Works by Skálová, Lenka

Results: 73

Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes.

Published in:

Chirality, 2003, v. 15, n. 5, p. 433, doi. 10.1002/chir.10229

By:

Skálová, Lenka;
Král, Radim;
Szotáková, Barbora;
Babú, Yogeeta N.;
Pichard-Garcia, Lydiane;
Wsól, Vladimír

Publication type:

Article

Reduction of flobufen in pig hepatocytes: Effect of pig breed (domestic, wild) and castration.

Published in:

Chirality, 2003, v. 15, n. 3, p. 213, doi. 10.1002/chir.10182

By:

Skálová, Lenka;
Wsól, Vladimír;
Baliharová, Vendula;
Král, Radim;
Szotáková, Barbora;
Velík, Jakub;
Lamka, Jirí

Publication type:

Article

Stereospecificity and stereoselectivity of flobufen metabolic profile in male rats in vitro and in vivo: Phase I of biotransformation.

Published in:

Chirality, 2001, v. 13, n. 10, p. 754, doi. 10.1002/chir.10005

By:

Wsól, Vladimír;
Král, Radim;
Skálová, Lenka;
Szotáková, Barbora;
Trejtnar, František;
Flieger, Miroslav

Publication type:

Article

Biotransformation of flobufen enantiomers in ruminant hepatocytes and subcellular fractions.

Published in:

Chirality, 2001, v. 13, n. 10, p. 760, doi. 10.1002/chir.10014

By:

Skálová, Lenka;
Szotáková, Barbora;
Lamka, Jiří;
Král, Radim;
Vaňková, Ilona;
Baliharová, Vendula;
Wsól, Vladimír

Publication type:

Article

Activity, stereospecificity, and stereoselectivity of microsomal enzymes in dependence on storage and freezing of rat liver samples.

Published in:

Chirality, 2000, v. 12, n. 9, p. 649, doi. 10.1002/1520-636X(2000)12:9<649::AID-CHIR1>3.0.CO;2-4

By:

Skálová, Lenka;
Szotáková, Barbora;
Wsól, Vladimír;
Král, Radim;
Baliharová, Vendula;
Lamka, Jiří

Publication type:

Article

A comparison between stereospecificity of oracin reduction and stereoselectivity of oxidation of 11-dihydrooracin enantiomers in vitro in rat and guinea pig.

Published in:

Chirality, 1999, v. 11, n. 5/6, p. 510, doi. 10.1002/(SICI)1520-636X(1999)11:5/6<510::AID-CHIR26>3.0.CO;2-G

By:

Skálová, Lenka;
Wsól, Vladimír;
Szotáková, Barbora;
Kvasničková, Eva

Publication type:

Article

Sex differences in stereospecificity of oracin reductases in rat in vitro and in vivo.

Published in:

Chirality, 1999, v. 11, n. 5/6, p. 505, doi. 10.1002/(SICI)1520-636X(1999)11:5/6<505::AID-CHIR25>3.0.CO;2-5

By:

Wsól, Vladimír;
Skálová, Lenka;
Szotáková, Barbora;
Trejtnar, František;
Kvasničková, Eva

Publication type:

Article

Flubendazole induces mitotic catastrophe and senescence in colon cancer cells in vitro.

Published in:

Journal of Pharmacy & Pharmacology, 2016, v. 68, n. 2, p. 208, doi. 10.1111/jphp.12503

By:

Králová, Věra;
Hanušová, Veronika;
Rudolf, Emil;
Čáňová, Kristýna;
Skálová, Lenka

Publication type:

Article

The stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes.

Published in:

Journal of Pharmacy & Pharmacology, 2005, v. 57, n. 3, p. 405

By:

Marek Link;
Romana Novotná;
Bohumila Suchanová;
Lenka Skálová;
Vladimír Wsól;
Barbora Szotáková

Publication type:

Article

Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes.

Published in:

Journal of Pharmacy & Pharmacology, 2004, v. 56, n. 2, p. 205

By:

Barbora Szotáková;
Lenka Skálová;
Vendula Baliharová;
Martina Dvorščáková;
Lenka Štorkánová;
Luděk Šišpera;
Vladimír Wsól

Publication type:

Article

Stereospecific reduction of the original anticancer drug oracin in rat extrahepatic tissues.

Published in:

Journal of Pharmacy & Pharmacology, 2003, v. 55, n. 7, p. 1003

By:

Barbora Szotáková;
Lenka Skálová;
Petr Jílek;
Vladimír Buchta;
Vladimír Wsól

Publication type:

Article

Reduction of the Potential Anticancer Drug Oracin in the Rat Liver In-vitro.

Published in:

Journal of Pharmacy & Pharmacology, 2000, v. 52, n. 5, p. 495, doi. 10.1211/0022357001774273

By:

SZOTÁKOVÁ, BARBORA;
SKÁLOVÁ, LENKA;
WSÓL, VLADIMÍR;
KVASNIÈČKOVÁ, EVA

Publication type:

Article

Design, Synthesis, and Biological Evaluation of Isothiosemicarbazones with Antimycobacterial Activity.

Published in:

Archiv der Pharmazie, 2017, v. 350, n. 8, p. n/a, doi. 10.1002/ardp.201700020

By:

Novotná, Eva;
Waisser, Karel;
Kuneš, Jiří;
Palát, Karel;
Skálová, Lenka;
Szotáková, Barbora;
Buchta, Vladimír;
Stolaříková, Jiřina;
Ulmann, Vít;
Pávová, Marcela;
Weber, Jan;
Komrsková, Jitka;
Hašková, Pavlína;
Vokřál, Ivan;
Wsól, Vladimír

Publication type:

Article

The Uptake of Ivermectin and Its Effects in Roots, Leaves and Seeds of Soybean (Glycine max).

Published in:

Molecules, 2020, v. 25, n. 16, p. 3655, doi. 10.3390/molecules25163655

By:

Navrátilová, Martina;
Raisová Stuchlíková, Lucie;
Moťková, Kateřina;
Szotáková, Barbora;
Skálová, Lenka;
Langhansová, Lenka;
Podlipná, Radka;
Guzik, Urszula;
Wojcieszyńska, Danuta

Publication type:

Article

The Effects of Selected Sesquiterpenes from Myrica rubra Essential Oil on the Efficacy of Doxorubicin in Sensitive and Resistant Cancer Cell Lines.

Published in:

Molecules, 2017, v. 22, n. 6, p. 1021, doi. 10.3390/molecules22061021

By:

Ambrož, Martin;
Matoušková, Petra;
Skarka, Adam;
Zajdlová, Martina;
Žáková, Kateřina;
Skálová, Lenka

Publication type:

Article

Nerolidol and Farnesol Inhibit Some Cytochrome P450 Activities but Did Not Affect Other Xenobiotic-Metabolizing Enzymes in Rat and Human Hepatic Subcellular Fractions.

Published in:

Molecules, 2017, v. 22, n. 4, p. 509, doi. 10.3390/molecules22040509

By:

Špičáková, Alena;
Szotáková, Barbora;
Dimunová, Diana;
Myslivečková, Zuzana;
Kubíček, Vladimír;
Ambrož, Martin;
Lněničková, Kateřina;
Krasulová, Kristýna;
Anzenbacher, Pavel;
Skálová, Lenka

Publication type:

Article

Catechins Variously Affect Activities of Conjugation Enzymes in Proliferating and Differentiated Caco-2 Cells.

Published in:

Molecules, 2016, v. 21, n. 9, p. 1186, doi. 10.3390/molecules21091186

By:

Lněničková, Kateřina;
Procházková, Eliška;
Skálová, Lenka;
Matoušková, Petra;
Bártíková, Hana;
Souček, Pavel;
Szotáková, Barbora

Publication type:

Article

The Influence of Sesquiterpenes from Myrica rubra on the Antiproliferative and Pro-Oxidative Effects of Doxorubicin and Its Accumulation in Cancer Cells.

Published in:

Molecules, 2015, v. 20, n. 8, p. 15343, doi. 10.3390/molecules200815343

By:

Ambrož, Martin;
Boušová, Iva;
Skarka, Adam;
Hanušová, Veronika;
Králová, Věra;
Matoušková, Petra;
Szotáková, Barbora;
Skálová, Lenka

Publication type:

Article

Effect of Standardized Cranberry Extract on the Activity and Expression of Selected Biotransformation Enzymes in Rat Liver and Intestine.

Published in:

Molecules, 2014, v. 19, n. 9, p. 14948, doi. 10.3390/molecules190914948

By:

Bártíková, Hana;
Boušová, Iva;
Jedlicková, Pavla;
Lnenicková, Katerina;
Skálová, Lenka;
Szotáková, Barbora

Publication type:

Article

MicroRNAs in the diagnosis and prevention of drug-induced cardiotoxicity.

Published in:

Archives of Toxicology, 2019, v. 93, n. 1, p. 1, doi. 10.1007/s00204-018-2356-z

By:

Skála, Mikuláš;
Hanousková, Barbora;
Skálová, Lenka;
Matoušková, Petra

Publication type:

Article

Hepatotoxicity of monoterpenes and sesquiterpenes.

Published in:

Archives of Toxicology, 2018, v. 92, n. 1, p. 1, doi. 10.1007/s00204-017-2062-2

By:

Zárybnický, Tomáš;
Boušová, Iva;
Ambrož, Martin;
Skálová, Lenka

Publication type:

Article

Inter-species comparisons of hepatic cytochrome P450 enzyme levels in male ruminants.

Published in:

Archives of Toxicology, 2003, v. 77, n. 10, p. 555, doi. 10.1007/s00204-003-0477-4

By:

Machala, Miroslay;
Souček, Pavel;
Neča, Jiří;
Ulrich, Robert;
Lamka, Jiří;
Szotáková, Barbora;
Skálová, Lenka

Publication type:

Article

Influence of diet supplementation with green tea extract on drug-metabolizing enzymes in a mouse model of monosodium glutamate-induced obesity.

Published in:

European Journal of Nutrition, 2016, v. 55, n. 1, p. 361, doi. 10.1007/s00394-015-0856-7

By:

Boušová, Iva;
Matoušková, Petra;
Bártíková, Hana;
Szotáková, Barbora;
Hanušová, Veronika;
Tománková, Veronika;
Anzenbacherová, Eva;
Lišková, Barbora;
Anzenbacher, Pavel;
Skálová, Lenka

Publication type:

Article

The metabolism of flubendazole in human liver and cancer cell lines.

Published in:

Drug Testing & Analysis, 2018, v. 10, n. 7, p. 1139, doi. 10.1002/dta.2369

By:

Stuchlíková, Lucie;
Králová, Věra;
Lněničková, Kateřina;
Zárybnický, Tomáš;
Matoušková, Petra;
Hanušová, Veronika;
Ambrož, Martin;
Šubrt, Zdeněk;
Skálová, Lenka

Publication type:

Article

Comparison of biotransformation and efficacy of aminoacetonitrile anthelmintics in vitro.

Published in:

Drug Testing & Analysis, 2016, v. 8, n. 2, p. 214, doi. 10.1002/dta.1806

By:

Stuchlíková, Lucie;
Lecová, Lenka;
Jirásko, Robert;
Lamka, Jiří;
Vokřál, Ivan;
Szotáková, Barbora;
Holčapek, Michal;
Skálová, Lenka

Publication type:

Article

Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite ( Haemonchus contortus).

Published in:

Drug Testing & Analysis, 2014, v. 6, n. 10, p. 1055, doi. 10.1002/dta.1630

By:

Stuchlíková, Lucie;
Jirásko, Robert;
Vokřál, Ivan;
Valát, Martin;
Lamka, Jiří;
Szotáková, Barbora;
Holčapek, Michal;
Skálová, Lenka

Publication type:

Article

Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa.

Published in:

Parasitology, 2015, v. 142, n. 5, p. 648, doi. 10.1017/S0031182014001711

By:

PRCHAL, LUKÁŠ;
BÁRTÍKOVÁ, HANA;
BEČANOVÁ, ANETA;
JIRÁSKO, ROBERT;
VOKŘÁL, IVAN;
STUCHLÍKOVÁ, LUCIE;
SKÁLOVÁ, LENKA;
KUBÍČEK, VLADIMÍR;
LAMKA, JIŘÍ;
TREJTNAR, FRANTIŠEK;
SZOTÁKOVÁ, BARBORA

Publication type:

Article

The metabolic fate of ivermectin in host (Ovis aries) and parasite (Haemonchus contortus).

Published in:

Parasitology, 2013, v. 140, n. 3, p. 361, doi. 10.1017/S0031182012001680

By:

VOKŘÁL, IVAN;
JEDLIČKOVÁ, VERONIKA;
JIRÁSKO, ROBERT;
STUCHLÍKOVÁ, LUCIE;
BÁRTÍKOVÁ, HANA;
SKÁLOVÁ, LENKA;
LAMKA, JIŘÍ;
HOLČAPEK, MICHAL;
SZOTÁKOVÁ, BARBORA

Publication type:

Article

The metabolism of flubendazole and the activities of selected biotransformation enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics.

Published in:

Parasitology, 2012, v. 139, n. 10, p. 1309, doi. 10.1017/S0031182012000595

By:

VOKŘÁL, IVAN;
BÁRTÍKOVÁ, HANA;
PRCHAL, LUKÁŠ;
STUCHLÍKOVÁ, LUCIE;
SKÁLOVÁ, LENKA;
SZOTÁKOVÁ, BARBORA;
LAMKA, JIŘÍ;
VÁRADY, MARIÁN;
KUBÍČEK, VLADIMÍR

Publication type:

Article

The activity of drug-metabolizing enzymes and the biotransformation of selected anthelmintics in the model tapeworm Hymenolepis diminuta.

Published in:

Parasitology, 2012, v. 139, n. 6, p. 809, doi. 10.1017/S0031182011002265

By:

BÁRTÍKOVÁ, HANA;
VOKŘÁL, IVAN;
SKÁLOVÁ, LENKA;
KUBÍČEK, VLADIMÍR;
FIRBASOVÁ, JANA;
BRIESTENSKÝ, DAVID;
LAMKA, JIŘÍ;
SZOTÁKOVÁ, BARBORA

Publication type:

Article

Carbonyl Reduction of Flubendazole in the Human Liver: Strict Stereospecificity, Sex Difference, Low Risk of Drug Interactions.

Published in:

Frontiers in Pharmacology, 2019, p. N.PAG, doi. 10.3389/fphar.2019.00600

By:

Kubíček, Vladimír;
Skálová, Lenka;
Skarka, Adam;
Králová, Věra;
Holubová, Jana;
Štěpánková, Jana;
Šubrt, Zdeněk;
Szotáková, Barbora

Publication type:

Article

Phenotypic screening of the 'Kurz-box' of chemicals identifies two compounds (BLK127 and HBK4) with anthelmintic activity in vitro against parasitic larval stages of Haemonchus contortus.

Published in:

Parasites & Vectors, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13071-019-3426-7

By:

Nguyen, Linh Thuy;
Kurz, Thomas;
Preston, Sarah;
Brueckmann, Hjoerdis;
Lungerich, Beate;
Herath, H. M. P. Dilrukshi;
Koehler, Anson V.;
Wang, Tao;
Skálová, Lenka;
Jabbar, Abdul;
Gasser, Robin B.

Publication type:

Article

Investigation of the metabolism of monepantel in ovine hepatocytes by UHPLC/MS/MS.

Published in:

Analytical & Bioanalytical Chemistry, 2013, v. 405, n. 5, p. 1705, doi. 10.1007/s00216-012-6584-4

By:

Stuchlíková, Lucie;
Jirásko, Robert;
Vokřál, Ivan;
Lamka, Jiří;
Špulák, Marcel;
Holčapek, Michal;
Szotáková, Barbora;
Bártíková, Hana;
Pour, Milan;
Skálová, Lenka

Publication type:

Article

The Modulation of Phase II Drug-Metabolizing Enzymes in Proliferating and Differentiated CaCo-2 Cells by Hop-Derived Prenylflavonoids.

Published in:

Nutrients, 2020, v. 12, n. 7, p. 2138, doi. 10.3390/nu12072138

By:

Lněničková, Kateřina;
Šadibolová, Michaela;
Matoušková, Petra;
Szotáková, Barbora;
Skálová, Lenka;
Boušová, Iva

Publication type:

Article

The Hepatotoxicity of Alantolactone and Germacrone: Their Influence on Cholesterol and Lipid Metabolism in Differentiated HepaRG Cells.

Published in:

Nutrients, 2020, v. 12, n. 6, p. 1720, doi. 10.3390/nu12061720

By:

Zárybnický, Tomáš;
Matoušková, Petra;
Skálová, Lenka;
Boušová, Iva

Publication type:

Article

Antiproliferative Effects of Hop-derived Prenylflavonoids and Their Influence on the Efficacy of Oxaliplatine, 5-fluorouracil and Irinotecan in Human ColorectalC Cells.

Published in:

Nutrients, 2019, v. 11, n. 4, p. 879, doi. 10.3390/nu11040879

By:

Ambrož, Martin;
Lněničková, Kateřina;
Matoušková, Petra;
Skálová, Lenka;
Boušová, Iva

Publication type:

Article

Sertraline as a new potential anthelmintic against Haemonchus contortus: toxicity, efficacy, and biotransformation.

Published in:

Veterinary Research, 2021, v. 52, n. 1, p. 1, doi. 10.1186/s13567-021-01012-x

By:

Zajíčková, Markéta;
Prchal, Lukáš;
Navrátilová, Martina;
Vodvárková, Nikola;
Matoušková, Petra;
Vokřál, Ivan;
Nguyen, Linh Thuy;
Skálová, Lenka

Publication type:

Article

The ATP bioluminescence assay: a new application and optimization for viability testing in the parasitic nematode Haemonchus contortus.

Published in:

Veterinary Research, 2021, v. 52, n. 1, p. 1, doi. 10.1186/s13567-021-00980-4

By:

Nguyen, Linh Thuy;
Zajíčková, Markéta;
Mašátová, Eva;
Matoušková, Petra;
Skálová, Lenka

Publication type:

Article

Sub-lethal doses of albendazole induce drug metabolizing enzymes and increase albendazole deactivation in Haemonchus contortus adults.

Published in:

Veterinary Research, 2020, v. 51, n. 1, p. 1, doi. 10.1186/s13567-020-00820-x

By:

Kellerová, Pavlína;
Raisová Stuchlíková, Lucie;
Matoušková, Petra;
Štěrbová, Karolína;
Lamka, Jiří;
Navrátilová, Martina;
Vokřál, Ivan;
Szotáková, Barbora;
Skálová, Lenka

Publication type:

Article

Effect of Green Tea Extract-Enriched Diets on Insulin and Leptin Levels, Oxidative Stress Parameters and Antioxidant Enzymes Activities in Obese Mice.

Published in:

Polish Journal of Food & Nutrition Sciences, 2017, v. 67, n. 3, p. 233, doi. 10.1515/pjfns-2017-0004

By:

Bártíková, Hana;
Boušová, Iva;
Matoušková, Petra;
Szotáková, Barbora;
Skálová, Lenka

Publication type:

Article

Soybean (Glycine max) Is Able to Absorb, Metabolize and Accumulate Fenbendazole in All Organs Including Beans.

Published in:

International Journal of Molecular Sciences, 2021, v. 22, n. 13, p. 6647, doi. 10.3390/ijms22136647

By:

Podlipná, Radka;
Navrátilová, Martina;
Raisová Stuchlíková, Lucie;
Moťková, Kateřina;
Langhansová, Lenka;
Skálová, Lenka;
Szotáková, Barbora

Publication type:

Article

The Identification of Metabolites and Effects of Albendazole in Alfalfa (Medicago sativa).

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 16, p. 5943, doi. 10.3390/ijms21165943

By:

Raisová Stuchlíková, Lucie;
Navrátilová, Martina;
Langhansová, Lenka;
Moťková, Kateřina;
Podlipná, Radka;
Szotáková, Barbora;
Skálová, Lenka

Publication type:

Article

Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver.

Published in:

International Journal of Molecular Sciences, 2019, v. 20, n. 18, p. 4562, doi. 10.3390/ijms20184562

By:

Šadibolová, Michaela;
Zárybnický, Tomáš;
Smutný, Tomáš;
Pávek, Petr;
Šubrt, Zdeněk;
Matoušková, Petra;
Skálová, Lenka;
Boušová, Iva

Publication type:

Article

Inter-Individual Variability in Acute Toxicity of R-Pulegone and R-Menthofuran in Human Liver Slices and Their Influence on miRNA Expression Changes in Comparison to Acetaminophen.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 6, p. 1805, doi. 10.3390/ijms19061805

By:

Zárybnický, Tomáš;
Matoušková, Petra;
Lancošová, Bibiána;
Šubrt, Zdeněk;
Skálová, Lenka;
Boušová, Iva

Publication type:

Article

MicroRNAs as Potential Regulators of Glutathione Peroxidases Expression and Their Role in Obesity and Related Pathologies.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 4, p. 1199, doi. 10.3390/ijms19040000

By:

Matoušková, Petra;
Hanousková, Barbora;
Skálová, Lenka

Publication type:

Article

LC–MS–MS identification of albendazole and flubendazole metabolites formed ex vivo by Haemonchus contortus.

Published in:

Analytical & Bioanalytical Chemistry, 2008, v. 391, n. 1, p. 337, doi. 10.1007/s00216-008-1863-9

By:

Cvilink, Viktor;
Skálová, Lenka;
Szotáková, Barbora;
Lamka, Jiří;
Kostiainen, Risto;
Ketola, Raimo A.

Publication type:

Article

The Effect of the Manure from Sheep Treated with Anthelmintics on Clover (Trifolium pratense).

Published in:

Agronomy, 2021, v. 11, n. 9, p. 1892, doi. 10.3390/agronomy11091892

By:

Langhansová, Lenka;
Navrátilová, Martina;
Skálová, Lenka;
Moťková, Kateřina;
Podlipná, Radka

Publication type:

Article

UDP-Glycosyltransferases and Albendazole Metabolism in the Juvenile Stages of Haemonchus contortus.

Published in:

Frontiers in Physiology, 2020, v. 11, p. N.PAG, doi. 10.3389/fphys.2020.594116

By:

Kellerová, Pavlína;
Navrátilová, Martina;
Nguyen, Linh Thuy;
Dimunová, Diana;
Raisová Stuchlíková, Lucie;
Štěrbová, Karolína;
Skálová, Lenka;
Matoušková, Petra

Publication type:

Article

Assessing the Anthelmintic Candidates BLK127 and HBK4 for Their Efficacy on Haemonchus contortus Adults and Eggs, and Their Hepatotoxicity and Biotransformation.

Published in:

Pharmaceutics, 2022, v. 14, n. 4, p. N.PAG, doi. 10.3390/pharmaceutics14040754

By:

Zajíčková, Markéta;
Prchal, Lukáš;
Vokřál, Ivan;
Nguyen, Linh Thuy;
Kurz, Thomas;
Gasser, Robin;
Bednářová, Klára;
Mičundová, Magdalena;
Lungerich, Beate;
Michel, Oliver;
Skálová, Lenka

Publication type:

Article

Reference Genes for Real-Time PCR Quantification of Messenger RNAs and MicroRNAs in Mouse Model of Obesity.

Published in:

PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0086033

By:

Matoušková, Petra;
Bártíková, Hana;
Boušová, Iva;
Hanušová, Veronika;
Szotáková, Barbora;
Skálová, Lenka

Publication type:

Article