Works by Shoda, Lisl K. M.

Results: 11

A well-characterized mechanistic model for exploring known or hypothesized T cell mediated drug induced liver injury: current capabilities and challenges for future predictivity.

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2025, v. 21, n. 6, p. 717, doi. 10.1080/17425255.2025.2499551

By:

Clemens, Lara;
Battista, Christina;
Kenz, Zackary R.;
Shoda, Lisl K. M.

Publication type:

Article

The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.

Published in:

International Journal of Molecular Sciences, 2023, v. 24, n. 11, p. 9692, doi. 10.3390/ijms24119692

By:

Beaudoin, James J.;
Clemens, Lara;
Miedel, Mark T.;
Gough, Albert;
Zaidi, Fatima;
Ramamoorthy, Priya;
Wong, Kari E.;
Sarangarajan, Rangaprasad;
Battista, Christina;
Shoda, Lisl K. M.;
Siler, Scott Q.;
Taylor, D. Lansing;
Howell, Brett A.;
Vernetti, Lawrence A.;
Yang, Kyunghee

Publication type:

Article

Dosing and Timing Effects of Anti-CD40L Therapy.

Published in:

Annals of the New York Academy of Sciences, 2007, v. 1103, p. 63, doi. 10.1196/annals.1394.013

By:

GADKAR, KAPIL G.;
SHODA, LISL K. M.;
KREUWEL, HUUB T. C.;
RAMANUJAN, SAROJA;
ZHENG, YANAN;
WHITING, CHAN C.;
YOUNG, DANIEL L.

Publication type:

Article

The Virtual NOD Mouse.

Published in:

Annals of the New York Academy of Sciences, 2007, v. 1103, p. 45, doi. 10.1196/annals.1394.014

By:

ZHENG, YANAN;
KREUWEL, HUUB T. C.;
YOUNG, DANIEL L.;
SHODA, LISL K. M.;
RAMANUJAN, SAROJA;
GADKAR, KAPIL G.;
ATKINSON, MARK A.;
WHITING, CHAN C.

Publication type:

Article

Linking physiology to toxicity using DILIsym<sup>®</sup>, a mechanistic mathematical model of drug-induced liver injury.

Published in:

Biopharmaceutics & Drug Disposition, 2014, v. 35, n. 1, p. 33, doi. 10.1002/bdd.1878

By:

Shoda, Lisl K. M.;
Woodhead, Jeffrey L.;
Siler, Scott Q.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.

Published in:

Pharmacology Research & Perspectives, 2019, v. 7, n. 6, p. 1, doi. 10.1002/prp2.523

By:

Generaux, Grant;
Lakhani, Vinal V.;
Yuching Yang;
Nadanaciva, Sashi;
Luping Qiu;
Riccardi, Keith;
Li Di;
Howell, Brett A.;
Siler, Scott Q.;
Watkins, Paul B.;
Barton, Hugh A.;
Aleo, Michael D.;
Shoda, Lisl K. M.

Publication type:

Article

Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses.

Published in:

Gene Regulation & Systems Biology, 2017, n. 11, p. 1, doi. 10.1177/1177625017696074

By:

Shoda, Lisl K. M.;
Battista, Christina;
Siler, Scott Q.;
Pisetsky, David S.;
Watkins, Paul B.;
Howell, Brett A.

Publication type:

Article

Assessing Effects of BHV-0223 40 mg Zydis Sublingual Formulation and Riluzole 50 mg Oral Tablet on Liver Function Test Parameters Utilizing DILIsym.

Published in:

Toxicological Sciences, 2020, v. 175, n. 2, p. 292, doi. 10.1093/toxsci/kfaa019

By:

Longo, Diane M;
Shoda, Lisl K M;
Howell, Brett A;
Coric, Vladimir;
Berman, Robert M;
Qureshi, Irfan A

Publication type:

Article

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Published in:

Toxicological Sciences, 2017, v. 155, n. 1, p. 61, doi. 10.1093/toxsci/kfw193

By:

Woodhead, Jeffrey L.;
Brock, William J.;
Roth, Sharin E.;
Shoaf, Susan E.;
Brouwer, Kim L. R.;
Church, Rachel;
Grammatopoulos, Tom N.;
Stiles, Linsey;
Siler, Scott Q.;
Howell, Brett A.;
Mosedale, Merrie;
Watkins, Paul B.;
Shoda, Lisl K. M.

Publication type:

Article

Modeling drug- and chemical- induced hepatotoxicity with systems biology approaches.

Published in:

Frontiers in Physiology, 2012, v. 3, p. 1, doi. 10.3389/fphys.2012.00462

By:

Bhattacharya, Sudin;
Shoda, Lisl K. M.;
Zhang, Qiang;
Woods, Courtney G.;
Howell, Brett A.;
Siler, Scott Q.;
Woodhead, Jeffrey L.;
Yang, Yuching;
McMullen, Patrick;
Watkins, Paul B.;
Andersen, Melvin E.

Publication type:

Article

Preexisting Autoantibodies Predict Efficacy of Oral Insulin to Cure Autoimmune Diabetes in Combination With Anti-CD3.

Published in:

Diabetes, 2012, v. 61, n. 6, p. 1490, doi. 10.2337/db11-1304

By:

Mamchak, Alusha A.;
Manenkova, Yulia;
Leconet, Wilhem;
Yanan Zheng;
Chan, Jason R.;
Stokes, Cynthia L.;
Shoda, Lisl K. M.;
Von Herrath, Matthias;
Bresson, Damien

Publication type:

Article