Works by Shamloo, Mehrdad

Results: 38

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.

Published in:

Acta Neuropathologica, 2019, v. 137, n. 6, p. 961, doi. 10.1007/s00401-019-01995-0

By:

Brahic, Michel;
Couthouis, Julien;
Ma, Rosanna;
Nakayama, Lisa;
Bieri, Gregor;
Kramer, Nicholas J.;
Gitler, Aaron D.;
Bousset, Luc;
Melki, Ronald;
Monbureau, Marie;
Defensor, Erwin;
Shamloo, Mehrdad;
Schüle, Birgitt

Publication type:

Article

Enantiomers of 2-methylglutamate and 2-methylglutamine selectively impact mouse brain metabolism and behavior.

Published in:

Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-87569-1

By:

Wawro, Adam M.;
Gajera, Chandresh R.;
Baker, Steven A.;
Leśniak, Robert K.;
Fischer, Curt R.;
Saw, Nay L.;
Shamloo, Mehrdad;
Montine, Thomas J.

Publication type:

Article

Upregulating Human Cathelicidin Antimicrobial Peptide LL-37 Expression May Prevent Severe COVID-19 Inflammatory Responses and Reduce Microthrombosis.

Published in:

Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.880961

By:

Aloul, Karim M.;
Nielsen, Josefine Eilsø;
Defensor, Erwin B.;
Lin, Jennifer S.;
Fortkort, John A.;
Shamloo, Mehrdad;
Cirillo, Jeffrey D.;
Gombart, Adrian F.;
Barron, Annelise E.

Publication type:

Article

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.

Published in:

EMBO Molecular Medicine, 2018, v. 10, n. 3, p. 1, doi. 10.15252/emmm.201708166

By:

Joshi, Amit U;
Saw, Nay L;
Vogel, Hannes;
Cunnigham, Anna D;
Shamloo, Mehrdad;
Mochly‐Rosen, Daria

Publication type:

Article

GluN2B Antagonism Affects Interneurons and Leads to Immediate and Persistent Changes in Synaptic Plasticity, Oscillations, and Behavior.

Published in:

Neuropsychopharmacology, 2013, v. 38, n. 7, p. 1221, doi. 10.1038/npp.2013.19

By:

Hanson, Jesse E;
Weber, Martin;
Meilandt, William J;
Wu, Tiffany;
Luu, Tom;
Deng, Lunbin;
Shamloo, Mehrdad;
Sheng, Morgan;
Scearce-Levie, Kimberly;
Zhou, Qiang

Publication type:

Article

Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia.

Published in:

European Journal of Neuroscience, 2008, v. 27, n. 9, p. 2444, doi. 10.1111/j.1460-9568.2008.06209.x

By:

Braithwaite, Steven P.;
Xu, Jian;
Leung, John;
Urfer, Roman;
Nikolich, Karoly;
Oksenberg, Donna;
Lombroso, Paul J.;
Shamloo, Mehrdad

Publication type:

Article

Npas4, a novel helix–loop–helix PAS domain protein, is regulated in response to cerebral ischemia.

Published in:

European Journal of Neuroscience, 2006, v. 24, n. 10, p. 2705, doi. 10.1111/j.1460-9568.2006.05172.x

By:

Shamloo, Mehrdad;
Soriano, Liza;
Von Schack, David;
Rickhag, Mattias;
Chin, Daniel J.;
Gonzalez‐Zulueta, Mirella;
Gido, Gunilla;
Urfer, Roman;
Wieloch, Tadeusz;
Nikolich, Karoly

Publication type:

Article

A Death Receptor 6-Amyloid Precursor Protein Pathway Regulates Synapse Density in the Mature CNS But Does Not Contribute to Alzheimer's Disease-Related Pathophysiology in Murine Models.

Published in:

Journal of Neuroscience, 2014, v. 34, n. 19, p. 6425, doi. 10.1523/JNEUROSCI.4963-13.2014

By:

Kallop, Dara Y.;
Meilandt, William J.;
Gogineni, Alvin;
Easley-Neal, Courtney;
Wu, Tiffany;
Jubb, Adrian M.;
Yaylaoglu, Murat;
Shamloo, Mehrdad;
Tessier-Lavigne, Marc;
Scearce-Levie, Kimberly;
Weimer, Robby M.

Publication type:

Article

A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 48, p. 18712, doi. 10.1523/JNEUROSCI.1310-13.2013

By:

Simmons, Danielle A.;
Belichenko, Nadia P.;
Tao Yang;
Condon, Christina;
Monbureau, Marie;
Shamloo, Mehrdad;
Jing, Deqiang;
Massa, Stephen M.;
Longo, Frank M.

Publication type:

Article

A Dramatic Increase of Clq Protein in the CNS during Normal Aging.

Published in:

Journal of Neuroscience, 2013, v. 33, n. 33, p. 13460, doi. 10.1523/JNEUROSCI.1333-13.2013

By:

Stephan, Alexander H.;
Madison, Daniel V.;
Mateos, José María;
Fraser, Deborah A.;
Lovelett, Emilie A.;
Coutellier, Laurence;
Kim, Leo;
Tsai, Hui-Hsin;
Huang, Eric J.;
Rowitch, David H.;
Berns, Dominic S.;
Tenner, Andrea J.;
Shamloo, Mehrdad;
Barres, Ben A.

Publication type:

Article

Persistent Phosphorylation of Synaptic Proteins Following Middle Cerebral Artery Occlusion.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2002, v. 22, n. 9, p. 1107, doi. 10.1097/00004647-200209000-00008

By:

Matsumoto, Shohei;
Shamloo, Mehrdad;
Isshiki, Atsushi;
Wieloch, Tadeusz

Publication type:

Article

Changes in Protein Tyrosine Phosphorylation in the Rat Brain After Cerebral Ischemia in a Model of Ischemic Tolerance.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 1999, v. 19, n. 2, p. 173, doi. 10.1097/00004647-199902000-00009

By:

Shamloo, Mehrdad;
Wieloch, Tadeusz

Publication type:

Article

Selective Vulnerability of the Locus Coeruleus Noradrenergic System and its Role in Modulation of Neuroinflammation, Cognition, and Neurodegeneration.

Published in:

Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.1030609

By:

Evans, Andrew K.;
Defensor, Erwin;
Shamloo, Mehrdad

Publication type:

Article

The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.

Published in:

Brain: A Journal of Neurology, 2011, v. 134, n. 3, p. 732, doi. 10.1093/brain/awq367

By:

Ruscher, Karsten;
Shamloo, Mehrdad;
Rickhag, Mattias;
Ladunga, Istvan;
Soriano, Liza;
Gisselsson, Lennart;
Toresson, Håkan;
Ruslim-Litrus, Lily;
Oksenberg, Donna;
Urfer, Roman;
Johansson, Barbro B.;
Nikolich, Karoly;
Wieloch, Tadeusz

Publication type:

Article

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.

Published in:

Nature Medicine, 2015, v. 21, n. 10, p. 1154, doi. 10.1038/nm.3951

By:

Min, Sang-Won;
Chen, Xu;
Tracy, Tara E;
Li, Yaqiao;
Zhou, Yungui;
Wang, Chao;
Shirakawa, Kotaro;
Minami, S Sakura;
Defensor, Erwin;
Mok, Sue Ann;
Sohn, Peter Dongmin;
Schilling, Birgit;
Cong, Xin;
Ellerby, Lisa;
Gibson, Bradford W;
Johnson, Jeffrey;
Krogan, Nevan;
Shamloo, Mehrdad;
Gestwicki, Jason;
Masliah, Eliezer

Publication type:

Article

Identification of a central role for complement in osteoarthritis.

Published in:

Nature Medicine, 2011, v. 17, n. 12, p. 1674, doi. 10.1038/nm.2543

By:

Wang, Qian;
Rozelle, Andrew L;
Lepus, Christin M;
Scanzello, Carla R;
Song, Jason J;
Larsen, D Meegan;
Crish, James F;
Bebek, Gurkan;
Ritter, Susan Y;
Lindstrom, Tamsin M;
Hwang, Inyong;
Wong, Heidi H;
Punzi, Leonardo;
Encarnacion, Angelo;
Shamloo, Mehrdad;
Goodman, Stuart B;
Wyss-Coray, Tony;
Goldring, Steven R;
Banda, Nirmal K;
Thurman, Joshua M

Publication type:

Article

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma.

Published in:

Nature Medicine, 2003, v. 9, n. 8, p. 1062, doi. 10.1038/nm903

By:

Mattiasson, Gustav;
Shamloo, Mehrdad;
Gido, Gunilla;
Mathi, Kavitha;
Tomasevic, Gregor;
Saili Yi;
Warden, Craig H.;
Castilho, Roger F.;
Melcher, Thorsten;
Gonzalez-Zulueta, Mirella;
Nikolich, Karoly;
Wieloch, Tadeusz

Publication type:

Article

Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer's disease.

Published in:

Journal of Neuroinflammation, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12974-024-03306-1

By:

Evans, Andrew K.;
Park, Heui Hye;
Woods, Claire E.;
Lam, Rachel K.;
Rijsketic, Daniel Ryskamp;
Xu, Christine;
Chu, Emily K.;
Ciari, Peter;
Blumenfeld, Sarah;
Vidano, Laura M.;
Saw, Nay Lui;
Heifets, Boris D.;
Shamloo, Mehrdad

Publication type:

Article

Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders.

Published in:

PLoS ONE, 2017, v. 12, n. 7, p. 1, doi. 10.1371/journal.pone.0180319

By:

Yi, Bitna;
Jahangir, Alam;
Evans, Andrew K.;
Briggs, Denise;
Ravina, Kristine;
Ernest, Jacqueline;
Farimani, Amir B.;
Sun, Wenchao;
Rajadas, Jayakumar;
Green, Michael;
Feinberg, Evan N.;
Pande, Vijay S.;
Shamloo, Mehrdad

Publication type:

Article

Collagen VI Regulates Motor Circuit Plasticity and Motor Performance by Cannabinoid Modulation.

Published in:

Journal of Neuroscience, 2022, v. 42, n. 8, p. 1557, doi. 10.1523/JNEUROSCI.0962-21.2021

By:

Lam, Daniel D.;
Williams, Rhîannan H.;
Lujan, Ernesto;
Tanabe, Koji;
Huber, Georg;
Saw, Nay Lui;
Merl-Pham, Juliane;
Salminen, Aaro V.;
Lohse, David;
Spendiff, Sally;
Plastini, Melanie J.;
Zech, Michael;
Arie Geerlof, Hanns Lochmüller,7,9,10;
Hauck, Stefanie M.;
Shamloo, Mehrdad;
Wernig, Marius;
Winkelmann, Juliane

Publication type:

Article

β1-adrenergic receptor activation enhances memory in Alzheimer's disease model.

Published in:

Annals of Clinical & Translational Neurology, 2014, v. 1, n. 5, p. 348, doi. 10.1002/acn3.57

By:

Coutellier, Laurence;
Ardestani, Pooneh Memar;
Shamloo, Mehrdad

Publication type:

Article

Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem®-C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke.

Published in:

International Journal of Molecular Sciences, 2018, v. 19, n. 12, p. 3782, doi. 10.3390/ijms19123782

By:

Ravina, Kristine;
Briggs, Denise I.;
Kislal, Sezen;
Warraich, Zuha;
Nguyen, Tiffany;
Lam, Rachel K.;
Zarembinski, Thomas I.;
Shamloo, Mehrdad

Publication type:

Article

Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease.

Published in:

Discover Mental Health, 2023, v. 3, n. 1, p. 1, doi. 10.1007/s44192-023-00050-5

By:

Bowen, Ellen R.;
DiGiacomo, Phillip;
Fraser, Hannah P.;
Guttenplan, Kevin;
Smith, Benjamin A. H.;
Heberling, Marlene L.;
Vidano, Laura;
Shah, Nigam;
Shamloo, Mehrdad;
Wilson, Jennifer L.;
Grimes, Kevin V.

Publication type:

Article

Thy1-hAPPLond/Swe+ mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function.

Published in:

Brain & Behavior, 2012, v. 2, n. 2, p. 142, doi. 10.1002/brb3.41

By:

Faizi, Mehrdad;
Bader, Patrick L.;
Saw, Nay;
Nguyen, Thuy-Vi V.;
Beraki, Simret;
Wyss-Coray, Tony;
Longo, Frank M.;
Shamloo, Mehrdad

Publication type:

Article

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo.

Published in:

Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-32228-1

By:

Kornfeld, Opher S.;
Qvit, Nir;
Haileselassie, Bereketeab;
Shamloo, Mehrdad;
Bernardi, Paolo;
Mochly-Rosen, Daria

Publication type:

Article

Enantiomers of 4‐aminopentanoic acid act as false GABAergic neurotransmitters and impact mouse behavior.

Published in:

Journal of Neurochemistry, 2021, v. 158, n. 5, p. 1074, doi. 10.1111/jnc.15474

By:

Wawro, Adam M.;
Gajera, Chandresh R.;
Baker, Steven A.;
Leśniak, Robert K.;
Montine, Kathleen S.;
Fischer, Curt R.;
Saw, Nay L.;
Shamloo, Mehrdad;
Montine, Thomas J.

Publication type:

Article

Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease.

Published in:

Journal of Neurochemistry, 2017, v. 140, n. 4, p. 561, doi. 10.1111/jnc.13917

By:

Yi, Bitna;
Sahn, James J.;
Ardestani, Pooneh Memar;
Evans, Andrew K.;
Scott, Luisa L.;
Chan, Jessica Z.;
Iyer, Sangeetha;
Crisp, Ashley;
Zuniga, Gabriella;
Pierce, Jonathan T.;
Martin, Stephen F.;
Shamloo, Mehrdad

Publication type:

Article

A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.

Published in:

Human Molecular Genetics, 2016, v. 25, n. 22, p. 4920, doi. 10.1093/hmg/ddw316

By:

Simmons, Danielle A.;
Belichenko, Nadia P.;
Ford, Ellen C.;
Semaan, Sarah;
Monbureau, Marie;
Aiyaswamy, Sruti;
Holman, Cameron M.;
Condon, Christina;
Shamloo, Mehrdad;
Massa, Stephen M.;
Longo, Frank M.

Publication type:

Article

A Pharmacological Screening Approach for Discovery of Neuroprotective Compounds in Ischemic Stroke.

Published in:

PLoS ONE, 2013, v. 8, n. 7, p. 1, doi. 10.1371/journal.pone.0069233

By:

Beraki, Simret;
Litrus, Lily;
Soriano, Liza;
Monbureau, Marie;
To, Lillian K.;
Braithwaite, Steven P.;
Nikolich, Karoly;
Urfer, Roman;
Oksenberg, Donna;
Shamloo, Mehrdad

Publication type:

Article

Npas4: A Neuronal Transcription Factor with a Key Role in Social and Cognitive Functions Relevant to Developmental Disorders.

Published in:

PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0046604

By:

Coutellier, Laurence;
Beraki, Simret;
Ardestani, Pooneh Memar;
Nay Lui Saw;
Shamloo, Mehrdad;
Hashimoto, Kenji

Publication type:

Article

Deficits in Cognition and Synaptic Plasticity in a Mouse Model of Down Syndrome Ameliorated by GABAB Receptor Antagonists.

Published in:

Journal of Neuroscience, 2012, v. 32, n. 27, p. 9217, doi. 10.1523/JNEUROSCI.1673-12.2012

By:

Kleschevnikov, Alexander M.;
Belichenko, Pavel V.;
Faizi, Mehrdad;
Jacobs, Lucia F.;
Htun, Khin;
Shamloo, Mehrdad;
Mobley, William C.

Publication type:

Article

Brain‐Wide Cellular Resolution Regional Quantification of Microglia and Amyloid in 5xFAD mice.

Published in:

Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.066431

By:

Guanzon, Nathaniel;
Murry, Alexandria;
May, Emily;
Wells, Alicia;
Gallegos, Yessenia;
Redd, Chase;
Azevedo, Ricardo;
Shamloo, Mehrdad;
Gandho, Sunil;
Wheeler, Damian G.

Publication type:

Article

Transplanted Stem Cell-Secreted Vascular Endothelial Growth Factor Effects Poststroke Recovery, Inflammation, and Vascular Repair.

Published in:

Stem Cells, 2011, v. 29, n. 2, p. 274, doi. 10.1002/stem.584

By:

Horie, Nobutaka;
Pereira, Marta P.;
Niizuma, Kuniyasu;
Sun, Guohua;
Keren-Gill, Hadar;
Encarnacion, Angelo;
Shamloo, Mehrdad;
Hamilton, Scott A.;
Jiang, Kewen;
Huhn, Stephen;
Palmer, Theo D.;
Bliss, Tonya M.;
Steinberg, Gary K.

Publication type:

Article

The asparaginyl endopeptidase legumain after experimental stroke.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2010, v. 30, n. 10, p. 1756, doi. 10.1038/jcbfm.2010.39

By:

Ishizaki, Taku;
Erickson, Agnes;
Kuric, Enida;
Shamloo, Mehrdad;
Hara-Nishimura, Ikuko;
Inácio, Ana Rita Lourenço;
Wieloch, Tadeusz;
Ruscher, Karsten

Publication type:

Article

Mapping of catecholaminergic denervation, neurodegeneration, and inflammation in 6-OHDA-treated Parkinson's disease mice.

Published in:

NPJ Parkinson's Disease, 2025, v. 11, n. 1, p. 1, doi. 10.1038/s41531-025-00872-w

By:

Santoro, Matteo;
Lam, Rachel K.;
Blumenfeld, Sarah E.;
Tan, Weiqi;
Ciari, Peter;
Chu, Emily K.;
Saw, Nay L.;
Rijsketic, Daniel Ryskamp;
Lin, Jennifer S.;
Heifets, Boris D.;
Shamloo, Mehrdad

Publication type:

Article

Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue.

Published in:

Journal of Neurochemistry, 2006, v. 96, n. 1, p. 14, doi. 10.1111/j.1471-4159.2005.03508.x

By:

Rickhag, Mattias;
Wieloch, Tadeusz;
Gid, Gunilla;
Elmér, Eskil;
Krogh, Morten;
Murray, Joseph;
Lohr, Scott;
Bitter, Hans;
Chin, Daniel J.;
von Schack, David;
Shamloo, Mehrdad;
Nikolich, Karoly

Publication type:

Article

Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.

Published in:

2013

By:

Guo, Xing;
Disatnik, Marie-Helene;
Monbureau, Marie;
Shamloo, Mehrdad;
Mochly-Rosen, Daria;
Qi, Xin

Publication type:

journal article

Inhibition of mitochondrial fragmentation diminishes Huntington's disease--associated neurodegeneration.

Published in:

Journal of Clinical Investigation, 2013, v. 123, n. 12, p. 5371, doi. 10.1172/JCI70911

By:

Xing Guo;
Disatnik, Marie-Helene;
Monbureau, Marie;
Shamloo, Mehrdad;
Mochly-Rosen, Daria;
Xin Qi

Publication type:

Article

Works by Shamloo, Mehrdad

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.

Enantiomers of 2-methylglutamate and 2-methylglutamine selectively impact mouse brain metabolism and behavior.

Upregulating Human Cathelicidin Antimicrobial Peptide LL-37 Expression May Prevent Severe COVID-19 Inflammatory Responses and Reduce Microthrombosis.

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.

GluN2B Antagonism Affects Interneurons and Leads to Immediate and Persistent Changes in Synaptic Plasticity, Oscillations, and Behavior.

Expression and function of striatal enriched protein tyrosine phosphatase is profoundly altered in cerebral ischemia.

Npas4, a novel helix–loop–helix PAS domain protein, is regulated in response to cerebral ischemia.

A Death Receptor 6-Amyloid Precursor Protein Pathway Regulates Synapse Density in the Mature CNS But Does Not Contribute to Alzheimer's Disease-Related Pathophysiology in Murine Models.

A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington's Disease.

A Dramatic Increase of Clq Protein in the CNS during Normal Aging.

Persistent Phosphorylation of Synaptic Proteins Following Middle Cerebral Artery Occlusion.

Changes in Protein Tyrosine Phosphorylation in the Rat Brain After Cerebral Ischemia in a Model of Ischemic Tolerance.

Selective Vulnerability of the Locus Coeruleus Noradrenergic System and its Role in Modulation of Neuroinflammation, Cognition, and Neurodegeneration.

The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.

Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.

Identification of a central role for complement in osteoarthritis.

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma.

Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer's disease.

Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders.

Collagen VI Regulates Motor Circuit Plasticity and Motor Performance by Cannabinoid Modulation.

β1-adrenergic receptor activation enhances memory in Alzheimer's disease model.

Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem®-C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke.

Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease.

Thy1-hAPP<sup>Lond/Swe+</sup> mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function.

Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo.

Enantiomers of 4‐aminopentanoic acid act as false GABAergic neurotransmitters and impact mouse behavior.

Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease.

A small molecule p75<sup>NTR</sup> ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.

A Pharmacological Screening Approach for Discovery of Neuroprotective Compounds in Ischemic Stroke.

Npas4: A Neuronal Transcription Factor with a Key Role in Social and Cognitive Functions Relevant to Developmental Disorders.

Deficits in Cognition and Synaptic Plasticity in a Mouse Model of Down Syndrome Ameliorated by GABA<sup>B</sup> Receptor Antagonists.

Brain‐Wide Cellular Resolution Regional Quantification of Microglia and Amyloid in 5xFAD mice.

Transplanted Stem Cell-Secreted Vascular Endothelial Growth Factor Effects Poststroke Recovery, Inflammation, and Vascular Repair.

The asparaginyl endopeptidase legumain after experimental stroke.

Mapping of catecholaminergic denervation, neurodegeneration, and inflammation in 6-OHDA-treated Parkinson's disease mice.

Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue.

Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.

Inhibition of mitochondrial fragmentation diminishes Huntington's disease--associated neurodegeneration.