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pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs.
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- Chemical Biology & Drug Design, 2018, v. 91, n. 1, p. 62, doi. 10.1111/cbdd.13057
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- Article
A Strategy for Selective O<sup>6</sup> -Alkylguanine-DNA Alkyltransferase Depletion Under Hypoxic Conditions.
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- Chemical Biology & Drug Design, 2012, v. 80, n. 2, p. 279, doi. 10.1111/j.1747-0285.2012.01401.x
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- Article
1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): a Cytotoxic Prodrug with Two Stable Conformations Differing in Biological and Physical Properties.
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- Chemical Biology & Drug Design, 2011, v. 78, n. 4, p. 513, doi. 10.1111/j.1747-0285.2011.01193.x
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- Article
Design Strategy for the EPR Tumor-Targeting of 1,2-Bis(sulfonyl)-1-alkylhydrazines.
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- Molecules, 2021, v. 26, n. 2, p. 259, doi. 10.3390/molecules26020259
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- Article
7-Nitro-4-(phenylthio)benzofurazan is a potent generator of superoxide and hydrogen peroxide.
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- Archives of Toxicology, 2012, v. 86, n. 10, p. 1613, doi. 10.1007/s00204-012-0872-9
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- Article
The Effects of the Methylating Agent 1,2-Bis(methylsulfonyl)-1-methylhydrazine on Morphology, DNA Content and Mitochondrial Function of Trypanosoma brucei Subspecies.
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- Journal of Eukaryotic Microbiology, 1991, v. 38, n. 3, p. 172, doi. 10.1111/j.1550-7408.1991.tb04425.x
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Preliminary Studies with a New Hypoxia-Selective Cytotoxin, KS119W, In Vitro and In Vivo.
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- Radiation Research, 2012, v. 178, n. 3, p. 126, doi. 10.1667/RR2934.1
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- Article