Works by Siebold, Christian

Results: 25

Repulsive guidance molecule is a structural bridge between neogenin and bone morphogenetic protein.

Published in:

Nature Structural & Molecular Biology, 2015, v. 22, n. 6, p. 458, doi. 10.1038/nsmb.3016

By:

Healey, Eleanor G;
Bishop, Benjamin;
Elegheert, Jonathan;
Bell, Christian H;
Padilla-Parra, Sergi;
Siebold, Christian

Publication type:

Article

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.

Published in:

Nature Structural & Molecular Biology, 2012, v. 19, n. 12, p. 1293, doi. 10.1038/nsmb.2416

By:

Janssen, Bert J C;
Malinauskas, Tomas;
Weir, Greg A;
Cader, M Zameel;
Siebold, Christian;
Jones, E Yvonne

Publication type:

Article

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1.

Published in:

Nature Structural & Molecular Biology, 2011, v. 18, n. 8, p. 886, doi. 10.1038/nsmb.2081

By:

Malinauskas, Tomas;
Aricescu, A. Radu;
Weixian Lu;
Siebold, Christian;
Jones, E. Yvonne

Publication type:

Article

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP.

Published in:

Nature Structural & Molecular Biology, 2009, v. 16, n. 7, p. 698, doi. 10.1038/nsmb.1607

By:

Bishop, Benjamin;
Aricescu, A. Radu;
Harlos, Karl;
O'Callaghan, Chris A.;
Jones, E. Yvonne;
Siebold, Christian

Publication type:

Article

MHC class II proteins and disease: a structural perspective.

Published in:

2006

By:

Jones, E. Yvonne;
Fugger, Lars;
Strominger, Jack L.;
Siebold, Christian

Publication type:

journal article

Secreted HHIP1 interacts with heparan sulfate and regulates Hedgehog ligand localization and function.

Published in:

Journal of Cell Biology, 2015, v. 209, n. 5, p. 739, doi. 10.1083/jcb.201411024

By:

Holtz, Alexander M.;
Griffiths, Samuel C.;
Davis, Samantha J.;
Bishop, Benjamin;
Siebold, Christian;
Allen, Benjamin L.

Publication type:

Article

Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes.

Published in:

eLife, 2021, p. 1, doi. 10.7554/eLife.70504

By:

Kinnebrew, Maia;
Luchetti, Giovanni;
Sircar, Ria;
Frigui, Sara;
Viti, Lucrezia Vittoria;
Tomoki Naito;
Beckert, Francis;
Yasunori Saheki;
Siebold, Christian;
Radhakrishnan, Arun;
Rohatgi, Rajat

Publication type:

Article

Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling.

Published in:

Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27475-2

By:

Griffiths, Samuel C.;
Schwab, Rebekka A.;
El Omari, Kamel;
Bishop, Benjamin;
Iverson, Ellen J.;
Malinauskas, Tomas;
Dubey, Ramin;
Qian, Mingxing;
Covey, Douglas F.;
Gilbert, Robert J. C.;
Rohatgi, Rajat;
Siebold, Christian

Publication type:

Article

A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling.

Published in:

Science Signaling, 2018, v. 11, n. 518, p. 1, doi. 10.1126/scisignal.aan3714

By:

Gorvin, Caroline M.;
Babinsky, Valerie N.;
Malinauskas, Tomas;
Nissen, Peter H.;
Schou, Anders J.;
Hanyaloglu, Aylin C.;
Siebold, Christian;
Jones, E. Yvonne;
Hannan, Fadil M.;
Thakker, Rajesh V.

Publication type:

Article

Cholesterol as a Second Messenger in the Hedgehog Signaling Pathway.

Published in:

FASEB Journal, 2021, v. 35, p. N.PAG, doi. 10.1096/fasebj.2021.35.S1.05394

By:

Kinnebrew, Maia;
Iverson, Ellen;
Patel, Bhaven;
Pusapati, Ganesh;
Kong, Jennifer;
Johnson, Kristen;
Luchetti, Giovanni;
Eckert, Kaitlyn;
McDonald, Jeffrey;
Covey, Douglas;
Siebold, Christian;
Radhakrishnan, Arun;
Rohatgi, Rajat

Publication type:

Article

Multiple sclerosis: MHC associations and therapeutic implications.

Published in:

Expert Reviews in Molecular Medicine, 2005, v. 7, n. 3, p. 1, doi. 10.1017/S1462399405008914

By:

Holmes, Samantha;
Friese, Manuel A.;
Siebold, Christian;
Jones, E. Yvonne;
Bell, John;
Fugger, Lars

Publication type:

Article

Calcium-sensing receptor residues with loss- and gain-of-function mutations are located in regions of conformational change and cause signalling bias.

Published in:

Human Molecular Genetics, 2018, v. 27, n. 21, p. 3720, doi. 10.1093/hmg/ddy263

By:

Gorvin, Caroline M;
Frost, Morten;
Malinauskas, Tomas;
Cranston, Treena;
Boon, Hannah;
Siebold, Christian;
Jones, E Yvonne;
Hannan, Fadil M;
Thakker, Rajesh V

Publication type:

Article

Strategy for membrane protein crystallization exemplified with OmpA and OmpX.

Published in:

Proteins, 1999, v. 34, n. 2, p. 167, doi. 10.1002/(SICI)1097-0134(19990201)34:2<167::AID-PROT2>3.0.CO;2-H

By:

Pautsch, Alex;
Vogt, Joachim;
Model, Kirstin;
Siebold, Christian;
Schulz, Georg E.

Publication type:

Article

A Dual Binding Mode for RhoGTPases in Plexin Signalling.

Published in:

PLoS Biology, 2011, v. 9, n. 8, p. 1, doi. 10.1371/journal.pbio.1001134

By:

Bell, Christian H.;
Aricescu, A. Radu;
Jones, E. Yvonne;
Siebold, Christian

Publication type:

Article

Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT).

Published in:

Angewandte Chemie, 2021, v. 133, n. 24, p. 13654, doi. 10.1002/ange.202014457

By:

Lanyon‐Hogg, Thomas;
Ritzefeld, Markus;
Zhang, Leran;
Andrei, Sebastian A.;
Pogranyi, Balazs;
Mondal, Milon;
Sefer, Lea;
Johnston, Callum D.;
Coupland, Claire E.;
Greenfield, Jake L.;
Newington, Joshua;
Fuchter, Matthew J.;
Magee, Anthony I.;
Siebold, Christian;
Tate, Edward W.

Publication type:

Article

Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.

Published in:

Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11683-y

By:

Rozbesky, Daniel;
Robinson, Ross A.;
Jain, Vitul;
Renner, Max;
Malinauskas, Tomas;
Harlos, Karl;
Siebold, Christian;
Jones, E. Yvonne

Publication type:

Article

Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT).

Published in:

Angewandte Chemie International Edition, 2021, v. 60, n. 24, p. 13542, doi. 10.1002/anie.202014457

By:

Lanyon‐Hogg, Thomas;
Ritzefeld, Markus;
Zhang, Leran;
Andrei, Sebastian A.;
Pogranyi, Balazs;
Mondal, Milon;
Sefer, Lea;
Johnston, Callum D.;
Coupland, Claire E.;
Greenfield, Jake L.;
Newington, Joshua;
Fuchter, Matthew J.;
Magee, Anthony I.;
Siebold, Christian;
Tate, Edward W.

Publication type:

Article

Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling.

Published in:

eLife, 2024, p. 1

By:

Griffiths, Samuel C.;
Jia Tan;
Wagner, Armin;
Blazer, Levi L.;
Adams, Jarrett J.;
Srinivasan, Srisathya;
Moghisaei, Shayan;
Sidhu, Sachdev S.;
Siebold, Christian;
Ho, Hsin-Yi Henry

Publication type:

Article

Molecular mechanism of BMP signal control by Twisted gastrulation.

Published in:

Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-49065-8

By:

Malinauskas, Tomas;
Moore, Gareth;
Rudolf, Amalie F.;
Eggington, Holly;
Belnoue-Davis, Hayley L.;
El Omari, Kamel;
Griffiths, Samuel C.;
Woolley, Rachel E.;
Duman, Ramona;
Wagner, Armin;
Leedham, Simon J.;
Baldock, Clair;
Ashe, Hilary L.;
Siebold, Christian

Publication type:

Article

Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins.

Published in:

Nature Protocols, 2018, v. 13, n. 12, p. 2991, doi. 10.1038/s41596-018-0075-9

By:

Elegheert, Jonathan;
Behiels, Ester;
Bishop, Benjamin;
Scott, Suzanne;
Woolley, Rachel E.;
Griffiths, Samuel C.;
Byrne, Eamon F. X.;
Chang, Veronica T.;
Stuart, David I.;
Jones, E. Yvonne;
Siebold, Christian;
Aricescu, A. Radu

Publication type:

Article

Structure of the fungal β-glucan-binding immune receptor dectin-1: Implications for function.

Published in:

Protein Science: A Publication of the Protein Society, 2007, v. 16, n. 6, p. 1042, doi. 10.1110/ps.072791207

By:

Brown, James;
O'Callaghan, Chris A.;
Marshall, Andrew S.J.;
Gilbert, Robert J.C.;
Siebold, Christian;
Gordon, Siamon;
Brown, Gordon D.;
Jones, E. Yvonne

Publication type:

Article

Structural basis of semaphorin-plexin signalling.

Published in:

Nature, 2010, v. 467, n. 7319, p. 1118, doi. 10.1038/nature09468

By:

Janssen, Bert J. C.;
Robinson, Ross A.;
Pérez-Brangulí, Francesc;
Bell, Christian H.;
Mitchell, Kevin J.;
Siebold, Christian;
Jones, E. Yvonne

Publication type:

Article

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling.

Published in:

eLife, 2016, p. 1, doi. 10.7554/eLife.20304

By:

Luchetti, Giovanni;
Sircar, Ria;
Kong, Jennifer H.;
Nachtergaele, Sigrid;
Sagner, Andreas;
Byrne, Eamon F. X.;
Covey, Douglas F.;
Siebold, Christian;
Rohatgi, Rajat

Publication type:

Article

Structure and functional analysis of the IGF-II/IGF2R interaction.

Published in:

EMBO Journal, 2008, v. 27, n. 1, p. 265, doi. 10.1038/sj.emboj.7601938

By:

Brown, James;
Delaine, Carlie;
Zaccheo, Oliver J.;
Siebold, Christian;
Gilbert, Robert J.;
van Boxel, Gijs;
Denley, Adam;
Wallace, John C.;
Hassan, A. Bassim;
Forbes, Briony E.;
Jones, E. Yvonne

Publication type:

Article

Molecular analysis of receptor protein tyrosine phosphatase μ-mediated cell adhesion.

Published in:

EMBO Journal, 2006, v. 25, n. 4, p. 701, doi. 10.1038/sj.emboj.7600974

By:

Aricescu, Alexandru Radu;
Wai-Ching Hon;
Siebold, Christian;
Weixian Lu;
van der Merwe, Philip Anton;
Jones, Edith Yvonne

Publication type:

Article