Works by Siler, Scott Q.

Results: 17

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition.

Published in:

Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2022.1085621

By:

Beaudoin, James J.;
Yang, Kyunghee;
Adiwidjaja, Jeffry;
Taneja, Guncha;
Watkins, Paul B.;
Siler, Scott Q.;
Howell, Brett A.;
Woodhead, Jeffrey L.

Publication type:

Article

Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.

Published in:

CTS: Clinical & Translational Science, 2018, v. 11, n. 5, p. 498, doi. 10.1111/cts.12560

By:

Woodhead, Jeffrey L.;
Paech, Franziska;
Maurer, Martina;
Engelhardt, Marc;
Schmitt‐Hoffmann, Anne H.;
Spickermann, Jochen;
Messner, Simon;
Wind, Mathias;
Witschi, Anne‐Therese;
Krähenbühl, Stephan;
Siler, Scott Q.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

Applications of Quantitative Systems Pharmacology (QSP) in Drug Development for NAFLD and NASH and Its Regulatory Application.

Published in:

Pharmaceutical Research, 2022, v. 39, n. 8, p. 1789, doi. 10.1007/s11095-022-03295-x

By:

Siler, Scott Q.

Publication type:

Article

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling.

Published in:

Pharmaceutical Research, 2019, v. 36, n. 3, p. 1, doi. 10.1007/s11095-019-2582-y

By:

Woodhead, Jeffrey L.;
Yang, Kyunghee;
Oldach, David;
MacLauchlin, Chris;
Fernandes, Prabhavathi;
Watkins, Paul B.;
Siler, Scott Q.;
Howell, Brett A.

Publication type:

Article

Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH).

Published in:

Clinical Pharmacology & Therapeutics, 2023, v. 113, n. 2, p. 275, doi. 10.1002/cpt.2614

By:

Murphy, William A.;
Adiwidjaja, Jeffry;
Sjöstedt, Noora;
Yang, Kyunghee;
Beaudoin, James J.;
Spires, Jessica;
Siler, Scott Q.;
Neuhoff, Sibylle;
Brouwer, Kim L.R.

Publication type:

Article

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9692, doi. 10.3390/ijms24119692

By:

Beaudoin, James J.;
Clemens, Lara;
Miedel, Mark T.;
Gough, Albert;
Zaidi, Fatima;
Ramamoorthy, Priya;
Wong, Kari E.;
Sarangarajan, Rangaprasad;
Battista, Christina;
Shoda, Lisl K. M.;
Siler, Scott Q.;
Taylor, D. Lansing;
Howell, Brett A.;
Vernetti, Lawrence A.;
Yang, Kyunghee

Publication type:

Article

Linking physiology to toxicity using DILIsym<sup>®</sup>, a mechanistic mathematical model of drug-induced liver injury.

Published in:

Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 1, p. 33, doi. 10.1002/bdd.1878

By:

Shoda, Lisl K. M.;
Woodhead, Jeffrey L.;
Siler, Scott Q.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.

Published in:

Pharmacology Research & Perspectives, 2019, v. 7, n. 6, p. 1, doi. 10.1002/prp2.523

By:

Generaux, Grant;
Lakhani, Vinal V.;
Yuching Yang;
Nadanaciva, Sashi;
Luping Qiu;
Riccardi, Keith;
Li Di;
Howell, Brett A.;
Siler, Scott Q.;
Watkins, Paul B.;
Barton, Hugh A.;
Aleo, Michael D.;
Shoda, Lisl K. M.

Publication type:

Article

Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses.

Published in:

Gene Regulation & Systems Biology, 2017, n. 11, p. 1, doi. 10.1177/1177625017696074

By:

Shoda, Lisl K. M.;
Battista, Christina;
Siler, Scott Q.;
Pisetsky, David S.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling.

Published in:

Toxicological Sciences, 2022, v. 188, n. 1, p. 108, doi. 10.1093/toxsci/kfac051

By:

Woodhead, Jeffrey L;
Siler, Scott Q;
Howell, Brett A;
Watkins, Paul B;
Conway, Charles

Publication type:

Article

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.

Published in:

Toxicological Sciences, 2019, v. 167, n. 2, p. 458, doi. 10.1093/toxsci/kfy253

By:

Longo, Diane M;
Woodhead, Jeffrey L;
Walker, Paul;
Herédi-Szabó, Krisztina;
Mogyorósi, Károly;
Wolenski, Francis S;
Dragan, Yvonne P;
Mosedale, Merrie;
Siler, Scott Q;
Watkins, Paul B;
Howell, Brett A

Publication type:

Article

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity.

Published in:

Toxicological Sciences, 2018, v. 166, n. 1, p. 123, doi. 10.1093/toxsci/kfy191

By:

Battista, Christina;
Yang, Kyunghee;
Stahl, Simone H;
Mettetal, Jerome T;
Watkins, Paul B;
Siler, Scott Q;
Howell, Brett A

Publication type:

Article

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Published in:

Toxicological Sciences, 2017, v. 155, n. 1, p. 61, doi. 10.1093/toxsci/kfw193

By:

Woodhead, Jeffrey L.;
Brock, William J.;
Roth, Sharin E.;
Shoaf, Susan E.;
Brouwer, Kim L. R.;
Church, Rachel;
Grammatopoulos, Tom N.;
Stiles, Linsey;
Siler, Scott Q.;
Howell, Brett A.;
Mosedale, Merrie;
Watkins, Paul B.;
Shoda, Lisl K. M.

Publication type:

Article

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

Published in:

Frontiers in Pharmacology, 2014, v. 5, p. 1, doi. 10.3389/fphar.2014.00240

By:

Woodhead, Jeffrey L.;
Kyunghee Yang;
Siler, Scott Q.;
Watkins, Paul B.;
Brouwer, Kim L. R.;
Barton, Hugh A.;
Howel, Brett A.;
Maggi, Adriana;
Lohman, Rink-Jan

Publication type:

Article

Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches.

Published in:

Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00462

By:

Bhattacharya, Sudin;
Shoda, Lisl K. M.;
Zhang, Qiang;
Woods, Courtney G.;
Howell, Brett A.;
Siler, Scott Q.;
Woodhead, Jeffrey L.;
Yang, Yuching;
McMullen, Patrick;
Watkins, Paul B.;
Andersen, Melvin E.

Publication type:

Article

Identification of a Novel Insulin Sensitivity Biomarker Comprised of Plasma Insulin, HbA1c, and Lactate.

Published in:

Diabetes, 2007, v. 56, p. A661

By:

Wennerberg, Leif;
Siler, Scott Q.;
Reed, Michael J.

Publication type:

Article

A Novel Method for Predicting the Concentration of Insulin and Glucagon in the Portal Vein and Hepatic Sinusoids.

Published in:

Diabetes, 2007, v. 56, p. A576

By:

Siler, Scott Q.

Publication type:

Article