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Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.
Published in:
Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-35135-2
By:
- Kneppers, Jeroen;
- Severson, Tesa M.;
- Siefert, Joseph C.;
- Schol, Pieter;
- Joosten, Stacey E. P.;
- Yu, Ivan Pak Lok;
- Huang, Chia-Chi Flora;
- Morova, Tunç;
- Altıntaş, Umut Berkay;
- Giambartolomei, Claudia;
- Seo, Ji-Heui;
- Baca, Sylvan C.;
- Carneiro, Isa;
- Emberly, Eldon;
- Pasaniuc, Bogdan;
- Jerónimo, Carmen;
- Henrique, Rui;
- Freedman, Matthew L.;
- Wessels, Lodewyk F. A.;
- Lack, Nathan A.
Publication type:
Article
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26612-1
By:
- Che, Meixia;
- Chaturvedi, Aashi;
- Munro, Sarah A.;
- Pitzen, Samuel P.;
- Ling, Alex;
- Zhang, Weijie;
- Mentzer, Josh;
- Ku, Sheng-Yu;
- Puca, Loredana;
- Zhu, Yanyun;
- Bergman, Andries M.;
- Severson, Tesa M.;
- Forster, Colleen;
- Liu, Yuzhen;
- Hildebrand, Jacob;
- Daniel, Mark;
- Wang, Ting-You;
- Selth, Luke A.;
- Hickey, Theresa;
- Zoubeidi, Amina
Publication type:
Article
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.
Published in:
Nature Genetics, 2010, v. 42, n. 2, p. 181, doi. 10.1038/ng.518
By:
- Morin, Ryan D.;
- Johnson, Nathalie A.;
- Severson, Tesa M.;
- Mungall, Andrew J.;
- Jianghong An;
- Goya, Rodrigo;
- Paul, Jessica E.;
- Boyle, Merrill;
- Woolcock, Bruce W.;
- Kuchenbauer, Florian;
- Yap, Damian;
- Humphries, R. Keith;
- Griffith, Obi L.;
- Shah, Sohrab;
- Zhu, Henry;
- Kimbara, Michelle;
- Shashkin, Pavel;
- Charlot, Jean F.;
- Tcherpakov, Marianna;
- Corbett, Richard
Publication type:
Article
Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.
Published in:
Scientific Reports, 2016, p. 18517, doi. 10.1038/srep18517
By:
- Michaut, Magali;
- Chin, Suet-Feung;
- Majewski, Ian;
- Severson, Tesa M.;
- Bismeijer, Tycho;
- de Koning, Leanne;
- Peeters, Justine K.;
- Schouten, Philip C.;
- Rueda, Oscar M.;
- Bosma, Astrid J.;
- Tarrant, Finbarr;
- Fan, Yue;
- He, Beilei;
- Xue, Zheng;
- Mittempergher, Lorenza;
- Kluin, Roelof J.C.;
- Heijmans, Jeroen;
- Snel, Mireille;
- Pereira, Bernard;
- Schlicker, Andreas
Publication type:
Article
DNA repair deficiency biomarkers and the 70-gene ultra-high risk signature as predictors of veliparib/carboplatin response in the I-SPY 2 breast cancer trial.
Published in:
NPJ Breast Cancer, 2017, v. 3, n. 1, p. N.PAG, doi. 10.1038/s41523-017-0025-7
By:
- Wolf, Denise M.;
- Yau, Christina;
- Sanil, Ashish;
- Glas, Annuska;
- Petricoin, Emanuel;
- Wulfkuhle, Julia;
- Severson, Tesa M.;
- Linn, Sabine;
- Brown-Swigart, Lamorna;
- Hirst, Gillian;
- Buxton, Meredith;
- DeMichele, Angela;
- Hylton, Nola;
- Symmans, Fraser;
- Yee, Doug;
- Paoloni, Melissa;
- Esserman, Laura;
- Berry, Don;
- Rugo, Hope;
- Olopade, Olufunmilayo
Publication type:
Article
CD4<sup>+</sup> T cell help creates memory CD8<sup>+</sup> T cells with innate and help-independent recall capacities.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-13438-1
By:
- Ahrends, Tomasz;
- Busselaar, Julia;
- Severson, Tesa M.;
- Bąbała, Nikolina;
- de Vries, Evert;
- Bovens, Astrid;
- Wessels, Lodewyk;
- van Leeuwen, Fred;
- Borst, Jannie
Publication type:
Article
The BRCA1ness signature is associated significantly with response to PARP inhibitor treatment versus control in the I-SPY 2 randomized neoadjuvant setting.
Published in:
2017
By:
- Severson, Tesa M.;
- Wolf, Denise M.;
- Yau, Christina;
- Peeters, Justine;
- Wehkam, Diederik;
- Schouten, Philip C.;
- Chin, Suet-Feung;
- Majewski, Ian J.;
- Michaut, Magali;
- Bosma, Astrid;
- Pereira, Bernard;
- Bismeijer, Tycho;
- Wessels, Lodewyk;
- Caldas, Carlos;
- Bernards, René;
- Simon, Iris M.;
- Glas, Annuska M.;
- Linn, Sabine;
- van't Veer, Laura
Publication type:
journal article
Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases.
Published in:
Molecular Oncology, 2021, v. 15, n. 7, p. 1942, doi. 10.1002/1878-0261.12923
By:
- Severson, Tesa M.;
- Zhu, Yanyun;
- De Marzo, Angelo M.;
- Jones, Tracy;
- Simons, Jonathan W.;
- Nelson, William G.;
- Yegnasubramanian, Srinivasan;
- Freedman, Matthew L.;
- Wessels, Lodewyk;
- Bergman, Andries M.;
- Haffner, Michael C.;
- Zwart, Wilbert
Publication type:
Article
The MSP‐RON axis stimulates cancer cell growth in models of triple negative breast cancer.
Published in:
Molecular Oncology, 2020, v. 14, n. 8, p. 1868, doi. 10.1002/1878-0261.12734
By:
- Millar, Rhona;
- Kilbey, Anna;
- Remak, Sarah‐Jane;
- Severson, Tesa M.;
- Dhayade, Sandeep;
- Sandilands, Emma;
- Foster, Kyla;
- Bryant, David M.;
- Blyth, Karen;
- Coffelt, Seth B.
Publication type:
Article
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma.
Published in:
Nature, 2011, v. 476, n. 7360, p. 298, doi. 10.1038/nature10351
By:
- Morin, Ryan D.;
- Mendez-Lago, Maria;
- Mungall, Andrew J.;
- Goya, Rodrigo;
- Mungall, Karen L.;
- Corbett, Richard D.;
- Johnson, Nathalie A.;
- Severson, Tesa M.;
- Chiu, Readman;
- Field, Matthew;
- Jackman, Shaun;
- Krzywinski, Martin;
- Scott, David W.;
- Trinh, Diane L.;
- Tamura-Wells, Jessica;
- Li, Sa;
- Firme, Marlo R.;
- Rogic, Sanja;
- Griffith, Malachi;
- Chan, Susanna
Publication type:
Article
PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2 and insulin-like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients.
Published in:
Breast Cancer Research, 2014, v. 16, n. 1, p. 1, doi. 10.1186/bcr3606
By:
- Beelen, Karin;
- Opdam, Mark;
- Severson, Tesa M.;
- Koornstra, Rutger H. T.;
- Vincent, Andrew D.;
- Wesseling, Jelle;
- Muris, Jettie J.;
- Berns, Els M. J. J.;
- Vermorken, Jan B.;
- van Diest, Paul J.;
- Linn, Sabine C.
Publication type:
Article
Phosphorylated p-70S6K predicts tamoxifen resistance in postmenopausal breast cancer patients randomized between adjuvant tamoxifen versus no systemic treatment.
Published in:
Breast Cancer Research, 2014, v. 16, n. 1, p. 1, doi. 10.1186/bcr3598
By:
- Beelen, Karin;
- Opdam, Mark;
- Severson, Tesa M.;
- Koornstra, Rutger H. T.;
- Vincent, Andrew D.;
- Wesseling, Jelle;
- Muris, Jettie J.;
- Berns, Els M. J. J.;
- Vermorken, Jan B.;
- van Diest, Paul J.;
- Linn, Sabine C.
Publication type:
Article
PIK3CA mutations, phosphatase and tensin homolog, human epidermal growth factor receptor 2, and insulin-like growth factor 1 receptor and adjuvant tamoxifen resistance in postmenopausal breast cancer patients.
Published in:
2014
By:
- Beelen, Karin;
- Opdam, Mark;
- Severson, Tesa M;
- Koornstra, Rutger Ht;
- Vincent, Andrew D;
- Wesseling, Jelle;
- Muris, Jettie J;
- Berns, Els Mjj;
- Vermorken, Jan B;
- van Diest, Paul J;
- Linn, Sabine C;
- Koornstra, Rutger H T;
- Berns, Els M J J
Publication type:
journal article
Phosphorylated p-70S6K predicts tamoxifen resistance in postmenopausal breast cancer patients randomized between adjuvant tamoxifen versus no systemic treatment.
Published in:
2014
By:
- Beelen, Karin;
- Opdam, Mark;
- Severson, Tesa M;
- Koornstra, Rutger Ht;
- Vincent, Andrew D;
- Wesseling, Jelle;
- Muris, Jettie J;
- Berns, Els Mjj;
- Vermorken, Jan B;
- van Diest, Paul J;
- Linn, Sabine C;
- Koornstra, Rutger H T;
- Berns, Els M J J
Publication type:
journal article
PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription.
Published in:
Nucleic Acids Research, 2023, v. 51, n. 18, p. 9576, doi. 10.1093/nar/gkad267
By:
- Mayayo-Peralta, Isabel;
- Gregoricchio, Sebastian;
- Schuurman, Karianne;
- Yavuz, Selçuk;
- Zaalberg, Anniek;
- Kojic, Aleksandar;
- Abbott, Nina;
- Geverts, Bart;
- Beerthuijzen, Suzanne;
- Siefert, Joseph;
- Severson, Tesa M;
- van Baalen, Martijn;
- Hoekman, Liesbeth;
- Lieftink, Cor;
- Altelaar, Maarten;
- Beijersbergen, Roderick L;
- Houtsmuller, Adriaan B;
- Prekovic, Stefan;
- Zwart, Wilbert
Publication type:
Article
Double-strand break toxicity is chromatin context independent.
Published in:
Nucleic Acids Research, 2022, v. 50, n. 17, p. 9930, doi. 10.1093/nar/gkac758
By:
- Friskes, Anoek;
- Koob, Lisa;
- Krenning, Lenno;
- Severson, Tesa M;
- Koeleman, Emma S;
- Vergara, Xabier;
- Schubert, Michael;
- van den Berg, Jeroen;
- Evers, Bastiaan;
- Manjón, Anna G;
- Joosten, Stacey;
- Kim, Yongsoo;
- Zwart, Wilbert;
- Medema, René H
Publication type:
Article
Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-02856-2
By:
- Severson, Tesa M.;
- Yongsoo Kim;
- Joosten, Stacey E. P.;
- Schuurman, Karianne;
- der Groep, Petra van;
- Moelans, Cathy B.;
- ter Hoeve, Natalie D.;
- Manson, Quirine F.;
- Martens, John W.;
- van Deurzen, Carolien H. M.;
- Barbe, Ellis;
- Hedenfalk, Ingrid;
- Bult, Peter;
- Smit, Vincent T. H. B. M.;
- Linn, Sabine C.;
- van Diest, Paul J.;
- Wessels, Lodewyk;
- Zwart, Wilbert
Publication type:
Article
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-020-20513-5
By:
- Shafi, Ayesha A.;
- McNair, Chris M.;
- McCann, Jennifer J.;
- Alshalalfa, Mohammed;
- Shostak, Anton;
- Severson, Tesa M.;
- Zhu, Yanyun;
- Bergman, Andre;
- Gordon, Nicolas;
- Mandigo, Amy C.;
- Chand, Saswati N.;
- Gallagher, Peter;
- Dylgjeri, Emanuela;
- Laufer, Talya S.;
- Vasilevskaya, Irina A.;
- Schiewer, Matthew J.;
- Brunner, Michael;
- Feng, Felix Y.;
- Zwart, Wilbert;
- Knudsen, Karen E.
Publication type:
Article
Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-14318-9
By:
- Zhou, Stanley;
- Hawley, James R.;
- Soares, Fraser;
- Grillo, Giacomo;
- Teng, Mona;
- Madani Tonekaboni, Seyed Ali;
- Hua, Junjie Tony;
- Kron, Ken J.;
- Mazrooei, Parisa;
- Ahmed, Musaddeque;
- Arlidge, Christopher;
- Yun, Hwa Young;
- Livingstone, Julie;
- Huang, Vincent;
- Yamaguchi, Takafumi N.;
- Espiritu, Shadrielle M. G.;
- Zhu, Yanyun;
- Severson, Tesa M.;
- Murison, Alex;
- Cameron, Sarina
Publication type:
Article
BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential.
Published in:
Molecular Oncology, 2015, v. 9, n. 8, p. 1528, doi. 10.1016/j.molonc.2015.04.011
By:
- Severson, Tesa M.;
- Peeters, Justine;
- Majewski, Ian;
- Michaut, Magali;
- Bosma, Astrid;
- Schouten, Philip C.;
- Chin, Suet-Feung;
- Pereira, Bernard;
- Goldgraben, Mae A.;
- Bismeijer, Tycho;
- Kluin, Roelof J.C.;
- Muris, Jettie J.F.;
- Jirström, Karin;
- Kerkhoven, Ron M.;
- Wessels, Lodewyk;
- Caldas, Carlos;
- Bernards, René;
- Simon, Iris M.;
- Linn, Sabine
Publication type:
Article
Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms.
Published in:
Molecular Oncology, 2015, v. 9, n. 7, p. 1274, doi. 10.1016/j.molonc.2015.03.002
By:
- Schouten, Philip C.;
- Grigoriadis, Anita;
- Kuilman, Thomas;
- Mirza, Hasan;
- Watkins, Johnathan A.;
- Cooke, Saskia A.;
- van Dyk, Ewald;
- Severson, Tesa M.;
- Rueda, Oscar M.;
- Hoogstraat, Marlous;
- Verhagen, Caroline V.M.;
- Natrajan, Rachael;
- Chin, Suet-Feung;
- Lips, Esther H.;
- Kruizinga, Janneke;
- Velds, Arno;
- Nieuwland, Marja;
- Kerkhoven, Ron M.;
- Krijgsman, Oscar;
- Vens, Conchita
Publication type:
Article

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