Works by Simon, Markus M.

Results: 53

Mode of Inoculation of the Lyme Disease Agent Borrelia burgdorferi Influences Infection and Immune Responses in Inbred Strains of Mice.

Published in:

Journal of Infectious Diseases, 1993, v. 167, n. 4, p. 971, doi. 10.1093/infdis/167.4.971

By:

Gern, Lise;
Schaible, Ulrich E.;
Simon, Markus M.

Publication type:

Article

Recombinant Outer Surface Protein A from Borrelia burgdorferi Induces Antibodies Protective against Spirochetal Infection in Mice.

Published in:

Journal of Infectious Diseases, 1991, v. 164, n. 1, p. 123, doi. 10.1093/infdis/164.1.123

By:

Simon, Markus M.;
Schaible, Ulrich E.;
Kramer, Michael D.;
Eckerskorn, Christoph;
Museteanu, C.;
Müller-Hermelink, Hans K.;
Wallich, Reinhard

Publication type:

Article

Acid sphingomyelinase is a key regulator of cytotoxic granule secretion by primary T lymphocytes.

Published in:

Nature Immunology, 2009, v. 10, n. 7, p. 761, doi. 10.1038/ni.1757

By:

Herz, Jasmin;
Pardo, Julian;
Kashkar, Hamid;
Schramm, Michael;
Kuzmenkina, Elza;
Bos, Erik;
Wiegmann, Katja;
Wallich, Reinhard;
Peters, Peter J.;
Herzig, Stefan;
Schmelzer, Elmon;
Krönke, Martin;
Simon, Markus M.;
Utermöhlen, Olaf

Publication type:

Article

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice.

Published in:

Journal of Cell Biology, 2006, v. 174, n. 4, p. 509, doi. 10.1083/jcb.200604044

By:

Pardo, Julian;
Urban, Christin;
Galvez, Eva M.;
Ekert, Paul G.;
Müller, Uwe;
Kwon-Chung, June;
Lobigs, Mario;
Müllbacher, Arno;
Wallich, Reinhard;
Borner, Christoph;
Simon, Markus M.

Publication type:

Article

Apoptotic pathways are selectively activated by granzyme A and/or granzyme B in CTL-mediated target cell lysis.

Published in:

Journal of Cell Biology, 2004, v. 167, n. 3, p. 457, doi. 10.1083/jcb.200406115

By:

Pardo, Julián;
Bosque, Alberto;
Brehm, Reina;
Wallich, Reinhard;
Naval, Javier;
Mullbocher, Arno;
Anei, Alberto;
Simon, Markus M.

Publication type:

Article

Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis.

Published in:

Arthritis & Rheumatology, 2017, v. 69, n. 2, p. 320, doi. 10.1002/art.39857

By:

Santiago, Llipsy;
Menaa, Cheikh;
Arias, Maykel;
Martin, Praxedis;
Jaime‐Sánchez, Paula;
Metkar, Sunil;
Comas, Laura;
Erill, Nadina;
Gonzalez‐Rumayor, Victor;
Esser, Erica;
Galvez, Eva M.;
Raja, Sri;
Simon, Markus M.;
Sprague, Stuart M.;
Gabay, Cem;
Martinez‐Lostao, Luis;
Pardo, Julian;
Froelich, Christopher J.

Publication type:

Article

Mapping the Ligand-Binding Region of <i>Borrelia hermsii</i> Fibronectin-Binding Protein

Published in:

PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0063437

By:

Brenner, Christiane;
Bomans, Katharina;
Habicht, Jüri;
Simon, Markus M.;
Wallich, Reinhard

Publication type:

Article

Caspase-Dependent Inhibition of Mousepox Replication by gzmB.

Published in:

PLoS ONE, 2009, v. 4, n. 10, p. 1, doi. 10.1371/journal.pone.0007512

By:

Pardo, Julián;
Gálvez, Eva M<sup>a</sup>;
Koskinen, Aulikki;
Simon, Markus M.;
Lobigs, Mario;
Regner, Matthias;
Müllbacher, Arno

Publication type:

Article

Borrelia recurrentis Employs a Novel Multifunctional Surface Protein with Anti-Complement, Anti-Opsonic and Invasive Potential to Escape Innate Immunity.

Published in:

PLoS ONE, 2009, v. 4, n. 3, p. 1, doi. 10.1371/journal.pone.0004858

By:

Grosskinsky, Sonja;
Schott, Melanie;
Brenner, Christiane;
Cutler, Sally J.;
Kraiczy, Peter;
Zipfel, Peter F.;
Simon, Markus M.;
Wallich, Reinhard

Publication type:

Article

A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi.

Published in:

Nature Structural & Molecular Biology, 2005, v. 12, n. 3, p. 276, doi. 10.1038/nsmb902

By:

Cordes, Frank S;
Roversi, Pietro;
Kraiczy, Peter;
Simon, Markus M;
Brade, Volker;
Jahraus, Oliver;
Wallis, Russell;
Skerka, Christine;
Zipfel, Peter F;
Wallich, Reinhard;
Lea, Susan M

Publication type:

Article

Comparative cryo-electron tomography of pathogenic Lyme disease spirochetes.

Published in:

Molecular Microbiology, 2009, v. 71, n. 6, p. 1415, doi. 10.1111/j.1365-2958.2009.06613.x

By:

Kudryashev, Mikhail;
Cyrklaff, Marek;
Baumeister, Wolfgang;
Simon, Markus M.;
Wallich, Reinhard;
Frischknecht, Friedrich

Publication type:

Article

Secretory lysosomes of mouse mast cells store and exocytose active caspase-3 in a strictly granzyme B dependent manner.

Published in:

European Journal of Immunology, 2013, v. 43, n. 12, p. 3209, doi. 10.1002/eji.201343941

By:

Zorn, Carolin N.;
Pardo, Julian;
Martin, Praxedis;
Kuhny, Marcel;
Simon, Markus M.;
Huber, Michael

Publication type:

Article

Production of a recombinant bacterial lipoprotein in higher plant chloroplasts.

Published in:

Nature Biotechnology, 2006, v. 24, n. 1, p. 76, doi. 10.1038/nbt1170

By:

Glenz, Karin;
Bouchon, Bernadette;
Stehle, Thomas;
Wallich, Reinhard;
Simon, Markus M;
Warzecha, Heribert

Publication type:

Article

Production of immune interferon is regulated by more than one T cell subset: Lyt-1,2,3 and Qat-5 phenotypes of murine T lymphocytes involved in IFN-γ production in primary and secondary mixed lymphocyte reaction.

Published in:

European Journal of Immunology, 1982, v. 12, n. 4, p. 295, doi. 10.1002/eji.1830120408

By:

Landolfo, Santo;
Kirchner, Holger;
Simon, Markus M.

Publication type:

Article

Expression of Qat-4 and Qat-5 alloantigens on cytotoxic precursor and effector cells: different surface phenotypes of alloreactive and H-2-restricted cytotoxic T Cells.

Published in:

European Journal of Immunology, 1982, v. 12, n. 1, p. 43, doi. 10.1002/eji.1830120110

By:

Zahn, Gabriele;
Hämmerling, Günther J.;
And, Klaus Eichmann;
Simon, Markus M.

Publication type:

Article

Generation of effector cells from T cell subsets III. Synergy between Lyt-1 and Lyt-123/23 lymphocytes in the generation of H-2-restricted and alloreactive cytotoxid T cells.

Published in:

European Journal of Immunology, 1981, v. 11, n. 3, p. 246, doi. 10.1002/eji.1830110315

By:

Simon, Markus M.;
Edwards, Andrew J.;
Hämmerling, Ulrich;
McKenzie, Ian F. C.;
Eichmann, Klaus;
Simpson, Elizabeth

Publication type:

Article

Generation of effector cells from T cell subsets. II. Lyt 123 T cells contain the precursors for all primary cytotoxic effector cells and for cells involved in the regulation of cytotoxic responses.

Published in:

European Journal of Immunology, 1980, v. 10, n. 5, p. 334, doi. 10.1002/eji.1830100504

By:

Simon, Markus M.;
Abenhardt, Birgit

Publication type:

Article

Generation of virus-specific cytotoxic T cells in vitro I. Induction conditions of primary and secondary Sendai virus-specific cytotoxic T cells.

Published in:

European Journal of Immunology, 1979, v. 9, n. 9, p. 715, doi. 10.1002/eji.1830090910

By:

Koszinowski, Ulrich H.;
Simon, Markus M.

Publication type:

Article

Human Complement Regulators C4b-Binding Protein and C1 Esterase Inhibitor Interact with a Novel Outer Surface Protein of Borrelia recurrentis.

Published in:

PLoS Neglected Tropical Diseases, 2010, v. 4, n. 6, p. 1, doi. 10.1371/journal.pntd.0000698

By:

Grosskinsky, Sonja;
Schott, Melanie;
Brenner, Christiane;
Cutler, Sally J.;
Simon, Markus M.;
Wallich, Reinhard

Publication type:

Article

Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi.

Published in:

Wiener Klinische Wochenschrift, 2006, v. 118, n. 21/22, p. 669, doi. 10.1007/s00508-006-0691-1

By:

Kraiczy, Peter;
Rossmann, Evelyn;
Brade, Volker;
Simon, Markus M.;
Skerka, Christine;
Zipfel, Peter F.;
Wallich, Reinhard

Publication type:

Article

Granzyme B of cytotoxic T cells induces extramitochondrial reactive oxygen species production via caspase-dependent NADPH oxidase activation.

Published in:

Immunology & Cell Biology, 2010, v. 88, n. 5, p. 545, doi. 10.1038/icb.2010.5

By:

Aguiló, Juan I.;
Anel, Alberto;
Catalán, Elena;
Sebastián, Alvaro;
Acín-Pérez, Rebeca;
Naval, Javier;
Wallich, Reinhard;
Simon, Markus M.;
Pardo, Julián

Publication type:

Article

NK cell-mediated immunopathology during an acute viral infection of the CNS.

Published in:

European Journal of Immunology, 2006, v. 36, n. 4, p. 887, doi. 10.1002/eji.200535342

By:

Alsharifi, Mohammed;
Lobigs, Mario;
Simon, Markus M.;
Kersten, Astrid;
Müller, Klaus;
Koskinen, Aulikki;
Lee, Eva;
Müllbacher, Arno

Publication type:

Article

Synthetic bacterial lipopeptide analogs facilitate naive CD4.

Published in:

European Journal of Immunology, 2005, v. 35, n. 8, p. 2434, doi. 10.1002/eji.200526241

By:

Ghielmetti, Mascia;
Zwicker, Marianne;
Ghielmetti, Tanja;
Simon, Markus M.;
Villiger, Peter M.;
Padovan, Elisabetta

Publication type:

Article

A fusion product of the complete Borrelia burgdorferi outer surface protein A (OspA) and the hepatitis B virus capsid protein is highly immunogenic and induces protective immunity similar to that seen with an effective lipidated OspA vaccine formula.

Published in:

European Journal of Immunology, 2005, v. 35, n. 2, p. 655, doi. 10.1002/eji.200425449

By:

Nassal, Michael;
Skamel, Claudia;
Kratz, Peter A.;
Wallich, Reinhard;
Stehle, Thomas;
Simon, Markus M.

Publication type:

Article

Artificial-infection protocols allow immunodetection of novel Borrelia burgdorferi antigens suitable as vaccine candidates against Lyme disease.

Published in:

European Journal of Immunology, 2003, v. 33, n. 3, p. 708, doi. 10.1002/eji.200323620

By:

Wallich, Reinhard;
Jahraus, Oliver;
Stehle, Thomas;
Tran, Thi Thanh Thao;
Brenner, Christiane;
Hofmann, Heidelore;
Gern, Lise;
Simon, Markus M.

Publication type:

Article

Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent onthe FasL/Fas pathway.

Published in:

European Journal of Immunology, 2003, v. 33, n. 1, p. 70, doi. 10.1002/immu.200390009

By:

Müller, Uwe;
Sobek, Vera;
Balkow, Sandra;
Hölscher, Christoph;
Müllbacher, Arno;
Museteanu, Crisan;
Mossmann, Horst;
Simon, Markus M.

Publication type:

Article

Differential recognition of structural details of bacterial lipopeptides by toll-like receptors.

Published in:

European Journal of Immunology, 2002, v. 32, n. 12, p. 3337, doi. 10.1002/1521-4141(200212)32:12<3337::AID-IMMU3337>3.0.CO;2-#

By:

Morr, Michael;
Takeuchi, Osamu;
Akira, Shizuo;
Simon, Markus M.;
Mühlradt, Peter F.

Publication type:

Article

Granzymes are essential for natural killer cell-mediated and perf-facilitated tumor control.

Published in:

European Journal of Immunology, 2002, v. 32, n. 10, p. 2881, doi. 10.1002/1521-4141(2002010)32:10<2881::AID-IMMU2881>3.0.CO;2-K

By:

Pardo, Julián;
Balkow, Sandra;
Anel, Alberto;
Simon, Markus M.

Publication type:

Article

Antigen-induced cell death of T effector cells in vitro proceeds via the Fas pathway, requires endogenous interferon-γ and is independent of perforin and granzymes.

Published in:

European Journal of Immunology, 2002, v. 32, n. 9, p. 2490, doi. 10.1002/1521-4141(200209)32:9<2490::AID-IMMU2490>3.0.CO;2-G

By:

Sobek, Vera;
Balkow, Sandra;
Körner, Heinrich;
Simon, Markus M.

Publication type:

Article

The differential contribution of granzyme A and granzyme B in cytotoxic T lymphocyte-mediated apoptosis is determined by the quality of target cells.

Published in:

European Journal of Immunology, 2002, v. 32, n. 7, p. 1980, doi. 10.1002/1521-4141(200207)32:7<1980::AID-IMMU1980>3.0.CO;2-Z

By:

Pardo, Julián;
Balkow, Sandra;
Anel, Alberto;
Simon, Markus M.

Publication type:

Article

Prominent T cell response to a selectively in vivo expressed Borrelia burgdorferi outer surface protein (pG) in patients with Lyme disease.

Published in:

European Journal of Immunology, 2001, v. 31, n. 3, p. 767, doi. 10.1002/1521-4141(200103)31:3<767::AID-IMMU767>3.0.CO;2-M

By:

Bauer, Yvonne;
Hofmann, Heidelore;
Jahraus, Oliver;
Mytilineos, Joannis;
Simon, Markus M.;
Wallich, Reinhard

Publication type:

Article

Murine cytomegalovirus replication in salivary glands is controlled by both perforin and granzymes during acute infection.

Published in:

European Journal of Immunology, 2000, v. 30, n. 5, p. 1350, doi. 10.1002/(SICI)1521-4141(200005)30:5<1350::AID-IMMU1350>3.0.CO;2-J

By:

Riera, Ludovica;
Gariglio, Marisa;
Valente, Guido;
Müllbacher, Arno;
Museteanu, Crisan;
Landolfo, Santo;
Simon, Markus M.

Publication type:

Article

Resolution of experimental and tick-borne Borrelia burgdorferiinfection in mice by passive, but not active immunization using recombinant OspC.

Published in:

European Journal of Immunology, 1999, v. 29, n. 3, p. 946, doi. 10.1002/(SICI)1521-4141(199903)29:03<946::AID-IMMU946>3.0.CO;2-P

By:

Zhong, Weimin;
Gern, Lise;
Stehle, Thomas;
Museteanu, Crisan;
Kramer, Michael;
Wallich, Reinhard;
Simon, Markus M.

Publication type:

Article

T helper cell priming of mice to Borrelia burgdorferi Osp A leads to induction of protective antibodies following experimental but not tickborne infection.

Published in:

European Journal of Immunology, 1997, v. 27, n. 11, p. 2942, doi. 10.1002/eji.1830271129

By:

Zhong, Weimin;
Gern, Lise;
Kramer, Michael;
Wallich, Reinhard;
Simon, Markus M.

Publication type:

Article

Protective immunization with plasmid DNA containing the outer surface lipoprotein A gene of Borrelia burgdorferi is independent of an eukaryotic promoter.

Published in:

European Journal of Immunology, 1996, v. 26, n. 12, p. 2831, doi. 10.1002/eji.1830261206

By:

Simon, Markus M.;
Gern, Lise;
Hauser, Pierre;
Zhong, Weimin;
Nielsen, Peter J.;
Kramer, Michael D.;
Brenner, Christiane;
Wallich, Reinhard

Publication type:

Article

Plasmid DNA and protein vaccination of mice to the outer surface protein A of Borrelia burgdorferi leads to induction of T helper cells with specificity for a major epitope and augmentation of protective IgG antibodies in vivo.

Published in:

European Journal of Immunology, 1996, v. 26, n. 11, p. 2749, doi. 10.1002/eji.1830261130

By:

Zhong, Weimin;
Wiesmüller, Karl-Heinz;
Kramer, Michael D.;
Wallich, Reinhard;
Simon, Markus M.

Publication type:

Article

The outer surface lipoprotein OspA of Borrelia burgdorferi provides co-stimulatory signals to normal human peripheral CD4.

Published in:

European Journal of Immunology, 1996, v. 26, n. 10, p. 2299, doi. 10.1002/eji.1830261005

By:

Knigge, Heidrun;
Simon, Markus M.;
Meuer, Stefan C.;
Kramer, Michael D.;
Wallich, Reinhard

Publication type:

Article

Experimental Borrelia burgdorferi infection in inbred mouse strains: Antibody response and association of H-2 genes with resistance and susceptibility to development of arthritis.

Published in:

European Journal of Immunology, 1991, v. 21, n. 10, p. 2397, doi. 10.1002/eji.1830211016

By:

Schaible, Ulrich E.;
Kramer, Michael D.;
Wallich, Reinhard;
Tran, Thao;
Simon, Markus M.

Publication type:

Article

Coordinate secretion and functional synergism of T cell-associated serine proteinase-1 (MTSP-1) and endoglycosidase(s) of activated T cells.

Published in:

European Journal of Immunology, 1991, v. 21, n. 9, p. 2247, doi. 10.1002/eji.1830210936

By:

Vettel, Ulrike;
Bar-Shavit, Rachel;
Simon, Markus M.;
Brunner, Georg;
Vlodavsky, Israel;
Kramer, Michael D.

Publication type:

Article

Expression of cytoplasmic granules with T cell-associated serine proteinase-1 activity in Ly-2(CD8) T lymphocytes responding to lymphocytic choriomeningitis virus in vivo.

Published in:

European Journal of Immunology, 1989, v. 19, n. 1, p. 151, doi. 10.1002/eji.1830190124

By:

Kramer, Michael D.;
Fruth, Uli;
Simon, Hans-Georg;
Simon, Markus M.

Publication type:

Article

Induction of T cell serine proteinase 1 (TSP-1)-specific mRNA in mouse T lymphocytes.

Published in:

European Journal of Immunology, 1988, v. 18, n. 6, p. 855, doi. 10.1002/eji.1830180605

By:

Simon, Hans-Georg;
Fruth, Uli;
Eckerskorn, Christoph;
Lottspeich, Friedrich;
Kramer, Michael D.;
Nerz, Gabi;
Simon, Markus M.

Publication type:

Article

Determination of frequency of T cells expressing the T cell-specific serine proteinase 1 (TSP-1) reveals two types of L3T4.

Published in:

European Journal of Immunology, 1988, v. 18, n. 5, p. 773, doi. 10.1002/eji.1830180518

By:

Fruth, Uli;
Nerz, Gaby;
Prester, Marlot;
Simon, Hans G.;
Kramer, Michael D.;
Simon, Markus M.

Publication type:

Article

A novel serine proteinase (HuTSP) isolated from a cloned human CD8.

Published in:

European Journal of Immunology, 1987, v. 17, n. 11, p. 1625, doi. 10.1002/eji.1830171116

By:

Fruth, Uli;
Sinigaglia, Francesco;
Schlesier, Michael;
Kilgus, Jochen;
Kramer, Michael D.;
Simon, Markus M.

Publication type:

Article

The immune response of the mouse to lymphocytic choriomeningitis virus V. High numbers of cytolytic T lymphocytes are generated in the spleen during acute infection.

Published in:

European Journal of Immunology, 1987, v. 17, n. 7, p. 937, doi. 10.1002/eji.1830170707

By:

Moskophidis, Demetrius;
Assmann-Wischer, Ursula;
Simon, Markus M.;
Lehmann-Grube, Fritz

Publication type:

Article

The T cell-specific serine proteinase TSP-1 is associated with cytoplasmic granules of cytolytic T lymphocytes.

Published in:

European Journal of Immunology, 1987, v. 17, n. 5, p. 613, doi. 10.1002/eji.1830170506

By:

Fruth, Ulli;
Prester, Marlot;
Golecki, Jochen R.;
Hengartner, Hans;
Simon, Hans Georg;
Kramer, Michael D.;
Simon, Markus M.

Publication type:

Article

A specific serine proteinase is inducible in Lyt-2.

Published in:

European Journal of Immunology, 1986, v. 16, n. 12, p. 1559, doi. 10.1002/eji.1830161215

By:

Simon, Markus M.;
Fruth, Ulli;
Simon, Hans Georg;
Kramer, Michael D.

Publication type:

Article

Leukemic cells arise from cloned cytotoxic lymphocytes during cell culture.

Published in:

European Journal of Immunology, 1986, v. 16, n. 10, p. 1269, doi. 10.1002/eji.1830161014

By:

Simon, Markus M.;
Ali, Sher;
Tewari, Rita;
Simon, Hans-Georg;
Müller-Hermelink, Hans K.;
Epplen, Jörg T.

Publication type:

Article

Immunoregulation by mouse T cell clones III. Cloned H-Y-specific cytotoxic T cells secrete a soluble mediator(s) that inhibits cytotoxic responses by acting on both Lyt-2.

Published in:

European Journal of Immunology, 1985, v. 15, n. 8, p. 773, doi. 10.1002/eji.1830150807

By:

Simon, Markus M.;
Nerz, Gaby;
Prester, Marlot;
Moll, Heidrun

Publication type:

Article

Regulation of Chemokine Gene Expression in Human Endothelial Cells by Proinflammatory Cytokines and Borrelia burgdorferi.

Published in:

Annals of the New York Academy of Sciences, 1996, v. 797, n. 1, p. 107, doi. 10.1111/j.1749-6632.1996.tb52953.x

By:

EBNET, KLAUS;
SIMON, MARKUS M.;
SHAW, STEPHEN

Publication type:

Article

An inhibitor specific for the mouse T-cell associated serine proteinase 1 (TSP-1) inhibits the cytolytic potential of cytoplasmic granules but not of intact cytolytic T cells.

Published in:

Journal of Cellular Biochemistry, 1989, v. 40, n. 1, p. 1, doi. 10.1002/jcb.240400102

By:

Simon, Markus M.;
Prester, Marlot;
Kramer, Michael D.;
Fruth, Uli

Publication type:

Article