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Identification of the Cirratiomycin Biosynthesis Gene Cluster in Streptomyces Cirratus: Elucidation of the Biosynthetic Pathways for 2,3‐Diaminobutyric Acid and Hydroxymethylserine.
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- Chemistry - A European Journal, 2024, v. 30, n. 28, p. 1, doi. 10.1002/chem.202400271
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- Article
Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds.
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- Journal of Antibiotics, 2024, v. 77, n. 5, p. 288, doi. 10.1038/s41429-024-00711-9
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- Article
Collagen Lattice Model, Populated with Heterogeneous Cancer-Associated Fibroblasts, Facilitates Advanced Reconstruction of Pancreatic Cancer Microenvironment.
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- International Journal of Molecular Sciences, 2024, v. 25, n. 7, p. 3740, doi. 10.3390/ijms25073740
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- Article
In Vitro Module Editing Of NRPS Enables Production Of Highly Potent G<sub>q</sub>‐Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont.
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- Angewandte Chemie, 2024, v. 136, n. 10, p. 1, doi. 10.1002/ange.202317805
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- Article
In Vitro Module Editing Of NRPS Enables Production Of Highly Potent G<sub>q</sub>‐Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont.
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- Angewandte Chemie International Edition, 2024, v. 63, n. 10, p. 1, doi. 10.1002/anie.202317805
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- Article
Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation.
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- Journal of Antibiotics, 2024, v. 77, n. 1, p. 30, doi. 10.1038/s41429-023-00673-4
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- Article
Carrier Protein Mediated Formation of the Dihydropyridazinone Ring in Actinopyridazinone Biosynthesis.
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- Angewandte Chemie, 2023, v. 135, n. 29, p. 1, doi. 10.1002/ange.202305155
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Carrier Protein Mediated Formation of the Dihydropyridazinone Ring in Actinopyridazinone Biosynthesis.
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- Angewandte Chemie International Edition, 2023, v. 62, n. 29, p. 1, doi. 10.1002/anie.202305155
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- Article
Acyltransferase Domain Exchange between Two Independent Type I Polyketide Synthases in the Same Producer Strain of Macrolide Antibiotics.
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- ChemBioChem, 2023, v. 24, n. 6, p. 1, doi. 10.1002/cbic.202200670
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- Article
Bacterial Avenalumic Acid Biosynthesis Includes Substitution of an Aromatic Amino Group for Hydride by Nitrous Acid Dependent Diazotization.
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- Angewandte Chemie, 2022, v. 134, n. 45, p. 1, doi. 10.1002/ange.202211728
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- Article
Bacterial Avenalumic Acid Biosynthesis Includes Substitution of an Aromatic Amino Group for Hydride by Nitrous Acid Dependent Diazotization.
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- Angewandte Chemie International Edition, 2022, v. 61, n. 45, p. 1, doi. 10.1002/anie.202211728
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- Article
Discovery of prescopranone, a key intermediate in scopranone biosynthesis.
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- Journal of Antibiotics, 2022, v. 75, n. 6, p. 305, doi. 10.1038/s41429-022-00521-x
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- Article
Structural Basis for the Prenylation Reaction of Carbazole‐Containing Natural Products Catalyzed by Squalene Synthase‐Like Enzymes.
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- Angewandte Chemie, 2022, v. 134, n. 20, p. 1, doi. 10.1002/ange.202117430
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- Article
Structural Basis for the Prenylation Reaction of Carbazole‐Containing Natural Products Catalyzed by Squalene Synthase‐Like Enzymes.
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- Angewandte Chemie International Edition, 2022, v. 61, n. 20, p. 1, doi. 10.1002/anie.202117430
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- Article
Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C6‐Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C6‐Methyltransferase.
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- Angewandte Chemie, 2022, v. 134, n. 1, p. 1, doi. 10.1002/ange.202111217
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Structural and Molecular Basis of the Catalytic Mechanism of Geranyl Pyrophosphate C6‐Methyltransferase: Creation of an Unprecedented Farnesyl Pyrophosphate C6‐Methyltransferase.
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- Angewandte Chemie International Edition, 2022, v. 61, n. 1, p. 1, doi. 10.1002/anie.202111217
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Chemical targeting of G-quadruplexes in telomeres and beyond for molecular cancer therapeutics.
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- Journal of Antibiotics, 2021, v. 74, n. 10, p. 617, doi. 10.1038/s41429-021-00454-x
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Phenotypic screening system using three-dimensional (3D) culture models for natural product screening.
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- Journal of Antibiotics, 2021, v. 74, n. 10, p. 660, doi. 10.1038/s41429-021-00457-8
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- Article
Structural and Functional Analyses of the Tridomain‐Nonribosomal Peptide Synthetase FmoA3 for 4‐Methyloxazoline Ring Formation.
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- Angewandte Chemie, 2021, v. 133, n. 26, p. 14675, doi. 10.1002/ange.202102760
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Structural and Functional Analyses of the Tridomain‐Nonribosomal Peptide Synthetase FmoA3 for 4‐Methyloxazoline Ring Formation.
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- Angewandte Chemie International Edition, 2021, v. 60, n. 26, p. 14554, doi. 10.1002/anie.202102760
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An Atypical Arginine Dihydrolase Involved in the Biosynthesis of Cyclic Hexapeptide Longicatenamides.
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- Chemistry - An Asian Journal, 2021, v. 16, n. 11, p. 1382, doi. 10.1002/asia.202100181
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Novel Plant-Associated Acidobacteria Promotes Growth of Common Floating Aquatic Plants, Duckweeds.
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- Microorganisms, 2021, v. 9, n. 6, p. 1133, doi. 10.3390/microorganisms9061133
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Identification of functional cytochrome P450 and ferredoxin from Streptomyces sp. EAS-AB2608 by transcriptional analysis and their heterologous expression.
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- Applied Microbiology & Biotechnology, 2021, v. 105, n. 10, p. 4177, doi. 10.1007/s00253-021-11304-z
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Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-88583-z
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- Article
A novel oxazole-containing tetraene compound, JBIR-159, produced by heterologous expression of the cryptic trans-AT type polyketide synthase biosynthetic gene cluster.
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- Journal of Antibiotics, 2021, v. 74, n. 5, p. 354, doi. 10.1038/s41429-021-00410-9
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- Article
A novel methymycin analog, 12-ketomethymycin N-oxide, produced by the heterologous expression of the large pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900.
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- Bioscience, Biotechnology & Biochemistry, 2021, v. 85, n. 4, p. 890, doi. 10.1093/bbb/zbaa111
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Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma.
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- Cancer Science, 2021, v. 112, n. 3, p. 1225, doi. 10.1111/cas.14786
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Pseudoalteropeptide A, a novel lipopeptide from the marine bacterium Pseudoalteromonas piscicida SWA4_PA4 isolated from marine seaweed.
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- Journal of Antibiotics, 2021, v. 74, n. 2, p. 105, doi. 10.1038/s41429-020-00377-z
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- Article
Dunaimycin C3, a new GRP78 downregulator from Streptomyces sp. RAN389.
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- Journal of Antibiotics, 2021, v. 74, n. 1, p. 76, doi. 10.1038/s41429-020-0356-8
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Neocurromycin A, a new GRP78 downregulator from Streptomyces sp. RAI364.
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- Journal of Antibiotics, 2020, v. 73, n. 11, p. 790, doi. 10.1038/s41429-020-0339-9
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Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy.
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- Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18189-y
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Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin.
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- Journal of Antibiotics, 2020, v. 73, n. 9, p. 650, doi. 10.1038/s41429-020-0319-0
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- Article
In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives.
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- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17769-2
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- Article
New phenylspirodrimane metabolites MBJ-0030, MBJ-0031, and MBJ-0032 isolated from the soil fungal strain Stachybotrys sp. f23793.
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- Bioscience, Biotechnology & Biochemistry, 2020, v. 84, n. 8, p. 1570, doi. 10.1080/09168451.2020.1757402
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C-Methylation of S-adenosyl-L-Methionine Occurs Prior to Cyclopropanation in the Biosynthesis of 1-Amino-2-Methylcyclopropanecarboxylic Acid (Norcoronamic Acid) in a Bacterium.
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- Biomolecules (2218-273X), 2020, v. 10, n. 5, p. 775, doi. 10.3390/biom10050775
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Novel macrolactam compound produced by the heterologous expression of a large cryptic biosynthetic gene cluster of Streptomyces rochei IFO12908.
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- Journal of Antibiotics, 2020, v. 73, n. 3, p. 171, doi. 10.1038/s41429-019-0265-x
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- Article
An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces.
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- Angewandte Chemie, 2019, v. 131, n. 38, p. 13483, doi. 10.1002/ange.201906864
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- Article
An Unprecedented Cyclization Mechanism in the Biosynthesis of Carbazole Alkaloids in Streptomyces.
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- Angewandte Chemie International Edition, 2019, v. 58, n. 38, p. 13349, doi. 10.1002/anie.201906864
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Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay.
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- Journal of Biochemistry, 2019, v. 166, n. 1, p. 41, doi. 10.1093/jb/mvz007
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Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution.
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- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05877-z
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JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp. OPMA00071.
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- Journal of Antibiotics, 2018, v. 71, n. 3, p. 390, doi. 10.1038/s41429-017-0010-2
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- Article
Reconstitution of a Type II Polyketide Synthase that Catalyzes Polyene Formation.
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- Angewandte Chemie, 2018, v. 130, n. 7, p. 1972, doi. 10.1002/ange.201709636
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- Article
Reconstitution of a Type II Polyketide Synthase that Catalyzes Polyene Formation.
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- Angewandte Chemie International Edition, 2018, v. 57, n. 7, p. 1954, doi. 10.1002/anie.201709636
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Complete genome sequence and expression profile of the commercial lytic enzyme producer Lysobacter enzymogenes M497-1.
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- DNA Research, 2017, v. 24, n. 2, p. 169, doi. 10.1093/dnares/dsw055
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Frontispiz: Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.
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- Angewandte Chemie, 2017, v. 129, n. 7, p. n/a, doi. 10.1002/ange.201780761
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- Article
Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.
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- Angewandte Chemie, 2017, v. 129, n. 7, p. 1766, doi. 10.1002/ange.201611371
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Frontispiece: Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.
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- Angewandte Chemie International Edition, 2017, v. 56, n. 7, p. n/a, doi. 10.1002/anie.201780761
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- Article
Characterization of Giant Modular PKSs Provides Insight into Genetic Mechanism for Structural Diversification of Aminopolyol Polyketides.
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- Angewandte Chemie International Edition, 2017, v. 56, n. 7, p. 1740, doi. 10.1002/anie.201611371
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Novel arginine-containing peptides MBJ-0173 and MBJ-0174 from Mortierella alpina f28740.
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- Journal of Antibiotics, 2017, v. 70, n. 2, p. 226, doi. 10.1038/ja.2016.116
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- Article
JBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77.
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- Journal of Antibiotics, 2016, v. 69, n. 9, p. 707, doi. 10.1038/ja.2015.135
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- Article