Works matching AU Smalley, Keiran S. M.

Results: 48

Modeling Melanoma Heterogeneity In Vitro: Redox, Resistance and Pigmentation Profiles.

Published in:

Antioxidants, 2024, v. 13, n. 5, p. 555, doi. 10.3390/antiox13050555

By:

Carvalho, Larissa Anastacio da Costa;
Noma, Isabella Harumi Yonehara;
Uehara, Adriana Hiromi;
Siena, Ádamo Davi Diógenes;
Osaki, Luciana Harumi;
Mori, Mateus Prates;
Pinto, Nadja Cristhina de Souza;
Freitas, Vanessa Morais;
Junior, Wilson Araújo Silva;
Smalley, Keiran S. M.;
Maria-Engler, Silvya Stuchi

Publication type:

Article

Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions.

Published in:

Pigment Cell & Melanoma Research, 2020, v. 33, n. 4, p. 527, doi. 10.1111/pcmr.12861

By:

Glitza, Isabella C.;
Smalley, Keiran S. M.;
Brastianos, Priscilla K.;
Davies, Michael A.;
McCutcheon, Ian;
Liu, James K. C.;
Ahmed, Kamran A.;
Arrington, John A.;
Evernden, Brittany R.;
Smalley, Inna;
Eroglu, Zeynep;
Khushalani, Nikhil;
Margolin, Kim;
Kluger, Harriet;
Atkins, Michael B.;
Tawbi, Hussein;
Boire, Adrienne;
Forsyth, Peter

Publication type:

Article

Decitabine limits escape from MEK inhibition in uveal melanoma.

Published in:

Pigment Cell & Melanoma Research, 2020, v. 33, n. 3, p. 507, doi. 10.1111/pcmr.12849

By:

Gonçalves, Jessica;
Emmons, Michael F.;
Faião‐Flores, Fernanda;
Aplin, Andrew E.;
Harbour, J. William;
Licht, Jonathan D.;
Wink, Márcia R.;
Smalley, Keiran S. M.

Publication type:

Article

Frontiers in pigment cell and melanoma research.

Published in:

Pigment Cell & Melanoma Research, 2018, v. 31, n. 6, p. 728, doi. 10.1111/pcmr.12728

By:

Filipp, Fabian V.;
Birlea, Stanca;
Bosenberg, Marcus W.;
Brash, Douglas;
Cassidy, Pamela B.;
Chen, Suzie;
D'Orazio, John A.;
Fujita, Mayumi;
Goh, Boon‐Kee;
Herlyn, Meenhard;
Indra, Arup K.;
Larue, Lionel;
Leachman, Sancy A.;
Le Poole, Caroline;
Liu‐Smith, Feng;
Manga, Prashiela;
Montoliu, Lluis;
Norris, David A.;
Shellman, Yiqun;
Smalley, Keiran S. M.

Publication type:

Article

Vertical inhibition of the MAPK pathway enhances therapeutic responses in NRAS-mutant melanoma.

Published in:

Pigment Cell & Melanoma Research, 2014, v. 27, n. 6, p. 1154, doi. 10.1111/pcmr.12303

By:

Rebecca, Vito W.;
Alicea, Gretchen M.;
Paraiso, Kim H. T.;
Lawrence, Harshani;
Gibney, Geoffrey T.;
Smalley, Keiran S. M.

Publication type:

Article

Inhibition of autophagy enhances the effects of the AKT inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma.

Published in:

Pigment Cell & Melanoma Research, 2014, v. 27, n. 3, p. 465, doi. 10.1111/pcmr.12227

By:

Rebecca, Vito W.;
Massaro, Renato R.;
Fedorenko, Inna V.;
Sondak, Vernon K.;
Anderson, Alexander R. A.;
Kim, Eunjung;
Amaravadi, Ravi K.;
Maria ‐ Engler, Silvya S.;
Messina, Jane L.;
Gibney, Geoffrey T.;
Kudchadkar, Ragini R.;
Smalley, Keiran S. M.

Publication type:

Article

Overcoming melanoma drug resistance through metabolic targeting?

Published in:

Pigment Cell & Melanoma Research, 2013, v. 26, n. 6, p. 793, doi. 10.1111/pcmr.12154

By:

Smalley, Keiran S. M.

Publication type:

Article

Meeting report from the 2011 international melanoma congress, Tampa, Florida.

Published in:

Pigment Cell & Melanoma Research, 2012, v. 25, n. 1, p. E1, doi. 10.1111/j.1755-148X.2011.00943.x

By:

Smalley, Keiran S. M.;
Aplin, Andrew E.;
Flaherty, Keith T.;
Hoeller, Christoph;
Bosserhoff, Anja K.;
Haass, Nikolas K.;
Bosenberg, Marcus;
Ribas, Antoni;
Barnhill, Raymond;
Kudchadkar, Ragini;
Messina, Jane L.

Publication type:

Article

PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas.

Published in:

Pigment Cell & Melanoma Research, 2010, v. 23, n. 6, p. 820, doi. 10.1111/j.1755-148X.2010.00763.x

By:

Lee, John T.;
Li, Ling;
Brafford, Patricia A.;
Van den Eijnden, Marcia;
Halloran, Molly B.;
Sproesser, Katrin;
Haass, Nikolas K.;
Smalley, Keiran S. M.;
Tsai, James;
Bollag, Gideon;
Herlyn, Meenhard

Publication type:

Article

Preclinical and clinical development of targeted therapy in melanoma: attention to schedule.

Published in:

Pigment Cell & Melanoma Research, 2009, v. 22, n. 5, p. 529, doi. 10.1111/j.1755-148X.2009.00607.x

By:

Flaherty, Keith T.;
Smalley, Keiran S. M.

Publication type:

Article

Dabrafenib inhibits the growth of BRAF-WT cancers through CDK16 and NEK9 inhibition.

Published in:

Molecular Oncology, 2018, v. 12, n. 1, p. 74, doi. 10.1002/1878-0261.12152

By:

Phadke, Manali;
Remsing Rix, Lily L.;
Smalley, Inna;
Bryant, Annamarie T.;
Luo, Yunting;
Lawrence, Harshani R.;
Schaible, Braydon J.;
Chen, Yian A.;
Rix, Uwe;
Smalley, Keiran S. M.

Publication type:

Article

Drepmel—A Multi-Omics Melanoma Drug Repurposing Resource for Prioritizing Drug Combinations and Understanding Tumor Microenvironment.

Published in:

Cells (2073-4409), 2022, v. 11, n. 18, p. N.PAG, doi. 10.3390/cells11182894

By:

Thompson, Zachary J.;
Teer, Jamie K.;
Li, Jiannong;
Chen, Zhihua;
Welsh, Eric A.;
Zhang, Yonghong;
Ayoubi, Noura;
Eroglu, Zeynep;
Tan, Aik Choon;
Smalley, Keiran S. M.;
Chen, Yian Ann

Publication type:

Article

Metabolomics of primary cutaneous melanoma and matched adjacent extratumoral microenvironment.

Published in:

PLoS ONE, 2020, v. 15, n. 10, p. 1, doi. 10.1371/journal.pone.0240849

By:

Taylor, Nicholas J.;
Gaynanova, Irina;
Eschrich, Steven A.;
Welsh, Eric A.;
Garrett, Timothy J.;
Beecher, Chris;
Sharma, Ritin;
Koomen, John M.;
Smalley, Keiran S. M.;
Messina, Jane L.;
Kanetsky, Peter A.

Publication type:

Article

Combined BRAF, MEK, and heat‐shock protein 90 inhibition in advanced BRAF V600‐mutant melanoma.

Published in:

Cancer (0008543X), 2024, v. 130, n. 2, p. 232, doi. 10.1002/cncr.35029

By:

Eroglu, Zeynep;
Chen, Y. Ann;
Smalley, Inna;
Li, Jiannong;
Markowitz, Joseph K.;
Brohl, Andrew S.;
Tetteh, Leticia;
Taylor, Hayley;
Sondak, Vernon K.;
Khushalani, Nikhil I.;
Smalley, Keiran S. M.

Publication type:

Article

Dose‐escalation trial of combination dabrafenib, trametinib, and AT13387 in patients with BRAF‐mutant solid tumors.

Published in:

Cancer (0008543X), 2023, v. 129, n. 12, p. 1904, doi. 10.1002/cncr.34730

By:

Mooradian, Meghan J.;
Cleary, James M.;
Giobbie‐Hurder, Anita;
Darville, Lancia N. F.;
Parikh, Aparna;
Buchbinder, Elizabeth I.;
Cohen, Justine V.;
Lawrence, Donald P.;
Shapiro, Geoffrey I.;
Keer, Harold;
Chen, Helen X.;
Ivy, Susan Percy;
Smalley, Keiran S. M.;
Koomen, John M.;
Sullivan, Ryan J.

Publication type:

Article

BRAF Inhibition Generates a Host-Tumor Niche that Mediates Therapeutic Escape.

Published in:

Journal of Investigative Dermatology, 2015, v. 135, n. 12, p. 3115, doi. 10.1038/jid.2015.329

By:

Fedorenko, Inna V;
Wargo, Jennifer A;
Flaherty, Keith T;
Messina, Jane L;
Smalley, Keiran S M

Publication type:

Article

XL888 Limits Vemurafenib-Induced Proliferative Skin Events by Suppressing Paradoxical MAPK Activation.

Published in:

Journal of Investigative Dermatology, 2015, v. 135, n. 10, p. 2542, doi. 10.1038/jid.2015.205

By:

Phadke, Manali;
Gibney, Geoffrey T;
Rich, Carolyn J;
Fedorenko, Inna V;
Chen, Y Ann;
Kudchadkar, Ragini R;
Sondak, Vernon K;
Weber, Jeffrey;
Messina, Jane L;
Smalley, Keiran S M

Publication type:

Article

Mutant BRAF: A Novel Mediator of Microenvironmental Escape in Melanoma?

Published in:

Journal of Investigative Dermatology, 2013, v. 133, n. 5, p. 1135, doi. 10.1038/jid.2012.474

By:

Smalley, Keiran S M

Publication type:

Article

GSK3β Inhibition Blocks Melanoma Cell/Host Interactions by Downregulating N-Cadherin Expression and Decreasing FAK Phosphorylation.

Published in:

Journal of Investigative Dermatology, 2012, v. 132, n. 12, p. 2818, doi. 10.1038/jid.2012.237

By:

John, Jobin K;
Paraiso, Kim H T;
Rebecca, Vito W;
Cantini, Liliana P;
Abel, Ethan V;
Pagano, Nicholas;
Meggers, Eric;
Mathew, Rahel;
Krepler, Clemens;
Izumi, Victoria;
Fang, Bin;
Koomen, John M;
Messina, Jane L;
Herlyn, Meenhard;
Smalley, Keiran S M

Publication type:

Article

Phosphoproteomic analysis of basal and therapy-induced adaptive signaling networks in BRAF and NRAS mutant melanoma.

Published in:

Proteomics, 2015, v. 15, n. 2/3, p. 327, doi. 10.1002/pmic.201400200

By:

Fedorenko, Inna V.;
Fang, Bin;
Munko, Ana Cecelia;
Gibney, Geoffrey T.;
Koomen, John M.;
Smalley, Keiran S. M.

Publication type:

Article

preclinical model of patient-derived cerebrospinal fluid circulating tumor cells for experimental therapeutics in leptomeningeal disease from melanoma.

Published in:

Neuro-Oncology, 2022, v. 24, p. 1673, doi. 10.1093/neuonc/noac054

By:

Law, Vincent;
Chen, Zhihua;
Vena, Francesca;
Smalley, Inna;
Macaulay, Robert;
Evernden, Brittany R;
Tran, Nam;
Pina, Yolanda;
Puskas, John;
Caceres, Gisela;
Bayle, Simon;
Johnson, Joseph;
Liu, James K C;
Etame, Arnold;
Vogelbaum, Michael;
Rodriguez, Paulo;
Duckett, Derek;
Czerniecki, Brian;
Chen, Ann;
Smalley, Keiran S M

Publication type:

Article

SinCHet: a MATLAB toolbox for single cell heterogeneity analysis in cancer.

Published in:

Bioinformatics, 2017, v. 33, n. 18, p. 2951, doi. 10.1093/bioinformatics/btx297

By:

Jiannong Li;
Smalley, Inna;
Schell, Michael J.;
Smalley, Keiran S. M.;
Chen, Y. Ann

Publication type:

Article

HDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis.

Published in:

Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-43519-1

By:

Emmons, Michael F.;
Bennett, Richard L.;
Riva, Alberto;
Gupta, Kanchan;
Carvalho, Larissa Anastasio Da Costa;
Zhang, Chao;
Macaulay, Robert;
Dupéré-Richér, Daphne;
Fang, Bin;
Seto, Edward;
Koomen, John M.;
Li, Jiannong;
Chen, Y. Ann;
Forsyth, Peter A.;
Licht, Jonathan D.;
Smalley, Keiran S. M.

Publication type:

Article

Leptomeningeal disease in melanoma: An update on the developments in pathophysiology and clinical care.

Published in:

Pigment Cell & Melanoma Research, 2024, v. 37, n. 1, p. 51, doi. 10.1111/pcmr.13116

By:

Smalley, Inna;
Boire, Adrienne;
Brastianos, Priscilla;
Kluger, Harriet M.;
Hernando‐Monge, Eva;
Forsyth, Peter A.;
Ahmed, Kamran A.;
Smalley, Keiran S. M.;
Ferguson, Sherise;
Davies, Michael A.;
Glitza Oliva, Isabella C.

Publication type:

Article

Understanding Melanoma Signaling Networks as the Basis for Molecular Targeted Therapy.

Published in:

Journal of Investigative Dermatology, 2010, v. 130, n. 1, p. 28, doi. 10.1038/jid.2009.177

By:

Smalley, Keiran S. M.

Publication type:

Article

Loitering with Intent: New Evidence for the Role of BRAF Mutations in the Proliferation of Melanocytic Lesions.

Published in:

Journal of Investigative Dermatology, 2004, v. 123, n. 4, p. xvi, doi. 10.1111/j.0022-202X.2004.23430.x

By:

Smalley, Keiran S. M.;
Herlyn, Meenhard

Publication type:

Article

Novel Anti-Melanoma Compounds Are Efficacious in A375 Cell Line Xenograft Melanoma Model in Nude Mice.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 9, p. 1276, doi. 10.3390/biom13091276

By:

Velayutham, Sadeeshkumar;
Seerattan, Ryan;
Sultan, Maab;
Seal, Trisha;
Danthurthy, Samaya;
Chinnappan, Baskaran;
Landi, Jessica;
Pearl, Kaitlyn;
Singh, Aveta;
Smalley, Keiran S. M.;
Zaias, Julia;
Choi, Jun Yong;
Minond, Dmitriy

Publication type:

Article

In Vivo Acute Toxicity Studies of Novel Anti-Melanoma Compounds Downregulators of hnRNPH1/H2.

Published in:

Biomolecules (2218-273X), 2023, v. 13, n. 2, p. 349, doi. 10.3390/biom13020349

By:

Velayutham, Sadeeshkumar;
Seal, Trisha;
Danthurthy, Samaya;
Zaias, Julia;
Smalley, Keiran S. M.;
Minond, Dmitriy

Publication type:

Article

Melanoma Biomarkers.

Published in:

Molecular Diagnosis & Therapy, 2010, v. 14, n. 1, p. 283

By:

Haass, Nikolas K.;
Smalley, Keiran S. M.

Publication type:

Article

Melanoma Biomarkers Current Status and Utility in Diagnosis, Prognosis, and Response to Therapy.

Published in:

Molecular Diagnosis & Therapy, 2009, v. 13, n. 5, p. 283, doi. 10.1007/BF03256334

By:

Haass, Nikolas K.;
Smalley, Keiran S. M.

Publication type:

Article

GP100 expression is variable in intensity in melanoma.

Published in:

Cancer Immunology, Immunotherapy, 2024, v. 73, n. 10, p. 1, doi. 10.1007/s00262-024-03776-5

By:

Mann, Jacqueline E.;
Hasson, Nitzan;
Su, David G.;
Adeniran, Adebowale J.;
Smalley, Keiran S. M.;
Djureinovic, Dijana;
Jilaveanu, Lucia B.;
Schoenfeld, David A.;
Kluger, Harriet M.

Publication type:

Article

Melanoma brain metastases: Biological basis and novel therapeutic strategies.

Published in:

Experimental Dermatology, 2022, v. 31, n. 1, p. 31, doi. 10.1111/exd.14286

By:

Phadke, Manali;
Ozgun, Alpaslan;
Eroglu, Zeynep;
Smalley, Keiran S. M.

Publication type:

Article

BAP1 Loss Promotes Suppressive Tumor Immune Microenvironment via Upregulation of PROS1 in Class 2 Uveal Melanomas.

Published in:

Cancers, 2022, v. 14, n. 15, p. 3678, doi. 10.3390/cancers14153678

By:

Kaler, Christopher J.;
Dollar, James J.;
Cruz, Anthony M.;
Kuznetsoff, Jeffim N.;
Sanchez, Margaret I.;
Decatur, Christina L.;
Licht, Jonathan D.;
Smalley, Keiran S. M.;
Correa, Zelia M.;
Kurtenbach, Stefan;
Harbour, J. William

Publication type:

Article

Ipilimumab.

Published in:

2011

By:

Sondak, Vernon K.;
Smalley, Keiran S. M.;
Kudchadkar, Ragini;
Grippon, Seden;
Kirkpatrick, Peter

Publication type:

journal article

Feeling energetic? New strategies to prevent metabolic reprogramming in melanoma.

Published in:

Experimental Dermatology, 2015, v. 24, n. 9, p. 657, doi. 10.1111/exd.12763

By:

Verduzco, Daniel;
Flaherty, Keith T.;
Smalley, Keiran S. M.

Publication type:

Article

Is knowledge about the genetic and epigenetic alterations in melanoma a basis for targeted therapy?

Published in:

Experimental Dermatology, 2006, v. 15, n. 10, p. 844, doi. 10.1111/j.1600-0625.2006.00496.x

By:

Smalley, Keiran S. M.;
Meenhard, Herlyn

Publication type:

Article

A database of reaction monitoring mass spectrometry assays for elucidating therapeutic response in cancer.

Published in:

Proteomics - Clinical Applications, 2011, v. 5, n. 7/8, p. 383, doi. 10.1002/prca.201000115

By:

Remily-Wood, Elizabeth R.;
Liu, Richard Z.;
Xiang, Yun;
Chen, Yi;
Thomas, C. Eric;
Rajyaguru, Neal;
Kaufman, Laura M.;
Ochoa, Joana E.;
Hazlehurst, Lori;
Pinilla-Ibarz, Javier;
Lancet, Jeffrey;
Zhang, Guolin;
Haura, Eric;
Shibata, David;
Yeatman, Timothy;
Smalley, Keiran S. M.;
Dalton, William S.;
Huang, Emina;
Scott, Ed;
Bloom, Gregory C.

Publication type:

Article

The Anti-Melanoma Activity of Dinaciclib, a Cyclin-Dependent Kinase Inhibitor, Is Dependent on p53 Signaling.

Published in:

PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0059588

By:

Desai, Brijal M.;
Villanueva, Jessie;
Nguyen, Thierry-Thien K.;
Lioni, Mercedes;
Xiao, Min;
Kong, Jun;
Krepler, Clemens;
Vultur, Adina;
Flaherty, Keith T.;
Nathanson, Katherine L.;
Smalley, Keiran S. M.;
Herlyn, Meenhard

Publication type:

Article

Improving patient outcomes to targeted therapies in melanoma.

Published in:

2016

By:

Eroglu, Zeynep;
Smalley, Keiran S. M.;
Sondak, Vernon K.

Publication type:

journal article

Targeting Lineage-Specific Functions of NR4A1 for Cancer Immunotherapy.

Published in:

International Journal of Molecular Sciences, 2025, v. 26, n. 11, p. 5266, doi. 10.3390/ijms26115266

By:

Kleberg, Jeremy;
Nataraj, Akhila;
Xiao, Yufeng;
Podder, Bristy R.;
Jin, Zeng;
Tithi, Tanzia Islam;
Zheng, Guangrong;
Smalley, Keiran S. M.;
Moser, Emily K.;
Safe, Stephen;
Maharjan, Chandra K.;
Kolb, Ryan;
Zhang, Weizhou

Publication type:

Article

Similar Biological Activities of Two Isostructural Ruthenium and Osmium Complexes.

Published in:

Chemistry - A European Journal, 2008, v. 14, n. 16, p. 4816, doi. 10.1002/chem.200800294

By:

Maksimoska, Jasna;
Williams, Douglas S.;
Atilla-Gokcumen, G. Ekin;
Smalley, Keiran S. M.;
Carroll, Patrick J.;
Webster, Richard D.;
Filippakopoulos, Panagis;
Knapp, Stefan;
Herlyn, Meenhard;
Meggers, Eric

Publication type:

Article

Up Close and Personal: The Challenges of Precision Medicine in Melanoma.

Published in:

2014

By:

Smalley, Keiran S. M.;
Weber, Jeffrey S.

Publication type:

Editorial

Taming the Wild-Types: Targeting PAK1 in Melanomas That Lack BRAF Mutations.

Published in:

2013

By:

Smalley, Keiran S M;
Weber, Jeffrey S

Publication type:

Journal Article

Taming the Wild-Types: Targeting PAK1 in Melanomas That Lack BRAF Mutations.

Published in:

JNCI: Journal of the National Cancer Institute, 2013, v. 105, n. 9, p. 591, doi. 10.1093/jnci/djt075

By:

Smalley, Keiran S. M.;
Weber, Jeffrey S.

Publication type:

Article

Why do women with melanoma do better than men? Harnessing female sex hormones may improve how all patients with melanoma respond to treatment.

Published in:

eLife, 2018, p. 1, doi. 10.7554/eLife.33511

By:

SMALLEY, KEIRAN S. M.

Publication type:

Article

A Mutational Survey of Acral Nevi.

Published in:

2021

By:

Smalley, Keiran S. M.;
Teer, Jamie K.;
Chen, Y. Ann;
Wu, Jheng-Yu;
Yao, Jiqiang;
Koomen, John M.;
Chen, Wei-Shen;
Rodriguez-Waitkus, Paul;
Karreth, Florian A.;
Messina, Jane L.

Publication type:

journal article

Vemurafenib Potently Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in BRAFV600E Melanoma Cells.

Published in:

Science Signaling, 2013, v. 6, n. 260, p. 1, doi. 10.1126/scisignal.2003057

By:

Beck, Daniela;
Niessner, Heike;
Smalley, Keiran S. M.;
Flaherty, Keith;
Paraiso, Kim H. T.;
Busch, Christian;
Sinnberg, Tobias;
Vasseur, Sophie;
Iovanna, Juan Lucio;
Drießen, Stefan;
Stork, Björn;
Wesselborg, Sebastian;
Schaller, Martin;
Biedermann, Tilo;
Bauer, Jürgen;
Lasithiotakis, Konstantinos;
Weide, Benjamin;
Eberle, Jürgen;
Schittek, Birgit;
Schadendorf, Dirk

Publication type:

Article

K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09844-0

By:

Yin, Qing;
Han, Tao;
Fang, Bin;
Zhang, Guolin;
Zhang, Chao;
Roberts, Evan R.;
Izumi, Victoria;
Zheng, Mengmeng;
Jiang, Shulong;
Yin, Xiu;
Kim, Minjung;
Cai, Jianfeng;
Haura, Eric B.;
Koomen, John M.;
Smalley, Keiran S. M.;
Wan, Lixin

Publication type:

Article