovas, Vytautas;
Stojkovič, Gorazd;
Morozova-Roche, Ludmilla A.;
Wanrooij, Sjoerd

Publication type:

Article

Variability of Amyloid Propensity in Imperfect Repeats of CsgA Protein of Salmonella enterica and Escherichia coli.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 10, p. 5127, doi. 10.3390/ijms22105127

By:

Szulc, Natalia;
Gąsior-Głogowska, Marlena;
Wojciechowski, Jakub W.;
Szefczyk, Monika;
Żak, Andrzej M.;
Burdukiewicz, Michał;
Kotulska, Malgorzata;
Smirnovas, Vytautas;
Turoverov, Konstantin K.

Publication type:

Article

Temperature-Dependent Structural Variability of Prion Protein Amyloid Fibrils.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 10, p. 5075, doi. 10.3390/ijms22105075

By:

Ziaunys, Mantas;
Sakalauskas, Andrius;
Mikalauskaite, Kamile;
Snieckute, Ruta;
Smirnovas, Vytautas;
Uversky, Vladimir N.

Publication type:

Article

Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer's Disease.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 7, p. 3430, doi. 10.3390/ijms22073430

By:

Paulus, Agnes;
Engdahl, Anders;
Yang, Yiyi;
Boza-Serrano, Antonio;
Bachiller, Sara;
Torres-Garcia, Laura;
Svanbergsson, Alexander;
Garcia, Megg G.;
Gouras, Gunnar K.;
Li, Jia-Yi;
Deierborg, Tomas;
Klementieva, Oxana;
Smirnovas, Vytautas

Publication type:

Article

Lysozyme Fibrils Alter the Mechanism of Insulin Amyloid Aggregation.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 4, p. 1775, doi. 10.3390/ijms22041775

By:

Ziaunys, Mantas;
Sakalauskas, Andrius;
Sneideris, Tomas;
Smirnovas, Vytautas;
Chaudhary, Himanshu;
Morozova-Roche, Ludmilla A.;
Ono, Kenjiro

Publication type:

Article

Self-Replication of Prion Protein Fragment 89-230 Amyloid Fibrils Accelerated by Prion Protein Fragment 107-143 Aggregates.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 19, p. 7410, doi. 10.3390/ijms21197410

By:

Sneideris, Tomas;
Ziaunys, Mantas;
Chu, Brett K.-Y.;
Chen, Rita P.-Y.;
Smirnovas, Vytautas

Publication type:

Article

Effects of Pulsed Electric Fields on Yeast with Prions and the Structure of Amyloid Fibrils.

Published in:

Applied Sciences (2076-3417), 2021, v. 11, n. 6, p. 2684, doi. 10.3390/app11062684

By:

Jurgelevičiūtė, Justina;
Bičkovas, Nedas;
Sakalauskas, Andrius;
Novickij, Vitalij;
Smirnovas, Vytautas;
Lastauskienė, Eglė;
Aggelis, George;
Oh, You-Kwan

Publication type:

Article

Investigating lysozyme amyloid fibril formation and structural variability dependence on its initial folding state under different pH conditions.

Published in:

Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 2, p. 1, doi. 10.1002/pro.4888

By:

Ziaunys, Mantas;
Mikalauskaite, Kamile;
Sakalauskas, Andrius;
Smirnovas, Vytautas

Publication type:

Article

Insulin forms amyloid in a strain-dependent manner: An FT-IR spectroscopic study.

Published in:

Protein Science: A Publication of the Protein Society, 2004, v. 13, n. 7, p. 1927, doi. 10.1110/ps.03607204

By:

Dzwolak, Wojciech;
Smirnovas, Vytautas;
Jansen, Ralf;
Winter, Roland

Publication type:

Article

dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments.

Published in:

Angewandte Chemie, 2024, v. 136, n. 49, p. 1, doi. 10.1002/ange.202407821

By:

Kitoka, Kristine;
Lends, Alons;
Kucinskas, Gytis;
Bula, Anna Lina;
Krasauskas, Lukas;
Smirnovas, Vytautas;
Zilkova, Monika;
Kovacech, Branislav;
Skrabana, Rostislav;
Hritz, Jozef;
Jaudzems, Kristaps

Publication type:

Article

Formation of distinct prion protein amyloid fibrils under identical experimental conditions.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-61663-2

By:

Ziaunys, Mantas;
Sneideris, Tomas;
Smirnovas, Vytautas

Publication type:

Article

Extracellular tau induces microglial phagocytosis of living neurons in cell cultures.

Published in:

Journal of Neurochemistry, 2020, v. 154, n. 3, p. 316, doi. 10.1111/jnc.14940

By:

Pampuscenko, Katryna;
Morkuniene, Ramune;
Sneideris, Tomas;
Smirnovas, Vytautas;
Budvytyte, Rima;
Valincius, Gintaras;
Brown, Guy C.;
Borutaite, Vilmante

Publication type:

Article

The Environment Is a Key Factor in Determining the Anti-Amyloid Efficacy of EGCG.

Published in:

Biomolecules (2218-273X), 2019, v. 9, n. 12, p. 855, doi. 10.3390/biom9120855

By:

Sneideris, Tomas;
Sakalauskas, Andrius;
Sternke-Hoffmann, Rebecca;
Peduzzo, Alessia;
Ziaunys, Mantas;
Buell, Alexander K.;
Smirnovas, Vytautas

Publication type:

Article

Using lysozyme amyloid fibrils as a means of scavenging aggregation‐inhibiting compounds.

Published in:

Biotechnology Journal, 2021, v. 16, n. 9, p. 1, doi. 10.1002/biot.202100138

By:

Ziaunys, Mantas;
Mikalauskaite, Kamile;
Sakalauskas, Andrius;
Smirnovas, Vytautas

Publication type:

Article

Rapid restructurization of conformationally-distinct alpha-synuclein amyloid fibrils at an elevated temperature.

Published in:

PeerJ, 2022, p. 1, doi. 10.7717/peerj.14137

By:

Ziaunys, Mantas;
Sakalauskas, Andrius;
Mikalauskaite, Kamile;
Smirnovas, Vytautas

Publication type:

Article

Interplay between epigallocatechin-3-gallate and ionic strength during amyloid aggregation.

Published in:

PeerJ, 2021, p. 1, doi. 10.7717/peerj.12381

By:

Ziaunys, Mantas;
Mikalauskaite, Kamile;
Sakalauskas, Andrius;
Smirnovas, Vytautas

Publication type:

Article

Exploring the occurrence of thioflavin-T-positive insulin amyloid aggregation intermediates.

Published in:

PeerJ, 2021, p. 1, doi. 10.7717/peerj.10918

By:

Ziaunys, Mantas;
Sakalauskas, Andrius;
Mikalauskaite, Kamile;
Smirnovas, Vytautas

Publication type:

Article

Methylene blue inhibits nucleation and elongation of SOD1 amyloid fibrils.

Published in:

PeerJ, 2020, p. 1, doi. 10.7717/peerj.9719

By:

Musteikyte, Greta;
Ziaunys, Mantas;
Smirnovas, Vytautas

Publication type:

Article

Concentration-dependent polymorphism of insulin amyloid fibrils.

Published in:

PeerJ, 2019, p. 1, doi. 10.7717/peerj.8208

By:

Sakalauskas, Andrius;
Ziaunys, Mantas;
Smirnovas, Vytautas

Publication type:

Article

Exploring the potential of deep-blue autofluorescence for monitoring amyloid fibril formation and dissociation.

Published in:

PeerJ, 2019, p. 1, doi. 10.7717/peerj.7554

By:

Ziaunys, Mantas;
Sneideris, Tomas;
Smirnovas, Vytautas

Publication type:

Article

Emergence of visible light optical properties of L-phenylalanine aggregates.

Published in:

PeerJ, 2019, p. 1, doi. 10.7717/peerj.6518

By:

Ziaunys, Mantas;
Smirnovas, Vytautas

Publication type:

Article

Exploring Epigallocatechin-3-Gallate Autoxidation Products: Specific Incubation Times Required for Emergence of Anti-Amyloid Properties.

Published in:

Antioxidants, 2022, v. 11, n. 10, p. N.PAG, doi. 10.3390/antiox11101887

By:

Ziaunys, Mantas;
Smirnovas, Vytautas

Publication type:

Article

Exploring the Formation of Polymers with Anti-Amyloid Properties within the 2′3′-Dihydroxyflavone Autoxidation Process.

Published in:

Antioxidants, 2022, v. 11, n. 9, p. 1711, doi. 10.3390/antiox11091711

By:

Sakalauskas, Andrius;
Janoniene, Agne;
Zvinys, Gediminas;
Mikalauskaite, Kamile;
Ziaunys, Mantas;
Smirnovas, Vytautas

Publication type:

Article

Autoxidation Enhances Anti-Amyloid Potential of Flavone Derivatives.

Published in:

Antioxidants, 2021, v. 10, n. 9, p. 1428, doi. 10.3390/antiox10091428

By:

Sakalauskas, Andrius;
Ziaunys, Mantas;
Snieckute, Ruta;
Smirnovas, Vytautas

Publication type:

Article

Extracellular tau stimulates phagocytosis of living neurons by activated microglia via Toll-like 4 receptor–NLRP3 inflammasome–caspase-1 signalling axis.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-37887-3

By:

Pampuscenko, Katryna;
Morkuniene, Ramune;
Krasauskas, Lukas;
Smirnovas, Vytautas;
Brown, Guy C.;
Borutaite, Vilmante

Publication type:

Article

Structural organization of brain-derived mammalian prions examined by hydrogen-deuterium exchange.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 4, p. 504, doi. 10.1038/nsmb.2035

By:

Smirnovas, Vytautas;
Baron, Gerald S.;
Offerdahl, Danielle K.;
Raymond, Gregory J.;
Caughey, Byron;
Surewicz, Witold K.

Publication type:

Article

Bioinformatics methods for identification of amyloidogenic peptides show robustness to misannotated training data.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-86530-6

By:

Szulc, Natalia;
Burdukiewicz, Michał;
Gąsior-Głogowska, Marlena;
Wojciechowski, Jakub W.;
Chilimoniuk, Jarosław;
Mackiewicz, Paweł;
Šneideris, Tomas;
Smirnovas, Vytautas;
Kotulska, Malgorzata

Publication type:

Article

Gallic acid oxidation products alter the formation pathway of insulin amyloid fibrils.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-70982-3

By:

Sakalauskas, Andrius;
Ziaunys, Mantas;
Smirnovas, Vytautas

Publication type:

Article

pH-Driven Polymorphism of Insulin Amyloid-Like Fibrils.

Published in:

PLoS ONE, 2015, v. 10, n. 8, p. 1, doi. 10.1371/journal.pone.0136602

By:

Sneideris, Tomas;
Darguzis, Domantas;
Botyriute, Akvile;
Grigaliunas, Martynas;
Winter, Roland;
Smirnovas, Vytautas

Publication type:

Article

Flavone Derivatives as Inhibitors of Insulin Amyloid-Like Fibril Formation.

Published in:

PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0121231

By:

Malisauskas, Ricardas;
Botyriute, Akvile;
Cannon, Jonathan G.;
Smirnovas, Vytautas

Publication type:

Article

Elongation of Mouse Prion Protein Amyloid-Like Fibrils: Effect of Temperature and Denaturant Concentration.

Published in:

PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094469

By:

Milto, Katazyna;
Michailova, Ksenija;
Smirnovas, Vytautas

Publication type:

Article

Amyloid-Like Fibril Elongation Follows Michaelis-Menten Kinetics.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0068684

By:

Milto, Katazyna;
Botyriute, Akvile;
Smirnovas, Vytautas

Publication type:

Article

Distinct Neurotoxic Effects of Extracellular Tau Species in Primary Neuronal-Glial Cultures.

Published in:

Molecular Neurobiology, 2021, v. 58, n. 2, p. 658, doi. 10.1007/s12035-020-02150-7

By:

Pampuscenko, Katryna;
Morkuniene, Ramune;
Krasauskas, Lukas;
Smirnovas, Vytautas;
Tomita, Taisuke;
Borutaite, Vilmante

Publication type:

Article

dGAE(297–391) Tau Fragment Promotes Formation of Chronic Traumatic Encephalopathy‐Like Tau Filaments.

Published in:

Angewandte Chemie International Edition, 2024, v. 63, n. 49, p. 1, doi. 10.1002/anie.202407821

By:

Kitoka, Kristine;
Lends, Alons;
Kucinskas, Gytis;
Bula, Anna Lina;
Krasauskas, Lukas;
Smirnovas, Vytautas;
Zilkova, Monika;
Kovacech, Branislav;
Skrabana, Rostislav;
Hritz, Jozef;
Jaudzems, Kristaps

Publication type:

Article

Solid-state NMR backbone chemical shift assignments of α-synuclein amyloid fibrils at fast MAS regime.

Published in:

Biomolecular NMR Assignments, 2024, v. 18, n. 2, p. 181, doi. 10.1007/s12104-024-10186-2

By:

Toleikis, Zigmantas;
Paluch, Piotr;
Kuc, Ewelina;
Petkus, Jana;
Sulskis, Darius;
Org-Tago, Mai-Liis;
Samoson, Ago;
Smirnovas, Vytautas;
Stanek, Jan;
Lends, Alons

Publication type:

Article