Works by Sleegers, Kristel

Results: 134

NanoSatellite: accurate characterization of expanded tandem repeat length and sequence through whole genome long-read sequencing on PromethION.

Published in:

Genome Biology, 2019, v. 20, n. 1, p. 1, doi. 10.1186/s13059-019-1856-3

By:

De Roeck, Arne;
De Coster, Wouter;
Bossaerts, Liene;
Cacace, Rita;
De Pooter, Tim;
Van Dongen, Jasper;
D'Hert, Svenn;
De Rijk, Peter;
Strazisar, Mojca;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Deciphering a Single‐cell atlas and loss‐of‐function analysis revealing ABCA7's transcriptome insights in Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.092265

By:

De Deyn, Lara;
Duchateau, Lena;
Watzeels, Tijs;
Vicente, Cristina;
Van Dongen, Jasper;
Bijnens, Baukje;
De Pooter, Tim;
De Rijk, Peter;
Strazisar, Mojca;
Vandenberghe, Wim;
Thal, Dietmar Rudolf;
Mancuso, Renzo;
Rademakers, Rosa;
Küçükali, Fahri;
Sleegers, Kristel

Publication type:

Article

Genome‐wide investigation of a neuropathological cohort offers novel insights in the genetic risk underlying hallmark and co‐morbid lesions implicated in Alzheimer's disease.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.092254

By:

Laureyssen, Celeste;
Gawor, Klara;
Van Dongen, Jasper;
Küçükali, Fahri;
Koper, Marta J;
Ronisz, Alicja;
Otto, Markus;
von Arnim, Christine;
Van Damme, Philip;
Vandenberghe, Rik;
Thal, Dietmar Rudolf;
Sleegers, Kristel

Publication type:

Article

Large‐scale Genome‐wide Investigation of Short Tandem Repeats Associated with Alzheimer's Disease Risk.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.091344

By:

Küçükali, Fahri;
Sleegers, Kristel

Publication type:

Article

Discrepancy between Apolipoprotein E genotyping and proteotyping as a result of a nonsense mutation.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.088844

By:

Vandenbroucke, Ina;
Yuri, Tatsushi;
Dobbels, Caroline;
Minczakiewicz, Dagmara;
Kamada, Jo;
Nojima, Hisashi;
Aoyagi, Katsumi;
Van Dongen, Jasper;
Kucukali, Fahri;
Sleegers, Kristel;
Degrieck, Rosina

Publication type:

Article

Connection between APOE4 and tau is mediated via amyloid‐beta and Alzheimer's co‐pathologies in human autopsy brains.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, p. 1, doi. 10.1002/alz.086811

By:

Gawor, Klara;
Verrept, Sam;
Laureyssen, Celeste;
Tomé, Sandra O.;
Vandenberghe, Rik;
Vandenbulcke, Mathieu;
Van Damme, Philip;
von Arnim, Christina;
Otto, Markus;
Ghebremedhin, Estifanos;
Ronisz, Alicja;
Ospitalieri, Simona;
Blaschko, Matthew;
Van Dongen, Jasper;
Sleegers, Kristel;
Thal, Dietmar Rudolf

Publication type:

Article

The ABC's of Alzheimer risk gene ABCA7.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 5, p. 3629, doi. 10.1002/alz.13805

By:

Duchateau, Lena;
Wawrzyniak, Nicole;
Sleegers, Kristel

Publication type:

Article

Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 3, p. 2282, doi. 10.1002/alz.13550

By:

Le Borgne, Julie;
Amouyel, Philippe;
Andreassen, Ole;
Frikke‐Schmidt, Ruth;
Hiltunen, Mikko;
Ingelsson, Martin;
Ramirez, Alfredo;
Rossi, Giacomina;
Ruiz, Agustin;
Sanchez‐Juan, Pascual;
Sims, Rebecca;
Sleegers, Kristel;
Tsolaki, Magda;
van der Lee, Sven J.;
Williams, Julie;
Lambert, Jean‐Charles;
Bellenguez, Céline

Publication type:

Article

Path integration deficits related to Alzheimer's disease pathology in clinically normal older adults.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078924

By:

Colmant, Lise;
Boyer, Emilien;
Gérard, Thomas;
Bierbrauer, Anne;
Kunz, Lukas;
Sleegers, Kristel;
Axmacher, Nikolai;
Lefèvre, Philippe;
Hanseeuw, Bernard J

Publication type:

Article

Guanosine triphosphate cyclohydrolase 1 promoter deletion causes dopa-responsive dystonia.

Published in:

Movement Disorders, 2012, v. 27, n. 11, p. 1451, doi. 10.1002/mds.25147

By:

Theuns, Jessie;
Crosiers, David;
Debaene, Luc;
Nuytemans, Karen;
Meeus, Bram;
Sleegers, Kristel;
Goossens, Dirk;
Corsmit, Ellen;
Elinck, Ellen;
Peeters, Karin;
Mattheijssens, Maria;
Pickut, Barbara;
Del-Favero, Jurgen;
Engelborghs, Sebastiaan;
De Deyn, Peter Paul;
Cras, Patrick;
Van Broeckhoven, Christine

Publication type:

Article

Motor-neuron disease: Rogue gene in the family.

Published in:

Nature, 2009, v. 458, n. 7237, p. 415, doi. 10.1038/458415a

By:

Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Article

Scywalker: scalable end-to-end data analysis workflow for long-read single-cell transcriptome sequencing.

Published in:

Bioinformatics, 2024, v. 40, n. 9, p. 1, doi. 10.1093/bioinformatics/btae549

By:

Rijk, Peter De;
Watzeels, Tijs;
Küçükali, Fahri;
Dongen, Jasper Van;
Faura, Júlia;
Willems, Patrick;
Deyn, Lara De;
Duchateau, Lena;
Grones, Carolin;
Eekhout, Thomas;
Pooter, Tim De;
Joris, Geert;
Rombauts, Stephane;
Rybel, Bert De;
Rademakers, Rosa;
Breusegem, Frank Van;
Strazisar, Mojca;
Sleegers, Kristel;
Coster, Wouter De

Publication type:

Article

Clinical Evidence of Disease Anticipation in Families Segregating a C9orf72 Repeat Expansion.

Published in:

JAMA Neurology, 2017, v. 74, n. 4, p. 445, doi. 10.1001/jamaneurol.2016.4847

By:

Van Mossevelde, Sara;
van der Zee, Julie;
Gijselinck, Ilse;
Sleegers, Kristel;
De Bleecker, Jan;
Sieben, Anne;
Vandenberghe, Rik;
Van Langenhove, Tim;
Baets, Jonathan;
Deryck, Olivier;
Santens, Patrick;
Ivanoiu, Adrian;
Willems, Christiana;
Bäumer, Veerle;
Van den Broeck, Marleen;
Peeters, Karin;
Mattheijssens, Maria;
De Jonghe, Peter;
Cras, Patrick;
Martin, Jean-Jacques

Publication type:

Article

A Report of the First Biennial Meeting on Capita Selecta in Complex Disease Analysis (CSCDA2010), Leuven, Belgium, August 25-27, 2010.

Published in:

Annals of Human Genetics, 2011, v. 75, n. 4, p. 554, doi. 10.1111/j.1469-1809.2011.00659.x

By:

Van Steen, Kristel;
Sleegers, Kristel

Publication type:

Article

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.

Published in:

Nature Genetics, 2009, v. 41, n. 10, p. 1094, doi. 10.1038/ng.439

By:

Lambert, Jean-Charles;
Heath, Simon;
Even, Gael;
Campion, Dominique;
Sleegers, Kristel;
Hiltunen, Mikko;
Combarros, Onofre;
Zelenika, Diana;
Bullido, Maria J.;
Tavernier, Béatrice;
Letenneur, Luc;
Bettens, Karolien;
Berr, Claudine;
Pasquier, Florence;
Fiévet, Nathalie;
Barberger-Gateau, Pascale;
Engelborghs, Sebastiaan;
de Deyn, Peter;
Mateo, Ignacio;
Franck, Ana

Publication type:

Article

Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis.

Published in:

Nature Genetics, 2008, v. 40, n. 1, p. 29, doi. 10.1038/ng.2007.52

By:

van Es, Michael A.;
van Vught, Paul W. J.;
Blauw, Hylke M.;
Franke, Lude;
Saris, Christiaan G. J.;
Van Den Bosch, Ludo;
de Jong, Sonja W.;
de Jong, Vianney;
Baas, Frank;
van't Slot, Ruben;
Lemmens, Robin;
Schelhaas, Helenius J.;
Birve, Anna;
Sleegers, Kristel;
Van Broeckhoven, Christine;
Schymick, Jennifer C.;
Traynor, Bryan J.;
Wokke, John H. J.;
Wijmenga, Cisca;
Robberecht, Wim

Publication type:

Article

Plasma Proteomic Biomarkers Relating to Alzheimer's Disease: A Meta-Analysis Based on Our Own Studies.

Published in:

Frontiers in Aging Neuroscience, 2021, v. 13, p. 1, doi. 10.3389/fnagi.2021.712545

By:

Shi, Liu;
Buckley, Noel J.;
Bos, Isabelle;
Engelborghs, Sebastiaan;
Sleegers, Kristel;
Frisoni, Giovanni B.;
Wallin, Anders;
Lléo, Alberto;
Popp, Julius;
Martinez-Lage, Pablo;
Legido-Quigley, Cristina;
Barkhof, Frederik;
Zetterberg, Henrik;
Visser, Pieter Jelle;
Bertram, Lars;
Lovestone, Simon;
Nevado-Holgado, Alejo J.

Publication type:

Article

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.

Published in:

Molecular Neurodegeneration, 2015, v. 10, n. 1, p. 1, doi. 10.1186/s13024-015-0024-9

By:

Bettens, Karolien;
Vermeulen, Steven;
Van Cauwenberghe, Caroline;
Heeman, Bavo;
Asselbergh, Bob;
Robberecht, Caroline;
Engelborghs, Sebastiaan;
Vandenbulcke, Mathieu;
Vandenberghe, Rik;
De Deyn, Peter Paul;
Cruts, Marc;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Definition of a Threshold for the Plasma Aβ42/Aβ40 Ratio Measured by Single-Molecule Array to Predict the Amyloid Status of Individuals without Dementia.

Published in:

International Journal of Molecular Sciences, 2024, v. 25, n. 2, p. 1173, doi. 10.3390/ijms25021173

By:

Colmant, Lise;
Boyer, Emilien;
Gerard, Thomas;
Sleegers, Kristel;
Lhommel, Renaud;
Ivanoiu, Adrian;
Lefèvre, Philippe;
Kienlen-Campard, Pascal;
Hanseeuw, Bernard

Publication type:

Article

IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 12, p. 4516, doi. 10.3390/ijms21124516

By:

Martins, Soraia;
Müller-Schiffmann, Andreas;
Erichsen, Lars;
Bohndorf, Martina;
Wruck, Wasco;
Sleegers, Kristel;
Van Broeckhoven, Christine;
Korth, Carsten;
Adjaye, James

Publication type:

Article

Cyclin-dependent kinase 5 is associated with risk for Alzheimer’s disease in a Dutch population-based study.

Published in:

Journal of Neurology, 2008, v. 255, n. 5, p. 655, doi. 10.1007/s00415-008-0770-5

By:

Arias-Vásquez, Alejandro;
Aulchenko, Yurii S.;
Isaacs, Aaron;
Van Oosterhout, Andy;
Sleegers, Kristel;
Hofman, Albert;
Van Broeckhoven, Christine;
Oostra, Ben A.;
Breteler, Monique;
Van Duijn, Cornelia M.

Publication type:

Article

Identification and description of three families with familial Alzheimer disease that segregate variants in the SORL1 gene.

Published in:

Acta Neuropathologica Communications, 2017, v. 5, p. 1, doi. 10.1186/s40478-017-0441-9

By:

Thonberg, Håkan;
Huei-Hsin Chiang;
Lilius, Lena;
Forsell, Charlotte;
Lindström, Anna-Karin;
Johansson, Charlotte;
Björkström, Jenny;
Thordardottir, Steinunn;
Sleegers, Kristel;
Van Broeckhoven, Christine;
Rönnbäck, Annica;
Graff, Caroline

Publication type:

Article

High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy.

Published in:

Human Molecular Genetics, 2005, v. 14, n. 21, p. 3281, doi. 10.1093/hmg/ddi361

By:

Rademakers, Rosa;
Melquist, Stacey;
Cruts, Marc;
Theuns, Jessie;
Del-Favero, Jurgen;
Poorkaj, Parvoneh;
Baker, Matt;
Sleegers, Kristel;
Crook, Richard;
De Pooter, Tim;
Kacem, Samira Bel;
Adamson, Jennifer;
Van den Bossche, Dirk;
Van den Broeck, Marleen;
Gass, Jennifer;
Corsmit, Ellen;
De Rijk, Peter;
Thomas, Natalie;
Engelborghs, Sebastiaan;
Heckman, Michael

Publication type:

Article

CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response.

Published in:

Alzheimer's Research & Therapy, 2023, v. 15, n. 1, p. 1, doi. 10.1186/s13195-023-01338-y

By:

Duchateau, Lena;
Küҫükali, Fahri;
De Roeck, Arne;
Wittens, Mandy M. J.;
Temmerman, Joke;
Weets, Ilse;
Timmers, Maarten;
Engelborghs, Sebastiaan;
Bjerke, Maria;
Sleegers, Kristel

Publication type:

Article

Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase.

Published in:

Journal of Neuroscience, 2011, v. 31, n. 5, p. 1885, doi. 10.1523/JNEUROSCI.5757-10.2011

By:

Capell, Anja;
Liebscher, Sabine;
Fellerer, Katrin;
Brouwers, Nathalie;
Willem, Michael;
Lammich, Sven;
Gijselinck, Ilse;
Bittner, Tobias;
Carlson, Aaron M.;
Sasse, Florenz;
Kunze, Brigitte;
Steinmetz, Heinrich;
Jansen, Rolf;
Dormann, Dorothee;
Sleegers, Kristel;
Cruts, Marc;
Herms, Jochen;
Van Broeckhoven, Christine;
Haass, Christian

Publication type:

Article

Association study of cholesterol-related genes in Alzheimer’s disease.

Published in:

Neurogenetics, 2007, v. 8, n. 3, p. 179, doi. 10.1007/s10048-007-0087-z

By:

Wollmer, M.;
Sleegers, Kristel;
Ingelsson, Martin;
Zekanowski, Cezary;
Brouwers, Nathalie;
Maruszak, Aleksandra;
Brunner, Fabienne;
Huynh, Kim-Dung;
Kilander, Lena;
Brundin, Rose-Marie;
Hedlund, Marie;
Giedraitis, Vilmantas;
Glaser, Anna;
Engelborghs, Sebastiaan;
Deyn, Peter;
Kapaki, Elisabeth;
Tsolaki, Magdalini;
Daniilidou, Makrina;
Molyva, Dimitra;
Paraskevas, George

Publication type:

Article

Potent amyloidogenicity and pathogenicity of A?43.

Published in:

Nature Neuroscience, 2011, v. 14, n. 8, p. 1023, doi. 10.1038/nn.2858

By:

Saito, Takashi;
Suemoto, Takahiro;
Brouwers, Nathalie;
Sleegers, Kristel;
Funamoto, Satoru;
Mihira, Naomi;
Matsuba, Yukio;
Yamada, Kazuyuki;
Nilsson, Per;
Takano, Jiro;
Nishimura, Masaki;
Iwata, Nobuhisa;
Van Broeckhoven, Christine;
Ihara, Yasuo;
Saido, Takaomi C.

Publication type:

Article

sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers.

Published in:

EMBO Molecular Medicine, 2016, v. 8, n. 5, p. 466, doi. 10.15252/emmm.201506123

By:

Suárez‐Calvet, Marc;
Kleinberger, Gernot;
Araque Caballero, Miguel Ángel;
Brendel, Matthias;
Rominger, Axel;
Alcolea, Daniel;
Fortea, Juan;
Lleó, Alberto;
Blesa, Rafael;
Gispert, Juan Domingo;
Sánchez‐Valle, Raquel;
Antonell, Anna;
Rami, Lorena;
Molinuevo, José L;
Brosseron, Frederic;
Traschütz, Andreas;
Heneka, Michael T;
Struyfs, Hanne;
Engelborghs, Sebastiaan;
Sleegers, Kristel

Publication type:

Article

Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation.

Published in:

EMBO Molecular Medicine, 2011, v. 3, n. 5, p. 291, doi. 10.1002/emmm.201100138

By:

Zhou, Lujia;
Brouwers, Nathalie;
Benilova, Iryna;
Vandersteen, Annelies;
Mercken, Marc;
Van Laere, Koen;
Van Damme, Philip;
Demedts, David;
Van Leuven, Fred;
Sleegers, Kristel;
Broersen, Kerensa;
Van Broeckhoven, Christine;
Vandenberghe, Rik;
De Strooper, Bart

Publication type:

Article

APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease.

Published in:

Human Mutation, 2009, v. 30, n. 8, p. 1207, doi. 10.1002/humu.21027

By:

Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
Van Miegroet, Helen;
De Deyn, Peter P.;
Theuns, Jessie;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Article

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.

Published in:

Human Mutation, 2009, v. 30, n. 4, p. E570, doi. 10.1002/humu.20990

By:

Sleegers, Kristel;
Brouwers, Nathalie;
Bettens, Karolien;
Engelborghs, Sebastiaan;
van Miegroet, Helen;
De Deyn, Peter P;
Van Broeckhoven, Christine

Publication type:

Article

Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia.

Published in:

Human Mutation, 2009, v. 30, n. 2, p. E338, doi. 10.1002/humu.20909

By:

Sleegers, Kristel;
Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
van Miegroet, Helen;
De Deyn, Peter P;
Van Broeckhoven, Christine

Publication type:

Article

SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population.

Published in:

Human Mutation, 2008, v. 29, n. 5, p. 769, doi. 10.1002/humu.20725

By:

Bettens, Karolien;
Brouwers, Nathalie;
Engelborghs, Sebastiaan;
De Deyn, Peter P.;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.

Published in:

Human Mutation, 2007, v. 28, n. 4, p. 416, doi. 10.1002/humu.9484

By:

van der Zee, Julie;
Le Ber, Isabelle;
Maurer-Stroh, Sebastian;
Engelborghs, Sebastiaan;
Gijselinck, Ilse;
Camuzat, Agnès;
Brouwers, Nathalie;
Vandenberghe, Rik;
Sleegers, Kristel;
Hannequin, Didier;
Dermaut, Bart;
Schymkowitz, Joost;
Campion, Dominique;
Santens, Patrick;
Martin, Jean-Jacques;
Lacomblez, Lucette;
De Pooter, Tim;
Peeters, Karin;
Mattheijssens, Maria;
Vercelletto, Martine

Publication type:

Article

Functional Changes in the Language Network in Response to Increased Amyloid β Deposition in Cognitively Intact Older Adults.

Published in:

Cerebral Cortex, 2016, v. 26, n. 1, p. 358, doi. 10.1093/cercor/bhu286

By:

Adamczuk, Katarzyna;
De Weer, An-Sofie;
Nelissen, Natalie;
Dupont, Patrick;
Sunaert, Stefan;
Bettens, Karolien;
Sleegers, Kristel;
Van Broeckhoven, Christine;
Van Laere, Koen;
Vandenberghe, Rik

Publication type:

Article

Predicting AT(N) pathologies in Alzheimer's disease from blood-based proteomic data using neural networks.

Published in:

Frontiers in Aging Neuroscience, 2022, v. 14, p. 1, doi. 10.3389/fnagi.2022.1040001

By:

Yuting Zhang;
Ghose, Upamanyu;
Buckley, Noel J.;
Engelborghs, Sebastiaan;
Sleegers, Kristel;
Frisoni, Giovanni B.;
Wallin, Anders;
Lleó, Alberto;
Popp, Julius;
Martinez-Lage, Pablo;
Legido-Quigley, Cristina;
Barkhof, Frederik;
Zetterberg, Henrik;
Visser, Pieter Jelle;
Bertram, Lars;
Lovestone, Simon;
Nevado-Holgado, Alejo J.;
Liu Shi

Publication type:

Article

Alteration of gene expression and protein solubility of the PI 5-phosphatase SHIP2 are correlated with Alzheimer's disease pathology progression.

Published in:

Acta Neuropathologica, 2024, v. 147, n. 1, p. 1, doi. 10.1007/s00401-024-02745-7

By:

Ando, Kunie;
Küçükali, Fahri;
Doeraene, Emilie;
Nagaraj, Siranjeevi;
Antonelli, Eugenia Maria;
Thazin Htut, May;
Yilmaz, Zehra;
Kosa, Andreea-Claudia;
Lopez-Guitierrez, Lidia;
Quintanilla-Sánchez, Carolina;
Aydin, Emmanuel;
Ramos, Ana Raquel;
Mansour, Salwa;
Turbant, Sabrina;
Schurmans, Stéphane;
Sleegers, Kristel;
Erneux, Christophe;
Brion, Jean-Pierre;
Leroy, Karelle

Publication type:

Article

Expression of ABCA7 in Alzheimer's disease.

Published in:

Acta Neuropathologica, 2020, v. 139, n. 5, p. 941, doi. 10.1007/s00401-020-02136-8

By:

Sleegers, Kristel

Publication type:

Article

Picalm reduction exacerbates tau pathology in a murine tauopathy model.

Published in:

Acta Neuropathologica, 2020, v. 139, n. 4, p. 773, doi. 10.1007/s00401-020-02125-x

By:

Ando, Kunie;
De Decker, Robert;
Vergara, Cristina;
Yilmaz, Zehra;
Mansour, Salwa;
Suain, Valérie;
Sleegers, Kristel;
de Fisenne, Marie-Ange;
Houben, Sarah;
Potier, Marie-Claude;
Duyckaerts, Charles;
Watanabe, Toshio;
Buée, Luc;
Leroy, Karelle;
Brion, Jean-Pierre

Publication type:

Article

Novel Alzheimer's disease risk genes: exhaustive investigation is paramount.

Published in:

2019

By:

Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Editorial

The role of ABCA7 in Alzheimer's disease: evidence from genomics, transcriptomics and methylomics.

Published in:

Acta Neuropathologica, 2019, v. 138, n. 2, p. 201, doi. 10.1007/s00401-019-01994-1

By:

De Roeck, Arne;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability.

Published in:

Acta Neuropathologica, 2019, v. 137, n. 6, p. 901, doi. 10.1007/s00401-019-01976-3

By:

Cacace, Rita;
Heeman, Bavo;
De Roeck, Arne;
Hoogmartens, Julie;
De Vos, Kristof;
Geerts, Nathalie;
Peeters, Karin;
van der Zee, Julie;
Sleegers, Kristel;
Van Broeckhoven, Christine;
Van Mossevelde, Sara;
Gossye, Helena;
Sieben, Anne;
De Rijk, Peter;
De Coster, Wouter;
Strazisar, Mojca;
De Pooter, Tim;
Vandenberghe, Rik;
C. van Swieten, John;
M. van Duijn, Cornelia

Publication type:

Article

An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer’s disease.

Published in:

Acta Neuropathologica, 2018, v. 135, n. 6, p. 827, doi. 10.1007/s00401-018-1841-z

By:

De Roeck, Arne;
Duchateau, Lena;
Van Dongen, Jasper;
Cacace, Rita;
Bjerke, Maria;
Van den Bossche, Tobi;
Cras, Patrick;
Vandenberghe, Rik;
De Deyn, Peter P.;
Engelborghs, Sebastiaan;
Van Broeckhoven, Christine;
Sleegers, Kristel;
On Behalf of the BELNEU Consortium

Publication type:

Article

The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study.

Published in:

Journal of Alzheimer's Disease, 2010, v. 22, n. 1, p. 247, doi. 10.3233/JAD-2010-100933

By:

Lambert, Jean-Charles;
Sleegers, Kristel;
González-Pérez, Antonio;
Ingelsson, Martin;
Beecham, Gary W.;
Hiltunen, Mikko;
Combarros, Onofre;
Bullido, Maria J.;
Brouwers, Nathalie;
Bettens, Karolien;
Berr, Claudine;
Pasquier, Florence;
Richard, Florence;
DeKosky, Steven T.;
Hannequin, Didier;
Haines, Jonathan L.;
Tognoni, Gloria;
Fiévet, Nathalie;
Dartigues, Jean-François;
Tzourio, Christophe

Publication type:

Article

Contribution of TARDBP to Alzheimer's Disease Genetic Etiology.

Published in:

Journal of Alzheimer's Disease, 2010, v. 21, n. 2, p. 423, doi. 10.3233/JAD-2010-100198

By:

Brouwers, Nathalie;
Bettens, Karolien;
Gijselinck, Ilse;
Engelborghs, Sebastiaan;
Pickut, Barbara A.;
Van Miegroet, Helen;
Montoya, Ana Gil;
Mattheijssens, Maria;
Peeters, Karin;
De Deyn, Peter P.;
Cruts, Marc;
Sleegers, Kristel;
Van Broeckhoven, Christine

Publication type:

Article

Follow-Up Study of Susceptibility Loci for Alzheimer's Disease and Onset Age Identified by Genome-Wide Association.

Published in:

Journal of Alzheimer's Disease, 2010, v. 19, n. 4, p. 1169, doi. 10.3233/JAD-2010-1310

By:

Bettens, Karolien;
Brouwers, Nathalie;
Van Miegroet, Helen;
Gil, Ana;
Engelborghs, Sebastiaan;
De Deyn, Peter P.;
Vandenberghe, Rik;
Van Broeckhoven, Christine;
Sleegers, Kristel

Publication type:

Article

A Study of the SORL1 Gene in Alzheimer's Disease and Cognitive Function.

Published in:

Journal of Alzheimer's Disease, 2009, v. 18, n. 1, p. 51, doi. 10.3233/JAD-2009-1137

By:

Fan Liu;
Ikram, M. Arfan;
Janssens, A. Cecile J. W.;
Schuur, Maaike;
De Koning, Inge;
Isaacs, Aaron;
Struchalin, Maksim;
Uitterlinden, Andre G.;
Den Dunnen, Johan T.;
Sleegers, Kristel;
Bettens, Karolien;
Van Broeckhoven, Christine;
Van Swieten, John;
Hofman, Albert;
Oostra, Ben A.;
Aulchenko, Yurii S.;
Breteler, Monique M. B.;
Van Duijn, Cornelia M.

Publication type:

Article

The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics.

Published in:

Alzheimer's Research & Therapy, 2018, v. 10, n. 1, p. N.PAG, doi. 10.1186/s13195-018-0396-5

By:

Bos, Isabelle;
Vos, Stephanie;
Vandenberghe, Rik;
Scheltens, Philip;
Engelborghs, Sebastiaan;
Frisoni, Giovanni;
Molinuevo, José Luis;
Wallin, Anders;
Lleó, Alberto;
Popp, Julius;
Martinez-Lage, Pablo;
Baird, Alison;
Dobson, Richard;
Legido-Quigley, Cristina;
Sleegers, Kristel;
Van Broeckhoven, Christine;
Bertram, Lars;
ten Kate, Mara;
Barkhof, Frederik;
Zetterberg, Henrik

Publication type:

Article

TDP-43 pathology is associated with increased tau burdens and seeding.

Published in:

Molecular Neurodegeneration, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13024-023-00653-0

By:

Tomé, Sandra O.;
Tsaka, Grigoria;
Ronisz, Alicja;
Ospitalieri, Simona;
Gawor, Klara;
Gomes, Luis Aragão;
Otto, Markus;
von Arnim, Christine A. F.;
Van Damme, Philip;
Van Den Bosch, Ludo;
Ghebremedhin, Estifanos;
Laureyssen, Celeste;
Sleegers, Kristel;
Vandenberghe, Rik;
Rousseau, Frederic;
Schymkowitz, Joost;
Thal, Dietmar Rudolf

Publication type:

Article

TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort.

Published in:

Brain: A Journal of Neurology, 2011, v. 134, n. 3, p. 808, doi. 10.1093/brain/awr007

By:

van der Zee, Julie;
Van Langenhove, Tim;
Kleinberger, Gernot;
Sleegers, Kristel;
Engelborghs, Sebastiaan;
Vandenberghe, Rik;
Santens, Patrick;
Van den Broeck, Marleen;
Joris, Geert;
Brys, Jolien;
Mattheijssens, Maria;
Peeters, Karin;
Cras, Patrick;
De Deyn, Peter P.;
Cruts, Marc;
Van Broeckhoven, Christine

Publication type:

Article