Works by Simonsson, Ulrika S. H.

Results: 53

Cough as Noninvasive Biomarker for Monitoring Tuberculosis Treatment: A Proof-of-Concept Study.

Published in:

Annals of the American Thoracic Society, 2023, v. 20, n. 12, p. 1822, doi. 10.1513/annalsats.202305-456rl

By:

Janssen, Saskia;
Upton, Caryn M.;
De Jager, Veronique R.;
Faraj, Alan;
Pahar, Madhurananda;
Miranda, Igor D. S.;
Diacon, Andreas H.;
Simonsson, Ulrika S. H.;
Niesler, Thomas R.

Publication type:

Article

Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-43412-3

By:

van Wijk, Rob C.;
Mockeliunas, Laurynas;
van den Hoogen, Gerben;
Upton, Caryn M.;
Diacon, Andreas H.;
Simonsson, Ulrika S. H.

Publication type:

Article

Reproducibility in pharmacometrics applied in a phase III trial of BCG-vaccination for COVID-19.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-43412-3

By:

van Wijk, Rob C.;
Mockeliunas, Laurynas;
van den Hoogen, Gerben;
Upton, Caryn M.;
Diacon, Andreas H.;
Simonsson, Ulrika S. H.

Publication type:

Article

Standards for model-based early bactericidal activity analysis and sample size determination in tuberculosis drug development.

Published in:

Frontiers in Pharmacology, 2023, p. 1, doi. 10.3389/fphar.2023.1150243

By:

Mockeliunas, Laurynas;
Faraj, Alan;
van Wijk, Rob C.;
Upton, Caryn M.;
van den Hoogen, Gerben;
Diacon, Andreas H.;
Simonsson, Ulrika S. H.

Publication type:

Article

Greater Early Bactericidal Activity at Higher Rifampicin Doses Revealed by Modeling and Clinical Trial Simulations.

Published in:

2018

By:

Svensson, Robin J;
Svensson, Elin M;
Aarnoutse, Rob E;
Diacon, Andreas H;
Dawson, Rodney;
Gillespie, Stephen H;
Moodley, Mischka;
Boeree, Martin J;
Simonsson, Ulrika S H

Publication type:

journal article

Model-Informed Support of Dose Selection for Prophylactic Treatment with Dalcinonacog Alfa in Adult and Paediatric Hemophilia B Patients.

Published in:

Advances in Therapy, 2023, v. 40, n. 9, p. 3739, doi. 10.1007/s12325-023-02570-6

By:

Faraj, Alan;
Le Moan, Natacha;
Gorina, Eduard;
Blouse, Grant E.;
Knudsen, Tom;
Simonsson, Ulrika S. H.

Publication type:

Article

Difference in persistent tuberculosis bacteria between in vitro and sputum from patients: implications for translational predictions.

Published in:

Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-72472-y

By:

Faraj, Alan;
Clewe, Oskar;
Svensson, Robin J.;
Mukamolova, Galina V.;
Barer, Michael R.;
Simonsson, Ulrika S. H.

Publication type:

Article

A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions.

Published in:

Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01929-y

By:

Wicha, Sebastian G.;
Chunli Chen;
Clewe, Oskar;
Simonsson, Ulrika S. H.

Publication type:

Article

Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial.

Published in:

2022

By:

De Jager, Veronique;
Gupte, Nikhil;
Nunes, Silvia;
Barnes, Grace L;
van Wijk, Rob Christiaan;
Mostert, Joni;
Dorman, Susan E;
Abulfathi, Ahmed A;
Upton, Caryn M;
Faraj, Alan;
Nuermberger, Eric L;
Lamichhane, Gyanu;
Svensson, Elin M;
Simonsson, Ulrika S H;
Diacon, Andreas H;
Dooley, Kelly E

Publication type:

journal article

Model-Informed Drug Discovery and Development Strategy for the Rapid Development of Anti-Tuberculosis Drug Combinations.

Published in:

Applied Sciences (2076-3417), 2020, v. 10, n. 7, p. 2376, doi. 10.3390/app10072376

By:

van Wijk, Rob C.;
Ayoun Alsoud, Rami;
Lennernäs, Hans;
Simonsson, Ulrika S. H.

Publication type:

Article

Population pharmacokinetics of edoxaban and its main metabolite in a dedicated renal impairment study.

Published in:

Journal of Clinical Pharmacology, 2015, v. 55, n. 11, p. 1268, doi. 10.1002/jcph.541

By:

Jönsson, Siv;
Simonsson, Ulrika S. H.;
Miller, Raymond;
Karlsson, Mats O.

Publication type:

Article

An Integrated Model for Glucose and Insulin Regulation in Healthy Volunteers and Type 2 Diabetic Patients Following Intravenous Glucose Provocations.

Published in:

Journal of Clinical Pharmacology, 2007, v. 47, n. 9, p. 1159, doi. 10.1177/0091270007304457

By:

Silber, Hanna E.;
Jauslin, Petra M.;
Frey, Nicolas;
Gieschke, Ronald;
Simonsson, Ulrika S. H.;
Karlsson, Mats O.

Publication type:

Article

Pharmacokinetics of Desmopressin Administrated as an Oral Lyophilisate Dosage Form in Children With Primary Nocturnal Enuresis and Healthy Adults.

Published in:

Journal of Clinical Pharmacology, 2006, v. 46, n. 10, p. 1204, doi. 10.1177/0091270006291838

By:

Østerberg, Ole;
Savic, Radojka M.;
Karlsson, Mats O.;
Simonsson, Ulrika S. H.;
Nørgaard, Jens Peter;
Walle, Johan Vande;
Agersø, Henrik

Publication type:

Article

Predictive Modeling to Study the Treatment-Shortening Potential of Novel Tuberculosis Drug Regimens, Toward Bundling of Preclinical Data.

Published in:

2022

By:

Mudde, Saskia E;
Alsoud, Rami Ayoun;
van der Meijden, Aart;
Upton, Anna M;
Lotlikar, Manisha U;
Simonsson, Ulrika S H;
Bax, Hannelore I;
Steenwinkel, Jurriaan E M de;
Ayoun Alsoud, Rami;
de Steenwinkel, Jurriaan E M

Publication type:

journal article

Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model.

Published in:

2021

By:

Pieterman, Elise D;
Keutzer, Lina;
van der Meijden, Aart;
van den Berg, Sanne;
Wang, Han;
Zimmerman, Matthew D;
Simonsson, Ulrika S H;
Bax, Hannelore I;
Steenwinkel, Jurriaan E M de;
de Steenwinkel, Jurriaan E M

Publication type:

journal article

Combined quantitative tuberculosis biomarker model for time-to-positivity and colony forming unit to support tuberculosis drug development.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2023.1067295

By:

Alsoud, Rami Ayoun;
Svensson, Robin J.;
Svensson, Elin M.;
Gillespie, Stephen H.;
Boeree, Martin J.;
Diacon, Andreas H.;
Dawson, Rodney;
Aarnoutse, Rob E.;
Simonsson, Ulrika S. H.

Publication type:

Article

Pharmacokinetics and pharmacodynamics of anti-tuberculosis drugs: An evaluation of in vitro, in vivo methodologies and human studies.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.1063453

By:

Alffenaar, Jan-Willem C.;
de Steenwinkel, Jurriaan E. M.;
Diacon, Andreas H.;
Simonsson, Ulrika S. H.;
Srivastava, Shashikant;
Wicha, Sebastian G.

Publication type:

Article

Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.

Published in:

Clinical Pharmacology & Therapeutics, 2003, v. 74, n. 1, p. 32, doi. 10.1016/S0009-9236(03)00092-4

By:

Simonsson, Ulrika S. H.;
Jansson, Britt;
Hai, Trinh Ngoc;
Huong, Dinh Xuan;
Tybring, Gunnel;
Ashton, Michael

Publication type:

Article

A model-based analysis identifies differences in phenotypic resistance between in vitro and in vivo: implications for translational medicine within tuberculosis.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2020, v. 47, n. 5, p. 421, doi. 10.1007/s10928-020-09694-0

By:

Clewe, Oskar;
Faraj, Alan;
Hu, Yanmin;
Coates, Anthony R. M.;
Simonsson, Ulrika S. H.

Publication type:

Article

A two-compartment effect site model describes the bispectral index after different rates of propofol infusion.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2010, v. 37, n. 3, p. 243, doi. 10.1007/s10928-010-9157-1

By:

Björnsson, Marcus A.;
Norberg, Åke;
Kalman, Sigridur;
Karlsson, Mats O.;
Simonsson, Ulrika S. H.

Publication type:

Article

Distribution of plasma concentrations of first-line anti-TB drugs and individual MICs: a prospective cohort study in a low endemic setting.

Published in:

2018

By:

Niward, Katarina;
Forsman, Lina Davies;
Bruchfeld, Judith;
Chryssanthou, Erja;
Carlström, Oskar;
Alomari, Teba;
Carlsson, Björn;
Pohanka, Anton;
Mansjö, Mikael;
Nordvall, Michaela Jonsson;
Davies Forsman, Lina;
Jonsson Nordvall, Michaela;
Johansson, Anders G;
Eliasson, Erik;
Werngren, Jim;
Paues, Jakob;
Simonsson, Ulrika S H;
Schön, Thomas

Publication type:

journal article

A model-informed preclinical approach for prediction of clinical pharmacodynamic interactions of anti-TB drug combinations.

Published in:

2018

By:

Clewe, Oskar;
Wicha, Sebastian G.;
Simonsson, Ulrika S. H.;
de Vogel, Corné P.;
de Steenwinkel, Jurriaan E. M.

Publication type:

journal article

Improved power for TB Phase IIa trials using a model-based pharmacokinetic-pharmacodynamic approach compared with commonly used analysis methods.

Published in:

2017

By:

Svensson, Robin J.;
Gillespie, Stephen H.;
Simonsson, Ulrika S. H.

Publication type:

journal article

A multistate tuberculosis pharmacometric model: a framework for studying anti-tubercular drug effects in vitro.

Published in:

2016

By:

Clewe, Oskar;
Aulin, Linda;
Yanmin Hu;
Coates, Anthony R. M.;
Simonsson, Ulrika S. H.;
Hu, Yanmin

Publication type:

journal article

Population pharmacokinetics of rifampicin, pyrazinamide and isoniazid in children with tuberculosis: in silico evaluation of currently recommended doses.

Published in:

Journal of Antimicrobial Chemotherapy (JAC), 2014, v. 69, n. 5, p. 1339, doi. 10.1093/jac/dkt524

By:

Zvada, Simbarashe P.;
Denti, Paolo;
Donald, Peter R.;
Schaaf, H. Simon;
Thee, Stephanie;
Seddon, James A.;
Seifart, Heiner I.;
Smith, Peter J.;
McIlleron, Helen M.;
Simonsson, Ulrika S. H.

Publication type:

Article

Seasonal influence on respiratory tract infection severity including COVID‐19 quantified through Markov Chain modeling.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 9, p. 1250, doi. 10.1002/psp4.13006

By:

van Wijk, Rob C.;
Mockeliunas, Laurynas;
Upton, Caryn M.;
Peter, Jonathan;
Diacon, Andreas H.;
Simonsson, Ulrika S. H.

Publication type:

Article

Model‐informed pediatric dose selection of marzeptacog alfa (activated): An exposure matching strategy.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 7, p. 977, doi. 10.1002/psp4.12967

By:

Faraj, Alan;
van Wijk, Rob C.;
Neuman, Linda;
Desai, Shraddha;
Blouse, Grant E.;
Knudsen, Tom;
Simonsson, Ulrika S. H.

Publication type:

Article

Phase III dose selection of marzeptacog alfa (activated) informed by population pharmacokinetic modeling: A novel hemostatic drug.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 12, p. 1628, doi. 10.1002/psp4.12872

By:

Faraj, Alan;
Knudsen, Tom;
Desai, Shraddha;
Neuman, Linda;
Blouse, Grant E.;
Simonsson, Ulrika S. H.

Publication type:

Article

Finding the right hazard function for time‐to‐event modeling: A tutorial and Shiny application.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 8, p. 991, doi. 10.1002/psp4.12797

By:

Van Wijk, Rob C.;
Simonsson, Ulrika S. H.

Publication type:

Article

A modeling‐based proposal for safe and efficacious reintroduction of bedaquiline after dose interruption: A population pharmacokinetics study.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2022, v. 11, n. 5, p. 628, doi. 10.1002/psp4.12768

By:

Keutzer, Lina;
Akhondipour Salehabad, Yasamin;
Davies Forsman, Lina;
Simonsson, Ulrika S. H.

Publication type:

Article

Assessing Pharmacodynamic Interactions in Mice Using the Multistate Tuberculosis Pharmacometric and General Pharmacodynamic Interaction Models.

Published in:

CPT: Pharmacometrics & Systems Pharmacology, 2017, v. 6, n. 11, p. 787, doi. 10.1002/psp4.12226

By:

Chen, Chunli;
Wicha, Sebastian G.;
de Knegt, Gerjo J.;
Ortega, Fatima;
Alameda, Laura;
Sousa, Veronica;
de Steenwinkel, Jurriaan E. M.;
Simonsson, Ulrika S. H.

Publication type:

Article

Evaluation of critical parameters in the hollow‐fibre system for tuberculosis: A case study of moxifloxacin.

Published in:

British Journal of Clinical Pharmacology, 2024, v. 90, n. 7, p. 1711, doi. 10.1111/bcp.16068

By:

Aguilar‐Ayala, Diana A.;
Sanz‐García, Fernando;
Rabodoarivelo, Marie Sylvianne;
Susanto, Budi O.;
Bailo, Rebeca;
Eveque‐Mourroux, Maxime R.;
Willand, Nicolas;
Simonsson, Ulrika S. H.;
Ramón‐García, Santiago;
Lucía, Ainhoa

Publication type:

Article

Population pharmacokinetics of edoxaban in patients with symptomatic deep-vein thrombosis and/or pulmonary embolism--the Hokusai-VTE phase 3 study.

Published in:

British Journal of Clinical Pharmacology, 2015, v. 80, n. 6, p. 1374, doi. 10.1111/bcp.12727

By:

Niebecker, Ronald;
Jönsson, Siv;
Karlsson, Mats O.;
Miller, Raymond;
Nyberg, Joakim;
Krekels, Elke H. J.;
Simonsson, Ulrika S. H.

Publication type:

Article

Model-based approach to dose optimization of lopinavir/ritonavir when co-administered with rifampicin.

Published in:

British Journal of Clinical Pharmacology, 2012, v. 73, n. 5, p. 758, doi. 10.1111/j.1365-2125.2011.04154.x

By:

Zhang, Chao;
Denti, Paolo;
Decloedt, Eric;
Maartens, Gary;
Karlsson, Mats O.;
Simonsson, Ulrika S. H.;
McIlleron, Helen

Publication type:

Article

Variability in the population pharmacokinetics of isoniazid in South African tuberculosis patients.

Published in:

British Journal of Clinical Pharmacology, 2011, v. 72, n. 1, p. 51, doi. 10.1111/j.1365-2125.2011.03940.x

By:

Wilkins, Justin J.;
Langdon, Grant;
McIlleron, Helen;
Pillai, Goonaseelan;
Smith, Peter J.;
Simonsson, Ulrika S. H.

Publication type:

Article

Modelling of pain intensity and informative dropout in a dental pain model after naproxcinod, naproxen and placebo administration.

Published in:

British Journal of Clinical Pharmacology, 2011, v. 71, n. 6, p. 899, doi. 10.1111/j.1365-2125.2011.03924.x

By:

Björnsson, Marcus A.;
Simonsson, Ulrika S. H.

Publication type:

Article

Population Pharmacokinetics of Edoxaban in Patients with Non-Valvular Atrial Fibrillation in the ENGAGE AF-TIMI 48 Study, a Phase III Clinical Trial.

Published in:

2016

By:

Krekels, Elke;
Niebecker, Ronald;
Karlsson, Mats;
Miller, Raymond;
Shimizu, Takako;
Karlsson, Kristin;
Ruff, Christian;
Simonsson, Ulrika;
Jönsson, Siv;
Krekels, Elke H J;
Karlsson, Mats O;
Karlsson, Kristin E;
Ruff, Christian T;
Simonsson, Ulrika S H;
Jönsson, Siv

Publication type:

journal article

Subcutaneous Marzeptacog Alfa (Activated) for On‐Demand Treatment of Bleeding Events in Subjects With Hemophilia A or B With Inhibitors.

Published in:

Clinical Pharmacology & Therapeutics, 2024, v. 115, n. 3, p. 498, doi. 10.1002/cpt.3172

By:

Faraj, Alan;
Nyberg, Joakim;
Blouse, Grant E.;
Knudsen, Tom;
Simonsson, Ulrika S. H.

Publication type:

Article

A Population Pharmacokinetic Model Incorporating Saturable Pharmacokinetics and Autoinduction for High Rifampicin Doses.

Published in:

Clinical Pharmacology & Therapeutics, 2018, v. 103, n. 4, p. 674, doi. 10.1002/cpt.778

By:

Svensson, Robin J.;
Aarnoutse, Rob E.;
Diacon, Andreas H.;
Dawson, Rodney;
Gillespie, Stephen H.;
Boeree, Martin J.;
Simonsson, Ulrika S. H.

Publication type:

Article

Individualized Dosing With High Inter-Occasion Variability Is Correctly Handled With Model-Informed Precision Dosing—Using Rifampicin as an Example.

Published in:

Frontiers in Pharmacology, 2020, v. 11, p. 1, doi. 10.3389/fphar.2020.00794

By:

Keutzer, Lina;
Simonsson, Ulrika S. H.

Publication type:

Article

Rifampicin Can Be Given as Flat-Dosing Instead of Weight-Band Dosing.

Published in:

Clinical Infectious Diseases, 2020, v. 71, n. 12, p. 3055, doi. 10.1093/cid/ciz1202

By:

Susanto, Budi O;
Svensson, Robin J;
Svensson, Elin M;
Aarnoutse, Rob;
Boeree, Martin J;
Simonsson, Ulrika S H

Publication type:

Article

Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects.

Published in:

Fundamental & Clinical Pharmacology, 2007, v. 21, n. 3, p. 307, doi. 10.1111/j.1472-8206.2007.00471.x

By:

Asimus, Sara;
Elsherbiny, Doaa;
Hai, Trinh N.;
Jansson, Britt;
Huong, Nguyen V.;
Petzold, Max G.;
Simonsson, Ulrika S. H.;
Ashton, Michael

Publication type:

Article

Machine Learning and Pharmacometrics for Prediction of Pharmacokinetic Data: Differences, Similarities and Challenges Illustrated with Rifampicin.

Published in:

Pharmaceutics, 2022, v. 14, n. 8, p. 1530, doi. 10.3390/pharmaceutics14081530

By:

Keutzer, Lina;
You, Huifang;
Farnoud, Ali;
Nyberg, Joakim;
Wicha, Sebastian G.;
Maher-Edwards, Gareth;
Vlasakakis, Georgios;
Moghaddam, Gita Khalili;
Svensson, Elin M.;
Menden, Michael P.;
Simonsson, Ulrika S. H.

Publication type:

Article

Model-Informed Precision Dosing of Linezolid in Patients with Drug-Resistant Tuberculosis.

Published in:

Pharmaceutics, 2022, v. 14, n. 4, p. N.PAG, doi. 10.3390/pharmaceutics14040753

By:

Mockeliunas, Laurynas;
Keutzer, Lina;
Sturkenboom, Marieke G. G.;
Bolhuis, Mathieu S.;
Hulskotte, Lotte M. G.;
Akkerman, Onno W.;
Simonsson, Ulrika S. H.

Publication type:

Article

Derivation and Clinical Utility of Safety Targets for Linezolid-Related Adverse Events in Drug-Resistant Tuberculosis Treatment.

Published in:

Pharmaceuticals (14248247), 2023, v. 16, n. 11, p. 1575, doi. 10.3390/ph16111575

By:

Keutzer, Lina;
Mockeliunas, Laurynas;
Sturkenboom, Marieke G. G.;
Bolhuis, Mathieu S.;
Akkerman, Onno W.;
Simonsson, Ulrika S. H.

Publication type:

Article

Comparisons of Analysis Methods for Assessment of Pharmacodynamic Interactions Including Design Recommendations.

Published in:

AAPS Journal, 2018, v. 20, n. 4, p. 1, doi. 10.1208/s12248-018-0239-0

By:

Chunli Chen;
Wicha, Sebastian G.;
Nordgren, Rikard;
Simonsson, Ulrika S. H.

Publication type:

Article

Population pharmacokinetics of nevirapine in combination with rifampicin-based short course chemotherapy in HIV- and tuberculosis-infected South African patients.

Published in:

European Journal of Clinical Pharmacology, 2009, v. 65, n. 1, p. 71, doi. 10.1007/s00228-008-0481-y

By:

Elsherbiny, Doaa;
Cohen, Karen;
Jansson, Britt;
Smith, Peter;
McIlleron, Helen;
Simonsson, Ulrika S. H.

Publication type:

Article

Variability in the population pharmacokinetics of pyrazinamide in South African tuberculosis patients.

Published in:

European Journal of Clinical Pharmacology, 2006, v. 62, n. 9, p. 727, doi. 10.1007/s00228-006-0141-z

By:

Wilkins, Justin J.;
Langdon, Grant;
McIlleron, Helen;
Pillai, Goonaseelan (Colin);
Smith, Peter J.;
Simonsson, Ulrika S. H.

Publication type:

Article

Risk Factors for COVID-19 and Respiratory Tract Infections during the Coronavirus Pandemic.

Published in:

Vaccines, 2024, v. 12, n. 3, p. 329, doi. 10.3390/vaccines12030329

By:

Mockeliunas, Laurynas;
van Wijk, Rob C.;
Upton, Caryn M.;
Peter, Jonathan;
Diacon, Andreas H.;
Simonsson, Ulrika S. H.

Publication type:

Article

Rotational thromboelastometry can predict the probability of bleeding events in a translational rat model of haemophilia A following gene‐based FVIIa prophylaxis.

Published in:

Haemophilia, 2020, v. 26, n. 1, p. 164, doi. 10.1111/hae.13899

By:

Larsen, Malte Selch;
Vestergaard Juul, Rasmus;
Zintner, Shannon M.;
T. Kristensen, Annemarie;
Margaritis, Paris;
Kjelgaard‐Hansen, Mads;
Wiinberg, Bo;
Simonsson, Ulrika S. H.;
Kreilgaard, Mads

Publication type:

Article