Works by Simpson, Thomas J.

Results: 42

Resistance to and synthesis of the antibiotic mupirocin.

Published in:

Nature Reviews Microbiology, 2010, v. 8, n. 4, p. 281, doi. 10.1038/nrmicro2278

By:

Thomas, Christopher M.;
Hothersall, Joanne;
Willis, Christine L.;
Simpson, Thomas J.

Publication type:

Article

Fine Tuning of Antibiotic Activity by a Tailoring Hydroxylase in a Trans‐AT Polyketide Synthase Pathway.

Published in:

ChemBioChem, 2018, v. 19, n. 8, p. 836, doi. 10.1002/cbic.201800036

By:

Mohammad, Hadi H.;
Connolly, Jack A.;
Song, Zhongshu;
Hothersall, Joanne;
Race, Paul R.;
Willis, Christine L.;
Simpson, Thomas J.;
Winn, Peter J.;
Thomas, Christopher M.

Publication type:

Article

Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390.

Published in:

Angewandte Chemie, 2011, v. 123, n. 14, p. 3329, doi. 10.1002/ange.201007029

By:

Murphy, Annabel C.;
Fukuda, Daisuke;
Song, Zhongshu;
Hothersall, Joanne;
Cox, Russell J.;
Willis, Christine L.;
Thomas, Christopher M.;
Simpson, Thomas J.

Publication type:

Article

Synthesis and Incorporation of the First Polyketide Synthase Free Intermediate in Monocerin Biosynthesis ( We thank the Engineering and Physical Sciences Research Council for support (GR/N21352) and for a research studentship (L.C.A.), and Dr. M. P. Crump for a 600 MHz NMR spectrum. )

Published in:

Angewandte Chemie, 2004, v. 116, n. 6, p. 745, doi. 10.1002/ange.200352652

By:

Lorraine C. Axford;
Thomas J. Simpson;
Christine L. Willis

Publication type:

Article

Manipulation of quorum sensing regulation in Pseudomonas fluorescens NCIMB 10586 to increase mupirocin production.

Published in:

Applied Microbiology & Biotechnology, 2011, v. 90, n. 3, p. 1017, doi. 10.1007/s00253-011-3145-2

By:

Hothersall, Joanne;
Murphy, Annabel C.;
Iqbal, Zafar;
Campbell, Genevieve;
Stephens, Elton R.;
Ji'en Wu;
Cooper, Helen;
Atkinson, Steve;
Williams, Paul;
Crosby, John;
Willis, Christine L.;
Cox, Russell J.;
Simpson, Thomas J.;
Thomas, Christopher M.

Publication type:

Article

Structure and Function of the α‐Hydroxylation Bimodule of the Mupirocin Polyketide Synthase.

Published in:

Angewandte Chemie, 2023, v. 135, n. 47, p. 1, doi. 10.1002/ange.202312514

By:

Winter, Ashley J.;
Khanizeman, R. Nisha;
Barker‐Mountford, Abigail M. C.;
Devine, Andrew J.;
Wang, Luoyi;
Song, Zhongshu;
Davies, Jonathan A.;
Race, Paul R.;
Williams, Christopher;
Simpson, Thomas J.;
Willis, Christine L.;
Crump, Matthew P.

Publication type:

Article

The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI.

Published in:

Angewandte Chemie, 2020, v. 132, n. 26, p. 10636, doi. 10.1002/ange.201915407

By:

Fage, Christopher D.;
Lathouwers, Thomas;
Vanmeert, Michiel;
Gao, Ling‐Jie;
Vrancken, Kristof;
Lammens, Eveline‐Marie;
Weir, Angus N. M.;
Degroote, Ruben;
Cuppens, Harry;
Kosol, Simone;
Simpson, Thomas J.;
Crump, Matthew P.;
Willis, Christine L.;
Herdewijn, Piet;
Lescrinier, Eveline;
Lavigne, Rob;
Anné, Jozef;
Masschelein, Joleen

Publication type:

Article

Control of β‐Branching in Kalimantacin Biosynthesis: Application of <sup>13</sup>C NMR to Polyketide Programming.

Published in:

Angewandte Chemie, 2019, v. 131, n. 36, p. 12576, doi. 10.1002/ange.201905482

By:

Walker, Paul D.;
Williams, Christopher;
Weir, Angus N. M.;
Wang, Luoyi;
Crosby, John;
Race, Paul R.;
Simpson, Thomas J.;
Willis, Christine L.;
Crump, Matthew P.

Publication type:

Article

Methods for the synthesis of carbon-13 labelled acids and esters.

Published in:

Journal of Labelled Compounds & Radiopharmaceuticals, 2007, v. 50, n. 5/6, p. 338, doi. 10.1002/jlcr.1198

By:

Jordan, Angela C.;
Axford, Lorraine C.;
Harding, John R.;
O'Connell, Yvonne;
Simpson, Thomas J.;
Willis, Christine L.

Publication type:

Article

Engineered Thiomarinol Antibiotics Active against MRSA Are Generated by Mutagenesis and Mutasynthesis of Pseudoalteromonas SANK73390.

Published in:

Angewandte Chemie International Edition, 2011, v. 50, n. 14, p. 3271, doi. 10.1002/anie.201007029

By:

Murphy, Annabel C.;
Fukuda, Daisuke;
Song, Zhongshu;
Hothersall, Joanne;
Cox, Russell J.;
Willis, Christine L.;
Thomas, Christopher M.;
Simpson, Thomas J.

Publication type:

Article

Structure and Function of the α‐Hydroxylation Bimodule of the Mupirocin Polyketide Synthase.

Published in:

Angewandte Chemie International Edition, 2023, v. 62, n. 47, p. 1, doi. 10.1002/anie.202312514

By:

Winter, Ashley J.;
Khanizeman, R. Nisha;
Barker‐Mountford, Abigail M. C.;
Devine, Andrew J.;
Wang, Luoyi;
Song, Zhongshu;
Davies, Jonathan A.;
Race, Paul R.;
Williams, Christopher;
Simpson, Thomas J.;
Willis, Christine L.;
Crump, Matthew P.

Publication type:

Article

The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI.

Published in:

Angewandte Chemie International Edition, 2020, v. 59, n. 26, p. 10549, doi. 10.1002/anie.201915407

By:

Fage, Christopher D.;
Lathouwers, Thomas;
Vanmeert, Michiel;
Gao, Ling‐Jie;
Vrancken, Kristof;
Lammens, Eveline‐Marie;
Weir, Angus N. M.;
Degroote, Ruben;
Cuppens, Harry;
Kosol, Simone;
Simpson, Thomas J.;
Crump, Matthew P.;
Willis, Christine L.;
Herdewijn, Piet;
Lescrinier, Eveline;
Lavigne, Rob;
Anné, Jozef;
Masschelein, Joleen

Publication type:

Article

Control of β‐Branching in Kalimantacin Biosynthesis: Application of <sup>13</sup>C NMR to Polyketide Programming.

Published in:

Angewandte Chemie International Edition, 2019, v. 58, n. 36, p. 12446, doi. 10.1002/anie.201905482

By:

Walker, Paul D.;
Williams, Christopher;
Weir, Angus N. M.;
Wang, Luoyi;
Crosby, John;
Race, Paul R.;
Simpson, Thomas J.;
Willis, Christine L.;
Crump, Matthew P.

Publication type:

Article

Genetic and Biosynthetic Studies of the Fungal Prenylated Xanthone Shamixanthone and Related Metabolites in Aspergillus spp. Revisited.

Published in:

ChemBioChem, 2012, v. 13, n. 11, p. 1680, doi. 10.1002/cbic.201200014

By:

Simpson, Thomas J.

Publication type:

Article

First Heterologous Reconstruction of a Complete Functional Fungal Biosynthetic Multigene Cluster.

Published in:

ChemBioChem, 2010, v. 11, n. 11, p. 1508, doi. 10.1002/cbic.201000259

By:

Heneghan, Mary N.;
Yakasai, Ahmed A.;
Halo, Laura M.;
Song, Zhongshu;
Bailey, Andrew M.;
Simpson, Thomas J.;
Cox, Russell J.;
Lazarus, Colin M.

Publication type:

Article

Phosphopantetheinylation and Specificity of Acyl Carrier Proteins in the Mupirocin Biosynthetic Cluster.

Published in:

ChemBioChem, 2010, v. 11, n. 2, p. 248, doi. 10.1002/cbic.200900565

By:

Shields, Jennifer A.;
Rahman, Ayesha S.;
Arthur, Christopher J.;
Crosby, John;
Hothersall, Joanne;
Simpson, Thomas J.;
Thomas, Christopher M.

Publication type:

Article

An ACP Structural Switch: Conformational Differences between the Apo and Holo Forms of the Actinorhodin Polyketide Synthase Acyl Carrier Protein.

Published in:

ChemBioChem, 2008, v. 9, n. 15, p. 2424, doi. 10.1002/cbic.200800180

By:

Evans, Simon E.;
Williams, Christopher;
Arthur, Christopher J.;
Burston, Steven G.;
Simpson, Thomas J.;
Crosby, John;
Crump, Matthew P.

Publication type:

Article

In vivo Mutational Analysis of the Mupirocin Gene Cluster Reveals Labile Points in the Biosynthetic Pathway: the 'Leaky Hosepipe' Mechanism.

Published in:

ChemBioChem, 2008, v. 9, n. 9, p. 1500, doi. 10.1002/cbic.200800085

By:

Wu, Ji'en;
Hothersall, Joanne;
Mazzetti, Carlo;
O'Connell, Yvonne;
Shields, Jennifer A.;
Rahman, Ayesha S.;
Cox, Russell J.;
Crosby, John;
Simpson, Thomas J.;
Thomas, Christopher M.;
Willis, Christine L.

Publication type:

Article

Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase.

Published in:

ChemBioChem, 2008, v. 9, n. 4, p. 585, doi. 10.1002/cbic.200700390

By:

Halo, Laura M.;
Marshall, James W.;
Yakasai, Ahmed A.;
Song, Zhongshu;
Butts, Craig P.;
Crump, Matthew P.;
Heneghan, Mary;
Bailey, Andrew M.;
Simpson, Thomas J.;
Lazarus, Colin. M.;
Cox, Russell J.

Publication type:

Article

Biosynthesis of the 2-Pyridone Tenellin in the Insect Pathogenic Fungus Beauveria bassiana.

Published in:

ChemBioChem, 2007, v. 8, n. 3, p. 289, doi. 10.1002/cbic.200600398

By:

Eley, Kirstin L.;
Halo, Laura M.;
Song, Zhongshu;
Powles, Henry;
Cox, Russell J.;
Bailey, Andrew M.;
Lazarus, Colin M.;
Simpson, Thomas J.

Publication type:

Article

Synthesis of [1,2-13C2,15N]-L-Homoserine and Its Incorporation by the PKS-NRPS System of Fusarium moniliforme into the Mycotoxin Fusarin C.

Published in:

ChemBioChem, 2007, v. 8, n. 1, p. 46, doi. 10.1002/cbic.200600404

By:

David O. Rees;
Nick Bushby;
Russell J. Cox;
John R. Harding;
Thomas J. Simpson;
Christine L. Willis

Publication type:

Article

Catalytic Relationships between Type I and Type II Iterative Polyketide Synthases: The Aspergillus parasiticus Norsolorinic Acid Synthase.

Published in:

ChemBioChem, 2006, v. 7, n. 12, p. 1951, doi. 10.1002/cbic.200600341

By:

Ma, Yue;
Smith, Leah H.;
Cox, Russell J.;
Beltran-Alvarez, Pedro;
Arthur, Christopher J.;
Simpson, Thomas J.

Publication type:

Article

Fusarin C Biosynthesis in Fusarium moniliforme and Fusarium venenatum.

Published in:

ChemBioChem, 2004, v. 5, n. 9, p. 1196, doi. 10.1002/cbic.200400138

By:

Zhongshu Song;
Russell J. Cox;
Colin M. Lazarus;
Thomas J. Simpson

Publication type:

Article

Synthesis and Characterisation of Acyl Carrier Protein Bound Polyketide Analogues.

Published in:

ChemBioChem, 2002, v. 3, n. 2/3, p. 253, doi. 10.1002/1439-7633(20020301)3:2/3<253::AID-CBIC253>3.0.CO;2-7

By:

Arthur, Christopher;
Cox, Russell J.;
Crosby, John;
Rahman, Mujiber M.;
Simpson, Thomas J.;
Soulas, Florilene;
Spogli, Roberto;
Szafranska, Anna E.;
Westcott, James;
Winfield, Christopher J.

Publication type:

Article

Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-38038-9

By:

Connolly, Jack A.;
Wilson, Amber;
Macioszek, Malgorzata;
Song, Zhongshu;
Wang, Luoyi;
Mohammad, Hadi H.;
Yadav, Mukul;
di Martino, Maura;
Miller, Claire E.;
Hothersall, Joanne;
Haines, Anthony S.;
Stephens, Elton R.;
Crump, Matthew P.;
Willis, Christine L.;
Simpson, Thomas J.;
Winn, Peter J.;
Thomas, Christopher M.

Publication type:

Article

Synthesis and Incorporation of the First Polyketide Synthase Free Intermediate in Monocerin Biosynthesis ( We thank the Engineering and Physical Sciences Research Council for support (GR/N21352) and for a research studentship (L.C.A.), and Dr. M. P. Crump for a 600 MHz NMR spectrum. )

Published in:

Angewandte Chemie International Edition, 2004, v. 43, n. 6, p. 727, doi. 10.1002/anie.200352652

By:

Lorraine C. Axford;
Thomas J. Simpson;
Christine L. Willis

Publication type:

Article

Ultraviolet-Irradiated Urocanic Acid Suppresses Delayed-Type Hypersensitivity to Herpes Simplex Virus in Mice.

Published in:

Journal of Investigative Dermatology, 1986, v. 87, n. 5, p. 630, doi. 10.1111/1523-1747.ep12456257

By:

Ross, James A.;
Howie, Sarah E. M.;
Norval, Mary;
Maingay, Jean;
Simpson, Thomas J.

Publication type:

Article

Rücktitelbild: Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics (Angew. Chem. 14/2017).

Published in:

Angewandte Chemie, 2017, v. 129, n. 14, p. 4126, doi. 10.1002/ange.201702123

By:

Gao, Shu ‐ Shan;
Wang, Luoyi;
Song, Zhongshu;
Hothersall, Joanne;
Stevens, Elton R.;
Connolly, Jack;
Winn, Peter J.;
Cox, Russell J.;
Crump, Matthew P.;
Race, Paul R.;
Thomas, Christopher M.;
Simpson, Thomas J.;
Willis, Christine L.

Publication type:

Article

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.

Published in:

Angewandte Chemie, 2017, v. 129, n. 14, p. 3988, doi. 10.1002/ange.201611590

By:

Gao, Shu ‐ Shan;
Wang, Luoyi;
Song, Zhongshu;
Hothersall, Joanne;
Stevens, Elton R.;
Connolly, Jack;
Winn, Peter J.;
Cox, Russell J.;
Crump, Matthew P.;
Race, Paul R.;
Thomas, Christopher M.;
Simpson, Thomas J.;
Willis, Christine L.

Publication type:

Article

Heterologe Produktion pilzlicher Maleidride enthüllt die kryptische Cyclisierung in ihrer Biosynthese.

Published in:

Angewandte Chemie, 2016, v. 128, n. 23, p. 6896, doi. 10.1002/ange.201511882

By:

Williams, Katherine;
Szwalbe, Agnieszka J.;
Mulholland, Nicholas P.;
Vincent, Jason L.;
Bailey, Andrew M.;
Willis, Christine L.;
Simpson, Thomas J.;
Cox, Russell J.

Publication type:

Article

The Biosynthesis and Catabolism of the Maleic Anhydride Moiety of Stipitatonic Acid.

Published in:

Angewandte Chemie, 2014, v. 126, n. 29, p. 7649, doi. 10.1002/ange.201403450

By:

al Fahad, Ahmed;
Abood, Amira;
Simpson, Thomas J.;
Cox, Russell J.

Publication type:

Article

Strobilurin biosynthesis in Basidiomycete fungi.

Published in:

Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06202-4

By:

Nofiani, Risa;
de Mattos-Shipley, Kate;
Lebe, Karen E.;
Han, Li-Chen;
Iqbal, Zafar;
Bailey, Andrew M.;
Willis, Christine L.;
Simpson, Thomas J.;
Cox, Russell J.

Publication type:

Article

The prenatal determination of glucose-6-phosphatase activity by fetal liver biopsy.

Published in:

Prenatal Diagnosis, 1988, v. 8, n. 6, p. 401, doi. 10.1002/pd.1970080603

By:

Golbus, Mitchell S.;
Simpson, Thomas J.;
Koresawa, Mitsuhiko;
Appelman, Zvi;
Alpers, Charles E.

Publication type:

Article

Ontogeny of fetal liver glucose-6-phosphatase activity.

Published in:

1987

By:

Simpson, Thomas J.;
Koresawa, Mitsuhiko;
Hogge, W. Allen;
Holzgreve, Wolfgang;
Golbus, Mitchell S.;
Simpson, T J;
Koresawa, M;
Hogge, W A;
Holzgreve, W;
Golbus, M S

Publication type:

journal article

A Chain initiation factor common to both modular and aromatic polyketide synthases.

Published in:

Nature, 1999, v. 401, n. 6752, p. 502, doi. 10.1038/46829

By:

Bisang, Christian;
Long, Paul F.;
Cortes, Jesus;
Westcott, James;
Crosby, John;
Matharu, Anne-Lise;
Cox, Russell J.;
Simpson, Thomas J.;
Staunton, James;
Leadlay, Peter F.

Publication type:

Article

A Natural Plasmid Uniquely Encodes Two Biosynthetic Pathways Creating a Potent Anti-MRSA Antibiotic.

Published in:

PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0018031

By:

Fukuda, Daisuke;
Haines, Anthony S.;
Song, Zhongshu;
Murphy, Annabel C.;
Hothersall, Joanne;
Stephens, Elton R.;
Gurney, Rachel;
Cox, Russell J.;
Crosby, John;
Willis, Christine L.;
Simpson, Thomas J.;
Thomas, Christopher M.

Publication type:

Article

Back Cover: Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics (Angew. Chem. Int. Ed. 14/2017).

Published in:

Angewandte Chemie International Edition, 2017, v. 56, n. 14, p. 4066, doi. 10.1002/anie.201702123

By:

Gao, Shu-Shan;
Wang, Luoyi;
Song, Zhongshu;
Crump, Matthew P.;
Simpson, Thomas J.;
Willis, Christine L.;
Cox, Russell J.;
Hothersall, Joanne;
Stevens, Elton R.;
Connolly, Jack;
Winn, Peter J.;
Thomas, Christopher M.;
Race, Paul R.

Publication type:

Article

Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics.

Published in:

Angewandte Chemie International Edition, 2017, v. 56, n. 14, p. 3930, doi. 10.1002/anie.201611590

By:

Gao, Shu-Shan;
Wang, Luoyi;
Song, Zhongshu;
Crump, Matthew P.;
Simpson, Thomas J.;
Willis, Christine L.;
Cox, Russell J.;
Hothersall, Joanne;
Stevens, Elton R.;
Connolly, Jack;
Winn, Peter J.;
Thomas, Christopher M.;
Race, Paul R.

Publication type:

Article

Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis.

Published in:

Angewandte Chemie International Edition, 2016, v. 55, n. 23, p. 6784, doi. 10.1002/anie.201511882

By:

Williams, Katherine;
Szwalbe, Agnieszka J.;
Mulholland, Nicholas P.;
Vincent, Jason L.;
Bailey, Andrew M.;
Willis, Christine L.;
Simpson, Thomas J.;
Cox, Russell J.

Publication type:

Article

The Biosynthesis and Catabolism of the Maleic Anhydride Moiety of Stipitatonic Acid.

Published in:

Angewandte Chemie International Edition, 2014, v. 53, n. 29, p. 7519, doi. 10.1002/anie.201403450

By:

al Fahad, Ahmed;
Abood, Amira;
Simpson, Thomas J.;
Cox, Russell J.

Publication type:

Article

A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis.

Published in:

Nature Chemical Biology, 2013, v. 9, n. 11, p. 685, doi. 10.1038/nchembio.1342

By:

Haines, Anthony S;
Dong, Xu;
Song, Zhongshu;
Farmer, Rohit;
Williams, Christopher;
Hothersall, Joanne;
Płoskoń, Eliza;
Wattana-amorn, Pakorn;
Stephens, Elton R;
Yamada, Erika;
Gurney, Rachel;
Takebayashi, Yuiko;
Masschelein, Joleen;
Cox, Russell J;
Lavigne, Rob;
Willis, Christine L;
Simpson, Thomas J;
Crosby, John;
Winn, Peter J;
Thomas, Christopher M

Publication type:

Article

A New Antioxidant Triterpenoid from the Stem Wood of Sorbus lanata.

Published in:

Records of Natural Products, 2014, v. 8, n. 1, p. 19

By:

Latif, Abdul;
Hussain, Syed Hamid;
Ali, Mumtaz;
Arfan, Mohammad;
Ahmed, Manzoor;
Cox, Russell J.;
Simpson, Thomas J.;
Uddin, Ghias

Publication type:

Article