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X-ray structure of human acid-ß-glucosidase, the defective enzyme in Gaucher disease.
- Published in:
- EMBO Reports, 2003, v. 4, n. 7, p. 704, doi. 10.1038/sj.embor.embor873
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- Article
The impact of molecular variants, crystallization conditions and the space group on ligand–protein complexes: a case study on bacterial phosphotriesterase.
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- Acta Crystallographica: Section D, Structural Biology, 2023, v. 79, n. 11, p. 992, doi. 10.1107/S2059798323007672
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- Article
Comparison of a molecular dynamics model with the X-ray structure of the N370S acid-β-glucosidase mutant that causes Gaucher disease.
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- PEDS: Protein Engineering, Design & Selection, 2011, v. 24, n. 10, p. 773, doi. 10.1093/protein/gzr032
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- Article
Design, expression and characterization of mutants of fasciculin optimized for interaction with its target, acetylcholinesterase.
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- PEDS: Protein Engineering, Design & Selection, 2009, v. 22, n. 10, p. 641, doi. 10.1093/protein/gzp045
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- Article
Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.
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- Protein Science: A Publication of the Protein Society, 2021, v. 30, n. 5, p. 966, doi. 10.1002/pro.4061
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- Article
Experimental autoimmune myasthenia induced in monkeys by purified acetylcholine receptor.
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- Nature, 1975, v. 256, n. 5513, p. 128, doi. 10.1038/256128a0
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- Article
Targeted oxidation of Torpedo californica acetylcholinesterase by singlet oxygen: identification of N-formylkynurenine tryptophan derivatives within the active-site gorge of its complex with the photosensitizer Methylene Blue.
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- Biochemical Journal, 2012, v. 448, n. 1, p. 83, doi. 10.1042/BJ20120992
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- Article
Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system.
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- Plant Biotechnology Journal, 2007, v. 5, n. 5, p. 579, doi. 10.1111/j.1467-7652.2007.00263.x
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- Article
Structural insights into substrate traffic and inhibition in acetylcholinesterase.
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- EMBO Journal, 2006, v. 25, n. 12, p. 2746, doi. 10.1038/sj.emboj.7601175
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- Article
The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix.
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- EMBO Journal, 2004, v. 23, n. 22, p. 4394, doi. 10.1038/sj.emboj.7600425
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- Article
Protein expression for structural studies.
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- 2006
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- Abstract
Design of a stable human acid‐β‐glucosidase: towards improved Gaucher disease therapy and mutation classification.
- Published in:
- FEBS Journal, 2023, v. 290, n. 13, p. 3383, doi. 10.1111/febs.16758
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- Article
Acetylcholinesterase.
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- Journal of Molecular Neuroscience, 2003, v. 20, n. 3, p. 369, doi. 10.1385/JMN:20:3:369
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- Article
6-Amino-6-deoxy-5,6-di- N-( N′-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β-Glucosidase.
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- ChemBioChem, 2009, v. 10, n. 9, p. 1480, doi. 10.1002/cbic.200900142
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- Article
A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides.
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- Molecules, 2020, v. 25, n. 5, p. 1198, doi. 10.3390/molecules25051198
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- Article
Increasing Polarity in Tacrine and Huprine Derivatives: Potent Anticholinesterase Agents for the Treatment of Myasthenia Gravis.
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- Molecules, 2018, v. 23, n. 3, p. 634, doi. 10.3390/molecules23030634
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- Article
Computational Studies on Acetylcholinesterases.
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- Molecules, 2017, v. 22, n. 8, p. 1324, doi. 10.3390/molecules22081324
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- Article
Characterization of gene-activated human acid-β-glucosidase: Crystal structure, glycan composition, and internalization into macrophages.
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- Glycobiology, 2010, v. 20, n. 1, p. 24, doi. 10.1093/glycob/cwp138
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- Article
PHOTO-INDUCED RELEASE OF AN ACETYLCHOLINESTERASE INHIBITOR.
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- Military Medical Science Letters / Vojenské zdravotnické Listy, 2018, v. 87, p. 47
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- Article
COUPLING OF ACETYLCHOLINESTERASE TO THE INTERFACIAL PHASE STATE.
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- Military Medical Science Letters / Vojenské zdravotnické Listy, 2018, v. 87, p. 4
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- Article
Preface: Cholinergic mechanisms: This is the Preface for the special issue "Cholinergic Mechanisms".
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- Journal of Neurochemistry, 2021, v. 158, n. 6, p. 1212, doi. 10.1111/jnc.15480
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- Article
Alexander George Karczmar (1917-2017).
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- Journal of Neurochemistry, 2017, v. 143, n. 5, p. 609, doi. 10.1111/jnc.14219
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- Article
Preface: Cholinergic Mechanisms.
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- Journal of Neurochemistry, 2017, v. 142, p. 3, doi. 10.1111/jnc.14027
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- Article
Recent developments in structural studies on acetylcholinesterase.
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- Journal of Neurochemistry, 2017, v. 142, p. 19, doi. 10.1111/jnc.13992
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- Article
Solubilization of Membrane-Bound Acetyicholinesterase by a Phosphatidylinositol-Specific Phospholipase C.
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- Journal of Neurochemistry, 1985, v. 45, n. 5, p. 1487, doi. 10.1111/j.1471-4159.1985.tb07217.x
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- Article
Comparison of the Molecular Forms of the Cholinesterases in Tissues of Normal and Dystrophic Chickens.
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- Journal of Neurochemistry, 1982, v. 38, n. 4, p. 1007, doi. 10.1111/j.1471-4159.1982.tb05342.x
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- Publication type:
- Article
Changes in the Levels and Forms of Cholinesterases in the Blood Plasma of Normal and Dystrophic Chickens.
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- Journal of Neurochemistry, 1980, v. 34, n. 4, p. 978, doi. 10.1111/j.1471-4159.1980.tb09674.x
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- Article
DEVELOPMENTAL CHANGES IN LEVELS AND FORMS OF CHOLINESTERASES IN MUSCLES OF NORMAL AND DYSTROPHIC CHICKENS.
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- Journal of Neurochemistry, 1979, v. 33, n. 3, p. 727, doi. 10.1111/j.1471-4159.1979.tb05218.x
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- Article
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
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- Nature Chemical Biology, 2012, v. 8, n. 3, p. 294, doi. 10.1038/nchembio.777
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- Article
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication.
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- Nature Chemical Biology, 2011, v. 7, n. 2, p. 120, doi. 10.1038/nchembio.510
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- Article
Structural studies on vertebrate and invertebrate acetylcholinesterases and their complexes with functional ligands.
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- Drug Development Research, 2000, v. 50, n. 3/4, p. 573, doi. 10.1002/1098-2299(200007/08)50:3/4<573::AID-DDR41>3.0.CO;2-7
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- Article
Evidence for the formation of disulfide radicals in protein crystals upon X-ray irradiation.
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- Journal of Synchrotron Radiation, 2002, v. 9, n. 6, p. 342, doi. 10.1107/S0909049502014589
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- Article
Targeted Oxidation of Torpedo californica Acetylcholinesterase by Singlet Oxygen.
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- Photochemistry & Photobiology, 2011, v. 87, n. 2, p. 308, doi. 10.1111/j.1751-1097.2010.00857.x
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- Article
Cover Image, Volume 91, Issue 8.
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- Proteins, 2023, v. 91, n. 8, p. C1, doi. 10.1002/prot.26553
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- Article
Do "Newly Born" orphan proteins resemble "Never Born" proteins? A study using three deep learning algorithms.
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- Proteins, 2023, v. 91, n. 8, p. 1097, doi. 10.1002/prot.26496
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- Article
Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.
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- Proteins, 2008, v. 70, n. 4, p. 1357, doi. 10.1002/prot.21614
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- Article
Proteomic signatures: Amino acid and oligopeptide compositions differentiate among phyla.
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- Proteins, 2004, v. 54, n. 1, p. 20, doi. 10.1002/prot.10559
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- Article
The intracellular domain of the Drosophila cholinesterase-like neural adhesion protein, gliotactin, is natively unfolded.
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- Proteins, 2003, v. 53, n. 3, p. 758, doi. 10.1002/prot.10471
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- Article
Rivastigmine and metabolite analogues with putative Alzheimer's disease-modifying properties in a Caenorhabditis elegans model.
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- Communications Chemistry, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42004-019-0133-4
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- Article
Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse.
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- Human Molecular Genetics, 2017, v. 26, n. 11, p. 2076, doi. 10.1093/hmg/ddx101
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- Article
Systemic Delivery of a Glucosylceramide Synthase Inhibitor Reduces CNS Substrates and Increases Lifespan in a Mouse Model of Type 2 Gaucher Disease.
- Published in:
- PLoS ONE, 2012, v. 7, n. 8, p. 1, doi. 10.1371/journal.pone.0043310
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- Article
Posttranslational modification as a means of anchoring acetylcholinesterase to the cell surface.
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- Biopolymers, 1987, v. 26, n. S0, p. S241, doi. 10.1002/bip.360260021
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- Article
Acid β-glucosidase: insights from structural analysis and relevance to Gaucher disease therapy.
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- Biological Chemistry, 2008, v. 389, n. 11, p. 1361, doi. 10.1515/BC.2008.163
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- Article
A paradigm for single nucleotide polymorphism analysis: The case of the acetylcholinesterase gene.
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- Human Mutation, 2004, v. 24, n. 5, p. 408, doi. 10.1002/humu.20106
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- Article
The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complex.
- Published in:
- Protein Science: A Publication of the Protein Society, 2016, v. 25, n. 6, p. 1096, doi. 10.1002/pro.2923
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- Article
Structural and functional characterization of the interaction of the photosensitizing probe methylene blue with Torpedo californica acetylcholinesterase.
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- Protein Science: A Publication of the Protein Society, 2012, v. 21, n. 8, p. 1138, doi. 10.1002/pro.2101
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- Publication type:
- Article
Context-dependent resistance to proteolysis of intrinsically disordered proteins.
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- Protein Science: A Publication of the Protein Society, 2011, v. 20, n. 8, p. 1285, doi. 10.1002/pro.657
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- Publication type:
- Article
Backdoor opening mechanism in acetylcholinesterase based on X-ray crystallography and molecular dynamics simulations.
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- Protein Science: A Publication of the Protein Society, 2011, v. 20, n. 7, p. 1114, doi. 10.1002/pro.661
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- Article
Induced-fit or preexisting equilibrium dynamics? Lessons from protein crystallography and MD simulations on acetylcholinesterase and implications for structure-based drug design.
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- Protein Science: A Publication of the Protein Society, 2008, v. 17, n. 4, p. 601, doi. 10.1110/ps.083453808
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- Article
Stabilization of a metastable state of Torpedo californica acetylcholinesterase by chemical chaperones.
- Published in:
- Protein Science: A Publication of the Protein Society, 2003, v. 12, n. 10, p. 2337, doi. 10.1110/ps.03110703
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- Article