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Alternatives to amyloid for Alzheimer's disease therapies—a symposium report.
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- Annals of the New York Academy of Sciences, 2020, v. 1475, n. 1, p. 3, doi. 10.1111/nyas.14371
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- Article
Translational profiling identifies sex‐specific metabolic and epigenetic reprogramming of microglia in cerebral amyloidosis models with an antibiotic‐altered gut microbiome.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.059695
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- Article
Evidence that the gut microbiota regulates progression of neurodegeneration in a mouse model of tauopathy, in a sex‐ and ApoE isoform‐dependent manner.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.049741
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- Article
Sex‐specific changes in amyloidosis and neuro‐immune modulation in response to alterations in the gut microbiome: Molecular and cell biology/neuroinflammation.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.045243
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- Article
Modulation of amyloid deposition and neuroinflammation by the microbiome: Microbiome in Alzheimer's disease: Pathogenesis and treatment implications.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.044154
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- Article
Gut microbiome perturbations influence brain amyloidosis only in the presence of microglia in APPPS1‐21 mice: Molecular and cell biology/others.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.040609
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- Article
P1‐216: SEX‐SPECIFIC PERTURBATIONS IN CEREBRAL AMYLOIDOSIS AND MICROGLIA PHENOTYPES IN ANTIBIOTIC‐TREATED APP<sub>SWE</sub>/PS1<sub>L166P</sub> TRANSGENIC MICE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P319, doi. 10.1016/j.jalz.2019.06.771
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- Article
EC‐03‐03: GUT MICROBIOME ALTERATIONS IN ALZHEIMER'S DISEASE: PRECLINICAL EVIDENCE.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1007, doi. 10.1016/j.jalz.2018.06.2767
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- Article
Secretion of the β-Amyloid Precursor Protein<sup>a</sup>.
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- Annals of the New York Academy of Sciences, 1992, v. 674, n. 1, p. 53, doi. 10.1111/j.1749-6632.1992.tb27476.x
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- Article
γ-SECRETASE, NOTCH, Aβ AND ALZHEIMER'S DISEASE: WHERE DO THE PRESENILINS FIT IN?
- Published in:
- Nature Reviews Neuroscience, 2002, v. 3, n. 4, p. 281, doi. 10.1038/nrn785
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- Article
Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer's disease.
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- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-20889-y
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- Article
Aβ star: a light onto synaptic dysfunction?
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- Nature Medicine, 2006, v. 12, n. 7, p. 760, doi. 10.1038/nm0706-760
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- Article
Presenilin 1 (PS1) is required for lysosome acidification: FAD mutations of PS1 cause loss of protein turnover by autophagy
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- 2010
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- Abstract
Effect of the components of gamma-secretase on activity and specificity
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- 2010
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- Abstract
P4-190: Role of gamma-secretase in lipoprotein endocytosis
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- 2008
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- Abstract
P3-336: Purification and cocrystallization of nicastrin ectodomain
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- 2008
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- Abstract
O4-03-01: Evidence that RER1 is the limiting cellular factor for the ER retrieval of gamma-secretase complex
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- 2008
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- Abstract
P4-088: Aged garlic extract reduces the secretion of Alzheimer’s beta-amyloid peptides in N2a cells transfected with human “Swedish” APP695
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- 2006
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- Abstract
P4-088: Aged garlic extract reduces the secretion of Alzheimer’s beta-amyloid peptides in N2a cells transfected with human “Swedish” APP695
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- 2006
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- Abstract
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
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- Scientific Reports, 2016, p. 30028, doi. 10.1038/srep30028
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- Article
Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of γ-Secretase In Vivo.
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- PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0028179
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- Article
Expression of Familial Alzheimer’s Disease-Linked Human Presenilin 1 Variants Impair Enrichment-Induced Adult Hippocampal Neurogenesis.
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- Neurodegenerative Diseases, 2010, v. 7, n. 1-3, p. 46, doi. 10.1159/000283482
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- Article
The Value of Transgenic Models for the Study of Neurodegenerative Diseases.
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- Annals of the New York Academy of Sciences, 2000, v. 920, n. 1, p. 179, doi. 10.1111/j.1749-6632.2000.tb06920.x
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- Article
Familial British Dementia: Expression and Metabolism of BRI.
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- Annals of the New York Academy of Sciences, 2000, v. 920, n. 1, p. 93, doi. 10.1111/j.1749-6632.2000.tb06909.x
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- Publication type:
- Article
Presenilin 1 Mutants Impair the Self-Renewal and Differentiation of Adult Murine Subventricular Zone-Neuronal Progenitors via Cell-Autonomous Mechanisms Involving Notch Signaling.
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- Journal of Neuroscience, 2010, v. 30, n. 20, p. 6903, doi. 10.1523/JNEUROSCI.0527-10.2010
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- Article
Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis.
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- Journal of Neuroscience, 2008, v. 28, n. 46, p. 12094, doi. 10.1523/JNEUROSCI.2635-08.2008
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- Article
Enhanced Accumulation of Phosphorylated α-Synuclein and Elevated β-Amyloid 42/40 Ratio Caused by Expression of the Presenilin-1 ΔT440 Mutant Associated with Familial Lewy Body Disease and Variant Alzheimer's Disease.
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- Journal of Neuroscience, 2007, v. 27, n. 48, p. 13092, doi. 10.1523/JNEUROSCI.4244-07.2007
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- Article
Impairments in Fast Axonal Transport and Motor Neuron Deficits in Transgenic Mice Expressing Familial Alzheimer's Disease-Linked Mutant Presenilin 1.
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- Journal of Neuroscience, 2007, v. 27, n. 26, p. 7011, doi. 10.1523/JNEUROSCI.4272-06.2007
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- Article
Accelerated Aβ Deposition in APPswe/PS1ΔE9 Mice with Hemizygous Deletions of TTR (Transthyretin).
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- Journal of Neuroscience, 2007, v. 27, n. 26, p. 7006, doi. 10.1523/JNEUROSCI.1919-07.2007
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- Article
Expression of a Familial Alzheimer's Disease-Linked Presenilin-1 Variant Enhances Perforant Pathway Lesion-Induced Neuronal Loss in the Entorhinal Cortex.
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- Journal of Neuroscience, 2006, v. 26, n. 2, p. 429, doi. 10.1523/JNEUROSCI.3961-05.2006
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- Article
Nigrostriatal Dysfunction in Familial Alzheimer's Disease-Linked APPswe/PS1ΔE9 Transgenic Mice.
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- Journal of Neuroscience, 2005, v. 25, n. 44, p. 10220, doi. 10.1523/JNEUROSCI.2773-05.2005
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- Article
Axonal Transport, Amyloid Precursor Protein, Kinesin-1, and the Processing Apparatus: Revisited.
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- Journal of Neuroscience, 2005, v. 25, n. 9, p. 2386, doi. 10.1523/JNEUROSCI.3089-04.2005
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- Article
Presenilin-1-Dependent Transcriptome Changes.
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- Journal of Neuroscience, 2005, v. 25, n. 6, p. 1571, doi. 10.1523/JNEUROSCI.4145-04.2005
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- Article
Presenilin Attenuates Receptor-Mediated Signaling and Synaptic Function.
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- Journal of Neuroscience, 2005, v. 25, n. 6, p. 1540, doi. 10.1523/JNEUROSCI.3850-04.2005
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- Article
Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-64797-5
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- Article
Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
- Published in:
- Nature Cell Biology, 2000, v. 2, n. 12, p. 863, doi. 10.1038/35046500
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- Article
Transgenic Mouse Models of Alzheimer's Disease and Amyotrophic Lateral Sclerosis.
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- Brain Pathology, 1998, v. 8, n. 4, p. 735, doi. 10.1111/j.1750-3639.1998.tb00198.x
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- Article
Inherited Neurodegenerative Diseases and Transgenic Models.
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- Brain Pathology, 1996, v. 6, n. 4, p. 467, doi. 10.1111/j.1750-3639.1996.tb00876.x
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- Article
Aged Non-Human Primates: An Animal Model of Age-Associated Neurodegenerative Disease.
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- Brain Pathology, 1991, v. 1, n. 4, p. 287, doi. 10.1111/j.1750-3639.1991.tb00672.x
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- Article
Acne Inversa Caused by Missense Mutations in NCSTN Is Not Fully Compatible with Impairments in Notch Signaling.
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- Journal of Investigative Dermatology, 2015, v. 135, n. 2, p. 618, doi. 10.1038/jid.2014.399
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- Article
Biogenesis of γ-secretase early in the secretory pathway.
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- Journal of Cell Biology, 2007, v. 179, n. 5, p. 951, doi. 10.1083/jcb.200709012
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- Article
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration.
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- Nature Neuroscience, 2011, v. 14, n. 10, p. 1227, doi. 10.1038/nn.2923
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- Article
Presenilins and Alzheimer disease: the calcium conspiracy.
- Published in:
- Nature Neuroscience, 2006, v. 9, n. 11, p. 1354, doi. 10.1038/nn1106-1354
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- Article
Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.
- Published in:
- Nature Neuroscience, 1999, v. 2, n. 11, p. 984, doi. 10.1038/14783
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- Article
Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.
- Published in:
- Nature Neuroscience, 1999, v. 2, n. 8, p. 695, doi. 10.1038/11154
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- Article
The topology of pen-2, a γ-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain.
- Published in:
- Molecular Neurodegeneration, 2015, v. 10, n. 1, p. 1, doi. 10.1186/s13024-015-0037-4
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- Publication type:
- Article
Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors.
- Published in:
- Molecular Neurodegeneration, 2013, v. 8, n. 1, p. 1, doi. 10.1186/1750-1326-8-41
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- Publication type:
- Article
Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.
- Published in:
- Molecular Neurodegeneration, 2008, v. 3, p. 1, doi. 10.1186/1750-1326-3-14
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- Publication type:
- Article
Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.
- Published in:
- Journal of Neuroscience, 2019, v. 39, n. 34, p. 6766, doi. 10.1523/JNEUROSCI.0884-19.2019
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- Publication type:
- Article
Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome.
- Published in:
- Molecular Neurodegeneration, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13024-023-00668-7
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- Publication type:
- Article