Works by Shynlova, Oksana

Results: 39

Landscape of Preterm Birth Therapeutics and a Path Forward.

Published in:

Journal of Clinical Medicine, 2021, v. 10, n. 13, p. 2912, doi. 10.3390/jcm10132912

By:

Coler, Brahm Seymour;
Shynlova, Oksana;
Boros-Rausch, Adam;
Lye, Stephen;
McCartney, Stephen;
Leimert, Kelycia B.;
Xu, Wendy;
Chemtob, Sylvain;
Olson, David;
Li, Miranda;
Huebner, Emily;
Curtin, Anna;
Kachikis, Alisa;
Savitsky, Leah;
Paul, Jonathan W.;
Smith, Roger;
Adams Waldorf, Kristina M.

Publication type:

Article

MYB and ELF3 differentially modulate labor-inducing gene expression in myometrial cells.

Published in:

PLoS ONE, 2023, v. 18, n. 1, p. 1, doi. 10.1371/journal.pone.0271081

By:

Shchuka, Virlana M.;
Khader, Nawrah;
Dorogin, Anna;
Shynlova, Oksana;
Mitchell, Jennifer A.

Publication type:

Article

A Broad-Spectrum Chemokine Inhibitor Drives M2 Macrophage Polarization Through Modulation of the Myometrial Secretome.

Published in:

Cells (2073-4409), 2025, v. 14, n. 7, p. 514, doi. 10.3390/cells14070514

By:

Boros-Rausch, Adam;
Dorogin, Anna;
Nadeem, Lubna;
Shynlova, Oksana;
Lye, Stephen James

Publication type:

Article

Promegestone Prevents Lipopolysaccharide-Induced Cervical Remodeling in Pregnant Mice.

Published in:

Cells (2073-4409), 2025, v. 14, n. 4, p. 242, doi. 10.3390/cells14040242

By:

Nadeem, Amna;
Nadeem, Lubna;
Lye, Stephen James;
Shynlova, Oksana

Publication type:

Article

A Broad-Spectrum Chemokine Inhibitor Blocks Inflammation-Induced Myometrial Myocyte–Macrophage Crosstalk and Myometrial Contraction.

Published in:

Cells (2073-4409), 2022, v. 11, n. 1, p. 128, doi. 10.3390/cells11010128

By:

Boros-Rausch, Adam;
Shynlova, Oksana;
Lye, Stephen James

Publication type:

Article

Maternal blood endotoxin activity in pregnancies complicated by preterm premature rupture of membranes.

Published in:

2018

By:

Ronzoni, Stefania;
D'Souza, Rohan;
Shynlova, Oksana;
Lye, Stephen;
Murphy, Kellie E

Publication type:

journal article

Transcriptional control of parturition: insights from gene regulation studies in the myometrium.

Published in:

Molecular Human Reproduction, 2021, v. 27, n. 5, p. 1, doi. 10.1093/molehr/gaab024

By:

Khader, Nawrah;
Shchuka, Virlana M;
Shynlova, Oksana;
Mitchell, Jennifer A

Publication type:

Article

Pro‐inflammatory signals induce 20α‐HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal.

Published in:

Journal of Cellular & Molecular Medicine, 2021, v. 25, n. 14, p. 6773, doi. 10.1111/jcmm.16681

By:

Nadeem, Lubna;
Balendran, Rathesh;
Dorogin, Anna;
Mesiano, Sam;
Shynlova, Oksana;
Lye, Stephen J.

Publication type:

Article

MicroRNA‐transcriptome networks in whole blood and monocytes of women undergoing preterm labour.

Published in:

Journal of Cellular & Molecular Medicine, 2019, v. 23, n. 10, p. 6835, doi. 10.1111/jcmm.14567

By:

Paquette, Alison G.;
Shynlova, Oksana;
Wu, Xiaogang;
Kibschull, Mark;
Wang, Kai;
Price, Nathan D.;
Lye, Stephen J.

Publication type:

Article

Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post‐menopausal women with severe pelvic organ prolapse.

Published in:

Journal of Cellular & Molecular Medicine, 2019, v. 23, n. 4, p. 2907, doi. 10.1111/jcmm.14199

By:

Tyagi, Tanya;
Alarab, May;
Leong, Yvonne;
Lye, Stephen;
Shynlova, Oksana

Publication type:

Article

Extracellular vesicle RNAs reflect placenta dysfunction and are a biomarker source for preterm labour.

Published in:

Journal of Cellular & Molecular Medicine, 2018, v. 22, n. 5, p. 2760, doi. 10.1111/jcmm.13570

By:

Fallen, Shannon;
Baxter, David;
Wu, Xiaogang;
Kim, Taek‐Kyun;
Shynlova, Oksana;
Lee, Min Young;
Scherler, Kelsey;
Lye, Stephen;
Hood, Leroy;
Wang, Kai

Publication type:

Article

Differential expression of myometrial AP-1 proteins during gestation and labour.

Published in:

Journal of Cellular & Molecular Medicine, 2018, v. 22, n. 1, p. 452, doi. 10.1111/jcmm.13335

By:

Nadeem, Lubna;
Farine, Tali;
Dorogin, Anna;
Matysiak‐Zablocki, Elzbieta;
Shynlova, Oksana;
Lye, Stephen

Publication type:

Article

Immunophenotyping and activation status of maternal peripheral blood leukocytes during pregnancy and labour, both term and preterm.

Published in:

Journal of Cellular & Molecular Medicine, 2017, v. 21, n. 10, p. 2386, doi. 10.1111/jcmm.13160

By:

Zhang, Jianhong;
Shynlova, Oksana;
Sabra, Sally;
Bang, Annie;
Briollais, Laurent;
Lye, Stephen J.

Publication type:

Article

Inhibition of infection-mediated preterm birth by administration of broad spectrum chemokine inhibitor in mice.

Published in:

Journal of Cellular & Molecular Medicine, 2014, v. 18, n. 9, p. 1816, doi. 10.1111/jcmm.12307

By:

Shynlova, Oksana;
Dorogin, Anna;
Li, Yunqing;
Lye, Stephen

Publication type:

Article

Infiltration of myeloid cells into decidua is a critical early event in the labour cascade and post-partum uterine remodelling.

Published in:

Journal of Cellular & Molecular Medicine, 2013, v. 17, n. 2, p. 311, doi. 10.1111/jcmm.12012

By:

Shynlova, Oksana;
Nedd‐Roderique, Tamara;
Li, Yunqing;
Dorogin, Anna;
Nguyen, Tina;
Lye, Stephen J.

Publication type:

Article

Myometrial immune cells contribute to term parturition, preterm labour and post-partum involution in mice.

Published in:

Journal of Cellular & Molecular Medicine, 2013, v. 17, n. 1, p. 90, doi. 10.1111/j.1582-4934.2012.01650.x

By:

Shynlova, Oksana;
Nedd‐Roderique, Tamara;
Li, Yunqing;
Dorogin, Anna;
Lye, Stephen J.

Publication type:

Article

The pregnant myometrium is epigenetically activated at contractility-driving gene loci prior to the onset of labor in mice.

Published in:

PLoS Biology, 2020, v. 18, n. 7, p. 1, doi. 10.1371/journal.pbio.3000710

By:

Shchuka, Virlana M.;
Abatti, Luis E.;
Hou, Huayun;
Khader, Nawrah;
Dorogin, Anna;
Wilson, Michael D.;
Shynlova, Oksana;
Mitchell, Jennifer A.

Publication type:

Article

Maternal blood endotoxin activity in pregnancies complicated by preterm premature rupture of membranes.

Published in:

Journal of Maternal-Fetal & Neonatal Medicine, 2019, v. 32, n. 20, p. 3473, doi. 10.1080/14767058.2018.1465560

By:

Ronzoni, Stefania;
D'Souza, Rohan;
Shynlova, Oksana;
Lye, Stephen;
Murphy, Kellie E.

Publication type:

Article

Probiotic Lactobacillus rhamnosus GR-1 is a unique prophylactic agent that suppresses infection-induced myometrial cell responses.

Published in:

Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-41133-0

By:

Kim, Bona;
Shynlova, Oksana;
Lye, Stephen

Publication type:

Article

HoxA13 Regulates Phenotype Regionalization of Human Pregnant Myometrium.

Published in:

2015

By:

Liu, LiangLiang;
Li, Haolong;
Dargahi, Daryanaz;
Shynlova, Oksana;
Slater, Donna;
Jones, Steven J M;
Lye, Stephen J;
Dong, Xuesen

Publication type:

journal article

Proliferative action of the androgen receptor in human uterine myometrial cells--a key regulator for myometrium phenotype programming.

Published in:

2013

By:

Liu L;
Li Y;
Xie N;
Shynlova O;
Challis JR;
Slater D;
Lye S;
Dong X;
Liu, Liangliang;
Li, Yunqing;
Xie, Ning;
Shynlova, Oksana;
Challis, John R G;
Slater, Donna;
Lye, Stephen;
Dong, Xuesen

Publication type:

journal article

JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium.

Published in:

PLoS Genetics, 2025, v. 21, n. 6, p. 1, doi. 10.1371/journal.pgen.1011261

By:

Khader, Nawrah;
Dorogin, Anna;
Shynlova, Oksana;
Mitchell, Jennifer A.

Publication type:

Article

Expression of genes encoding smooth muscle contractile proteins in vaginal tissue of women with and without pelvic organ prolapse.

Published in:

Neurourology & Urodynamics, 2012, v. 31, n. 1, p. 109, doi. 10.1002/nau.21175

By:

Bortolini, Maria A.T.;
Shynlova, Oksana;
Drutz, Harold P.;
Castro, Rodrigo A.;
Girão, Manoel J.B.C.;
Lye, Stephen;
Alarab, May

Publication type:

Article

The effect of local estrogen therapy on the urinary microbiome composition of postmenopausal women with and without recurrent urinary tract infections.

Published in:

International Urogynecology Journal, 2022, v. 33, n. 8, p. 2107, doi. 10.1007/s00192-021-04832-9

By:

Anglim, Breffini;
Phillips, Caleb;
Shynlova, Oksana;
Alarab, May

Publication type:

Article

Foundational science and mechanistic insights for a shared disease model: an expert consensus: Developed by the AUGS Basic Science Subcommittee and IUGA Special Interest Group.

Published in:

International Urogynecology Journal, 2022, v. 33, n. 6, p. 1387, doi. 10.1007/s00192-022-05253-y

By:

Alperin, Marianna;
Abramowitch, Steven;
Alarab, May;
Bortolini, Maria;
Brown, Bryan;
Burnett, Lindsey A.;
Connell, Kathleen A.;
Damaser, Margot;
de Vita, Raffaella;
Gargett, Caroline E.;
Guess, Marsha K.;
Guler, Zeliha;
Jorge, Renato Natal;
Kelley, Robert S.;
Kibschull, Mark;
Miller, Kristin;
Moalli, Pamela A.;
Mysorekar, Indira U.;
Routzong, Megan R.;
Shynlova, Oksana

Publication type:

Article

Age and/or postmenopausal status as risk factors for pelvic organ prolapse development: systematic review with meta-analysis.

Published in:

International Urogynecology Journal, 2022, v. 33, n. 1, p. 15, doi. 10.1007/s00192-021-04953-1

By:

Brito, Luiz Gustavo Oliveira;
Pereira, Glaucia Miranda Varella;
Moalli, Pamela;
Shynlova, Oksana;
Manonai, Jittima;
Weintraub, Adi Yehuda;
Deprest, Jan;
Bortolini, Maria Augusta T.

Publication type:

Article

LOX family enzymes expression in vaginal tissue of premenopausal women with severe pelvic organ prolapse.

Published in:

International Urogynecology Journal, 2010, v. 21, n. 11, p. 1397, doi. 10.1007/s00192-010-1199-9

By:

Alarab, May;
Bortolini, Maria A. T.;
Drutz, Harold;
Lye, Stephen;
Shynlova, Oksana

Publication type:

Article

Molecular evidence of functional progesterone withdrawal in human myometrium.

Published in:

Nature Communications, 2016, v. 7, n. 5, p. 11565, doi. 10.1038/ncomms11565

By:

Nadeem, Lubna;
Shynlova, Oksana;
Matysiak-Zablocki, Elzbieta;
Mesiano, Sam;
Dong, Xuesen;
Lye, Stephen

Publication type:

Article

SOX4 exerts contrasting regulatory effects on labor-associated gene promoters in myometrial cells.

Published in:

PLoS ONE, 2024, v. 19, n. 4, p. 1, doi. 10.1371/journal.pone.0297847

By:

Khader, Nawrah;
Shchuka, Virlana M.;
Dorogin, Anna;
Shynlova, Oksana;
Mitchell, Jennifer A.

Publication type:

Article

The Future of Basic Science: Development of the Next Generation of Mechanistic Researchers in Female Pelvic Medicine.

Published in:

International Urogynecology Journal, 2024, v. 35, n. 4, p. 775, doi. 10.1007/s00192-024-05766-8

By:

Alperin, Marianna;
Alarab, May;
Botros-Brey, Sylvia;
Drutz, Harold;
King, Jenny;
Shynlova, Oksana

Publication type:

Article

Combination of histochemical analyses and micro-MRI reveals regional changes of the murine cervix in preparation for labor.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-84036-9

By:

Chatterjee, Antara;
Saghian, Rojan;
Dorogin, Anna;
Cahill, Lindsay S.;
Sled, John G.;
Lye, Stephen;
Shynlova, Oksana

Publication type:

Article

Low-intensity physical activity may protect pregnant women against spontaneous preterm labour: a prospective case-control study.

Published in:

Applied Physiology, Nutrition & Metabolism, 2021, v. 46, n. 4, p. 337, doi. 10.1139/apnm-2019-0911

By:

Steckle, Valerie;
Shynlova, Oksana;
Lye, Stephen;
Bocking, Alan

Publication type:

Article

A Broad Spectrum Chemokine Inhibitor Prevents Preterm Labor but Not Microbial Invasion of the Amniotic Cavity or Neonatal Morbidity in a Non-human Primate Model.

Published in:

Frontiers in Immunology, 2020, v. 11, p. 1, doi. 10.3389/fimmu.2020.00770

By:

Coleman, Michelle;
Orvis, Austyn;
Wu, Tsung-Yen;
Dacanay, Matthew;
Merillat, Sean;
Ogle, Jason;
Baldessari, Audrey;
Kretzer, Nicole M.;
Munson, Jeff;
Boros-Rausch, Adam J.;
Shynlova, Oksana;
Lye, Stephen;
Rajagopal, Lakshmi;
Adams Waldorf, Kristina M.

Publication type:

Article

Cytokine Changes in Maternal Peripheral Blood Correlate With Time-to-Delivery in Pregnancies Complicated by Premature Prelabor Rupture of the Membranes.

Published in:

Reproductive Sciences, 2019, v. 26, n. 9, p. 1266, doi. 10.1177/1933719118815590

By:

Ronzoni, Stefania;
Steckle, Valerie;
D'Souza, Rohan;
Murphy, Kellie E.;
Lye, Stephen;
Shynlova, Oksana

Publication type:

Article

Static Mechanical Loading Influences the Expression of Extracellular Matrix and Cell Adhesion Proteins in Vaginal Cells Derived From Premenopausal Women With Severe Pelvic Organ Prolapse.

Published in:

Reproductive Sciences, 2016, v. 23, n. 8, p. 978, doi. 10.1177/1933719115625844

By:

Kufaishi, Hala;
Alarab, May;
Drutz, Harold;
Lye, Stephen;
Shynlova, Oksana

Publication type:

Article

Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse.

Published in:

Reproductive Sciences, 2016, v. 23, n. 7, p. 931, doi. 10.1177/1933719115625840

By:

Kufaishi, Hala;
Alarab, May;
Drutz, Harold;
Lye, Stephen;
Shynlova, Oksana

Publication type:

Article

Expression of Extracellular Matrix-Remodeling Proteins Is Altered in Vaginal Tissue of Premenopausal Women With Severe Pelvic Organ Prolapse.

Published in:

Reproductive Sciences, 2014, v. 21, n. 6, p. 704, doi. 10.1177/1933719113512529

By:

Alarab, May;
Kufaishi, Hala;
Lye, Stephen;
Drutz, Harold;
Shynlova, Oksana

Publication type:

Article

Physiologic Uterine Inflammation and Labor Onset: Integration of Endocrine and Mechanical Signals.

Published in:

Reproductive Sciences, 2013, v. 20, n. 2, p. 154, doi. 10.1177/1933719112446084

By:

Shynlova, Oksana;
Lee, Yu-Hui;
Srikhajon, Khetsopon;
Lye, Stephen J

Publication type:

Article

Expression and Organization of Basement Membranes and Focal Adhesion Proteins in Pregnant Myometrium is Regulated by Uterine Stretch.

Published in:

Reproductive Sciences, 2009, v. 16, n. 10, p. 960, doi. 10.1177/1933719109338220

By:

Shynlova, Oksana;
Chow, Michelle;
Lye, Stephen J.

Publication type:

Article