Works by Sharma, Amarnath

Results: 37

Pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors: correlations with clinical characteristics and safety.

Published in:

Cancer Chemotherapy & Pharmacology, 2008, v. 62, n. 1, p. 97, doi. 10.1007/s00280-007-0579-4

By:

Guo, Feng;
Letrent, Stephen P.;
Munster, Pamela;
Britten, Carolyn D.;
Gelmon, Karen;
Tolcher, Anthony W.;
Sharma, Amarnath

Publication type:

Article

Population pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors.

Published in:

Cancer Chemotherapy & Pharmacology, 2007, v. 60, n. 6, p. 799, doi. 10.1007/s00280-007-0427-6

By:

Feng Guo;
Letrent, Stephen P.;
Sharma, Amarnath

Publication type:

Article

A phase I and pharmacokinetic study of a powder-filled capsule formulation of oral irinotecan (CPT-11) given daily for 5 days every 3 weeks in patients with advanced solid tumors.

Published in:

2006

By:

Pitot, Henry C.;
Adjei, Alex A.;
Reid, Joel M.;
Sloan, Jeff A.;
Atherton, Pamela J.;
Rubin, Joseph;
Alberts, Steven R.;
Duncan, Barbara A.;
Denis, Louis;
Schaaf, Larry J.;
Donghua Yin;
Sharma, Amarnath;
McGovren, Patrick;
Miller, Langdon L.;
Erlichman, Charles;
Yin, Donghua

Publication type:

journal article

Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models.

Published in:

Cancer Chemotherapy & Pharmacology, 2005, v. 56, n. 6, p. 569, doi. 10.1007/s00280-005-1017-0

By:

Qingyu Zhou;
Olivo, Malini;
Lye, Karen;
Moore, Shirley;
Sharma, Amarnath;
Chowbay, Balram

Publication type:

Article

Adaptive Approaches in Clinical Drug Development.

Published in:

Pharmaceutical Medicine, 2009, v. 23, n. 3, p. 139, doi. 10.1007/BF03256762

By:

Krams, Michael;
Sharma, Amarnath;
Dragalin, Vlad;
Burns, Daniel D.;
Fardipour, Parvin;
Padmanabhan, S. Krishna;
Perevozskaya, Inna;
Littman, Gary;
Maguire, Robert

Publication type:

Article

Pharmacokinetics and Safety of Duloxetine, a Dual-Serotonin and Norepinephrine Reuptake Inhibitor.

Published in:

Journal of Clinical Pharmacology, 2000, v. 40, n. 2, p. 161, doi. 10.1177/009127000004000207

By:

Sharma, Amarnath;
Goldberg, Mark J.;
Cerimele, Benito J.

Publication type:

Article

Pharmacokinetics and Pharmacodynamics of Avitriptan during Intravenous Administration in Healthy Subjects.

Published in:

Journal of Clinical Pharmacology, 1999, v. 39, n. 7, p. 685, doi. 10.1177/00912709922008326

By:

Sharma, Amarnath;
Jusko, William J.;
Fulmor, I. Edgar;
Norton, Jean;
Uderman, Howard D.;
Salazar, Daniel E.

Publication type:

Article

Clinical Pharmacokinetics and Pharmacodynamics of a New Squalene Synthase Inhibitor, BMS-188494, in Healthy Volunteers.

Published in:

Journal of Clinical Pharmacology, 1998, v. 38, n. 12, p. 1116, doi. 10.1177/009127009803801205

By:

Sharma, Amarnath;
Slugg, Peter H.;
Hammett, Janis L.;
Jusko, William J.

Publication type:

Article

Population Pharmacokinetics and Exposure‐Response Modeling of Daratumumab Subcutaneous Administration in Patients With Light‐Chain Amyloidosis.

Published in:

Journal of Clinical Pharmacology, 2022, v. 62, n. 5, p. 656, doi. 10.1002/jcph.1994

By:

Luo, Man;
Zhu, Peijuan;
Nnane, Ivo;
Xiong, Yuan;
Merlini, Giampaolo;
Comenzo, Raymond L;
Kastritis, Efstathios;
Wechalekar, Ashutosh D.;
Weiss, Brendan M.;
Tran, NamPhuong;
Qin, Xiang;
Vermeulen, Jessica;
Sharma, Amarnath;
Sun, Yu‐Nien;
Zhou, Honghui

Publication type:

Article

Population Pharmacokinetics and Exposure‐Response Modeling Analyses of Ustekinumab in Adults With Moderately to Severely Active Ulcerative Colitis.

Published in:

Journal of Clinical Pharmacology, 2020, v. 60, n. 7, p. 889, doi. 10.1002/jcph.1582

By:

Xu, Yan;
Hu, Chuanpu;
Chen, Yang;
Miao, Xin;
Adedokun, Omoniyi J.;
Xu, Zhenhua;
Sharma, Amarnath;
Zhou, Honghui

Publication type:

Article

Pharmacokinetics, Pharmacodynamics, Immunogenicity, Safety, and Tolerability of JNJ‐61178104, a Novel Tumor Necrosis Factor‐Alpha and Interleukin‐17A Bispecific Antibody, in Healthy Subjects.

Published in:

Journal of Clinical Pharmacology, 2019, v. 59, n. 7, p. 968, doi. 10.1002/jcph.1393

By:

Akpalu, Derrick E.;
Frederick, Bart;
Nnane, Ivo P.;
Yao, Zhenling;
Shen, Fang;
Ort, Tatiana;
Fink, Damien;
Dogmanits, Shannon;
Raible, Donald;
Sharma, Amarnath;
Xu, Zhenhua

Publication type:

Article

Exposure‐Response Modeling Analyses for Sirukumab, a Human Monoclonal Antibody Targeting Interleukin 6, in Patients With Moderately to Severely Active Rheumatoid Arthritis.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 11, p. 1501, doi. 10.1002/jcph.1272

By:

Xu, Yan;
Hu, Chuanpu;
Zhuang, Yanli;
Hsu, Benjamin;
Xu, Zhenhua;
Sharma, Amarnath;
Zhou, Honghui

Publication type:

Article

Population Pharmacokinetic Modeling of Guselkumab, a Human IgG1λ Monoclonal Antibody Targeting IL‐23, in Patients with Moderate to Severe Plaque Psoriasis.

Published in:

Journal of Clinical Pharmacology, 2018, v. 58, n. 5, p. 613, doi. 10.1002/jcph.1063

By:

Yao, Zhenling;
Hu, Chuanpu;
Zhu, Yaowei;
Xu, Zhenhua;
Randazzo, Bruce;
Wasfi, Yasmine;
Chen, Yang;
Sharma, Amarnath;
Zhou, Honghui

Publication type:

Article

CYP3A and P-Glycoprotein Activity Induction With St. John’s Wort in Healthy Volunteers From 6 Ethnic Populations.

Published in:

Journal of Clinical Pharmacology, 2005, v. 45, n. 3, p. 352, doi. 10.1177/0091270004273320

By:

Xie, Rujia;
Tan, Lai Hock;
Polasek, Emery C.;
Hong, Catherine;
Teillol-Foo, Melvyn;
Gordi, Toufigh;
Sharma, Amarnath;
Nickens, Dana J.;
Arakawa, Tomoko;
Knuth, Dean W.;
Antal, Edward J.

Publication type:

Article

Therapeutic protein-drug interactions: plausible mechanisms and assessment strategies.

Published in:

Expert Opinion on Drug Metabolism & Toxicology, 2016, v. 12, n. 11, p. 1323, doi. 10.1080/17425255.2016.1211109

By:

Zhou, Honghui;
Sharma, Amarnath

Publication type:

Article

Population pharmacokinetics and exposure‐response modeling analyses of guselkumab in patients with psoriatic arthritis.

Published in:

CTS: Clinical & Translational Science, 2022, v. 15, n. 3, p. 749, doi. 10.1111/cts.13197

By:

Chen, Yang;
Miao, Xin;
Hsu, Chyi‐Hung;
Zhuang, Yanli;
Kollmeier, Alexa;
Xu, Zhenhua;
Zhou, Honghui;
Sharma, Amarnath

Publication type:

Article

Evaluating Potential Disease‐Mediated Protein‐Drug Interactions in Patients With Moderate‐to‐Severe Plaque Psoriasis Receiving Subcutaneous Guselkumab.

Published in:

CTS: Clinical & Translational Science, 2020, v. 13, n. 6, p. 1217, doi. 10.1111/cts.12807

By:

Zhu, Yaowei;
Xu, Yan;
Zhuang, Yanli;
Piantone, Alexa;
Shu, Cathye;
Chen, Dion;
Zhou, Honghui;
Xu, Zhenhua;
Sharma, Amarnath

Publication type:

Article

Modeling near-continuous clinical endpoint as categorical: application to longitudinal exposure-response modeling of Mayo scores for golimumab in patients with ulcerative colitis.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 6, p. 803, doi. 10.1007/s10928-018-9610-0

By:

Hu, Chuanpu;
Adedokun, Omoniyi J.;
Zhang, Liping;
Sharma, Amarnath;
Zhou, Honghui

Publication type:

Article

Joint longitudinal model development: application to exposure-response modeling of ACR and DAS scores in rheumatoid arthritis patients treated with sirukumab.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 5, p. 679, doi. 10.1007/s10928-018-9598-5

By:

Hu, Chuanpu;
Xu, Yan;
Zhuang, Yanli;
Hsu, Benjamin;
Sharma, Amarnath;
Xu, Zhenhua;
Zhang, Liping;
Zhou, Honghui

Publication type:

Article

A comprehensive evaluation of exposure-response relationships in clinical trials: application to support guselkumab dose selection for patients with psoriasis.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2018, v. 45, n. 4, p. 523, doi. 10.1007/s10928-018-9581-1

By:

Hu, Chuanpu;
Yao, Zhenling;
Chen, Yang;
Randazzo, Bruce;
Zhang, Liping;
Xu, Zhenhua;
Sharma, Amarnath;
Zhou, Honghui

Publication type:

Article

Challenges in longitudinal exposure-response modeling of data from complex study designs: a case study of modeling CDAI score for ustekinumab in patients with Crohn's disease.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2017, v. 44, n. 5, p. 425, doi. 10.1007/s10928-017-9529-x

By:

Hu, Chuanpu;
Adedokun, Omoniyi;
Chen, Yang;
Szapary, Philippe;
Gasink, Christopher;
Sharma, Amarnath;
Zhou, Honghui

Publication type:

Article

Improvement in latent variable indirect response modeling of multiple categorical clinical endpoints: application to modeling of guselkumab treatment effects in psoriatic patients.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2017, v. 44, n. 5, p. 437, doi. 10.1007/s10928-017-9531-3

By:

Hu, Chuanpu;
Randazzo, Bruce;
Sharma, Amarnath;
Zhou, Honghui

Publication type:

Article

Landmark and longitudinal exposure-response analyses in drug development.

Published in:

Journal of Pharmacokinetics & Pharmacodynamics, 2017, v. 44, n. 5, p. 503, doi. 10.1007/s10928-017-9534-0

By:

Hu, Chuanpu;
Zhou, Honghui;
Sharma, Amarnath

Publication type:

Article

Influence of model-predicted rivaroxaban exposure and patient characteristics on efficacy and safety outcomes in patients with acute coronary syndrome.

Published in:

Therapeutic Advances in Cardiovascular Disease, 2019, v. 13, p. N.PAG, doi. 10.1177/1753944719863641

By:

Zhang, Liping;
Yan, Xiaoyu;
Nandy, Partha;
Willmann, Stefan;
Fox, Keith A. A.;
Berkowitz, Scott D.;
Sharma, Amarnath;
Hermanowski-Vosatka, Anne;
Schmidt, Stephan;
Weitz, Jeffrey I.;
Garmann, Dirk;
Peters, Gary

Publication type:

Article

Activity of paclitaxel liposome formulations against human ovarian tumor xenografts.

Published in:

International Journal of Cancer, 1997, v. 71, n. 1, p. 103, doi. 10.1002/(SICI)1097-0215(19970328)71:1<103::AID-IJC17>3.0.CO;2-J

By:

Sharma, Amarnath;
Mayhew, Eric;
Bolcsak, Lois;
Cavanaugh, C.;
Harmon, P.;
Janoff, Andrew;
Bernacki, Ralph J.

Publication type:

Article

Extrapolating Pharmacodynamic Effects From Adults to Pediatrics: A Case Study of Ustekinumab in Pediatric Patients With Moderate to Severe Plaque Psoriasis.

Published in:

Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 1, p. 131, doi. 10.1002/cpt.2033

By:

Zhou, Wangda;
Hu, Chuanpu;
Zhu, Yaowei;
Randazzo, Bruce;
Song, Michael;
Sharma, Amarnath;
Xu, Zhenhua;
Zhou, Honghui

Publication type:

Article

Characteristics of indirect pharmacodynamic models and applications to clinical drug responses.

Published in:

British Journal of Clinical Pharmacology, 1998, v. 45, n. 3, p. 229, doi. 10.1046/j.1365-2125.1998.00676.x

By:

Sharma, Amarnath;
Jusko, William J.

Publication type:

Article

Clinical pharmacokinetics and gastrointestinal tolerability of a novel extended-release microsphere formulation of azithromycin.

Published in:

2007

By:

Chandra, Richa;
Ping Liu;
Breen, Jeanne D.;
Fisher, Jeannine;
Xie, Charles;
LaBadie, Robert;
Benner, Rebecca J.;
Benincosa, Lisa J.;
Sharma, Amarnath;
Liu, Ping

Publication type:

journal article

Pharmacokinetics and Pharmacodynamics of JNJ-55920839, an Antibody Targeting Interferon α/ω, in Healthy Subjects and Subjects with Mild-to-Moderate Systemic Lupus Erythematosus.

Published in:

Clinical Drug Investigation, 2020, v. 40, n. 12, p. 1127, doi. 10.1007/s40261-020-00978-4

By:

Yao, Zhenling;
Loggia, Laura;
Fink, Damien;
Chevrier, Marc;
Marciniak, Stanley;
Sharma, Amarnath;
Xu, Zhenhua

Publication type:

Article

Application of Beta-Distribution and Combined Uniform and Binomial Methods in Longitudinal Modeling of Bounded Outcome Score Data.

Published in:

AAPS Journal, 2020, v. 22, n. 5, p. N.PAG, doi. 10.1208/s12248-020-00478-5

By:

Hu, Chuanpu;
Zhou, Honghui;
Sharma, Amarnath

Publication type:

Article

Facilitating Longitudinal Exposure-Response Modeling of a Composite Endpoint Using the Joint Modeling of Sparsely and Frequently Collected Subcomponents.

Published in:

AAPS Journal, 2020, v. 22, n. 4, p. 1, doi. 10.1208/s12248-020-00452-1

By:

Hu, Chuanpu;
Zhou, Honghui;
Sharma, Amarnath

Publication type:

Article

Applying Beta Distribution in Analyzing Bounded Outcome Score Data.

Published in:

AAPS Journal, 2020, v. 22, n. 3, p. 1, doi. 10.1208/s12248-020-00441-4

By:

Hu, Chuanpu;
Zhou, Honghui;
Sharma, Amarnath

Publication type:

Article

Risk-Based Comparability Assessment for Monoclonal Antibodies During Drug Development: A Clinical Pharmacology Perspective.

Published in:

AAPS Journal, 2018, v. 20, n. 6, p. 1, doi. 10.1208/s12248-018-0268-8

By:

Zhuang, Yanli;
Chen, Di;
Sharma, Amarnath;
Xu, Zhenhua

Publication type:

Article

Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations.

Published in:

AAPS Journal, 2018, v. 20, n. 3, p. 1, doi. 10.1208/s12248-018-0204-y

By:

Parasrampuria, Dolly A.;
Benet, Leslie Z.;
Sharma, Amarnath

Publication type:

Article

How Adaptive Trial Designs Can Increase Efficiency in Psychiatric Drug Development: A Case Study.

Published in:

2011

By:

SHEN, JOAN;
PRESKORN, SHELDON;
DRAGALIN, VLADIMIR;
SLOMKOWSKI, MARY;
PADMANABHAN, S. KRISHNA;
FARDIPOUR, PARVIN;
SHARMA, AMARNATH;
KRAMS, MICHAEL

Publication type:

Case Study

Correction: Translational Modeling Predicts Efficacious Therapeutic Dosing Range of Teclistamab for Multiple Myeloma.

Published in:

2022

By:

Girgis, Suzette;
Lin, Shun Xin Wang;
Pillarisetti, Kodandaram;
Banerjee, Arnob;
Stephenson, Tara;
Ma, Xuewen;
Shetty, Shoba;
Yang, Tong-Yuan;
Hilder, Brandi W.;
Jiao, Qun;
Hanna, Brett;
Adams III, Homer C.;
Sun, Yu-Nien;
Sharma, Amarnath;
Smit, Jennifer;
Infante, Jeffrey R.;
Goldberg, Jenna D.;
Elsayed, Yusri;
Adams, Homer C 3rd

Publication type:

corrected article

Translational Modeling Predicts Efficacious Therapeutic Dosing Range of Teclistamab for Multiple Myeloma.

Published in:

Targeted Oncology, 2022, v. 17, n. 4, p. 433, doi. 10.1007/s11523-022-00893-y

By:

Girgis, Suzette;
Lin, Shun Xin Wang;
Pillarisetti, Kodandaram;
Banerjee, Arnob;
Stephenson, Tara;
Ma, Xuewen;
Shetty, Shoba;
Yang, Tong-Yuan;
Hilder, Brandi W.;
Jiao, Qun;
Hanna, Brett;
Adams III, Homer C;
Sun, Yu-Nien;
Sharma, Amarnath;
Smit, Jennifer;
Infante, Jeffrey R.;
Goldberg, Jenna D.;
Elsayed, Yusri

Publication type:

Article