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Structural and functional validation of a highly specific Smurf2 inhibitor.
- Published in:
- Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 2, p. 1, doi. 10.1002/pro.4885
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- Article
Engineered antigen‐binding fragments for enhanced crystallization of antibody:antigen complexes.
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- Protein Science: A Publication of the Protein Society, 2024, v. 33, n. 1, p. 1, doi. 10.1002/pro.4824
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- Article
A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay.
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- Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-29915-z
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- Article
SCF<sup>FBXW7</sup> regulates G2‐M progression through control of CCNL1 ubiquitination.
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- EMBO Reports, 2022, v. 23, n. 12, p. 1, doi. 10.15252/embr.202255044
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- Article
First‐in‐class Deubiquitylase Inhibitors Reveal New Enzyme Conformations.
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- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R4428
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- Article
structural and functional workings of KEOPS.
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- Nucleic Acids Research, 2021, v. 49, n. 19, p. 10818, doi. 10.1093/nar/gkab865
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- Article
A substrate binding model for the KEOPS tRNA modifying complex.
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- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-19990-5
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Comprehensive analysis of all evolutionary paths between two divergent PDZ domain specificities.
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- Protein Science: A Publication of the Protein Society, 2020, v. 29, n. 2, p. 433, doi. 10.1002/pro.3759
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- Article
Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif.
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- Protein Science: A Publication of the Protein Society, 2019, v. 28, n. 5, p. 848, doi. 10.1002/pro.3593
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- Article
The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency.
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- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-40815-z
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- Article
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1.
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- Nature Communications, 2018, v. 9, p. 1, doi. 10.1038/s41467-018-06854-2
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- Article
A feed forward loop enforces YAP/TAZ signaling during tumorigenesis.
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- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05939-2
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- Article
Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.
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- BMC Biology, 2018, v. 16, n. 1, p. 1, doi. 10.1186/s12915-018-0554-z
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- Article
Structural and functional characterization of a ubiquitin variant engineered for tight and specific binding to an alpha-helical ubiquitin interacting motif.
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- Protein Science: A Publication of the Protein Society, 2017, v. 26, n. 5, p. 1060, doi. 10.1002/pro.3155
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- Article
Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7.
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- Nucleic Acids Research, 2017, v. 45, n. 2, p. 805, doi. 10.1093/nar/gkw1181
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- Article
An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF<sup>Cdc4</sup> ubiquitin ligase.
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- Nature Communications, 2017, v. 8, n. 1, p. 13943, doi. 10.1038/ncomms13943
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- Article
Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t<sup>6</sup>A biosynthesis.
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- Nucleic Acids Research, 2016, v. 44, n. 14, p. 6971, doi. 10.1093/nar/gkw542
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- Article
Crystal structure of a BRAF kinase domain monomer explains basis for allosteric regulation.
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- Nature Structural & Molecular Biology, 2015, v. 22, n. 1, p. 37, doi. 10.1038/nsmb.2924
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- Article
E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
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- Nature Chemical Biology, 2014, v. 10, n. 2, p. 156, doi. 10.1038/nchembio.1412
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Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions.
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- Science Signaling, 2013, v. 6, n. 302, p. 1, doi. 10.1126/scisignal.2004712
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- Article
53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.
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- Nature, 2013, v. 499, n. 7456, p. 50, doi. 10.1038/nature12318
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- Article
Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.
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- Nature Chemical Biology, 2013, v. 9, n. 7, p. 428, doi. 10.1038/nchembio.1257
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- Article
Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system.
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- Nucleic Acids Research, 2013, v. 41, n. 12, p. 6332, doi. 10.1093/nar/gkt322
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- Article
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
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- Nature, 2013, v. 498, n. 7454, p. 318, doi. 10.1038/nature12296
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- Article
Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function.
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- EMBO Journal, 2011, v. 30, n. 16, p. 3259, doi. 10.1038/emboj.2011.234
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Putting the brakes on the unfolded protein response.
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- Journal of Cell Biology, 2011, v. 193, n. 1, p. 17, doi. 10.1083/jcb.201101105
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- Article
Mechanistic principles of RAF kinase signaling.
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- Cellular & Molecular Life Sciences, 2011, v. 68, n. 4, p. 553, doi. 10.1007/s00018-010-0520-6
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- Article
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1.
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- Nature, 2010, v. 466, n. 7309, p. 941, doi. 10.1038/nature09297
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- Article
An allosteric inhibitor of substrate recognition by the SCF<sup>Cdc4</sup> ubiquitin ligase.
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- Nature Biotechnology, 2010, v. 28, n. 7, p. 733, doi. 10.1038/nbt.1646
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- Article
Allosteric Protein Kinase Regulation by Pseudokinases: Insights from STRAD.
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- Science Signaling, 2010, v. 3, n. 111, p. 1, doi. 10.1126/scisignal.3111pe8
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- Article
A dimerization-dependent mechanism drives RAF catalytic activation.
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- Nature, 2009, v. 461, n. 7263, p. 542, doi. 10.1038/nature08314
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Grb-ing hold of insulin signaling.
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- Nature Structural & Molecular Biology, 2009, v. 16, n. 8, p. 803, doi. 10.1038/nsmb0809-803
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- Article
Interactome and interface protocol (2IP): A novel strategy for high sensitivity topology mapping of protein complexes.
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- Proteomics, 2007, v. 7, n. 21, p. 3835, doi. 10.1002/pmic.200700688
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- Article
Determination of the Plk4/Sak consensus phosphorylation motif using peptide spots arrays
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- FEBS Letters, 2007, v. 581, n. 1, p. 77, doi. 10.1016/j.febslet.2006.11.080
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- Article
A change in conformational dynamics underlies the activation of Eph receptor tyrosine kinases.
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- EMBO Journal, 2006, v. 25, n. 19, p. 4686, doi. 10.1038/sj.emboj.7601315
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- Article
Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p.
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- Nature Structural & Molecular Biology, 2006, v. 13, n. 2, p. 168, doi. 10.1038/nsmb1053
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- Article
Bone recognition mechanism of porcine osteocalcin from crystal structure.
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- Nature, 2003, v. 425, n. 6961, p. 977, doi. 10.1038/nature02079
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- Article
The RNA-binding SAM domain of Smaug defines a new family of post-transcriptional regulators.
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- Nature Structural Biology, 2003, v. 10, n. 8, p. 614, doi. 10.1038/nsb956
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The Sak polo-box comprises a structural domain sufficient for mitotic subcellular localization.
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- Nature Structural Biology, 2002, v. 9, n. 10, p. 719, doi. 10.1038/nsb848
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Structural and biochemical characterization of the type III secretion chaperones CesT and SigE.
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- Nature Structural Biology, 2001, v. 8, n. 12, p. 1031, doi. 10.1038/nsb717
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- Article
Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication.
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- Nature, 2001, v. 414, n. 6863, p. 514, doi. 10.1038/35107009
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- Article
The crystal structure of an Eph receptor SAM domain reveals a mechanism for modular dimerization.
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- Nature Structural Biology, 1999, v. 6, n. 1, p. 44
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Crystal structure of the Src family tyrosine kinase Hck.
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- Nature, 1997, v. 385, n. 6617, p. 602, doi. 10.1038/385602a0
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- Article