Works by Simpkins, James W.

Results: 78

MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma.

Published in:

Aging & Disease, 2019, v. 10, n. 2, p. 329, doi. 10.14336/AD.2018.0409

By:

Sarkar, Saumyendra N.;
Russell, Ashley E.;
Engler-Chiurazzi, Elizabeth B.;
Porter, Keyana N.;
Simpkins, James W.

Publication type:

Article

Mitochondrial Impairment in Cerebrovascular Endothelial Cells is Involved in the Correlation between Body Temperature and Stroke Severity.

Published in:

Aging & Disease, 2016, v. 7, n. 1, p. 1, doi. 10.14336/AD.2015.0906

By:

Heng Hu;
Doll, Danielle N.;
Jiahong Sun;
Lewis, Sara E.;
Wimsatt, Jeffrey H.;
Kessler, Matthew J.;
Simpkins, James W.;
Xuefang Ren

Publication type:

Article

The Critical Need to Promote Research of Aging and Aging-related Diseases to Improve Health and Longevity of the Elderly Population.

Published in:

Aging & Disease, 2015, v. 6, n. 1, p. 1, doi. 10.14336/AD.2014.1210

By:

Jin, Kunlin;
Simpkins, James W.;
Xunming Jin;
Leis, Miriam;
Stambler, Ilia

Publication type:

Article

17β-Estradiol and Inflammation: Implications for Ischemic Stroke.

Published in:

Aging & Disease, 2014, v. 5, n. 5, p. 340, doi. 10.14336/AD.2014.0500340

By:

Petrone, Ashley B.;
Simpkins, James W.;
Barr, Taura L.

Publication type:

Article

Cytokines: Their Role in Stroke and Potential Use as Biomarkers and Therapeutic Targets.

Published in:

Aging & Disease, 2014, v. 5, n. 5, p. 294, doi. 10.14336/AD.2014.0500294

By:

Doll, Danielle N.;
Barr, Taura L.;
Simpkins, James W.

Publication type:

Article

Neuroprotective Actions of Methylene Blue and Its Derivatives.

Published in:

PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0048279

By:

Poteet, Ethan;
Winters, Ali;
Liang-Jun Yan;
Shufelt, Kyle;
Green, Kayla N.;
Simpkins, James W.;
Yi Wen;
Shao-Hua Yang

Publication type:

Article

Estrogen Prevents Oxidative Damage to the Mitochondria in Friedreich's Ataxia Skin Fibroblasts.

Published in:

PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0034600

By:

Richardson, Timothy E.;
Amanda E. Yu;
Yi Wen;
Shao-Hua Yang;
Simpkins, James W.

Publication type:

Article

Role of Protein Phosphatases in Estrogen-Mediated Neuroprotection.

Published in:

Journal of Neuroscience, 2005, v. 25, n. 31, p. 7191, doi. 10.1523/JNEUROSCI.1328-05.2005

By:

Kun Don Yi;
Jaegwon Chung;
Pang, Priscilla;
Simpkins, James W.

Publication type:

Article

Lipopolysaccharide exacerbates infarct size and results in worsened post-stroke behavioral outcomes.

Published in:

Behavioral & Brain Functions, 2015, v. 11, p. 1, doi. 10.1186/s12993-015-0077-5

By:

Doll, Danielle N.;
Engler-Chiurazzi, Elizabeth B.;
Lewis, Sara E.;
Heng Hu;
Kerr, Ashley E.;
Xuefang Ren;
Simpkins, James W.

Publication type:

Article

Suppression of plasma testosterone and prostate carcinoma size by a redox-based, brain-targeted estrogen delivery system in the rat.

Published in:

Prostate, 1993, v. 23, n. 1, p. 79, doi. 10.1002/pros.2990230108

By:

Rahimy, Mohamad H.;
Bodor, Nicolas;
Simpkins, James W.

Publication type:

Article

Opiate Stimulation of Prolactin Secretion Is Reversed by Ovarian Hormone Treatment.

Published in:

Neuroendocrinology, 1992, v. 56, n. 2, p. 195, doi. 10.1159/000126228

By:

Singh, Meharvan;
Millard, WilliamJ.;
Layden, Meri P.;
Romano, Teresa M.;
Simpkins, James W.

Publication type:

Article

Opiate Modulation of Growth Hormone Secretion Is Compromised during the Steroid-Induced Luteinizing Hormone Surge.

Published in:

Neuroendocrinology, 1992, v. 55, n. 2, p. 214, doi. 10.1159/000126117

By:

Singh, Meharvan;
Simpkins, James W.;
Layden, Meri P.;
Romano, Teresa M.;
Millard, William J.

Publication type:

Article

Evaluation of the Sites of Opioid Influence on Anterior Pituitary Hormone Secretion Using a Quaternary Opiate Antagonist.

Published in:

Neuroendocrinology, 1991, v. 54, n. 4, p. 384, doi. 10.1159/000125918

By:

Simpkins, James W.;
Swager, David;
Millard, William J.

Publication type:

Article

Opiate-Thyroid Hormone Interactions in the Regulation of Thyrotropin Secretion in the Rat.

Published in:

Neuroendocrinology, 1990, v. 52, n. 3, p. 303, doi. 10.1159/000125602

By:

Berglund, Ann;
Millard, William J.;
Gabriel, Steve M.;
Simpkins, James W.

Publication type:

Article

Evidence for Prolonged Suppression of Stress-Induced Release of Adrenocorticotropic Hormone and Corticosterone with a Brain-Enhanced Dexamethasone-Redox Delivery System.

Published in:

Neuroendocrinology, 1989, v. 50, n. 1, p. 9, doi. 10.1159/000125196

By:

Anderson, Wesley R.;
Simpkins, James W.;
Brewster, Marcus E.;
Bodor, Nicholas S.

Publication type:

Article

Alterations in Brain Opiate Receptor Mechanisms on Proestrous Afternoon.

Published in:

Neuroendocrinology, 1988, v. 48, n. 4, p. 394, doi. 10.1159/000125040

By:

Berglund, Ann;
Simpkins, James W.

Publication type:

Article

Chronic Morphine and Testosterone Treatment.

Published in:

Neuroendocrinology, 1988, v. 48, n. 1, p. 97, doi. 10.1159/000124996

By:

Clark, John T.;
Gabriel, Steven M.;
Simpkins, James W.;
Kalra, Satya P.;
Kalra, Pushpa S.

Publication type:

Article

Role of Hypothermia in the Pentobarbital-Induced Blockade of Luteinizing Hormone Secretion in Female Rats.

Published in:

Neuroendocrinology, 1987, v. 46, n. 3, p. 217, doi. 10.1159/000124822

By:

Simpkins, James W.;
Katovich, Michael J.

Publication type:

Article

Long-Term Weekly Gonadal Steroid Treatment: Effects on Plasma Prolactin, Sexual Behavior and Hypothalamic-Preoptic Area Catecholamines.

Published in:

Neuroendocrinology, 1986, v. 44, n. 4, p. 488, doi. 10.1159/000124691

By:

Clark, John T.;
Simpkins, James W.;
Kalra, Satya P.

Publication type:

Article

Effects of Naloxone on Catecholamine and LHRH Release from the Perifused Hypothalamus of the Steroid-Primed Rat.

Published in:

Neuroendocrinology, 1985, v. 40, n. 6, p. 497, doi. 10.1159/000124121

By:

Leadem, Christopher A.;
Crowley, William R.;
Simpkins, James W.;
Kalra, Satya P.

Publication type:

Article

Chronic Morphine Treatment Induces Hypersensitivity to Testosterone-Negative Feedback in Castrated Male Rats.

Published in:

Neuroendocrinology, 1985, v. 40, n. 1, p. 39, doi. 10.1159/000124049

By:

Gabriel, Steven M.;
Simpkins, James W.;
Kalra, Satya P.;
Kalra, Pushpa S.

Publication type:

Article

Evidence that Chronic Hyperprolactinemia Effects Skin Temperature Regulation through an Opioid Mechanism.

Published in:

Neuroendocrinology, 1984, v. 39, n. 4, p. 321, doi. 10.1159/000123999

By:

Simpkins, James W.;
Taylor, Susan T.;
Gabriel, Steven M.;
Katovich, Michael J.;
Millard, William J.

Publication type:

Article

Testosterone Raises LHRH Levels Exclusively in the Median Eminence of Castrated Rats.

Published in:

Neuroendocrinology, 1984, v. 39, n. 1, p. 45, doi. 10.1159/000123953

By:

Kalra, Pushpa S.;
Simpkins, James W.;
Kalra, Satya P.

Publication type:

Article

Effects of a Sustained-Release Naloxone Pellet on Luteinizing Hormone Secretion in Female Rats.

Published in:

Neuroendocrinology, 1983, v. 37, n. 5, p. 342, doi. 10.1159/000123573

By:

Gabriel, Steven M.;
Simpkins, James W.

Publication type:

Article

Not all clots are created equal: a review of deficient thrombolysis with tissue plasminogen activator (tPA) in patients with metabolic syndrome.

Published in:

International Journal of Neuroscience, 2019, v. 129, n. 6, p. 612, doi. 10.1080/00207454.2018.1550400

By:

Mosimah, Charles I.;
Murray, Pamela J.;
Simpkins, James W.

Publication type:

Article

Extracellular Vesicles Secreted in Response to Cytokine Exposure Increase Mitochondrial Oxygen Consumption in Recipient Cells.

Published in:

Frontiers in Cellular Neuroscience, 2019, p. N.PAG, doi. 10.3389/fncel.2019.00051

By:

Russell, Ashley E.;
Jun, Sujung;
Sarkar, Saumyendra;
Geldenhuys, Werner J.;
Lewis, Sara E.;
Rellick, Stephanie L.;
Simpkins, James W.

Publication type:

Article

Inducible microRNA‐34a overexpression impairs cognition and promotes Alzheimer's pathology.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.064580

By:

Freitas, Raul;
McDonald, Katherine;
Wang, Hanyun;
Sarkar, Saumyendra;
Corbin, Deborah;
Bix, Gregory J;
Simpkins, James W;
Engler‐Chiurazzi, Elizabeth

Publication type:

Article

Psychosocial Stress‐Accelerates Alzheimer's Disease Progression via the Xanthine Oxidase Pathway.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.061504

By:

Burrage, Emily;
Prabhu, Saina;
Oudomvilay, Crystal;
Simpkins, James W;
Kelley, Eric E;
Chantler, Paul D

Publication type:

Article

R- and S-Equol have equivalent cytoprotective effects in Friedreich’s Ataxia.

Published in:

BMC Pharmacology & Toxicology, 2012, v. 13, p. 1, doi. 10.1186/2050-6511-13-12

By:

Richardson, Timothy E.;
Simpkins, James W.

Publication type:

Article

Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats

Published in:

FEBS Letters, 2005, v. 579, n. 21, p. 4591, doi. 10.1016/j.febslet.2005.07.028

By:

Wen, Yi;
Yang, Shaohua;
Liu, Ran;
Simpkins, James W.

Publication type:

Article

Mitochondrial DNA deletions in Alzheimer's brains: A review.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, n. 3, p. 393, doi. 10.1016/j.jalz.2013.04.508

By:

Phillips, Nicole R.;
Simpkins, James W.;
Roby, Rhonda K.

Publication type:

Article

Commentary on “Alzheimer's disease drug development and the problem of the blood-brain barrier”

Published in:

2009

By:

Simpkins, James W.

Publication type:

Editorial

Commentary on “A roadmap for the prevention of dementia II. Leon Thal Symposium 2008.” Rationale and recommendations for first evaluating anti-Alzheimer's disease medications in acute brain injury patients

Published in:

2009

By:

Simpkins, James W.;
Gatson, Joshua W.;
Wigginton, Jane G.

Publication type:

Editorial

More than a decade of estrogen neuroprotection

Published in:

2008

By:

Simpkins, James W.;
Singh, Meharvan

Publication type:

Editorial

MiR-34a regulates blood-brain barrier permeability and mitochondrial function by targeting cytochrome c.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2016, v. 36, n. 2, p. 387, doi. 10.1177/0271678X15606147

By:

Bukeirat, Mimi;
Sarkar, Saumyendra N.;
Heng Hu;
Quintana, Dominic D.;
Simpkins, James W.;
Xuefang Ren

Publication type:

Article

17-β Estradiol Can Reduce Secondary Ischemic Damage and Mortality of Subarachnoid Hemorrhage.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2001, v. 21, n. 2, p. 174, doi. 10.1097/00004647-200102000-00009

By:

Yang, Shao-Hua;
He, Zhen;
Wu, Samuel S;
He, Yun-Ju;
Cutright, Jason;
Millard, William J;
Day, Arthur L;
Simpkins, James W

Publication type:

Article

Mechanistic insights into the direct antioxidant effects of estrogens.

Published in:

Drug Development Research, 2005, v. 66, n. 2, p. 118, doi. 10.1002/ddr.20050

By:

Laszlo Prokai;
Katalin Prokai‐Tatrai;
Pál Perjési;
James W. Simpkins

Publication type:

Article

Neuroprotective effects of estratriene analogs: structure‐activity relationships and molecular optimization.

Published in:

Drug Development Research, 2005, v. 66, n. 2, p. 78, doi. 10.1002/ddr.20047

By:

Evelyn Perez;
Zu Yun Cai;
Douglas F. Covey;
James W. Simpkins

Publication type:

Article

Author Correction: Blood substitution therapy rescues the brain of mice from ischemic damage.

Published in:

2021

By:

Ren, Xuefang;
Hu, Heng;
Farooqi, Imran;
Simpkins, James W.

Publication type:

Correction Notice

Blood substitution therapy rescues the brain of mice from ischemic damage.

Published in:

Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-17930-x

By:

Ren, Xuefang;
Hu, Heng;
Farooqi, Imran;
Simpkins, James W.

Publication type:

Article

Review: The potential for estrogens in preventing Alzheimer's disease and vascular dementia.

Published in:

Therapeutic Advances in Neurological Disorders, 2009, v. 2, n. 1, p. 31, doi. 10.1177/1756285608100427

By:

Simpkins, James W.;
Perez, Evelyn;
Xiaofei Wang;
ShaoHua Yang;
Yi Wen;
Singh, Meharvan

Publication type:

Article

Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neurons.

Published in:

Journal of Neurochemistry, 2007, v. 100, n. 5, p. 1300, doi. 10.1111/j.1471-4159.2006.04297.x

By:

Xianrong Mao;
Shao-Hua Yang;
Simpkins, James W.;
Barger, Steven W.

Publication type:

Article

Suppression of protein kinase Cε mediates 17β-estradiol-induced neuroprotection in an immortalized hippocampal cell line.

Published in:

Journal of Neurochemistry, 2005, v. 95, n. 3, p. 745, doi. 10.1111/j.1471-4159.2005.03424.x

By:

Jung, Marianna E.;
Watson, David G.;
Simpkins, James W.

Publication type:

Article

Pre-exposure of Cells to Cationic Lipids Enhances Transgene Delivery and Expression in a Tissue Culture Cell Line.

Published in:

Journal of Drug Targeting, 1999, v. 7, n. 3, p. 207, doi. 10.3109/10611869909085503

By:

Wang, Wei;
Ajmani, Preeti S.;
Meyer, Edwin M.;
Simpkins, James W.;
Hughes, Jeffrey A.

Publication type:

Article

Neuroprotection and Estrogen Receptors.

Published in:

Neuroendocrinology, 2012, v. 96, n. 2, p. 119, doi. 10.1159/000338409

By:

Simpkins, James W.;
Singh, Meharvan;
Brock, Courtney;
Etgen, Anne M.

Publication type:

Article

miR-146a Dysregulates Energy Metabolism During Neuroinflammation.

Published in:

Journal of NeuroImmune Pharmacology, 2022, v. 17, n. 1/2, p. 228, doi. 10.1007/s11481-021-09999-y

By:

Kim, Sujung Jun;
Russell, Ashley E.;
Wang, Wei;
Gemoets, Darren E.;
Sarkar, Saumyendra N.;
Simpkins, James W.;
Brown, Candice M.

Publication type:

Article

Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity.

Published in:

Journal of Neurochemistry, 2015, v. 132, n. 4, p. 443, doi. 10.1111/jnc.13008

By:

Doll, Danielle N.;
Rellick, Stephanie L.;
Barr, Taura L.;
Ren, Xuefang;
Simpkins, James W.

Publication type:

Article

Mechanism of okadaic acid-induced neuronal death and the effect of estrogens.

Published in:

Journal of Neurochemistry, 2009, v. 108, n. 3, p. 732, doi. 10.1111/j.1471-4159.2008.05805.x

By:

Kun Don Yi;
Covey, Douglas F.;
Simpkins, James W.

Publication type:

Article

Dose-Dependent Effects of Chronic Treatment with Estradiol or Progesterone on Lh Secretion in Ovariectomized Rats.

Published in:

Endocrine Research, 1990, v. 16, n. 2, p. 165, doi. 10.1080/07435809009032997

By:

Ratka, Anna;
Simpkins, James W.

Publication type:

Article

Effects of A Brain-Enhanced Chemical Delivery System for Estradiol on Body Weight and Serum Hormones in Middle-Aged Male Rats.

Published in:

Endocrine Research, 1988, v. 14, n. 2/3, p. 131, doi. 10.3109/07435808809032982

By:

Anderson, Wesley R.;
Simpkins, James W.;
Brewster, Marcus E.;
Bodor, Nicholas

Publication type:

Article