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The middle domain of Hsp104 can ensure substrates are functional after processing.
- Published in:
- PLoS Genetics, 2024, v. 20, n. 10, p. 1, doi. 10.1371/journal.pgen.1011424
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- Publication type:
- Article
C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy.
- Published in:
- Science Translational Medicine, 2020, v. 12, n. 559, p. 1, doi. 10.1126/scitranslmed.abb3774
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- Publication type:
- Article
Prime Time for α-Synuclein. .
- Published in:
- Journal of Neuroscience, 2007, v. 27, n. 10, p. 2433, doi. 10.1523/JNEUROSCI.0094-07.2007
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- Publication type:
- Article
RNA-binding proteins with prion-like domains in health and disease.
- Published in:
- Biochemical Journal, 2017, v. 474, n. 8, p. 1417, doi. 10.1042/BCJ20160499
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- Publication type:
- Article
Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly.
- Published in:
- Biochemical Journal, 2014, v. 464, n. 1, p. 85, doi. 10.1042/BJ20131609
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- Publication type:
- Article
Arginine-rich dipeptide-repeat proteins as phase disruptors in C9-ALS/FTD.
- Published in:
- Emerging Topics in Life Sciences, 2020, v. 4, n. 3, p. 293, doi. 10.1042/ETLS20190167
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- Publication type:
- Article
Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides.
- Published in:
- Life Science Alliance, 2023, v. 6, n. 9, p. 1, doi. 10.26508/lsa.202201824
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- Publication type:
- Article
Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drive Golgi membrane fusion.
- Published in:
- Journal of Cell Biology, 2002, v. 157, n. 7, p. 1161, doi. 10.1083/jcb.200202082
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- Publication type:
- Article
Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.
- Published in:
- Journal of Cell Biology, 2002, v. 157, n. 1, p. 45, doi. 10.1083/jcb.200112127
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- Publication type:
- Article
Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions.
- Published in:
- EMBO Journal, 2008, v. 27, n. 20, p. 2712, doi. 10.1038/emboj.2008.194
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- Publication type:
- Article
A direct role for GRASP65 as a mitotically regulated Golgi stacking factor.
- Published in:
- 2003
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- Publication type:
- Correction notice
A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways.
- Published in:
- EMBO Journal, 2000, v. 19, n. 10, p. 2181, doi. 10.1093/emboj/19.10.2181
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- Publication type:
- Article
GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system.
- Published in:
- EMBO Journal, 1999, v. 18, n. 18, p. 4949, doi. 10.1093/emboj/18.18.4949
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- Publication type:
- Article
Hsp104: A Weapon to Combat Diverse Neurodegenerative Disorders.
- Published in:
- NeuroSignals (Karger AG), 2008, v. 16, n. 1, p. 63, doi. 10.1159/000109760
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- Publication type:
- Article
The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching.
- Published in:
- Journal of Cell Biology, 2008, v. 183, n. 5, p. 761, doi. 10.1083/jcb.200808122
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- Publication type:
- Article
Applying Hsp104 to protein-misfolding disorders.
- Published in:
- Biochemistry & Cell Biology, 2010, v. 88, n. 1, p. 1, doi. 10.1139/O09-121
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- Publication type:
- Article
A synergistic small-molecule combination directly eradicates diverse prion strain structures.
- Published in:
- Nature Chemical Biology, 2009, v. 5, n. 12, p. 936, doi. 10.1038/nchembio.246
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- Publication type:
- Article
Hsp104 Suppresses Polyglutamine-Induced Degeneration Post Onset in a Drosophila MJD/SCA3 Model.
- Published in:
- PLoS Genetics, 2013, v. 9, n. 9, p. 1, doi. 10.1371/journal.pgen.1003781
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- Publication type:
- Article
The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future.
- Published in:
- Medicinal Research Reviews, 2020, v. 40, n. 4, p. 1352, doi. 10.1002/med.21661
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- Publication type:
- Article
C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD.
- Published in:
- Acta Neuropathologica, 2023, v. 145, n. 6, p. 793, doi. 10.1007/s00401-023-02565-1
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- Publication type:
- Article
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-12191-8
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- Publication type:
- Article
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS.
- Published in:
- Molecular Neurodegeneration, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13024-024-00737-5
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- Publication type:
- Article
Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD.
- Published in:
- Molecular Neurodegeneration, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13024-023-00698-1
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- Publication type:
- Article
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly.
- Published in:
- PLoS Genetics, 2024, v. 20, n. 2, p. 1, doi. 10.1371/journal.pgen.1011138
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- Publication type:
- Article
Therapeutic genetic variation revealed in diverse Hsp104 homologs.
- Published in:
- eLife, 2021, p. 1, doi. 10.7554/eLife.57457
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- Publication type:
- Article
A PDZ-Binding Motif Controls Basolateral Targeting of Syndecan-1 Along the Biosynthetic Pathway in Polarized Epithelial Cells.
- Published in:
- Traffic, 2008, v. 9, n. 11, p. 1915, doi. 10.1111/j.1600-0854.2008.00805.x
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- Publication type:
- Article
Suramin Inhibits Hsp104 ATPase and Disaggregase Activity.
- Published in:
- PLoS ONE, 2014, v. 9, n. 10, p. 1, doi. 10.1371/journal.pone.0110115
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- Publication type:
- Article
The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System.
- Published in:
- PLoS ONE, 2011, v. 6, n. 10, p. 1, doi. 10.1371/journal.pone.0026319
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- Publication type:
- Article
Hsp110 Chaperones Regulate Prion Formation and Propagation in S. cerevisiae by Two Discrete Activities.
- Published in:
- PLoS ONE, 2008, v. 3, n. 3, p. 1, doi. 10.1371/journal.pone.0001763
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- Publication type:
- Article
Developing therapeutic protein disaggregases for neurodegenerative disease: Developing topics.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.047421
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- Publication type:
- Article
Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology.
- Published in:
- Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-12191-8
- By:
- Publication type:
- Article
Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease.
- Published in:
- Frontiers in Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fnins.2017.00099
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- Publication type:
- Article
Chaperones in Neurodegeneration.
- Published in:
- Journal of Neuroscience, 2015, v. 35, n. 41, p. 13853, doi. 10.1523/JNEUROSCI.2600-15.2015
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- Publication type:
- Article
Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models.
- Published in:
- Nature Genetics, 2012, v. 44, n. 12, p. 1302, doi. 10.1038/ng.2434
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- Publication type:
- Article
Small Heat Shock Proteins Potentiate Amyloid Dissolution by Protein Disaggregases from Yeast and Humans.
- Published in:
- PLoS Biology, 2012, v. 10, n. 6, p. 1, doi. 10.1371/journal.pbio.1001346
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- Publication type:
- Article
Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS.
- Published in:
- PLoS Biology, 2011, v. 9, n. 4, p. 1, doi. 10.1371/journal.pbio.1000614
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- Publication type:
- Article
An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion.
- Published in:
- Nature Cell Biology, 1999, v. 1, n. 6, p. 335, doi. 10.1038/14025
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- Publication type:
- Article
Navigating the ClpB channel to solution.
- Published in:
- Nature Structural & Molecular Biology, 2005, v. 12, n. 1, p. 4, doi. 10.1038/nsmb0105-4
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- Publication type:
- Article
RNA-Binding Proteins in Amyotrophic Lateral Sclerosis and Neurodegeneration.
- Published in:
- Neurology Research International, 2012, p. 1, doi. 10.1155/2012/432780
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- Publication type:
- Article
AAA+ proteins: one motor, multiple ways to work.
- Published in:
- Biochemical Society Transactions, 2022, v. 50, n. 2, p. 895, doi. 10.1042/BST20200350
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- Publication type:
- Article
Engineered Nuclear Import Receptor Karyopherin‐β2 Chaperones Aberrant Phase Transitions of Disease‐Associated Cargo.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2282
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- Publication type:
- Article
Exploring the Effect of RNA Binding on TDP‐43 Liquid‐Liquid Phase Separation.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3072
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- Publication type:
- Article
Identifying Therapeutic Inhibitors of TDP43 Phase‐Separation.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R4947
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- Publication type:
- Article
Increased Nuclear Localization of Engineered Hsp104 Variants Mitigates aS, FUS, and TDP‐43 Toxicity in Yeast.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R2730
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- Publication type:
- Article
Elucidating the mechanism of potentiated Hsp104 NBD2 variants against proteotoxicity.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3428
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- Publication type:
- Article
Optimization of a Chaperone Protein Disaggregase Complex for Neurodegenerative Disease.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3204
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- Publication type:
- Article
Developing therapeutic protein disaggregases for Neurodegenerative Disease.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R3344
- By:
- Publication type:
- Article
Developing RNA Therapeutics for TDP‐43 Proteinopathy in ALS/FTD.
- Published in:
- FASEB Journal, 2022, v. 36, p. N.PAG, doi. 10.1096/fasebj.2022.36.S1.R4365
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- Publication type:
- Article
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
- Published in:
- 2021
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- Publication type:
- journal article
ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects.
- Published in:
- Journal of Clinical Investigation, 2014, v. 124, n. 3, p. 981, doi. 10.1172/JCI72723
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- Publication type:
- Article