Works by Sisodia, Sangram S.

Results: 65

In Memoriam of Edward H. Koo, MD 1954–2025.

Published in:

Molecular Neurodegeneration, 2025, v. 20, n. 1, p. 1, doi. 10.1186/s13024-025-00862-9

By:

Zheng, Hui;
Galasko, Douglas;
Sisodia, Sangram S.

Publication type:

Article

Plug-Based Microfluidics with Defined Surface Chemistry to Miniaturize and Control Aggregation of Amyloidogenic Peptides.

Published in:

Angewandte Chemie International Edition, 2009, v. 48, n. 8, p. 1487, doi. 10.1002/anie.200805225

By:

Meier, Matthias;
Kennedy-Darling, Julia;
Choi, Se Hoon;
Norstrom, Eric M.;
Sisodia, Sangram S.;
Ismagilov, Rustem F.

Publication type:

Article

Transgenic Mouse Models of Alzheimer's Disease and Amyotrophic Lateral Sclerosis.

Published in:

Brain Pathology, 1998, v. 8, n. 4, p. 735, doi. 10.1111/j.1750-3639.1998.tb00198.x

By:

Borchelt, David R.;
Wong, Philip C.;
Sisodia, Sangram S.;
Price, Donald L.

Publication type:

Article

Inherited Neurodegenerative Diseases and Transgenic Models.

Published in:

Brain Pathology, 1996, v. 6, n. 4, p. 467, doi. 10.1111/j.1750-3639.1996.tb00876.x

By:

Price, Donald L.;
Becher, Mark W.;
Wong, Philip C.;
Borchelt, David R.;
Lee, Michael K.;
Sisodia, Sangram S.

Publication type:

Article

Aged Non-Human Primates: An Animal Model of Age-Associated Neurodegenerative Disease.

Published in:

Brain Pathology, 1991, v. 1, n. 4, p. 287, doi. 10.1111/j.1750-3639.1991.tb00672.x

By:

Price, Donald L.;
Martin, Lee J.;
Sisodia, Sangram S.;
Wagster, Molly V.;
Koo, Edward H.;
Walker, Lary C.;
Koliatsos, Vassilis E.;
Cork, Linda C.

Publication type:

Article

Aβ star: a light onto synaptic dysfunction?

Published in:

Nature Medicine, 2006, v. 12, n. 7, p. 760, doi. 10.1038/nm0706-760

By:

Seong-Hun Kim;
Ya-Ping Tang;
Sisodia, Sangram S

Publication type:

Article

Alzheimer disease ? when and why?

Published in:

Nature Genetics, 1998, v. 19, n. 4, p. 314, doi. 10.1038/1196

By:

Price, Donald L;
Sisodia, Sangram S;
Borchelt, David R

Publication type:

Article

Biogenesis of γ-secretase early in the secretory pathway.

Published in:

Journal of Cell Biology, 2007, v. 179, n. 5, p. 951, doi. 10.1083/jcb.200709012

By:

Kim, Jinoh;
Kleizen, Bertrand;
Choy, Regina;
Thinakaran, Gopal;
Sisodia, Sangram S.;
Schekman, Randy W.

Publication type:

Article

Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.

Published in:

Nature Neuroscience, 1999, v. 2, n. 11, p. 984, doi. 10.1038/14783

By:

Kim, Seong-Hun;
Wang, Rong;
Gordon, David J.;
Bass, Joseph;
Steiner, Donald F.;
Lynn, David G.;
Thinakaran, Gopal;
Meredith, Stephen C.;
Sisodia, Sangram S.

Publication type:

Article

Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.

Published in:

Nature Neuroscience, 1999, v. 2, n. 8, p. 695, doi. 10.1038/11154

By:

Lamb, Bruce A.;
Bardel, Kimberly A.;
Kulnane, Laura S.;
Anderson, Jeff J.;
Holtz, Greg;
Wagner, Steven L.;
Sisodia, Sangram S.;
Hoeger, Emily J.

Publication type:

Article

Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo.

Published in:

PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0028179

By:

Tong Li;
Yue-Ming Li;
Ahn, Kwangwook;
Price, Donald L.;
Sisodia, Sangram S.;
Wong, Philip C.

Publication type:

Article

Expression of a Familial Alzheimer's Disease-Linked Presenilin-1 Variant Enhances Perforant Pathway Lesion-Induced Neuronal Loss in the Entorhinal Cortex.

Published in:

Journal of Neuroscience, 2006, v. 26, n. 2, p. 429, doi. 10.1523/JNEUROSCI.3961-05.2006

By:

Lazarov, Orly;
Peterson, Letia D.;
Peterson, Daniel A.;
Sisodia, Sangram S.

Publication type:

Article

Nigrostriatal Dysfunction in Familial Alzheimer's Disease-Linked APPswe/PS1ΔE9 Transgenic Mice.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 44, p. 10220, doi. 10.1523/JNEUROSCI.2773-05.2005

By:

Perez, Sylvia E.;
Lazarov, Orly;
Koprich, James B.;
Er-Yun Chen;
Rodriguez-Menendez, Virginia;
Lipton, Jack W.;
Sisodia, Sangram S.;
Mufson, Elliott J.

Publication type:

Article

Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 9, p. 2386, doi. 10.1523/JNEUROSCI.3089-04.2005

By:

Lazarov, Orly;
Morfini, Gerardo A.;
Lee, Edward B.;
Farah, Mohamed H.;
Szodorai, Anita;
DeBoer, Scott R.;
Koliatsos, Vassilis E.;
Kins, Stefan;
Lee, Virginia M.-Y.;
Wong, Philip C.;
Price, Donald L.;
Brady, Scott T.;
Sisodia, Sangram S.

Publication type:

Article

Presenilin-1-Dependent Transcriptome Changes.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 6, p. 1571, doi. 10.1523/JNEUROSCI.4145-04.2005

By:

Mirnics, Károly;
Korade, Zeljka;
Schor, Nina F.;
Arion, Dominique;
Unger, Travis;
Macioce, Melissa;
Douglass, Katherine C.;
Lazarov, Orly;
Terrano, David;
Sabatini, Michael;
Sisodia, Sangram S.

Publication type:

Article

Presenilin Attenuates Receptor-Mediated Signaling and Synaptic Function.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 6, p. 1540, doi. 10.1523/JNEUROSCI.3850-04.2005

By:

Parent, Angèle T.;
Barnes, Natalie Y.;
Thinakaran, Gopal;
Sisodia, Sangram S.;
Taniguchi, Yoshihito

Publication type:

Article

Differential Release of δ-Amyloid from Dendrite- Versus Axon-Targeted APP.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 37, p. 12313, doi. 10.1523/JNEUROSCI.2255-14.2014

By:

DeBoer, Scott R.;
Dolios, Georgia;
Rong Wang;
Sisodia, Sangram S.

Publication type:

Article

Age-Dependent, Non-Cell-Autonomous Deposition of Amyloid from Synthesis of β-Amyloid by Cells Other Than Excitatory Neurons.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 10, p. 3668, doi. 10.1523/JNEUROSCI.5079-13.2014

By:

Veeraraghavalu, Karthikeyan;
Can Zhang;
Xiaoqiong Zhang;
Tanzi, Rudolph E.;
Sisodia, Sangram S.

Publication type:

Article

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2.

Published in:

Journal of Neuroscience, 2012, v. 32, n. 25, p. 8633, doi. 10.1523/JNEUROSCI.0556-12.2012

By:

Zhang, Xulun;
Garbett, Krassimira;
Veeraraghavalu, Karthikeyan;
Wilburn, Brian;
Gilmore, Reid;
Mirnics, Karoly;
Sisodia, Sangram S.

Publication type:

Article

Translational profiling identifies sex‐specific metabolic and epigenetic reprogramming of microglia in cerebral amyloidosis models with an antibiotic‐altered gut microbiome.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.059695

By:

Shaik, Shabana M;
Cao, Yajun;
Dodiya, Hemraj B.;
Zhang, Xulun;
Boutej, Hejer;
Han, Weinong;
Kriz, Jasna;
Sisodia, Sangram S.

Publication type:

Article

Evidence that the gut microbiota regulates progression of neurodegeneration in a mouse model of tauopathy, in a sex‐ and ApoE isoform‐dependent manner.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.049741

By:

Seo, Dong‐oh;
Stanley, Jack G.;
Shi, Yang;
Wang, Chao;
Serrano, Javier R.;
Bao, Xin;
O'Donnell, David;
Lelwala‐Guruge, Janaki;
Griffin, Nicholas;
Meier, Marty;
Dodiya, Hemraj B.;
Sisodia, Sangram S.;
Gordon, Jeffrey I.;
Holtzman, David M.

Publication type:

Article

Sex‐specific changes in amyloidosis and neuro‐immune modulation in response to alterations in the gut microbiome: Molecular and cell biology/neuroinflammation.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045243

By:

Shaik, Shabana M.;
Dodiya, Hemraj B.;
Cao, Yajun;
Boutej, Hajer;
Olszewski, Monica;
Sisodia, Sangram S.

Publication type:

Article

Modulation of amyloid deposition and neuroinflammation by the microbiome: Microbiome in Alzheimer's disease: Pathogenesis and treatment implications.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.044154

By:

Sisodia, Sangram S.

Publication type:

Article

Gut microbiome perturbations influence brain amyloidosis only in the presence of microglia in APPPS1‐21 mice: Molecular and cell biology/others.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.040609

By:

Dodiya, Hemraj B.;
Lutz, Holy;
Weigle, Ian;
Roman‐Santiago, Carlos;
Patel, Priyam;
Olszewski, Monica;
Zhang, Can;
Zhang, Xiaoqiong;
Schipma, Matthew John;
Tanzi, Rudolph E.;
Gilbert, Jack A.;
Sisodia, Sangram S.

Publication type:

Article

P1‐216: SEX‐SPECIFIC PERTURBATIONS IN CEREBRAL AMYLOIDOSIS AND MICROGLIA PHENOTYPES IN ANTIBIOTIC‐TREATED APP<sub>SWE</sub>/PS1<sub>L166P</sub> TRANSGENIC MICE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P319, doi. 10.1016/j.jalz.2019.06.771

By:

Dodiya, Hemraj B.;
Kuntz, Thomas;
Shaik, Shabana M.;
Baufeld, Caroline;
Leibowitz, Jeffrey;
Zhang, Xulun;
Gottel, Neil;
Zhang, Xiaoqiong;
Butovsky, Oleg;
Gilbert, Jack A.;
Sisodia, Sangram S.

Publication type:

Article

EC‐03‐03: GUT MICROBIOME ALTERATIONS IN ALZHEIMER'S DISEASE: PRECLINICAL EVIDENCE.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1007, doi. 10.1016/j.jalz.2018.06.2767

By:

Sisodia, Sangram S.

Publication type:

Article

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.

Published in:

Scientific Reports, 2016, p. 30028, doi. 10.1038/srep30028

By:

Minter, Myles R.;
Zhang, Can;
Leone, Vanessa;
Ringus, Daina L.;
Zhang, Xiaoqiong;
Oyler-Castrillo, Paul;
Musch, Mark W.;
Liao, Fan;
Ward, Joseph F.;
Holtzman, David M.;
Chang, Eugene B.;
Tanzi, Rudolph E.;
Sisodia, Sangram S.

Publication type:

Article

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration.

Published in:

Nature Neuroscience, 2011, v. 14, n. 10, p. 1227, doi. 10.1038/nn.2923

By:

Prinz, Marco;
Priller, Josef;
Sisodia, Sangram S;
Ransohoff, Richard M

Publication type:

Article

Presenilins and Alzheimer disease: the calcium conspiracy.

Published in:

Nature Neuroscience, 2006, v. 9, n. 11, p. 1354, doi. 10.1038/nn1106-1354

By:

Thinakaran, Gopal;
Sisodia, Sangram S.

Publication type:

Article

Altered Metabolism of Familial Alzheimer's Disease-Linked Amyloid Precursor Protein Variants in Yeast Artificial Chromosome Transgenic Mice.

Published in:

Human Molecular Genetics, 1997, v. 6, n. 9, p. 1535, doi. 10.1093/hmg/6.9.1535

By:

Lamb, Bruce T.;
Call, Linda M.;
Slunt, Hilda H.;
Bardel, Kimberly A.;
Lawler, Ann M.;
Eckman, Christopher B.;
Younkin, Steven G.;
Holtz, Greg;
Wagner, Steven L.;
Price, Donald L.;
Sisodia, Sangram S.;
Gearhart, John D.

Publication type:

Article

cDNA Cloning and Chromosome Mapping of the Human Fe65 Gene: Interaction of the Conserved Cytoplasmic Domains of the Human β-amyloid Precursor Protein and Its Homologues with the Mouse Fe65 Protein.

Published in:

Human Molecular Genetics, 1996, v. 5, n. 10, p. 1589

By:

Brassler, Steven L.;
Gray, Matthew D.;
Sopher, Bryce L.;
Hu, Qubai;
Hearn, Mark G.;
Pham, Dao G.;
Dinulos, Mary Beth;
Fukuchi, Ken-Ichiro;
Sisodia, Sangram S.;
Miller, Margaret A.;
Disteche, Christine M.;
Martin, George M.

Publication type:

Article

Presenilin 1 (PS1) is required for lysosome acidification: FAD mutations of PS1 cause loss of protein turnover by autophagy

Published in:

2010

By:

Lee, Ju-Hyun;
Yu, W. Haung;
Kumar, Asok;
Lee, Sooyeon;
Mohan, Panaiyur S.;
Peterhoff, Corrinne M.;
Martinez-Vicente, Marta;
Massey, Ashish C.;
Sovak, Guy;
Uchiyama, Yasuo;
Westaway, David;
Sisodia, Sangram S.;
Cuervo, Ana Maria;
Nixon, Ralph A.

Publication type:

Abstract

Effect of the components of gamma-secretase on activity and specificity

Published in:

2010

By:

Crump, Christina J.;
Sisodia, Sangram S.;
Li, Yue-Ming

Publication type:

Abstract

P4-190: Role of gamma-secretase in lipoprotein endocytosis

Published in:

2008

By:

Walter, Jochen;
Thelen, Karin;
Lütjohann, Dieter;
DeWachter, Ilse;
van Leuven, Fred;
Sisodia, Sangram S.;
St. George-Hyslop, Peter;
Thal, Dietmar;
Tamboli, Irfan

Publication type:

Abstract

P3-336: Purification and cocrystallization of nicastrin ectodomain

Published in:

2008

By:

Lin, Guoqing;
Kim, Seong-Hun;
Leung, Brenda;
Koide, Akiko;
Koide, Shohei;
Sisodia, Sangram S.

Publication type:

Abstract

O4-03-01: Evidence that RER1 is the limiting cellular factor for the ER retrieval of gamma-secretase complex

Published in:

2008

By:

Kim, Seong-Hun;
Park, Hyo-Jin;
Ikeuchi, Takeshi;
Sisodia, Sangram S.

Publication type:

Abstract

P4-088: Aged garlic extract reduces the secretion of Alzheimer’s beta-amyloid peptides in N2a cells transfected with human “Swedish” APP695

Published in:

2006

By:

Chauhan, Neelima B.;
Sandoval, Jimena S.;
Sisodia, Sangram S.

Publication type:

Abstract

P4-088: Aged garlic extract reduces the secretion of Alzheimer’s beta-amyloid peptides in N2a cells transfected with human “Swedish” APP695

Published in:

2006

By:

Chauhan, Neelima B.;
Sandoval, Jimena S.;
Sisodia, Sangram S.

Publication type:

Abstract

Alternatives to amyloid for Alzheimer's disease therapies—a symposium report.

Published in:

Annals of the New York Academy of Sciences, 2020, v. 1475, n. 1, p. 3, doi. 10.1111/nyas.14371

By:

Cable, Jennifer;
Holtzman, David M.;
Hyman, Bradley T.;
Tansey, Malú Gámez;
Colonna, Marco;
Kellis, Manolis;
Brinton, Roberta D.;
Albert, Marilyn;
Wellington, Cheryl L.;
Sisodia, Sangram S.;
Tanzi, Rudolph E.

Publication type:

Article

Amyloid $$sZ-protein stimulates parallel increases in cellular levels of its precursor and amyloid precursor-like protein 2 (APLP2) in human cerebrovascular smooth muscle cells.

Published in:

Amyloid, 1997, v. 4, n. 1, p. 54, doi. 10.3109/13506129708995270

By:

Saporito-irwin, Susan M.;
Thinakaran, Gopal;
Ruffini, Lynda;
Sisodia, Sangram S.;
Van Nostrand, William E.

Publication type:

Article

Nucleotide sequence of the chromosome 14-encoded S182 cDNA and revised secondary structure prediction.

Published in:

Amyloid, 1995, v. 2, n. 3, p. 188, doi. 10.3109/13506129509036925

By:

Slunt, Hilda H;
Thinakaran, Gopal;
Lee, Michael K.;
Sisodia, Sangram S.

Publication type:

Article

Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-64797-5

By:

Dodiya, Hemraj B.;
Frith, Mary;
Sidebottom, Ashley;
Cao, Yajun;
Koval, Jason;
Chang, Eugene;
Sisodia, Sangram S.

Publication type:

Article

The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain.

Published in:

Molecular Neurodegeneration, 2015, v. 10, n. 1, p. 1, doi. 10.1186/s13024-015-0037-4

By:

Xulun Zhang;
Yu, Chunjiang J.;
Sisodia, Sangram S.

Publication type:

Article

Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors.

Published in:

Molecular Neurodegeneration, 2013, v. 8, n. 1, p. 1, doi. 10.1186/1750-1326-8-41

By:

Veeraraghavalu, Karthikeyan;
Se Hoon Choi;
Xiaoqiong Zhang;
Sisodia, Sangram S.

Publication type:

Article

Neuronal Disorders: Studies of Animal Models and Human Diseases.

Published in:

Toxicologic Pathology, 1990, v. 18, n. 1, p. 128, doi. 10.1177/019262339001800118

By:

Price, Donald L.;
Sisodia, Sangram S.;
Koo, Edward H.;
Muma, Nancy A.;
Kitt, Cheryl A.;
Walker, Lary C.;
Martin, Lee J.;
Troncoso, Juan C.;
Griffin, John W.;
Hoffman, Paul N.;
Cork, Linda C.

Publication type:

Article

γ-SECRETASE, NOTCH, Aβ AND ALZHEIMER'S DISEASE: WHERE DO THE PRESENILINS FIT IN?

Published in:

Nature Reviews Neuroscience, 2002, v. 3, n. 4, p. 281, doi. 10.1038/nrn785

By:

Sisodia, Sangram S.;
St George-Hyslop, Peter H.

Publication type:

Article

Acne Inversa Caused by Missense Mutations in NCSTN Is Not Fully Compatible with Impairments in Notch Signaling.

Published in:

Journal of Investigative Dermatology, 2015, v. 135, n. 2, p. 618, doi. 10.1038/jid.2014.399

By:

Zhang, Xulun;
Sisodia, Sangram S

Publication type:

Article

Nanoscale organization of Nicastrin, the substrate receptor of the γ-secretase complex, as independent molecular domains.

Published in:

Molecular Brain, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13041-021-00855-x

By:

Kedia, Shekhar;
Mandal, Kousik;
Netrakanti, Pallavi Rao;
Jose, Mini;
Sisodia, Sangram S.;
Nair, Deepak

Publication type:

Article

The Value of Transgenic Models for the Study of Neurodegenerative Diseases.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 920, n. 1, p. 179, doi. 10.1111/j.1749-6632.2000.tb06920.x

By:

PRICE, DONALD L.;
WONG, PHILIP C.;
MARKOWSKA, ALICJA L.;
LEE, MICHAEL K.;
THINAKAREN, GOPAL;
CLEVELAND, DONALD W.;
SISODIA, SANGRAM S.;
BORCHELT, DAVID R.

Publication type:

Article

Familial British Dementia: Expression and Metabolism of BRI.

Published in:

Annals of the New York Academy of Sciences, 2000, v. 920, n. 1, p. 93, doi. 10.1111/j.1749-6632.2000.tb06909.x

By:

KIM, SEONG-HUN;
WANG, RONG;
GORDON, DAVID J.;
BASS, JOSEPH;
STEINER, DONALD F.;
THINAKARAN, GOPAL;
LYNN, DAVID G.;
MEREDITH, STEPHEN C.;
SISODIA, SANGRAM S.

Publication type:

Article