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Muscarinic acetylcholine receptors: novel opportunities for drug development.
- Published in:
- Nature Reviews Drug Discovery, 2014, v. 13, n. 7, p. 549, doi. 10.1038/nrd4295
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- Article
Emerging paradigms in GPCR allostery: implications for drug discovery.
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- Nature Reviews Drug Discovery, 2013, v. 12, n. 8, p. 630, doi. 10.1038/nrd4052
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- Publication type:
- Article
In vitro autoradiographic localization of calcitonin binding sites in human medulla oblongata.
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- Journal of Comparative Neurology, 1994, v. 341, n. 4, p. 449, doi. 10.1002/cne.903410403
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- Publication type:
- Article
Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 15, p. 8069, doi. 10.3390/ijms23158069
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- Publication type:
- Article
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation.
- Published in:
- Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-021-27760-0
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- Publication type:
- Article
Routine sub-2.5 Å cryo-EM structure determination of GPCRs.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-24650-3
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- Publication type:
- Article
Development of Novel 4‐Arylpyridin‐2‐one and 6‐Arylpyrimidin‐4‐one Positive Allosteric Modulators of the M<sub>1</sub> Muscarinic Acetylcholine Receptor.
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- ChemMedChem, 2021, v. 16, n. 1, p. 216, doi. 10.1002/cmdc.202000540
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- Publication type:
- Article
Addition of a Carboxy-Terminal Green Fluorescent Protein Does Not Alter the Binding and Signaling Properties of Relaxin Family Peptide Receptor 3.
- Published in:
- Annals of the New York Academy of Sciences, 2009, v. 1160, p. 105, doi. 10.1111/j.1749-6632.2008.03818.x
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- Article
Monotreme glucagon-like peptide-1 in venom and gut: one gene - two very different functions.
- Published in:
- Scientific Reports, 2016, p. 37744, doi. 10.1038/srep37744
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- Publication type:
- Article
Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure.
- Published in:
- Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.628060
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- Article
Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias.
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- Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.606656
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- Publication type:
- Article
G-PROTEIN-COUPLED RECEPTOR-PROTEIN INTERACTIONS: BASIS FOR NEW CONCEPTS ON RECEPTOR STRUCTURE AND FUNCTION.
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- Clinical & Experimental Pharmacology & Physiology, 2005, v. 32, n. 11, p. 979, doi. 10.1111/j.1440-1681.2005.04295.x
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- Article
Xanomeline displays concomitant orthosteric and allosteric binding modes at the M<sub>4</sub> mAChR.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41199-5
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- Article
Prolonged Calcitonin Receptor Signaling by Salmon, but Not Human Calcitonin, Reveals Ligand Bias.
- Published in:
- PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0092042
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- Article
A Nuclear Transport Inhibitor That Modulates the Unfolded Protein Response and Provides In Vivo Protection Against Lethal Dengue virus Infection.
- Published in:
- Journal of Infectious Diseases, 2014, v. 210, n. 11, p. 1780, doi. 10.1093/infdis/jiu319
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- Article
Complexing Receptor Pharmacology.
- Published in:
- Annals of the New York Academy of Sciences, 2006, v. 1070, n. 1, p. 90, doi. 10.1196/annals.1317.076
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- Publication type:
- Article
Responses of GPCR135 to Human Gene 3 (H3) Relaxin in CHO-K1 Cells Determined by Microphysiometry.
- Published in:
- Annals of the New York Academy of Sciences, 2005, v. 1041, n. 1, p. 332, doi. 10.1196/annals.1282.053
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- Publication type:
- Article
Cognitive behavioral markers of neurodevelopmental trajectories in rodents.
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- Translational Psychiatry, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41398-021-01662-7
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- Article
Photoaffinity scanning in the mapping of the peptide receptor interface of class II G protein-coupled receptors.
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- Journal of Peptide Science, 2004, v. 10, n. 4, p. 179, doi. 10.1002/psc.541
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- Article
Cryptic pocket formation underlies allosteric modulator selectivity at muscarinic GPCRs.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11062-7
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- Publication type:
- Article
Localization and characterization of renal calcitonin receptors by in vitro autoradiography.
- Published in:
- Kidney International, 1987, v. 32, n. 6, p. 862, doi. 10.1038/ki.1987.287
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- Publication type:
- Article
Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.
- Published in:
- PLoS Biology, 2024, v. 22, n. 7, p. 1, doi. 10.1371/journal.pbio.3002673
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- Article
Molecular Mechanisms of Action and In Vivo Validation of an M<sub>4</sub> Muscarinic Acetylcholine Receptor Allosteric Modulator with Potential Antipsychotic Properties.
- Published in:
- Neuropsychopharmacology, 2010, v. 35, n. 4, p. 855, doi. 10.1038/npp.2009.194
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- Publication type:
- Article
Discovery of a Positive Allosteric Modulator of Cholecystokinin Action at CCK1R in Normal and Elevated Cholesterol.
- Published in:
- Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.789957
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- Publication type:
- Article
Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics.
- Published in:
- Frontiers in Endocrinology, 2021, v. 12, p. 1, doi. 10.3389/fendo.2021.684656
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- Publication type:
- Article
Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping.
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- FASEB Journal, 2012, v. 26, n. 12, p. 5092, doi. 10.1096/fj.12-212399
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- Article
M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss.
- Published in:
- 2017
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- Publication type:
- journal article
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
- Published in:
- PLoS Biology, 2021, v. 19, n. 6, p. 1, doi. 10.1371/journal.pbio.3001295
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- Publication type:
- Article
Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice.
- Published in:
- Nature Communications, 2017, v. 8, n. 2, p. 14232, doi. 10.1038/ncomms14232
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- Article
The role of kinetic context in apparent biased agonism at GPCRs.
- Published in:
- Nature Communications, 2016, v. 7, n. 2, p. 10842, doi. 10.1038/ncomms10842
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- Article
Investigating the structural determinants underlying allosteric agonism at M2 muscarinic acetylcholine receptors.
- Published in:
- FASEB Journal, 2007, v. 21, n. 6, p. A789
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- Publication type:
- Article
Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas.
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- 2019
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- Publication type:
- journal article
Opportunities and challenges for the development of M<sub>1</sub> muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.
- Published in:
- British Journal of Pharmacology, 2024, v. 181, n. 14, p. 2114, doi. 10.1111/bph.15982
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- Publication type:
- Article
Divergent effects of strontium and calcium‐sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity.
- Published in:
- British Journal of Pharmacology, 2018, v. 175, n. 21, p. 4095, doi. 10.1111/bph.14344
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- Publication type:
- Article
Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity.
- Published in:
- 2018
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- Publication type:
- journal article
M<sub>1</sub> muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease.
- Published in:
- Science Signaling, 2022, v. 15, n. 760, p. 1, doi. 10.1126/scisignal.abm3720
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- Article
Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants.
- Published in:
- PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0146846
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- Article
The complexity of signalling mediated by the glucagon-like peptide-1 receptor.
- Published in:
- Biochemical Society Transactions, 2016, v. 44, n. 2, p. 582, doi. 10.1042/BST20150244
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- Publication type:
- Article
Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.
- Published in:
- Biochemical Society Transactions, 2013, v. 41, n. 1, p. 172, doi. 10.1042/BST20120236
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- Publication type:
- Article
Lipopolysaccharide supports survival and fusion of preosteoclasts independent of TNF-α, IL-1, and RANKL.
- Published in:
- Journal of Cellular Physiology, 2002, v. 190, n. 1, p. 101, doi. 10.1002/jcp.10041
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- Article
Activation and allosteric modulation of a muscarinic acetylcholine receptor.
- Published in:
- Nature, 2013, v. 504, n. 7478, p. 101, doi. 10.1038/nature12735
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- Publication type:
- Article
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.
- Published in:
- Nature, 2013, v. 503, n. 7475, p. 295, doi. 10.1038/nature12595
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- Publication type:
- Article
Structural biology: Meet the B family.
- Published in:
- Nature, 2013, v. 499, n. 7459, p. 417, doi. 10.1038/nature12413
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- Article
Consequences of splice variation on Secretin family G protein-coupled receptor function.
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- 2012
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- Publication type:
- journal article
Consequences of splice variation on Secretin family G protein-coupled receptor function.
- Published in:
- British Journal of Pharmacology, 2012, v. 166, n. 1, p. 98, doi. 10.1111/j.1476-5381.2011.01571.x
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- Publication type:
- Article
Effects of urea pretreatment on the binding properties of adenosine A1 receptors.
- Published in:
- 2005
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- Publication type:
- journal article
Correspondence: Reply to 'Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury'.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-017-02656-0
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- Publication type:
- Article
New Insights into the Structure and Function of Class B1 GPCRs.
- Published in:
- Endocrine Reviews, 2023, v. 44, n. 3, p. 492, doi. 10.1210/endrev/bnac033
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- Article
Impact of secretin receptor homo-dimerization on natural ligand binding.
- Published in:
- Nature Communications, 2024, v. 15, n. 1, p. 1, doi. 10.1038/s41467-024-48853-6
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- Publication type:
- Article
Characterization of serotonin 5-HT<sub>2C</sub> receptor signaling to extracellular signal-regulated kinases 1 and 2.
- Published in:
- Journal of Neurochemistry, 2005, v. 93, n. 6, p. 1603, doi. 10.1111/j.1471-4159.2005.03161.x
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- Publication type:
- Article