Works by Sgarioto, Nicolas

Results: 17

The Lipid Metabolism as Target and Modulator of BOLD‐100 Anticancer Activity: Crosstalk with Histone Acetylation.

Published in:

Advanced Science, 2023, v. 10, n. 32, p. 1, doi. 10.1002/advs.202301939

By:

Baier, Dina;
Mendrina, Theresa;
Schoenhacker‐Alte, Beatrix;
Pirker, Christine;
Mohr, Thomas;
Rusz, Mate;
Regner, Benedict;
Schaier, Martin;
Sgarioto, Nicolas;
Raynal, Noël J.‐M.;
Nowikovsky, Karin;
Schmidt, Wolfgang M.;
Heffeter, Petra;
Meier‐Menches, Samuel M.;
Koellensperger, Gunda;
Keppler, Bernhard K.;
Berger, Walter

Publication type:

Article

Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-43219-2

By:

Beaudry, Annie;
Jacques-Ricard, Simon;
Darracq, Anaïs;
Sgarioto, Nicolas;
Garcia, Araceli;
García, Teresita Rode;
Lemieux, William;
Béland, Kathie;
Haddad, Elie;
Cordeiro, Paulo;
Duval, Michel;
McGraw, Serge;
Richer, Chantal;
Caron, Maxime;
Marois, François;
St-Onge, Pascal;
Sinnett, Daniel;
Banquy, Xavier;
Raynal, Noël J.-M.

Publication type:

Article

Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion.

Published in:

Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-43219-2

By:

Beaudry, Annie;
Jacques-Ricard, Simon;
Darracq, Anaïs;
Sgarioto, Nicolas;
Garcia, Araceli;
García, Teresita Rode;
Lemieux, William;
Béland, Kathie;
Haddad, Elie;
Cordeiro, Paulo;
Duval, Michel;
McGraw, Serge;
Richer, Chantal;
Caron, Maxime;
Marois, François;
St-Onge, Pascal;
Sinnett, Daniel;
Banquy, Xavier;
Raynal, Noël J.-M.

Publication type:

Article

SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome.

Published in:

EMBO Molecular Medicine, 2016, v. 8, n. 9, p. 1019, doi. 10.15252/emmm.201506159

By:

Janer, Alexandre;
Prudent, Julien;
Paupe, Vincent;
Fahiminiya, Somayyeh;
Majewski, Jacek;
Sgarioto, Nicolas;
Des Rosiers, Christine;
Forest, Anik;
Lin, Zhen‐Yuan;
Gingras, Anne‐Claude;
Mitchell, Grant;
McBride, Heidi M;
Shoubridge, Eric A

Publication type:

Article

Synergistic effects of type I PRMT and PARP inhibitors against non-small cell lung cancer cells.

Published in:

Clinical Epigenetics, 2021, v. 13, n. 1, p. 1, doi. 10.1186/s13148-021-01037-1

By:

Dominici, Claudia;
Sgarioto, Nicolas;
Yu, Zhenbao;
Sesma-Sanz, Laura;
Masson, Jean-Yves;
Richard, Stéphane;
Raynal, Noël J.-M.

Publication type:

Article

Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle.

Published in:

Scientific Reports, 2015, p. 8717, doi. 10.1038/srep08717

By:

Gouspillou, Gilles;
Scheede-Bergdahl, Celena;
Spendiff, Sally;
Vuda, Madhusudanarao;
Meehan, Brian;
Mlynarski, Heather;
Archer-Lahlou, Elodie;
Sgarioto, Nicolas;
Purves-Smith, Fennigje M.;
Konokhova, Yana;
Rak, Janusz;
Chevalier, Stéphanie;
Taivassalo, Tanja;
Hepple, Russell T.;
Jagoe, R. Thomas

Publication type:

Article

The leukodystrophy mutation Polr3b R103H causes homozygote mouse embryonic lethality and impairs RNA polymerase III biogenesis.

Published in:

Molecular Brain, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13041-019-0479-7

By:

Choquet, Karine;
Pinard, Maxime;
Yang, Sharon;
Moir, Robyn D.;
Poitras, Christian;
Dicaire, Marie-Josée;
Sgarioto, Nicolas;
Larivière, Roxanne;
Kleinman, Claudia L.;
Willis, Ian M.;
Gauthier, Marie-Soleil;
Coulombe, Benoit;
Brais, Bernard

Publication type:

Article

Sacs R272C missense homozygous mice develop an ataxia phenotype.

Published in:

Molecular Brain, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13041-019-0438-3

By:

Larivière, Roxanne;
Sgarioto, Nicolas;
Márquez, Brenda Toscano;
Gaudet, Rébecca;
Choquet, Karine;
McKinney, R. Anne;
Watt, Alanna J.;
Brais, Bernard

Publication type:

Article

Structural insight into the cGAS active site explains differences between therapeutically relevant species.

Published in:

Communications Chemistry, 2025, v. 8, n. 1, p. 1, doi. 10.1038/s42004-025-01481-7

By:

Skeldon, Alexander M.;
Wang, Li;
Sgarioto, Nicolas;
Beveridge, Ramsay E.;
Chan, Silas;
Dorich, Stephane;
Dumais, Valerie;
Fradet, Nadine;
Gaudreault, Samuel;
LeGros, Philippe;
McKay, Daniel;
Seliniotakis, Ria;
Sietsema, Daniel V.;
Zhang, Lingling;
Boily, Marc-Olivier;
Burch, Jason D.;
Caron, Alex;
Fader, Lee D.;
Lama, Lodoe;
Xie, Wei

Publication type:

Article

Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin.

Published in:

Human Molecular Genetics, 2017, v. 26, n. 16, p. 3130, doi. 10.1093/hmg/ddx197

By:

Duncan, Emma J.;
Larivière, Roxanne;
Bradshaw, Teisha Y.;
Longo, Fabiana;
Sgarioto, Nicolas;
Hayes, Matthew J.;
Romano, Lisa E. L.;
Nethisinghe, Suran;
Giunti, Paola;
Bruntraeger, Michaela B.;
Durham, Heather D.;
Brais, Bernard;
Maltecca, Francesca;
Gentil, Benoit J.;
Chapple, J. Paul

Publication type:

Article

The Relationship between Muscle Fiber Type-Specific PGC-1α Content and Mitochondrial Content Varies between Rodent Models and Humans.

Published in:

PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0103044

By:

Gouspillou, Gilles;
Sgarioto, Nicolas;
Norris, Brandon;
Barbat-Artigas, Sébastien;
Aubertin-Leheudre, Mylène;
Morais, Jose A.;
Burelle, Yan;
Taivassalo, Tanja;
Hepple, Russell T.

Publication type:

Article

Protective role of Parkin in skeletal muscle contractile and mitochondrial function.

Published in:

Journal of Physiology, 2018, v. 596, n. 13, p. 2565, doi. 10.1113/JP275604

By:

Gouspillou, Gilles;
Godin, Richard;
Piquereau, Jérome;
Picard, Martin;
Mofarrahi, Mahroo;
Mathew, Jasmin;
Purves‐Smith, Fennigje M.;
Sgarioto, Nicolas;
Hepple, Russell T.;
Burelle, Yan;
Hussain, Sabah N. A.

Publication type:

Article

The impact of ageing, physical activity, and pre-frailty on skeletal muscle phenotype, mitochondrial content, and intramyocellular lipids in men.

Published in:

Journal of Cachexia, Sarcopenia & Muscle, 2017, v. 8, n. 2, p. 213, doi. 10.1002/jcsm.12139

By:

St ‐ Jean ‐ Pelletier, Félix;
Pion, Charlotte H;
Leduc ‐ Gaudet, Jean ‐ Philippe;
Sgarioto, Nicolas;
Zovilé, Igor;
Barbat ‐ Artigas, Sébastien;
Reynaud, Olivier;
Alkaterji, Feras;
Lemieux, François C;
Grenon, Alexis;
Gaudreau, Pierrette;
Hepple, Russell T;
Chevalier, Stéphanie;
Belanger, Marc;
Morais, José A;
Aubertin ‐ Leheudre, Mylène;
Gouspillou, Gilles

Publication type:

Article

NPTX1 mutations trigger endoplasmic reticulum stress and cause autosomal dominant cerebellar ataxia.

Published in:

2022

By:

Coutelier, Marie;
Jacoupy, Maxime;
Janer, Alexandre;
Renaud, Flore;
Auger, Nicolas;
Saripella, Ganapathi-Varma;
Ancien, François;
Pucci, Fabrizio;
Rooman, Marianne;
Gilis, Dimitri;
Larivière, Roxanne;
Sgarioto, Nicolas;
Valter, Rémi;
Guillot-Noel, Léna;
Ber, Isabelle Le;
Sayah, Sabrina;
Charles, Perrine;
Nümann, Astrid;
Pauly, Martje G;
Helmchen, Christoph

Publication type:

journal article

Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation.

Published in:

Molecular Brain, 2017, v. 10, p. 1, doi. 10.1186/s13041-017-0294-y

By:

Choquet, Karine;
Sharon Yang;
Moir, Robyn D.;
Forget, Diane;
Larivière, Roxanne;
Bouchard, Annie;
Poitras, Christian;
Sgarioto, Nicolas;
Dicaire, Marie-Josée;
Noohi, Forough;
Kennedy, Timothy E.;
Rochford, Joseph;
Bernard, Geneviève;
Teichmann, Martin;
Coulombe, Benoit;
Willis, Ian M.;
Kleinman, Claudia L.;
Brais, Bernard

Publication type:

Article

Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans.

Published in:

FASEB Journal, 2014, v. 28, n. 4, p. 1621, doi. 10.1096/fj.13-242750

By:

Gouspillou, Gilles;
Sgarioto, Nicolas;
Kapchinsky, Sophia;
Purves-Smith, Fennigje;
Norris, Brandon;
Pion, Charlotte H.;
Barbat-Artigas, Sébastien;
Lemieux, Francois;
Taivassalo, Tanja;
Morais, José A.;
Aubertin-Leheudre, Mylène;
Hepple, Russell T.

Publication type:

Article

Fiber type specific PGC‐1α content and its relation to capillarization and mitochondrial content.

Published in:

FASEB Journal, 2013, v. 27, p. 1152.23, doi. 10.1096/fasebj.27.1_supplement.1152.23

By:

Gouspillou, Gilles;
Sgarioto, Nicolas;
Norris, Brandon;
Hepple, Russell Thomas

Publication type:

Article