Works by Semple, Bridgette D.

Results: 42

A Pro-social Pill? The Potential of Pharmacological Treatments to Improve Social Outcomes After Pediatric Traumatic Brain Injury.

Published in:

Frontiers in Neurology, 2021, v. 12, p. 1, doi. 10.3389/fneur.2021.714253

By:

Semple, Bridgette D.;
Raghupathi, Ramesh

Publication type:

Article

Interleukin-1 Receptor in Seizure Susceptibility after Traumatic Injury to the Pediatric Brain.

Published in:

Journal of Neuroscience, 2017, v. 37, n. 33, p. 7864, doi. 10.1523/JNEUROSCI.0982-17.2017

By:

Semple, Bridgette D.;
O'Brien, Terence;
Gimlin, Kayleen;
Wright, David K.;
Shi Eun Kim;
Casillas-Espinosa, Pablo M.;
Webster, Kyria M.;
Petrou, Steven;
Noble-Haeusslein, Linda J.

Publication type:

Article

Incidence and risk factors of posttraumatic epilepsy following pediatric traumatic brain injury: A systematic review and meta‐analysis.

Published in:

Epilepsia (Series 4), 2022, v. 63, n. 11, p. 2802, doi. 10.1111/epi.17398

By:

Mariajoseph, Frederick P.;
Chen, Zhibin;
Sekhar, Praba;
Rewell, Sarah S.;
O'Brien, Terence J.;
Antonic‐Baker, Ana;
Semple, Bridgette D.

Publication type:

Article

An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats.

Published in:

Epilepsia (Series 4), 2019, v. 60, n. 10, p. 2023, doi. 10.1111/epi.16329

By:

Leung, Wai Lam;
Casillas‐Espinosa, Pablo;
Sharma, Pragati;
Perucca, Piero;
Powell, Kim;
O'Brien, Terence J.;
Semple, Bridgette D.

Publication type:

Article

Regulation of Microglial Signaling by Lyn and SHIP-1 in the Steady-State Adult Mouse Brain.

Published in:

Cells (2073-4409), 2023, v. 12, n. 19, p. 2378, doi. 10.3390/cells12192378

By:

Chu, Erskine;
Mychasiuk, Richelle;
Tsantikos, Evelyn;
Raftery, April L.;
L'Estrange-Stranieri, Elan;
Dill, Larissa K.;
Semple, Bridgette D.;
Hibbs, Margaret L.

Publication type:

Article

Pre-existing Toxoplasma gondii infection increases susceptibility to pentylenetetrazol-induced seizures independent of traumatic brain injury in mice.

Published in:

Frontiers in Molecular Neuroscience, 2023, v. 15, p. 1, doi. 10.3389/fnmol.2022.1079097

By:

Baker, Tamara L.;
Uboldi, Alessandro D.;
Tonkin, Christopher J.;
Wright, David K.;
Vo, Anh;
Wilson, Trevor;
Mychasiuk, Richelle;
McDonald, Stuart J.;
Semple, Bridgette D.;
Mujun Sun;
Shultz, Sandy R.

Publication type:

Article

Modelling lung infection with Klebsiella pneumoniae after murine traumatic brain injury.

Published in:

Journal of Neuroinflammation, 2024, v. 21, p. 1, doi. 10.1186/s12974-024-03093-9

By:

Shad, Ali;
Rewell, Sarah S. J.;
Macowan, Matthew;
Gandasasmita, Natasha;
Wang, Jiping;
Chen, Ke;
Marsland, Ben;
O'Brien, Terence J.;
Li, Jian;
Semple, Bridgette D.

Publication type:

Article

A pre-existing Toxoplasma gondii infection exacerbates the pathophysiological response and extent of brain damage after traumatic brain injury in mice.

Published in:

Journal of Neuroinflammation, 2024, v. 21, n. 1, p. 1, doi. 10.1186/s12974-024-03014-w

By:

Baker, Tamara L.;
Wright, David K.;
Uboldi, Alessandro D.;
Tonkin, Christopher J.;
Vo, Anh;
Wilson, Trevor;
McDonald, Stuart J.;
Mychasiuk, Richelle;
Semple, Bridgette D.;
Sun, Mujun;
Shultz, Sandy R.

Publication type:

Article

Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries.

Published in:

Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-18643-5

By:

Dill, Larissa K.;
Sims, Natalie A.;
Shad, Ali;
Anyaegbu, Chidozie;
Warnock, Andrew;
Mao, Yilin;
Fitzgerald, Melinda;
Semple, Bridgette D.

Publication type:

Article

Long-Term Anesthetic-Dependent Hypoactivity after Repetitive Mild Traumatic Brain Injuries in Adolescent Mice.

Published in:

Developmental Neuroscience, 2016, v. 38, n. 3, p. 220, doi. 10.1159/000448089

By:

Semple, Bridgette D.;
Sadjadi, Raha;
Carlson, Jaclyn;
Chen, Yiran;
Xu, Duan;
Ferriero, Donna M.;
Noble-Haeusslein, Linda J.

Publication type:

Article

Traumatic Injury to the Immature Frontal Lobe: A New Murine Model of Long-Term Motor Impairment in the Absence of Psychosocial or Cognitive Deficits.

Published in:

Developmental Neuroscience, 2013, v. 35, n. 6, p. 474, doi. 10.1159/000355874

By:

Chen, Chien-Yi;
Noble-Haeusslein, Linda J.;
Ferriero, Donna;
Semple, Bridgette D.

Publication type:

Article

Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice.

Published in:

PLoS ONE, 2016, v. 11, n. 1, p. 1, doi. 10.1371/journal.pone.0146886

By:

Bajwa, Nikita M.;
Halavi, Shina;
Hamer, Mary;
Semple, Bridgette D.;
Noble-Haeusslein, Linda J.;
Baghchechi, Mohsen;
Hiroto, Alex;
Hartman, Richard E.;
Obenaus, André

Publication type:

Article

Immune Challenges and Seizures: How Do Early Life Insults Influence Epileptogenesis?

Published in:

Frontiers in Pharmacology, 2020, p. 1, doi. 10.3389/fphar.2020.00002

By:

Semple, Bridgette D.;
Dill, Larissa K.;
O'Brien, Terence J.

Publication type:

Article

Progesterone treatment reduces neuroinflammation, oxidative stress and brain damage and improves long-term outcomes in a rat model of repeated mild traumatic brain injury.

Published in:

2015

By:

Webster, Kyria M.;
Wright, David K.;
Mujun Sun;
Semple, Bridgette D.;
Ozturk, Ezgi;
Stein, Donald G.;
O'Brien, Terence J.;
Shultz, Sandy R.;
Sun, Mujun

Publication type:

journal article

CCL2 modulates cytokine production in cultured mouse astrocytes.

Published in:

Journal of Neuroinflammation, 2010, v. 7, p. 67, doi. 10.1186/1742-2094-7-67

By:

Semple, Bridgette D.;
Frugier, Tony;
Morganti-Kossmann, M. Cristina

Publication type:

Article

'Would you take a drug for this?': attitudes by individuals with traumatic brain injury towards medication to improve social functioning.

Published in:

Brain Impairment (CSIRO Publishing), 2025, v. 26, n. 1, p. 1, doi. 10.1071/IB24051

By:

Reeder, Sandra;
Sewell, Katherine;
Lannin, Natasha A.;
Smith, Madeleine J.;
Semple, Bridgette D.

Publication type:

Article

Shaking into deficits: investigating behavioural and neuropathological outcomes associated with a novel preclinical model of infant abusive head trauma.

Published in:

Acta Neuropathologica Communications, 2025, v. 13, n. 1, p. 1, doi. 10.1186/s40478-025-02029-5

By:

Harris, Sydney A.;
Sgro, Marissa;
Salberg, Sabrina;
Li, Crystal;
Vlassopoulos, Elaina;
Smith, Madeleine;
Semple, Bridgette D.;
Chinnery, Holly R.;
Mychasiuk, Richelle

Publication type:

Article

Cover Image, Volume 527, Issue 5.

Published in:

Journal of Comparative Neurology, 2019, v. 527, n. 6, p. C1, doi. 10.1002/cne.24651

By:

Webster, Kyria M.;
Sun, Mujun;
Crack, Peter J.;
O'Brien, Terence J.;
Shultz, Sandy R.;
Semple, Bridgette D.

Publication type:

Article

Age‐dependent release of high‐mobility group box protein‐1 and cellular neuroinflammation after traumatic brain injury in mice.

Published in:

Journal of Comparative Neurology, 2019, v. 527, n. 6, p. 1102, doi. 10.1002/cne.24589

By:

Webster, Kyria M.;
Sun, Mujun;
Crack, Peter J.;
O'Brien, Terence J.;
Shultz, Sandy R.;
Semple, Bridgette D.

Publication type:

Article

Book Review: Posttraumatic Epilepsy: Basic and Clinical Aspects.

Published in:

2024

By:

Semple, Bridgette D.;
Reid, Christopher A.

Publication type:

Book Review

High mobility group box 1 (HMGB1) as a novel frontier in epileptogenesis: from pathogenesis to therapeutic approaches.

Published in:

Journal of Neurochemistry, 2019, v. 151, n. 5, p. 542, doi. 10.1111/jnc.14663

By:

Paudel, Yam Nath;
Semple, Bridgette D.;
Jones, Nigel C.;
Othman, Iekhsan;
Shaikh, Mohd. Farooq

Publication type:

Article

Temporal proteomics of human cerebrospinal fluid after severe traumatic brain injury.

Published in:

Journal of Neuroinflammation, 2022, v. 19, n. 1, p. 1, doi. 10.1186/s12974-022-02654-0

By:

Shultz, Sandy R.;
Shah, Anup D.;
Huang, Cheng;
Dill, Larissa K.;
Schittenhelm, Ralf B.;
Morganti-Kossmann, M. Cristina;
Semple, Bridgette D.

Publication type:

Article

Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation.

Published in:

2021

By:

Chu, Erskine;
Mychasiuk, Richelle;
Hibbs, Margaret L.;
Semple, Bridgette D.

Publication type:

journal article

Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets.

Published in:

Brain Sciences (2076-3425), 2019, v. 9, n. 11, p. 318, doi. 10.3390/brainsci9110318

By:

Sharma, Rishabh;
Leung, Wai Lam;
Zamani, Akram;
O'Brien, Terence J.;
Casillas Espinosa, Pablo M.;
Semple, Bridgette D.

Publication type:

Article

Editorial: Long-term consequences of pediatric traumatic brain injury: Improved understanding to help young patients survive and thrive.

Published in:

Frontiers in Neurology, 2022, v. 13, p. 1, doi. 10.3389/fneur.2022.1011998

By:

Huh, Jimmy;
Semple, Bridgette D.;
Raghupathi, Ramesh

Publication type:

Article

Challenging the dogma that 'rest is best' after concussion (Commentary on Mychasiuk et al.).

Published in:

European Journal of Neuroscience, 2016, v. 44, n. 7, p. 2405, doi. 10.1111/ejn.13346

By:

Semple, Bridgette D.

Publication type:

Article

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments.

Published in:

Acta Neuropathologica, 2019, v. 137, n. 5, p. 731, doi. 10.1007/s00401-018-1944-6

By:

Morganti-Kossmann, Maria Cristina;
Semple, Bridgette D.;
Hellewell, Sarah C.;
Bye, Nicole;
Ziebell, Jenna M.

Publication type:

Article

Hospital‐acquired infections as a risk factor for post‐traumatic epilepsy: A registry‐based cohort study.

Published in:

Epilepsia Open, 2024, v. 9, n. 4, p. 1333, doi. 10.1002/epi4.12957

By:

Chen, Zhibin;
Laing, Joshua;
Li, Jian;
O'Brien, Terence J.;
Gabbe, Belinda J.;
Semple, Bridgette D.

Publication type:

Article

Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury.

Published in:

Brain: A Journal of Neurology, 2025, v. 148, n. 4, p. 1062, doi. 10.1093/brain/awae350

By:

Lisi, Ilaria;
Moro, Federico;
Mazzone, Edoardo;
Marklund, Niklas;
Pischiutta, Francesca;
Kobeissy, Firas;
Mao, Xiang;
Corrigan, Frances;
Helmy, Adel;
Nasrallah, Fatima;
Pietro, Valentina Di;
Ngwenya, Laura B;
Portela, Luis V;
Semple, Bridgette D;
Schneider, Andrea L C;
Arrastia, Ramon Diaz;
Menon, David K;
Smith, Douglas H;
Wellington, Cheryl;
Loane, David J

Publication type:

Article

A systemic immune challenge to model hospital-acquired infections independently regulates immune responses after pediatric traumatic brain injury.

Published in:

2021

By:

Sharma, Rishabh;
Zamani, Akram;
Dill, Larissa K.;
Sun, Mujun;
Chu, Erskine;
Robinson, Marcus J.;
O'Brien, Terence J.;
Shultz, Sandy R.;
Semple, Bridgette D.

Publication type:

journal article

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?

Published in:

2020

By:

Baker, Tamara L.;
Sun, Mujun;
Semple, Bridgette D.;
Tyebji, Shiraz;
Tonkin, Christopher J.;
Mychasiuk, Richelle;
Shultz, Sandy R.

Publication type:

journal article

Early Gelatinase Activity Is Not a Determinant of Long-Term Recovery after Traumatic Brain Injury in the Immature Mouse.

Published in:

PLoS ONE, 2015, v. 10, n. 11, p. 1, doi. 10.1371/journal.pone.0143386

By:

Semple, Bridgette D.;
Noble-Haeusslein, Linda J.;
Gooyit, Major;
Tercovich, Kayleen G.;
Peng, Zhihong;
Nguyen, Trung T.;
Schroeder, Valerie A.;
Suckow, Mark A.;
Chang, Mayland;
Raber, Jacob;
Trivedi, Alpa

Publication type:

Article

Sociosexual and Communication Deficits after Traumatic Injury to the Developing Murine Brain.

Published in:

PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0103386

By:

Semple, Bridgette D.;
Noble-Haeusslein, Linda J.;
Jun Kwon, Yong;
Sam, Pingdewinde N.;
Gibson, A. Matt;
Grissom, Sarah;
Brown, Sienna;
Adahman, Zahra;
Hollingsworth, Christopher A.;
Kwakye, Alexander;
Gimlin, Kayleen;
Wilde, Elisabeth A.;
Hanten, Gerri;
Levin, Harvey S.;
Schenk, A. Katrin

Publication type:

Article

Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury.

Published in:

Scientific Reports, 2016, p. 28713, doi. 10.1038/srep28713

By:

Wright, David K.;
Trezise, Jack;
Kamnaksh, Alaa;
Bekdash, Ramsey;
Johnston, Leigh A.;
Ordidge, Roger;
Semple, Bridgette D.;
Gardner, Andrew J.;
Stanwell, Peter;
O'Brien, Terence J.;
Agoston, Denes V.;
Shultz, Sandy R.

Publication type:

Article

Repetitive concussions in adolescent athletes - translating clinical and experimental research into perspectives on rehabilitation strategies.

Published in:

Frontiers in Neurology, 2015, v. 6, p. 1, doi. 10.3389/fneur.2015.00069

By:

Semple, Bridgette D.;
Sangmi Lee;
Sadjadi, Raha;
Fritz, Nora;
Carlson, Jaclyn;
Griep, Carrie;
Ho, Vanessa;
Jang, Patrice;
Lamb, Annick;
Popolizio, Beth;
Saini, Sonia;
Bazarian, Jeffrey J.;
Prins, Mayumi L.;
Ferriero, Donna M.;
Basso, D. Michele;
Noble-Haeusslein, Linda J.

Publication type:

Article

Imaging of cerebral blood flow in patients with severe traumatic brain injury in the neurointensive care.

Published in:

Frontiers in Neurology, 2014, v. 5, p. 1, doi. 10.3389/fneur.2014.00114

By:

Rostami, Elham;
Engquist, Henrik;
Enblad, Per;
Villapol, Sonia;
Semple, Bridgette D.

Publication type:

Article

Research priorities for diagnosis, prognosis, and rehabilitation following concussion: results from a national survey of Australian health professionals.

Published in:

Disability & Rehabilitation, 2025, v. 47, n. 9, p. 2258, doi. 10.1080/09638288.2024.2391108

By:

Smith, Madeleine J.;
Major, Brendan P.;
Cowen, Gill;
Fini, Natalie A.;
Grant, Samantha;
Kramer, Sharon F.;
Hamilton, Megan J.;
Lawlor, Kate;
Patterson, Brooke;
Salberg, Sabrina;
Shultz, Sandy R.;
Semple, Bridgette D.;
Sewell, Katherine;
Trevena-Peters, Jessica;
Lannin, Natasha A.;
Mychasiuk, Richelle

Publication type:

Article

Regulation of microglial responses after pediatric traumatic brain injury: exploring the role of SHIP-1.

Published in:

Frontiers in Neuroscience, 2023, p. 01, doi. 10.3389/fnins.2023.1276495

By:

Erskine Chu;
Mychasiuk, Richelle;
Green, Tabitha R. F.;
Zamani, Akram;
Dill, Larissa K.;
Sharma, Rishabh;
Raftery, April L.;
Tsantikos, Evelyn;
Hibbs, Margaret L.;
Semple, Bridgette D.

Publication type:

Article

White matter changes following experimental pediatric traumatic brain injury: an advanced diffusion-weighted imaging investigation.

Published in:

Brain Imaging & Behavior, 2021, v. 15, n. 6, p. 2766, doi. 10.1007/s11682-020-00433-0

By:

Zamani, Akram;
O'Brien, Terence J.;
Kershaw, Jeff;
Johnston, Leigh A.;
Semple, Bridgette D.;
Wright, David K.

Publication type:

Article

Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2−/− mice.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2010, v. 30, n. 4, p. 769, doi. 10.1038/jcbfm.2009.262

By:

Semple, Bridgette D.;
Bye, Nicole;
Rancan, Mario;
Ziebell, Jenna M.;
Morganti-Kossmann, M. Cristina

Publication type:

Article

Role of chemokines in CNS health and pathology: a focus on the CCL2/CCR2 and CXCL8/CXCR2 networks.

Published in:

Journal of Cerebral Blood Flow & Metabolism, 2010, v. 30, n. 3, p. 459, doi. 10.1038/jcbfm.2009.240

By:

Semple, Bridgette D.;
Kossmann, Thomas;
Morganti-Kossmann, Maria Cristina

Publication type:

Article

Inflammation in epileptogenesis after traumatic brain injury.

Published in:

2017

By:

Webster, Kyria M.;
Mujun Sun;
Crack, Peter;
O'Brien, Terence J.;
Shultz, Sandy R.;
Semple, Bridgette D.;
Sun, Mujun

Publication type:

journal article