Found: 167
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Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway.
- Published in:
- Scientific Reports, 2014, p. 1, doi. 10.1038/srep05664
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- Publication type:
- Article
Drug repurposing screens and synergistic drug-combinations for infectious diseases.
- Published in:
- 2018
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- Publication type:
- journal article
Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40537-x
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- Publication type:
- Article
A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).
- Published in:
- PLoS ONE, 2019, v. 14, n. 01, p. 1, doi. 10.1371/journal.pone.0210525
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- Publication type:
- Article
Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.
- Published in:
- 2018
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- Publication type:
- Correction Notice
Small molecule inhibitors of DNA repair nuclease activities of APE1.
- Published in:
- Cellular & Molecular Life Sciences, 2010, v. 67, n. 21, p. 3621, doi. 10.1007/s00018-010-0488-2
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- Publication type:
- Article
Application of biophysical methods for improved protein production and characterization: A case study on an high‐temperature requirement A‐family bacterial protease.
- Published in:
- Protein Science: A Publication of the Protein Society, 2022, v. 31, n. 12, p. 1, doi. 10.1002/pro.4498
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- Publication type:
- Article
Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.
- Published in:
- FASEB Journal, 2018, v. 32, n. 3, p. 1677, doi. 10.1096/fj.201700711R
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- Publication type:
- Article
Discovery and characterization of potent and selective inhibitors to human epithelial 15‐lipoxygenase‐2 (582.5).
- Published in:
- FASEB Journal, 2014, v. 28, p. N.PAG, doi. 10.1096/fasebj.28.1_supplement.582.5
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- Publication type:
- Article
A High Throughput Apoptosis Assay using 3D Cultured Cells.
- Published in:
- Molecules, 2019, v. 24, n. 18, p. 3362, doi. 10.3390/molecules24183362
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- Publication type:
- Article
Set-Up and Validation of a High Throughput Screening Method for Human Monoacylglycerol Lipase (MAGL) Based on a New Red Fluorescent Probe.
- Published in:
- Molecules, 2019, v. 24, n. 12, p. 2241, doi. 10.3390/molecules24122241
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- Publication type:
- Article
Inheritance of rare functional GCKR variants and their contribution to triglyceride levels in families.
- Published in:
- Human Molecular Genetics, 2014, v. 23, n. 20, p. 5570, doi. 10.1093/hmg/ddu269
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- Publication type:
- Article
Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.
- Published in:
- Nature Communications, 2016, v. 7, n. 1, p. 10425, doi. 10.1038/ncomms10425
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- Publication type:
- Article
Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition.
- Published in:
- Nature Communications, 2014, v. 5, n. 11, p. 5165, doi. 10.1038/ncomms6165
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- Publication type:
- Article
Erratum: A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.
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- Nature Communications, 2013, v. 4, n. 10, p. 2639, doi. 10.1038/ncomms3639
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- Publication type:
- Article
Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion.
- Published in:
- Nature Communications, 2013, v. 4, n. 8, p. 2261, doi. 10.1038/ncomms3261
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- Publication type:
- Article
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.
- Published in:
- Nature Communications, 2013, v. 4, n. 6, p. 2035, doi. 10.1038/ncomms3035
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- Publication type:
- Article
Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.
- Published in:
- Science Translational Medicine, 2018, v. 10, n. 428, p. 1, doi. 10.1126/scitranslmed.aaf7444
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- Publication type:
- Article
A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model.
- Published in:
- PLoS ONE, 2022, v. 17, n. 1, p. 1, doi. 10.1371/journal.pone.0261821
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- Publication type:
- Article
KDM5 histone demethylases repress immune response via suppression of STING.
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- PLoS Biology, 2018, v. 16, n. 8, p. 1, doi. 10.1371/journal.pbio.2006134
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- Publication type:
- Article
Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.
- Published in:
- Journal of Computer-Aided Molecular Design, 2014, v. 28, n. 7, p. 765, doi. 10.1007/s10822-014-9758-7
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- Publication type:
- Article
Use of in vitro methods combined with in silico analysis to identify potential skin sensitizers in the Tox21 10K compound library.
- Published in:
- Frontiers in Toxicology, 2024, p. 1, doi. 10.3389/ftox.2024.1321857
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- Publication type:
- Article
Gene expression analysis identifies global gene dosage sensitivity in cancer.
- Published in:
- Nature Genetics, 2015, v. 47, n. 2, p. 115, doi. 10.1038/ng.3173
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- Publication type:
- Article
High-throughput screening for modulators of cellular contractile force.
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- Integrative Biology, 2015, v. 7, n. 10, p. 1318, doi. 10.1039/c5ib00054h
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- Publication type:
- Article
Efficient and safe single-cell cloning of human pluripotent stem cells using the CEPT cocktail.
- Published in:
- Nature Protocols, 2023, v. 18, n. 1, p. 58, doi. 10.1038/s41596-022-00753-z
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- Publication type:
- Article
Erratum: Prediction of human population responses to toxic compounds by a collaborative competition.
- Published in:
- Nature Biotechnology, 2015, v. 33, n. 10, p. 1109, doi. 10.1038/nbt1015-1109a
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- Publication type:
- Article
The US Federal Tox21 Program: A Strategic and Operational Plan for Continued Leadership.
- Published in:
- Altex, 2018, v. 35, n. 2, p. 163, doi. 10.14573/altex.1803011
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- Publication type:
- Article
Good Cell Culture Practice for Stem Cells and Stem-Cell-Derived Models.
- Published in:
- Altex, 2017, v. 34, n. 1, p. 95, doi. 10.14573/altex.1607121
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- Publication type:
- Article
Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer.
- Published in:
- Molecular Oncology, 2014, v. 8, n. 7, p. 1326, doi. 10.1016/j.molonc.2014.04.009
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- Publication type:
- Article
Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties.
- Published in:
- Molecular Carcinogenesis, 2016, v. 55, n. 5, p. 688, doi. 10.1002/mc.22313
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- Publication type:
- Article
Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation.
- Published in:
- Archives of Toxicology, 2022, v. 96, n. 7, p. 1975, doi. 10.1007/s00204-022-03291-5
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- Publication type:
- Article
A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-61082-3
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- Publication type:
- Article
A High Throughput Screen Identifies Potent and Selective Inhibitors to Human Epithelial 15-Lipoxygenase-2.
- Published in:
- PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0104094
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- Publication type:
- Article
A High-Throughput Assay for Small Molecule Destabilizers of the KRAS Oncoprotein.
- Published in:
- PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0103836
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- Publication type:
- Article
A Panel of Diverse Assays to Interrogate the Interaction between Glucokinase and Glucokinase Regulatory Protein, Two Vital Proteins in Human Disease.
- Published in:
- PLoS ONE, 2014, v. 9, n. 2, p. 1, doi. 10.1371/journal.pone.0089335
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- Publication type:
- Article
Inhibition of DNA Glycosylases via Small Molecule Purine Analogs.
- Published in:
- PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0081667
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- Publication type:
- Article
Discovery of a Novel Dual Fungal CYP51/Human 5-Lipoxygenase Inhibitor: Implications for Anti-Fungal Therapy.
- Published in:
- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0065928
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- Publication type:
- Article
A Homogeneous, High-Throughput Assay for Phosphatidylinositol 5-Phosphate 4-Kinase with a Novel, Rapid Substrate Preparation.
- Published in:
- PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054127
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- Publication type:
- Article
Diverse Small Molecule Inhibitors of Human Apurinic/ Apyrimidinic Endonuclease APE1 Identified from a Screen of a Large Public Collection.
- Published in:
- PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0047974
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- Publication type:
- Article
A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ.
- Published in:
- PLoS ONE, 2012, v. 7, n. 10, p. 1, doi. 10.1371/journal.pone.0045032
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- Publication type:
- Article
High-Throughput 1,536-Well Fluorescence Polarization Assays for α<sub>1</sub>-Acid Glycoprotein and Human Serum Albumin Binding.
- Published in:
- PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0045594
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- Publication type:
- Article
Differential Scanning Fluorometry Signatures as Indicators of Enzyme Inhibitor Mode of Action: Case Study of Glutathione S-Transferase.
- Published in:
- PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0036219
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- Publication type:
- Article
Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors.
- Published in:
- PLoS ONE, 2010, v. 5, n. 11, p. 1, doi. 10.1371/journal.pone.0015535
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- Publication type:
- Article
High-Affinity Inhibitors of Human NAD<sup>+</sup>-Dependent 15- Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships.
- Published in:
- PLoS ONE, 2010, v. 5, n. 11, p. 1, doi. 10.1371/journal.pone.0013719
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- Publication type:
- Article
A High-Throughput Approach for Identification of Novel General Anesthetics.
- Published in:
- PLoS ONE, 2009, v. 4, n. 9, p. 1, doi. 10.1371/journal.pone.0007150
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- Publication type:
- Article
Identification and Characterization of Inhibitors of Human Apurinic/apyrimidinic Endonuclease APE1.
- Published in:
- PLoS ONE, 2009, v. 4, n. 6, p. 1, doi. 10.1371/journal.pone.0005740
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- Publication type:
- Article
A fluorescence-based high throughput assay for the determination of small molecule−human serum albumin protein binding.
- Published in:
- Analytical & Bioanalytical Chemistry, 2014, v. 406, n. 7, p. 1867, doi. 10.1007/s00216-013-7560-3
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- Publication type:
- Article
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.
- Published in:
- Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.592737
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- Publication type:
- Article
Targeting the JMJD2 Histone Demethylases to Epigenetically Control Herpesvirus Infection and Reactivation from Latency.
- Published in:
- Science Translational Medicine, 2013, v. 5, n. 167, p. 1, doi. 10.1126/scitranslmed.3005145
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- Publication type:
- Article
A Highly Potent and Selective Caspase 1 Inhibitor that Utilizes a Key 3-Cyanopropanoic Acid Moiety.
- Published in:
- ChemMedChem, 2010, v. 5, n. 5, p. 730, doi. 10.1002/cmdc.200900531
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- Publication type:
- Article